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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence
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Inhibiting acute injury–induced senescence mediated by TGFβ signaling in regenerative epithelium improves liver regeneration.
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“Similarly, transforming growth factor-β improves liver regeneration on injury by blocking paracrine senescence in neighbouring uninjured hepatocytes188.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [188]
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“While the role of paracrine senescence in cancer is yet undefined, it has been found to contribute to liver dysfunction upon acetaminophen overdose (Bird et al. 2018).”
From Senescence and the SASP: many therapeutic avenues (2020) · cites this paper as Bird et al. 2018
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“Other times, individual SASP components, such as TGF-β, might be pinpointed as disease drivers and targeting them specifically might be appropriate (Bird et al. 2018).”
From Senescence and the SASP: many therapeutic avenues (2020) · cites this paper as Bird et al. 2018
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Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · cited 3×
“M. I. Love, W. Huber, S. Anders, Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.”
InfluentialFast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1×
“Macrophages are a known source of TGF ligands, particularly in the context of tissue injury (32).”
BackgroundCellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · cited 1×
“These findings contrast with previous reports in which senescence after injury in other organs may facilitate regeneration (37) and limit fibrosis after liver injury (11).”
Self-citationSenescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., & Lowe, S. W. (2007) · Nature · doi:10.1038/nature05529 · Cited by 2,473 · cited 1×
“Macrophage recruitment in liver injury shares similarities to the p21-dependent recruitment observed during hepatic oncogene-induced senescence (40) and the clearance of early hepatocellular carcinoma (13).”
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 17×
“An OIS signature was defined by the top 100 up-regulated genes in the IMR90 ER:RAS model (15).”
InfluentialSelf-citationEarly indicators of prognosis in fulminant hepatic failure
O'Grady, J. G., Alexander, G. J. M., Hayllar, K. M., & Williams, R. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90081-4 · Cited by 2,085 · cited 1×
“However, once acute liver failure of a defined clinical severity is established, no specific medical therapies exist, recovery is unlikely, and, unless liver transplantation occurs, death usually ensues (5).”
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027 · cited 3×
“SASP may also modulate fibrosis and regeneration in response to acute tissue injury (11, 16, 17).”
Research works printed but not linked: 1
- 10.1016/j.cell.2008.06.049 · DOI · Paper page
Cited by
Sorted by citations
Items 101–200 of 264
Zhang, N., Han, Z., Zhang, R., Liu, L., Gao, Y., Li, J., & Yan, M. (2024) · Nutrients · doi:10.3390/nu16121859 · Cited by 25
“Acute liver injury (ALI) caused by drugs, alcohol, viruses, diet, or other elements has turned into a crucial reason for acute liver failure (ALF) worldwide [1].”
BackgroundWang, Q., Peng, X., Chen, Y., Tang, X., Qin, Y., He, M., Chen, W., & Chen, H. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.02.043 · Cited by 24
Bhushan, B., Gunewardena, S., Edwards, G., & Apte, U. M. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111186 · Cited by 24
Self-citationGallanis, G. T., Sharif, G. M., Schmidt, M. O., Friedland, B., Battina, R., Rahhal, R., Davis, J. W., Khan, I., Wellstein, A., & Riegel, A. T. (2023) · Cancers · doi:10.3390/cancers15061908 · Cited by 25
“In models of acetaminophen-induced liver injury, small-molecule inhibitors of TGF-β receptor type 1 improved survival and enhanced tissue recovery after acute hepatotoxicity by blocking TGF-β-induced paracrine senescence [65].”
BackgroundLi, B., Huang, Y., Bao, J., Xu, Z., Yan, X., & Zou, Q. (2023) · Small · doi:10.1002/smll.202304675 · Cited by 24
Cellular Senescence, Inflammaging and Cardiovascular Disease
Zanders, L., Arifaj, D., Wagner, J. U. G., & Dimmeler, S. (2026) · Immunological Reviews · doi:10.1111/imr.70084 · Cited by 27
“TGF-β plays a central role in the SASP-mediated induction of senescence in embryogenic senescence, as well as postnatal senescence in the liver and the tumor microenvironment [50, 51].”
Wu, H., Kim, T. H., Kim, A., Koo, J. H., Joo, M. S., & Kim, S. G. (2019) · Hepatology Communications · doi:10.1002/hep4.1415 · Cited by 22
“7E). aCetaminopHen-inDuCeD liVeR inJuRy moDel Because acetaminophen (APAP) overdose highly contributes to drug-induced liver injury in human, and APAP-induced liver injury was associated with activation of TGF-β signaling,(19,20) we assessed whether inhibition of TGF-β signaling ameliorates APAPinduced apoptosis.”
BackgroundMethodInfluentialModulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease
Pedroza-Díaz, J., Arroyave-Ospina, J. C., Salas, S. S., & Moshage, H. J. (2022) · Antioxidants · doi:10.3390/antiox11050975 · Cited by 27
“When TGF-β signaling is inhibited in mice, senescence is impeded, regeneration is accelerated and survival is improved [45].”
BackgroundNavigating the complex role of senescence in liver disease
Li, Q.-J., & Wang, L. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003439 · Cited by 24
The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging
Lavarti, R., Alvarez-Diaz, T., Marti, K., Kar, P., & Raju, R. P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102760 · Cited by 21
Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
Heldring, M. M., Shaw, A. H., & Beltman, J. B. (2022) · npj Systems Biology and Applications · doi:10.1038/s41540-022-00238-5 · Cited by 23
“12–15, in which the time-dependent parameter values were modified to match the time units of our spatial model (see Supplementary Table 5): dP53 dt ¼ ksp53 þ kdp P53p kp P53 C kdp53 P53 kdp53mdm2 P53 MDM2; (12) dP53p dt ¼ kp P53 C kdp P53p kdp53p P53p kdp53pmdm2 P53p MDM2; (13) dMDM2 dt ¼ ksmdm2 þ ksmdm2 p53p P534p Km…”
InfluentialIsolation of senescent cells by iodixanol (OptiPrep) density gradient‐based separation
Kovačovicova, K. L., & Vinciguerra, M. (2019) · Cell Proliferation · doi:10.1111/cpr.12674 · Cited by 20
Chen, G., Hu, X., Huang, Y., Xiang, X., Pan, S., Chen, R., & Xu, X. (2023) · MedComm · doi:10.1002/mco2.444 · Cited by 22
Bhushan, B., & Apte, U. M. (2020) · Gene Expression · doi:10.3727/105221620x15901763757677 · Cited by 20
Self-citationTsuboi, A., Khanom, H., Kawabata, R., Matsui, T., Murakami, S., & Ito, T. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103640 · Cited by 19
“It has also been reported that inhibition of TGF-β suppresses cellular senescence [47], suggesting that TGF-β promotes surrounding cellular senescence.”
The crosstalk between cellular reprogramming and senescence in aging and regeneration
Chiche, A., Chen, C., & Li, H. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111005 · Cited by 21
Cellular senescence in vivo: From cells to tissues to pathologies
Kumar, A., Bano, D., & Ehninger, D. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111308 · Cited by 19
Common mechanisms in pediatric acute liver failure
Mann, J. P., Lenz, D., Stamataki, Z., & Kelly, D. A. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.11.006 · Cited by 21
Smith, A. R., Rizvi, F., Everton, E., Adeagbo, A., Wu, S., Tam, Y., Muramatsu, H., Pardi, N., Weissman, D., & Gouon-Evans, V. (2024) · Nature Communications · doi:10.1038/s41467-024-49332-8 · Cited by 18
Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice
Gee, L. M. V., Barron-Millar, B., Leslie, J., Richardson, C., Zaki, M. Y. W., Luli, S., Burgoyne, R. A., Cameron, R. I. T., Smith, G. R., Brain, J. G., et al. (2023) · The American Journal of Pathology · doi:10.1016/j.ajpath.2022.09.005 · Cited by 18
Self-citationRole of cellular senescence in hepatic diseases (Review)
Xing, Y., & Zhu, J. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5623 · Cited by 19
“Mechanistically, liver macrophages promote bystander cell senescence through TGF‑ β 1 signaling, thereby accelerating aging‑related pathologies (such as fibrosis) during hepatic injury (57).”
Fan, L., Tang, Q., Wang, Y., Sun, H., Li, G., Yang, Y., Zhu, H., Liu, Z., Wang, H., Wang, H., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.008 · Cited by 21
Stavropoulos, A., Divolis, G., Manioudaki, M., Gavriil, A., Kloukina, I., Perrea, D. N., Sountoulidis, A., Ford, E., Doulou, A., Apostolidou, A. C., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abn4395 · Cited by 18
Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver
Huppert, S. S., & Schwartz, R. E. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032822-094134 · Cited by 21
Flanagan, D. J., Amirkhah, R., Vincent, D. F., Gündüz, N., Gentaz, P., Cammareri, P., McCooey, A. J., McCorry, A. M. B., Fisher, N. C., Belnoue-Davis, H. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35134-3 · Cited by 21
Self-citationInflammatory Network of Liver Fibrosis and How It Can Be Targeted Therapeutically
Lowe, K., Tanase, C. E., Maghami, S., Fisher, L. E., & Ghaemmaghami, A. M. (2023) · Immuno · doi:10.3390/immuno3040023 · Cited by 19
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure
Meseguer-Ripolles, J., Lucendo‐Villarin, B., Tucker, C. S., Ferreira-González, S., Homer, N. Z. M., Wang, Y., Lewis, P. J. S., Toledo, E. M., Mellado-Gomez, E., Simpson, J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102552 · Cited by 18
Self-citationRegeneration and Recovery after Acetaminophen Hepatotoxicity
Bhushan, B., & Apte, U. M. (2023) · Livers · doi:10.3390/livers3020021 · Cited by 17
“Other doses of APAP such as 350, 450, and 525 mg/kg of APAP have also been utilized for investigating liver regeneration [23].”
BackgroundInfluentialSelf-citationPhosphate and Cellular Senescence
Hu, M. C., & Moe, O. W. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-91623-7_7 · Cited by 18
Senescence, Aging and Disease Throughout the Gastrointestinal System
Ferreira-González, S., Matsumoto, T., Hara, E., & Forbes, S. J. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.06.010 · Cited by 18
Self-citationCellular Senescence and Ageing
Reed, R., & Miwa, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_7 · Cited by 16
Cen, Y., Lou, G., Qi, J., Li, M., Zheng, M., & Liu, Y. (2023) · Antioxidants · doi:10.3390/antiox12010158 · Cited by 16
Overview of Innate Immune Cell Landscape in Liver Aging
Lin, Y., Li, Q., Liang, G., Xiao, N., Yang, J., Yang, X. M., Zhang, H., Zhang, C., & Liu, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010181 · Cited by 19
McMillin, M., Grant, S. M., Frampton, G. A., Petrescu, A. D., Williams, E., Jefferson, B., & DeMorrow, S. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz122 · Cited by 16
“Transforming growth factor beta 1 has been shown to be a primary driver of hepatic fibrosis, though recently other researchers and ourselves have shown TGFb1 is upregulated during ALF in mice, indicating it may have a direct role in acute liver injury (Bird et al., 2018; McMillin et al., 2014).”
BackgroundInfluentialRubio‐Tomás, T., Aguado, D. M., Blaya, D., Ariño, S., Aguilar‐Bravo, B., de la Torre, R. A. M. G., Miravet-Marti, M., Ferrer‐Lorente, R., Zanatto, L., Xu, Z., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101478 · Cited by 15
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
Li, J., Wang, S., Yuan, J., Mao, X., Wang, X., Zhang, L., Dong, Q., Chen, Z., Wang, Y., & Tang, N. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.002 · Cited by 19
Kirchner, V. A., Badshah, J. S., Hong, S. K., Martinez, O. M., Pruett, T. L., & Niedernhofer, L. J. (2023) · Transplantation · doi:10.1097/tp.0000000000004838 · Cited by 15
Brain sensing of metabolic state regulates circulating monocytes
Cavalcanti‐de‐Albuquerque, J. P., Hunter, J., Domingues, R. G., Harno, E., Worth, A. A., Liguori, F. M., D'Alessio, A., Aviello, G., Bechtold, D. A., White, A. E., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adr3226 · Cited by 16
Rodrigo‐Torres, D., Kilpatrick, A. M., Ferreira-González, S., Aird, R. E., Atkinson, S. R., Gadd, V. L., Man, T. Y., Tyson, L. D., Dhondalay, G. K., Vergis, N., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-334094 · Cited by 17
Self-citationAging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship
Chen, C., & Wang, L. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1133-7 · Cited by 15
Therapeutic targets for liver regeneration after acute severe injury: a preclinical overview
Kojima, H., Nakamura, K., & Kupiec‐Weglinski, J. W. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1712361 · Cited by 13
Regeneration in acute-on-chronic liver failure – the phantom lost its camouflage
Engelmann, C., Mehta, G., & Tacke, F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.01.003 · Cited by 14
Gadd, V. L., Ferreira-González, S., Man, T. Y., Kilpatrick, A. M., Aird, R. E., Smith, I. P., Rodrigo‐Torres, D., Kurian, D., Hallett, J. M., Ashmore‐Harris, C., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2024.12.039 · Cited by 14
Self-citationChronic liver diseases: From development to novel pharmacological therapies: IUPHAR Review 37
Borrello, M. T., & Mann, D. A. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15853 · Cited by 15
“Hepatocyte senescence not only limits the regenerative capacity of the liver (Bird et al., 2018) but can also promotes inflammation and fibrosis through the senescence-associated secretory phenotype (SASP), which comprises a plethora of cytokines, chemokines, angiogenic factors and profibrogenic…”
BackgroundBandi, S., Tchaikovskaya, T. L., & Gupta, S. K. (2019) · Differentiation · doi:10.1016/j.diff.2019.01.005 · Cited by 13
Moradnezhadi, H., Aliabadi, V., Gholamrezai, S., & Mahdizade, H. (2023) · Local Environment · doi:10.1080/13549839.2022.2155940 · Cited by 12
“Thus, many researchers have studied other variables that are not in this framework and argue that including other variables can improve the prediction ability of the model (Ataei et al. 2021; Aliabadi, Gholamrezai, and Ataei 2020; Gholamrezai, Aliabadi, and Ataei 2021; Bird et al., 2018).”
BackgroundGVHD targets organoid-forming bile duct stem cells in a TGF-β–dependent manner
Hasegawa, Y., Hashimoto, D., Zhang, Z., Miyajima, T., Saito, Y., Li, W., Kikuchi, R., Senjo, H., Sekiguchi, T., Tateno, T., et al. (2024) · Blood · doi:10.1182/blood.2023023060 · Cited by 12
Mogadem, A., Naqvi, A., Al-Mamary, M., Ahmad, W. A., Jemon, K. B., & El-Alfy, S. H. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116022 · Cited by 12
Liver regeneration: unraveling the molecular mechanisms and clinical application
Wang, N., Guo, M., Zhang, C., Jiang, R., Bi, J., Sun, J., & Liu, B. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07412-3 · Cited by 15
“Inhibition of TGF-βR1 or TGF-βR2 signaling prolongs hepatocyte proliferation and enhances liver regeneration after acute injury [102, 104].”
Chemically induced revitalization of damaged hepatocytes for regenerative liver repair
Lin, P., Bai, Y., Nian, X.-X., Chi, J., Chen, T., Zhang, J., Zhang, W., Zhou, B., Liu, Y., & Zhao, Y. (2023) · iScience · doi:10.1016/j.isci.2023.108532 · Cited by 11
“Hepatocellularsenescencehasbeenproposedtodecreasehepaticregenerationinmodelsofsevereliverdamage,includingextended hepatectomy, 29 acetaminophen treatment, 30 and cirrhosis.”
Wang, X., Liu, H., Wang, Y., Wang, P., Yi, Y., Lin, Y., & Li, X. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16538 · Cited by 13
Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair
Gupta, P., Sharma, Y., Viswanathan, P., & Gupta, S. K. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154946 · Cited by 11
Frampton, G. A., Reddy, P., Jefferson, B., Ali, M., Khan, D., & McMillin, M. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115323 · Cited by 11
“In addition, treatment of mice with the TGFβ receptor 1 inhibitor AZ12601011 during APAP-induced hepatotoxicity reduced both mortality and hepatic cellular senescence, giving further support for the deleterious role of TGFβ1 during this disease state (Bird et al., 2018).”
BackgroundWang, E., Liao, Z., Wang, L., Liao, Y., Xu, X., Liu, P., Wang, X., Hou, J., Jiang, H., Wu, X., et al. (2021) · Parasitology · doi:10.1017/s0031182021000287 · Cited by 11
Blunting senescence boosts liver regenerationPreprint
Birch, J., & Gil, J. (2020) · Genes & Development · doi:10.1101/gad.337394.120 · Cited by 11
“(2020) corroborate past studies demonstrating that hepatocyte and nonparenchymal cell senescence occurs following acute liver damage, leading to impaired regeneration (Krizhanovsky et al. 2008; Bird et al. 2018).”
BackgroundResultCharacterizing primary and secondary senescence in vivo
Sogabe, Y., Shibata, H., Kabata, M., Tanaka, A., Mitsunaga, K., Sunadome, K., Nakajima‐Koyama, M., Hirano, M., Nishida, E., Woltjen, K., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00917-y · Cited by 14
“Recent studies have uncovered that SASP factors, IL-1, transforming growth factor-β and Notch, can induce secondary senescence through paracrine or juxtracrine mechanisms 11,22,24,44 .”
InfluentialImpaired reciprocal regulation between SIRT6 and TGF‐β signaling in fatty liver
Xiang, X., Ohshiro, K., Zaidi, S., Yang, X., Bhowmick, K., Vegesna, A. K., Bernstein, D., Crawford, J. M., Mishra, B., Latham, P. S., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101518r · Cited by 11
Kim, K. W., Shin, Y. J., & Lee, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314690 · Cited by 11
Xiang, W., Wei, J., Lv, L., Yu, X., Xie, Y., Zhang, L., Lu, N., & Jiang, W. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2272287 · Cited by 10
“Acute liver injury (ALI) is a serious clinical syndrome characterised by the rapid onset of liver dysfunction, which generally leads to hepatic encephalopathy and multiorgan failure (Bird et al. 2018).”
Li, M., Qin, X., Furutani, Y., Inoue, I., Sekihara, S., Kagechika, H., & Kojima, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.026 · Cited by 10
Wang, A., Wang, J., Wu, J., Deng, X., & Zou, Y. (2019) · The Journal of Physiological Sciences · doi:10.1007/s12576-019-00666-9 · Cited by 10
“Anti-inflammatory therapy was shown to be beneficial for damaged liver tissues in animal studies and human clinical trials [5, 6].”
BackgroundGantier, M., Rispal, R., Fourrier, A., Ménoret, S., Delbos, F., Anegón, I., & Nguyen, T. H. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03673-9 · Cited by 9
“…that TGFβ1, which is known to inhibit hepatocyte proliferation after partial hepatectomy and to inhibit liver regeneration after APAP toxicity, is increased in untreated APAP-ALF mice but significantly decreased in GStemHep-treated APAP-ALF mice to a similar level to that of healthy mice [60].”
BackgroundZhang, Y., Qu, J., Luo, R., Jia, K., Fan, G., Li, F., Wu, R., Li, J., & Li, X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155923 · Cited by 10
Redefining senescence through hepatocyte fate changes in liver diseases
Umbaugh, D. S., Diehl, A. M., & Du, K. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.08.003 · Cited by 10
Sleep disorders are associated with acetaminophen-induced adverse reactions and liver injury.
Fan, X., Zhang, K., Wang, X.-Y., Zhang, X.-G., Zeng, L., Li, N., Han, Q., & Liu, Z.-W. (2021) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2020.111150 · Cited by 5
Loss of microRNA-21 protects against acetaminophen-induced hepatotoxicity in mice
Huffman, A. M., Syed, M., Rezq, S., Anderson, C. D., Cardozo, L. L. Y., & Romero, D. G. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03499-z · Cited by 9
“TGF-β inhibition has been shown to benefit liver regeneration in mice treated with APAP by reduced senescence and increased regeneration (Bird et al. 2018).”
BackgroundWilkinson, A. L., Hulme, S., Kennedy, J. I., Mann, E. R., Horn, P., Shepherd, E. L., Yin, K., Zaki, M. Y. W., Hardisty, G. R., Lu, W., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107966 · Cited by 10
Self-citationLi, S., Fu, X., Wang, J., Yang, H., Wang, D., Dong, X., Duan, Y., Wang, H., Yan, Y., & Si, W. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03934-7 · Cited by 8
“Hepatic stellate cells also produce large amounts of chemokines and cytokines, which links hepatic inflammation to fibro-genesis [30, 31].”
BackgroundWittke, C. I., Cheung, E. C., Athineos, D., Clements, N., Butler, L., Hughes, M., Morrison, V., Watt, D. M., Blyth, K., Vousden, K. H., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101397 · Cited by 8
Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation
Qoura, L. A., Churov, A. V., Maltseva, O. N., Ерусланова, К. А., & Zeng, G. (2026) · Biogerontology · doi:10.1007/s10522-026-10449-6 · Cited by 9
“…viral infection, alcohol exposure, or metabolic stress accelerates telomere erosion and DNA damage responses, producing widespread hepatocyte senescence in advanced chronic liver disease and contributing to impaired regeneration, fibrogenesis, and cirrhosis (Bird et al. 2018; Xing and Zhu 2025).”
Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury
Raith, J., Bachmann, M., Gonther, S., Stülb, H., Aghdassi, A. A., Pham, C. T. N., & Mühl, H. (2024) · Theranostics · doi:10.7150/thno.96092 · Cited by 9
“This observation should be relevant in the given context because transforming growth factor-β 1 likewise restrains regeneration in APAP-induced ALI [ 67 ] .”
BackgroundDong, Y., Kong, W.-N., & An, W. (2021) · Stem Cells · doi:10.1002/stem.3439 · Cited by 8
Humpton, T. J., Hock, A. K., Kiourtis, C., Donatis, M. D., Fercoq, F., Nixon, C., Bryson, S., Strathdee, D., Carlin, L. M., Bird, T. G., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abd9099 · Cited by 8
Self-citationGrowth differentiation factor 15 is dispensable for acetaminophen‐induced liver injury in mice
Jiang, P., Liu, Z., Fang, T., Zhang, Z., Zhang, Y., Wang, D., Little, P. J., Xu, S., & Weng, J. (2023) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13834 · Cited by 8
“A marked elevation of Gdf15 was also presented in the GEO database at 6 or 12 h after APAP overdose.(22,23) Previous studies indicated that GDF15 could alleviate NASH in mice(13) and inhibit LPS-induced acute liver injury with anti-inflammatory effects,(16) suggesting a beneficial effect of GDF15 on liver disease or l…”
BackgroundZhou, J., Huang, Y., Wang, W., Li, J., Hou, Y., Yi, Z., Yang, H., Hu, K., Zhu, Y., Wang, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202305925 · Cited by 8
Moreno‐Gonzalez, M., Hampton, K., Ruiz, P. S. B., Beasy, G., Nagies, F. S. P., Parker, A., Lazenby, J., Bone, C., Alava-Arteaga, A., Patel, M. P., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101159 · Cited by 8
Tian, T., Xue, Y., Song, Z., Jin-Smith, B., Barkin, J., Ottallah, M., Mannan, M., Zhirkova, A. M., Zhou, D., & Pi, L. (2025) · GeroScience · doi:10.1007/s11357-025-01952-8 · Cited by 7
“However, acute liver injury [6] or chronic conditions, especially alcohol exposure, disrupt this process, accelerating hepatocyte senescence and concomitant oxidative stress [7, 8].”
Decellularized diseased tissues: current state‐of‐the‐art and future directions
Li, X., Shan, J., Chen, X., Cui, H., Wen, G., & Yu, Y. (2023) · MedComm · doi:10.1002/mco2.399 · Cited by 8
Exploring the roles of non-coding RNAs in liver regeneration
Li, P., Ma, X., Huang, D., & Gu, X. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.04.003 · Cited by 8
Mitochondrial dysfunction attenuates rapid regeneration in livers with toxin-induced fibrosis
Li, Z., Liang, Y., Ying, H., Chen, M., He, X., Wang, Y., Tong, Y., & Cai, X. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-4639 · Cited by 7
“The development and progression of hepatic fibrosis negatively regulate hepatocyte self-renewal by remodeling the microenvironment, intercellular interactions, changes in lipid and energy metabolism, and activation of targeted pathways, which comprehensively impairs rapid regeneration in livers with fibrosis (11-13).”
BackgroundHe, K., Wei, D., Liu, Q., Liu, X., Zhou, D., Chen, S., Zhu, D., & Xu, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-78183-y · Cited by 6
“However, the conflicting results suggest that the role of cellular senescence in ALI is complex 5,24 .”
BackgroundSenescence prevents regeneration after acute liver injury
Thomas, H. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0068-8 · Cited by 6
Li, D., Liu, Y., Zhou, J., Chen, Y., Yang, C., Liu, H., Li, W., & You, J. (2023) · Inflammation · doi:10.1007/s10753-023-01841-2 · Cited by 6
“ALF is caused by various injuries, including viruses, toxins, and drugs; and in developing countries, viral hepatitis remains the most common cause of ALF, while in developed countries, hepatocyte injury caused by acetaminophen (APAP) is the main cause of ALF [4, 5].”
BackgroundChen, Y., Wu, Y., Sun, H., Zhang, H., Tang, D., Yuan, T., Chen, C., Huang, W., Zhou, X. Y., Wu, H., et al. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09954-6 · Cited by 8
Mechanism of liver regeneration: 20-year bibliometric analyses
Qi, J., Dai, Y., Sun, X., & Liu, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1190559 · Cited by 6
Regenerative human liver organoids (HLOs) in a pillar/perfusion plate for hepatotoxicity assaysPreprint
Shrestha, S., Acharya, P., Kang, S. Y., Vanga, M. G., Lekkala, V. K. R., Liu, J., Yang, Y. S., Joshi, P., & Lee, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.25.586638 · Cited by 5
“Nonetheless, the liver organoids used were at an immature expandable stage, thus less sensitive to metabolism-sensitive compounds such as acetaminophen.”
BackgroundKondo, T., Fujimoto, K., Fujiwara, K., Yumita, S., Ishino, T., Ogawa, K., Nakagawa, M., Iwanaga, T., Koroki, K., Kanzaki, H., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41425-6 · Cited by 5
“It is reported that acute severe liver injury impairs hepatocyte regeneration through the induction of senescence 25 , and RIPK3 and caspase-8 induced T-cell senescence 26 .”
Utilising an in silico model to predict outcomes in senescence-driven acute liver injury
Ashmore‐Harris, C., Antonopoulou, E., Aird, R. E., Man, T. Y., Finney, S. M., Speel, A. M., Lu, W., Forbes, S. J., Gadd, V. L., & Waters, S. L. (2024) · npj Regenerative Medicine · doi:10.1038/s41536-024-00371-1 · Cited by 5
“This has been demonstrated across a range of liver injury models including APAP, carbon tetrachloride (CCl 4 ) and dietary models inducing hepatocellular steatosis [via choline-de fi cient ethionine diet] or biliary-related liver injury [3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)] 2 .”
BackgroundMethodInfluentialSelf-citationZhang, J., Zhai, H., Yu, P., Shang, D., Mo, R., Li, Z., Wang, X., Lu, J. L., Xie, Q., & Xiang, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.924464 · Cited by 6
Li, K., Cui, Y. A., Zheng, X., Min, C., Zhang, J., Yan, Z., Ji, Y., Ge, F., Ji, H., & Zhu, F. (2024) · European journal of medical research · doi:10.1186/s40001-024-01827-2 · Cited by 5
“The lysate was centrifuged at 12,000 rpm for 10 min at 4 °C, and protein concentration in the supernatant was measured using the BCA assay (Catalog No. 23225, Thermo Fisher Scientific) [32].”
MethodCellular Senescence in Acute Liver Injury: What Happens to the Young Liver?
He, K., Zhou, D., Pu, Z., Chen, S., Shen, Y., Zhao, S., Qian, X., Hu, Q., Wu, X., Xie, Z., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0586 · Cited by 5
“Hepatocyte senescence is common in various ALIs, such as partial hepatectomy (PH) [51], viral hepatitis [52], drug-induced liver injury (DILI) [52, 53], radiation-induced liver disease (RILD) [54], hereditary tyrosinemia (HT) [55], and liver ischemia-reperfusion injury (IRI) [56].”
InfluentialPremature senescence of the liver in Alagille patients
Jannone, G., de Magnée, C., Tambucci, R., Evraerts, J., Ravau, J., Najimi, M., & Sokal, E. M. (2023) · PLoS ONE · doi:10.1371/journal.pone.0285019 · Cited by 5
“Jagged1 deficiency might also affect the transient increase in Notch1 and in the active Notch1 intracellular domain (N1ICD) necessary to induce the TGF-β1-rich primary SASP, TGF-β being an important promotor of the paracrine transmission of senescence in liver disease [6, 17, 18].”
BackgroundMitochondrial dysfunction-mediated hepatocyte senescence is involved in cholestatic liver injury
Tong, C.-C., Xue, Y.-F., He, X., Shen, X., Wang, H., & Chen, X. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.08.006 · Cited by 4
Two types of regenerative cell populations appear in acute liver injury
Aoyagi, T., Goya, T., Imoto, K., Azuma, Y., Hioki, T., Kohjima, M., Tanaka, M., Oda, Y., & Ogawa, Y. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102503 · Cited by 5
Azuma, I., Mizuno, T., Morita, K., Suzuki, Y., & Kusuhara, H. (2023) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqad111 · Cited by 3
Li, Q., Xu, Q., Shi, J., Dong, W., Jin, J., & Zhang, C. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000531 · Cited by 4
“[15,16] Notably, blocking of TGF-β and IL-11 accelerated liver repair and improved survival of mice treated with a lethal dose of APAP.”
BackgroundA systemic effect for liver senescence
Du, K., Umbaugh, D. S., Dutta, R. K., & Diehl, A. M. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01520-w · Cited by 4
Cardot‐Ruffino, V., Chauvet, V., Caligaris, C., Bertrand‐Chapel, A., Chuvin, N., Pommier, R. M., Valcourt, U., Vincent, D. F., Martel, S., Aires, S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-60272-3 · Cited by 4
Self-citationDong, W., Liu, J., Zhang, Y., Huang, M., Lin, M., & Peng, X.-M. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155391 · Cited by 3
Characterization of hepatic pathology during azoxymethane-induced acute liver failure
Bhattarai, S. M., Jhawer, A., Frampton, G. A., Troyanovskaya, E., DeMorrow, S., & McMillin, M. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i12.103952 · Cited by 3
“During acetaminophen-induced ALF, measures of hepato-cellular senescence and paracrine senescence were shown to be driven by macrophage-derived TGF β 1 signaling[12].”
Influential
Metadata
- Authors
- Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., Ferreira-Gonzalez, S., Cole, A. M., Hay, T., Simpson, K. J., Clark, W., Hedley, A., Clarke, M., Gentaz, P., Nixon, C., Bryce, S., Kiourtis, C., Sprangers, J., Nibbs, R. J. B., Van Rooijen, N., Bartholin, L., McGreal, S. R., Apte, U., Barry, S. T., Iredale, J. P., Clarke, A. R., Serrano, M., Roskams, T. A., Sansom, O. J., & Forbes, S. J.
- Affiliations
- MRC Centre for Regenerative Medicine (GB)
- Cancer Research UK Scotland Institute (GB)
- Spanish National Cancer Research Centre (ES)
- Universitair Ziekenhuis Leuven (BE)
- Medical Research Council (MRC) Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh EH16 4SB, UK.
- Cardiff University (GB)
- University of Glasgow (GB)
- Vrije Universiteit Medical Center, Department of Molecular Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, Netherlands.
- Lyon 1 Université (FR)
- University of Kansas Medical Center (US)
- AstraZeneca (United Kingdom) (GB)
- University of Bristol (GB)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Bird, Thomas G.
- Clarke, Alan R.
- ORCID
- Bird, Thomas G.
- Müller, Miryam
- Boulter, Luke
- Vincent, David F.
- Ridgway, Rachel A.
- Lopez-Guadamillas, Elena
- Lu, Wei-Yu
- Jamieson, Thomas
- Govaere, Olivier
- Campbell, Andrew D.
- Ferreira-Gonzalez, Sofía
- Cole, Alicia M.
- Hay, Trevor
- Clark, William
- Hedley, Ann
- Clarke, Mairi
- Gentaz, Pauline
- Nixon, Colin
- Bryce, Steven
- Kiourtis, Christos
- Nibbs, Robert J. B.
- Van Rooijen, Nico
- Bartholin, Laurent
- McGreal, Steven R.
- Apte, Udayan
- Barry, Simon T.
- Iredale, John P.
- Clarke, Alan R.
- Serrano, Manuel
- Roskams, Tania A.
- Sansom, Owen J.
- Forbes, Stuart J.
- Venue
- Science Translational Medicine
- Published
- 2018-08-15
- Volume
- 10
- Issue
- 454
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6420144
- OpenAlex
- W2887276938
- Cited by
- 261
- References
- 61
- Citations by year
- 2026: 16 · 2025: 34 · 2024: 47 · 2023: 42 · 2022: 31 · 2021: 28 · 2020: 37 · 2019: 24 · 2018: 2
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, other-oa)
- Bristol Research (University of Bristol) (publishedVersion, other-oa)
- Explore Bristol Research (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (R01 DK98414)
- Wellcome Trust (107492Z, 081604AIA)
- Medical Research Council (G1000868, G0900992)
- Cancer Research UK (2016-CRUK core running, A12481)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- acute liver injury, liver regeneration, hepatocyte senescence, paracrine senescence, TGF-β1, acetaminophen toxicity, p21, macrophages, hepatocyte proliferation, acute liver failure
- MeSH terms
- Animals, Disease Models, Animal, Humans, Liver, Liver Regeneration, Macrophages, Male, Mice, Inbred C57BL, Necrosis, Signal Transduction, Transforming Growth Factor beta, Cellular Senescence, Paracrine Communication, Hepatocytes, Cyclin-Dependent Kinase Inhibitor p21
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