The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
Abstract
Inhibiting a specific isoform of TGFβ augments the effectiveness of checkpoint blockade therapy in cancer treatment.
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In the citing paper
“Recent results in fact highlight the role of increased TGF-β signaling in intrinsic resistance to checkpoint blockade therapy21,23,38,71,145.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [71]
In the citing paper
“Finally, an antibody was developed that binds the TGF-β1 prosegment and prevents dissociation of mature TGF-β1 from LAP, thus keeping TGF-β1 latent without affecting TGF-β2 or TGF-β3 activation71.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [71]
In the citing paper
“However, in contrast to treatment with the TβRI kinase inhibitor LY2109761 or a pan-TGF-β antibody, antibody-mediated repression of TGF-β1 activation did not result in cardiac valvulopathies in a rat toxicity model71.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [71]
In the citing paper
“An underlying and predominant rationale focuses on the ability of TGF-β released and activated by cancer cells, stromal fibroblasts and/or immune cells to dampen anti-tumor immunity and responses to immunotherapeutics through direct and indirect mechanisms21,23,71,145,353,354.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [71]
In the citing paper
“treatments that combine TGF-β inhibition with immune checkpoint inhibition are likely to increase therapeutic efficacy21,23,71,145,346,362.”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [71]
In the citing paper
“Considering that TGF-β, CTLA-4 and PD-L1/PD-1 signaling act as parallel immunosuppressive pathways that repress cytotoxic T cell, NK cell and macrophage activities through distinct mechanisms”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [71]
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Metadata
- Authors
- Martin, C. J., Datta, A., Littlefield, C., Kalra, A., Chapron, C., Wawersik, S., Dagbay, K. B., Brueckner, C. T., Nikiforov, A., Danehy, F. T., Streich, F. C., Boston, C., Simpson, A., Jackson, J. W., Lin, S., Danek, N., Faucette, R. R., Raman, P., Capili, A. D., Buckler, A., Carven, G. J., & Schürpf, T.
- Affiliations
- Scholar Rock (United States) (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Martin, Constance J.
- Datta, Abhishek
- Schürpf, Thomas
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-03-25
- Volume
- 12
- Issue
- 536
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W3013319043
- Cited by
- 224
- References
- 68
- Citations by year
- 2026: 13 · 2025: 32 · 2024: 40 · 2023: 28 · 2022: 49 · 2021: 41 · 2020: 21
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- cancer immunotherapy, tumor immune microenvironment, T cells, immunosuppressive myeloid cells, cardiac valvulopathy
- MeSH terms
- Animals, Humans, Neoplasms, Signal Transduction, Transforming Growth Factor beta, CD8-Positive T-Lymphocytes, Cell Line, Tumor, Mice, Rats, Cardiotoxicity
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