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A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
Abstract
Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid mice that age prematurely.
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In the citing paper
“Moreover, intravenous injection of lentiviral vectors encoding Cas9/sg-Kat7 ameliorates hepatocyte senescence and liver aging, and extends lifespan in both normal and progeroid mice 60 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [60]
In the citing paper
“| | Mouse | Transgenic expression of OSKM | Longevity extension of HGPS progeroid mice. Preservation of hippocampal neuro- genesis and function in normal mice. Improved tissue repair immediately after injury or in a subsequent injury | 60 , 214 , 218 219 220 221 222 216”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [60]
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Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
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Self-citation
Metadata
- Authors
- Wang, W., Zheng, Y., Sun, S., Li, W., Song, M., Ji, Q., Wu, Z., Liu, Z., Fan, Y., Liu, F., Li, J., Esteban, C. R., Wang, S., Zhou, Q., Belmonte, J. C. I., Zhang, W., Qu, J., Tang, F., & Liu, G.-H.
- Affiliations
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
- Beijing Advanced Innovation Center for Genomics, Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University, Beijing 100871, China.
- Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
- State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
- CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
- Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
- University of Chinese Academy of Sciences, Beijing 100049, China.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2021-01-06
- Volume
- 13
- Issue
- 575
- ISSN
- 1946-6234
- 1946-6242
- Cited by
- 178
- References
- 22
- Language
- en
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