Cited by 131Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

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Candida tropicalis Antifungal Cross-Resistance Is Related to Different Azole Target (Erg11p) Modifications

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Forastiero, A., Mesa-Arango, A. C., Alastruey-Izquierdo, A., Alcazar-Fuoli, L., Bernal-Martinez, L., Pelaez, T., Lopez, J. F., Grimalt, J. O., Gomez-Lopez, A., Cuesta, I., Zaragoza, O., Mellado, E.·2013·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.00477-13PMC PMC3811422

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Abstract

Candida tropicalis ranks between third and fourth among Candida species most commonly isolated from clinical specimens. Invasive candidiasis and candidemia are treated with amphotericin B or echinocandins as first-line therapy, with extended-spectrum triazoles as acceptable alternatives. Candida tropicalis is usually susceptible to all antifungal agents, although several azole drug-resistant clinical isolates are being reported. However, C. tropicalis resistant to amphotericin B is uncommon, and only a few strains have reliably demonstrated a high level of resistance to this agent. The resistance mechanisms operating in C. tropicalis strains isolated from clinical samples showing resistance to azole drugs alone or with amphotericin B cross-resistance were elucidated. Antifungal drug resistance was related to mutations of the azole target (Erg11p) with or without alterations of the ergosterol biosynthesis pathway. The antifungal drug resistance shown in vitro correlated very well with the results obtained in vivo using the model host Galleria mellonella. Using this panel of strains, the G. mellonella model system was validated as a simple, nonmammalian minihost model that can be used to study in vitro-in vivo correlation of antifungals in C. tropicalis. The development in C. tropicalis of antifungal drug resistance with different mechanisms during antifungal treatment has potential clinical impact and deserves specific prospective studies.

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“…AMB resistance has been linked to several potential mechanisms, such as increase in catalase activity, changes in mitochondrial potential, low accumulation of reactive oxygen species, and deficiency in ergosterol at the cell membrane (Forastiero et al., 2013; Mesa-Arango et al., 2014).”
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Authors: Forastiero, A., Mesa-Arango, A. C., Alastruey-Izquierdo, A., Alcazar-Fuoli, L., Bernal-Martinez, L., Pelaez, T., Lopez, J. F., Grimalt, J. O., Gomez-Lopez, A., Cuesta, I., Zaragoza, O., & Mellado, E.
Affiliations: Instituto de Salud Carlos III (ES)
Mycology Reference Laboratory, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain
Departamento de Química Ambiental, Institute of Environmental Assessment and Water Research (IDÆA), Consejo Superior de Investigaciones Científicas, Barcelona, Spain
Consejo Superior de Investigaciones Científicas (ES)
ORCID: Forastiero, A.
Mesa-Arango, A. C.
Grimalt, J. O.
Cuesta, I.
Mellado, E.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2013-10
Volume: 57
Issue: 10
Pages: 4769-4781
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.00477-13
PMC: PMC3811422
OpenAlex: W2115223992
Cited by: 131
References: 78
Citations by year: 2026: 3 · 2025: 14 · 2024: 7 · 2023: 15 · 2022: 13 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 15 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 9 · 2013: 1
FWCI: 6.30
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Institutional Repository University of Antioquia (University of Antioquia) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Keywords: Candida tropicalis, antifungal resistance, azole resistance, cross-resistance, amphotericin B resistance, ergosterol biosynthesis, Galleria mellonella, in vitro-in vivo correlation, invasive candidiasis, candidemia, echinocandins, triazoles
MeSH terms: Amphotericin B, Antifungal Agents, Azoles, Fungal Proteins, Drug Resistance, Fungal, Candida tropicalis

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Candida tropicalis Antifungal Cross-Resistance Is Related to Different Azole Target (Erg11p) Modifications

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