Cited by 608Antifungal resistance and susceptibilityDrug Transport and Resistance MechanismsFungal and yeast genetics research

The DOI matches its Crossref record; 399 of the 399 references it cites were found in a registry or an index.

Efflux-Mediated Antifungal Drug Resistance

Open access

Cannon, Richard D., Lamping, Erwin, Holmes, Ann R., Niimi, Kyoko, Baret, Philippe V., Keniya, Mikhail V., Tanabe, Koichi, Niimi, Masakazu, Goffeau, Andre, Monk, Brian C.·2009·Clinical Microbiology Reviews

DOI 10.1128/cmr.00051-08PMC PMC2668233

Open this paper in CoChat — free account

Abstract

SUMMARY: Fungi cause serious infections in the immunocompromised and debilitated, and the incidence of invasive mycoses has increased significantly over the last 3 decades. Slow diagnosis and the relatively few classes of antifungal drugs result in high attributable mortality for systemic fungal infections. Azole antifungals are commonly used for fungal infections, but azole resistance can be a problem for some patient groups. High-level, clinically significant azole resistance usually involves overexpression of plasma membrane efflux pumps belonging to the ATP-binding cassette (ABC) or the major facilitator superfamily class of transporters. The heterologous expression of efflux pumps in model systems, such Saccharomyces cerevisiae, has enabled the functional analysis of efflux pumps from a variety of fungi. Phylogenetic analysis of the ABC pleiotropic drug resistance family has provided a new view of the evolution of this important class of efflux pumps. There are several ways in which the clinical significance of efflux-mediated antifungal drug resistance can be mitigated. Alternative antifungal drugs, such as the echinocandins, that are not efflux pump substrates provide one option. Potential therapeutic approaches that could overcome azole resistance include targeting efflux pump transcriptional regulators and fungal stress response pathways, blockade of energy supply, and direct inhibition of efflux pumps.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/cmr.00051-08

Cites

399 of 399 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Items 201–399 of 399

Candida albicansStrain Maintenance, Replacement, and Microvariation Demonstrated by Multilocus Sequence Typing
Odds, F. C., Davidson, A. D., Jacobsen, M. D., Tavanti, A., Whyte, J. A., Kibbler, C. C., Ellis, D. H., Maiden, M. C. J., Shaw, D. J., & Gow, N. A. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00934-06 · Cited by 149
Acquired resistance to echinocandins in Candida albicans: case report and review
Baixench, M.-T., Aoun, N. B. T., Desnos‐Ollivier, M., Garcia‐Hermoso, D., Bretagne, S., Ramires, S., Piketty, C., & Dannaoui, É. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm095 · Cited by 149
Candida biofilm: a well-designed protected environment
Mukherjee, P. K., Zhou, G., Munyon, R., & Ghannoum, M. A. (2005) · Medical Mycology · doi:10.1080/13693780500107554 · Cited by 149
In Vitro Evolution of Itraconazole Resistance in Aspergillus fumigatus Involves Multiple Mechanisms of Resistance
Ferreira, M. E. D. S., Capellaro, J. L., Marques, E. D. R., Malavazi, I., Perlin, D. S., Park, S., Anderson, J. B., Colombo, A. L., Arthington, B. A., Goldman, M. H. S., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.11.4405-4413.2004 · Cited by 147
A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5
Ernst, R., Kueppers, P., Klein, C. M., Schwarzmueller, T., Kuchler, K., & Schmitt, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800191105 · Cited by 146
ATP-Binding cassette (ABC) transporters mediate nonvesicular, raft-Modulated sterol movement from the plasma membrane to the endoplasmic reticulum
Li, Y., & Prinz, W. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407600200 · Cited by 144
Large Scale Purification of Detergent-soluble P-glycoprotein fromPichia pastoris Cells and Characterization of Nucleotide Binding Properties of Wild-type, Walker A, and Walker B Mutant Proteins
Lerner‐Marmarosh, N., Gimi, K., Urbatsch, I. L., Gros, P., & Senior, A. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34711 · Cited by 144
Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter‐encoding gene, CnAFR1, involved in the resistance to fluconazole
Posteraro, B., Sanguinetti, M., Sanglard, D., La Sorda, M., Boccia, S., Romano, L., Morace, G., & Fadda, G. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03281.x · Cited by 143
Flip-flop: The transmembrane translocation of lipids
Higgins, C. F. (1994) · Cell · doi:10.1016/0092-8674(94)90248-8 · Cited by 143
Multilocus Sequence Typing of Pathogenic Candida Species
Odds, F. C., & Jacobsen, M. D. (2008) · Eukaryotic Cell · doi:10.1128/ec.00062-08 · Cited by 143
The ATP‐binding cassette transporter–encoding gene CgSNQ2 is contributing to the CgPDR1‐dependent azole resistance of Candida glabrata
Torelli, R., Posteraro, B., Ferrari, S., La Sorda, M., Fadda, G., Sanglard, D., & Sanguinetti, M. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06143.x · Cited by 141
Specific Chromosome Alterations in Fluconazole-Resistant Mutants of Candida albicans
Perepnikhatka, V. I., Fischer, F. J., Niimi, M., Baker, R. A., Cannon, R. D., Wang, Y.-K., Sherman, F., & Rustchenko, E. P. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.13.4041-4049.1999 · Cited by 141
Self-citation
Heteroresistance to Fluconazole and Voriconazole in Cryptococcus neoformans
Mondon, P., Petter, R., Amalfitano, G., Luzzati, R., Concia, E., Polacheck, I., & Kwon-Chung, K. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.8.1856 · Cited by 139
G484S Amino Acid Substitution in Lanosterol 14-α Demethylase ( ERG11 ) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate
Rodero, L., Mellado, E., Rodriguez, A. C., Salve, A., Guelfand, L., Cahn, P., Cuenca-Estrella, M., Davel, G., & Rodriguez-Tudela, J. L. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.11.3653-3656.2003 · Cited by 139
Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification
Wolfger, H., Mamnun, Y. M., & Kuchler, K. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01209-8 · Cited by 138
Update on antifungal drug resistance mechanisms of Aspergillus fumigatus
Chamilos, G., & Kontoyiannis, D. P. (2005) · Drug Resistance Updates · doi:10.1016/j.drup.2006.01.001 · Cited by 137
Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters
Sorbo, G. D., Andrade, A. C., van Nistelrooy, J. G. M., van Kan, J. A. L., Balzi, E., & Waard, M. A. D. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050434 · Cited by 137
Functional Characterization of Candida albicans ABC Transporter Cdr1p
Shukla, S., Saini, P., Smriti, Jha, S., Ambudkar, S. V., & Prasad, R. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.6.1361-1375.2003 · Cited by 135
Overexpression of Candida albicans CDR1,CDR2, or MDR1 Does Not Produce Significant Changes in Echinocandin Susceptibility
Niimi, K., Maki, K., Ikeda, F., Holmes, A. R., Lamping, E., Niimi, M., Monk, B. C., & Cannon, R. D. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.4.1148-1155.2006 · Cited by 134
Clade-Specific Flucytosine Resistance Is Due to a Single Nucleotide Change in the FUR1 Gene of Candida albicans
Dodgson, A. R., Dodgson, K. J., Pujol, C., Pfaller, M. A., & Soll, D. R. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.6.2223-2227.2004 · Cited by 133
Resistance to amphotericin B associated with defective sterol Î8â7isomerase in a Cryptococcus neoformans strain from an AIDS patient
Kelly, S. L., Lamb, D. C., Taylor, M., Corran, A. J., Baldwin, B. C., & Powderly, W. G. (1994) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1994.tb07140.x · Cited by 133
The ABC transporter AtrB from Aspergillus nidulans mediates resistance to all major classes of fungicides and some natural toxic compounds
Andrade, A. C., Sorbo, G. D., van Nistelrooy, J. G. M., & Waard, M. A. D. (2000) · Microbiology · doi:10.1099/00221287-146-8-1987 · Cited by 132
Recent advances and challenges in the treatment of invasive fungal infections
Shao, P., Huang, L., & Hsueh, P. (2007) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2007.07.019 · Cited by 131
Targeted Gene Disruption of the 14-α Sterol Demethylase ( cyp51A ) in Aspergillus fumigatus and Its Role in Azole Drug Susceptibility
Mellado, E., García‐Effrón, G., Buitrago, M. J., Alcázar‐Fuoli, L., Cuenca‐Estrella, M., & Rodríguez-Tudela, J. L. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2536-2538.2005 · Cited by 129
Genes encoding multiple drug resistance-like proteins in Aspergillus fumigatus and Aspergillus flavus
Tobin, M. B., Peery, R. B., & Skatrud, P. L. (1997) · Gene · doi:10.1016/s0378-1119(97)00281-3 · Cited by 129
Multiple Pdr1p/Pdr3p Binding Sites Are Essential for Normal Expression of the ATP Binding Cassette Transporter Protein-encoding Gene
Katzmann, D. J., Hallstrom, T. C., Mahé, Y., & Moye-Rowley, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.38.23049 · Cited by 129
The role of ABC transporters from Aspergillus nidulans in protection against cytotoxic agents and in antibiotic production
Andrade, A. C., van Nistelrooy, J. G. M., Peery, R. B., Skatrud, P. L., & Waard, M. A. D. (2000) · Molecular and General Genetics MGG · doi:10.1007/pl00008697 · Cited by 126
The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo‐ and heterodimers in vivo
Mamnun, Y. M., Pandjaitan, R., Mahé, Y., Delahodde, A., & Kuchler, K. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03262.x · Cited by 125
Trends in Antifungal Drug Susceptibility of Cryptococcus neoformans Isolates in the United States: 1992 to 1994 and 1996 to 1998
Brandt, M. E., Pfaller, M. A., Hajjeh, R. A., Hamill, R. J., Pappas, P. G., Reingold, A. L., Rimland, D., & Warnock, D. W. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.3065-3069.2001 · Cited by 125
Oral candidosis in patients with advanced cancer
Davies, A. N., Brailsford, S. R., & Beighton, D. (2006) · Oral Oncology · doi:10.1016/j.oraloncology.2005.11.010 · Cited by 125
Fungal ATP-Binding Cassette (ABC) Transporters in Drug Resistance & Detoxification
Sipos, G., & Kuchler, K. (2006) · Current Drug Targets · doi:10.2174/138945006776359403 · Cited by 123
Genome-Wide Expression and Location Analyses of the Candida albicans Tac1p Regulon
Liu, T. T., Znaidi, S., Barker, K. S., Xu, L., Homayouni, R., Saidane, S., Morschhäuser, J., Nantel, A., Raymond, M., & Rogers, P. D. (2007) · Eukaryotic Cell · doi:10.1128/ec.00327-07 · Cited by 123
How can we best use structural information on P-glycoprotein to design inhibitors?
McDevitt, C. A., & Callaghan, R. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.10.003 · Cited by 122
Genetics of Candida albicans, a Diploid Human Fungal Pathogen
Noble, S. M., & Johnson, A. D. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.042007.170146 · Cited by 122
The Calcineurin Target, Crz1, Functions in Azole Tolerance but Is Not Required for Virulence of Candida albicans
Onyewu, C., Wormley, F. L., Perfect, J. R., & Heitman, J. (2004) · Infection and Immunity · doi:10.1128/iai.72.12.7330-7333.2004 · Cited by 121
Chromosome instability in Candida albicans
Rustchenko, E. P. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00150.x · Cited by 120
Expression of the human multidrug transporter in insect cells by a recombinant baculovirus
Germann, U. A., Willingham, M. C., Pastan, I. H., et al. (1990) · Biochemistry · doi:10.1021/bi00461a013 · Cited by 120
Increased Fluconazole Resistance of Cryptococcus neoformans Isolated from a Patient with AIDS and Recurrent Meningitis
Paugam, A., Dupouy‐Camet, J., Blanche, P., Gangneux, J., Tourte-Schaefer, C., & Sicard, D. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.5.975-a · Cited by 117
Divergence in Fitness and Evolution of Drug Resistance in Experimental Populations of Candida albicans
Cowen, L. E., Kohn, L. M., & Anderson, J. B. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.10.2971-2978.2001 · Cited by 116
Chemosensitization of Fluconazole Resistance in Saccharomyces cerevisiae and Pathogenic Fungi by a d -Octapeptide Derivative
Niimi, K., Harding, D. R. K., Parshot, R., King, A., Lun, D. J., Decottignies, A., Niimi, M., Lin, S., Cannon, R. D., Goffeau, A., et al. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1256-1271.2004 · Cited by 115
Self-citation
Role of AFR1 , an ABC Transporter-Encoding Gene, in the In Vivo Response to Fluconazole and Virulence of Cryptococcus neoformans
Sanguinetti, M., Posteraro, B., Sorda, M. L., Torelli, R., Fiori, B., Santangelo, R., Delogu, G., & Fadda, G. (2006) · Infection and Immunity · doi:10.1128/iai.74.2.1352-1359.2006 · Cited by 115
ABC transporters and inhibitors: new targets, new agents.
Leonard, G. D., Polgár, O., & Bates, S. E. (2002) · PubMed · Cited by 113
ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators
Smriti, S., Krishnamurthy, S., Dixit, B. L., Gupta, C. M., Milewski, S., & Prasad, R. (2002) · Yeast · doi:10.1002/yea.818 · Cited by 113
Adherence of Candida albicans to Silicone Induces Immediate Enhanced Tolerance to Fluconazole
Mateus, C., Crow, S. A., & Ahearn, D. G. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.9.3358-3366.2004 · Cited by 113
Evolution of gene families: the multidrug resistance transporter genes in five related yeast species
Gbelská, Y., Krijger, J., & Breunig, K. D. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00058.x · Cited by 112
The Candida albicans Cdr2p ATP‐binding cassette (ABC) transporter confers resistance to caspofungin
Schuetzer‐Muehlbauer, M., Willinger, B., Krapf, G., Enzinger, S., Presterl, E., & Kuchler, K. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03430.x · Cited by 111
Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis
Tsujimura, S., Saito, K., Nawata, M., Nakayamada, S., & Tanaka, Y. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.070821 · Cited by 111
Calcineurin Is Required forCandida albicansTo Survive Calcium Stress in Serum
Blankenship, J. R., & Heitman, J. (2005) · Infection and Immunity · doi:10.1128/iai.73.9.5767-5774.2005 · Cited by 111
Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain
Nourani, A., Papajova, D., Delahodde, A., Jacq, C., & Subik, J. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050583 · Cited by 109
Rapid Acquisition of Stable Azole Resistance by Candida glabrata Isolates Obtained before the Clinical Introduction of Fluconazole
Borst, A., Raimer, M. T., Warnock, D. W., Morrison, C. J., & Arthington, B. A. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.783-787.2005 · Cited by 107
Antifungal Susceptibilities of Clinical Isolates of Candida Species, Cryptococcus neoformans , and Aspergillus Species from Taiwan: Surveillance of Multicenter Antimicrobial Resistance in Taiwan Program Data from 2003
Hsueh, P., Lau, Y.-J., Chuang, Y.-C., Wan, J.-H., Huang, W.-K., Shyr, J.-M., Yan, J.-J., Yu, K.-W., Wu, J.-J., Ko, W., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.512-517.2005 · Cited by 107
Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking
Khalil, I. A., Kogure, K., Futaki, S., & Harashima, H. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.12.003 · Cited by 106
Correlation between Steady-state ATP Hydrolysis and Vanadate-induced ADP Trapping in Human P-glycoprotein
Kerr, K. M., Sauna, Z. E., & Ambudkar, S. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010044200 · Cited by 106
Identification and expression of multidrug resistancerelated ABC transporter genes in Candida krusei
Katiyar, S. K., & Edlind, T. D. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.109.116 · Cited by 104
Crystallization of a mammalian membrane protein overexpressed in Saccharomyces cerevisiae
Jidenko, M., Nielsen, R. C., Sørensen, T. L.-M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503986102 · Cited by 104
Management of oral lesions in HIV-positive patients
Baccaglini, L., Atkinson, J. C., Patton, L. L., Glick, M., Ficarra, G., & Peterson, D. E. (2007) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2006.11.002 · Cited by 103
Candida: Comparative and Functional Genomics
D'Enfert, C., & Hube, B. (2007) · Estudis Romànics (Institut d'Estudis Catalans) · Cited by 102
The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter
Balan, I., Alarco, A., & Raymond, M. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.23.7210-7218.1997 · Cited by 102
Rapid Detection of Triazole Antifungal Resistance in Aspergillus fumigatus
García‐Effrón, G., Dilger, A., Alcázar‐Fuoli, L., Park, S., Mellado, E., & Perlin, D. S. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.02330-07 · Cited by 102
Clinical profile of HIV in India.
Kumarasamy, N., Vallabhaneni, S., Flanigan, T., et al. (2005) · PubMed · Cited by 101
Correlation between rhodamine 123 accumulation and azole sensitivity in Candida species: possible role for drug efflux in drug resistance
Clark, F. S., Parkinson, T., Hitchcock, C. A., & Gow, N. A. R. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.2.419 · Cited by 101
New Insights into the Pleiotropic Drug Resistance Network from Genome-Wide Characterization of the YRR1 Transcription Factor Regulation System
Crom, S. L., Devaux, F., Marc, P., Zhang, X., Moye-Rowley, S., & Jacq, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2642-2649.2002 · Cited by 100
Abc1p Is a Multidrug Efflux Transporter That Tips the Balance in Favor of Innate Azole Resistance in Candida krusei
Lamping, E., Ranchod, A., Nakamura, K., Tyndall, J. D. A., Niimi, K., Holmes, A. R., Niimi, M., & Cannon, R. D. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01095-08 · Cited by 100
Self-citation
Antigen detection, serology, and molecular diagnosis of invasive mycoses in the immunocompromised host
Wheat, L. J. (2006) · Transplant Infectious Disease · doi:10.1111/j.1399-3062.2006.00165.x · Cited by 99
Increasing in vitro resistance to fluconazole in Cryptococcus neoformans Cambodian isolates: April 2000 to March 2002
Sar, B. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh361 · Cited by 99
The zinc cluster transcription factor Tac1p regulates PDR16 expression in Candida albicans
Znaidi, S., Deken, X. D., Weber, S., Rigby, T., Nantel, A., & Raymond, M. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05931.x · Cited by 97
Mutational Disruption of Plasma Membrane Trafficking of Saccharomyces cerevisiae Yor1p, a Homologue of Mammalian Multidrug Resistance Protein
Katzmann, D. J., Epping, E. A., & Moye-Rowley, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2998 · Cited by 97
Genetic Basis for Differential Activities of Fluconazole and Voriconazole against Candida krusei
Fukuoka, T., Johnston, D. A., Winslow, C. A., de Groot, M. J., Burt, C., Hitchcock, C. A., & Filler, S. G. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.4.1213-1219.2003 · Cited by 97
Differentiation of Candida albicans and Candida dubliniensis by Fluorescent In Situ Hybridization with Peptide Nucleic Acid Probes
Oliveira, K., Haase, G., Kurtzman, C. P., Hyldig‐Nielsen, J. J., & Stender, H. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.11.4138-4141.2001 · Cited by 93
Antimicrobials as a contributory factor in oral candidosis – a brief overview
Soysa, N., Samaranayake, L. P., & Ellepola, A. N. B. (2007) · Oral Diseases · doi:10.1111/j.1601-0825.2006.01357.x · Cited by 91
Structure and Function Analysis of CaMdr1p, a Major Facilitator Superfamily Antifungal Efflux Transporter Protein of Candida albicans : Identification of Amino Acid Residues Critical for Drug/H + Transport
Pasrija, R., Banerjee, D., & Prasad, R. (2007) · Eukaryotic Cell · doi:10.1128/ec.00315-06 · Cited by 91
Early Expression of Yeast Genes Affected by Chemical Stress
Lucau‐Danila, A., Lelandais, G., Kozovská, Z., Tanty, V., Delaveau, T., Devaux, F., & Jacq, C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1860-1868.2005 · Cited by 91
The fight against fungi
Goffeau, A. (2008) · Nature · doi:10.1038/452541a · Cited by 90
Self-citation
Overexpression of the MDR1 Gene Is Sufficient To Confer Increased Resistance to Toxic Compounds in Candida albicans
Hiller, D., Sanglard, D., & Morschhäuser, J. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.4.1365-1371.2006 · Cited by 90
In Vitro Analyses, Animal Models, and 60 Clinical Cases of Invasive Aspergillus terreus Infection
Steinbach, W. J., Perfect, J. R., Schell, W. A., Walsh, T. J., & Benjamin, D. K. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.9.3217-3225.2004 · Cited by 89
Yeast ATP‐Binding Cassette Transporters: Cellular Cleaning Pumps
Ernst, R., Klemm, R. W., Schmitt, L., & Kuchler, K. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)00026-1 · Cited by 88
Complete Inventory of ABC Proteins in Human Pathogenic Yeast, Candida albicans
Gaur, M., Choudhury, D., & Prasad, R. (2005) · Microbial Physiology · doi:10.1159/000088141 · Cited by 85
Two-component signal transduction in human fungal pathogens
Kruppa, M., & Calderone, R. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00024.x · Cited by 84
Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae.
Kuchler, K., & Thorner, J. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2302 · Cited by 83
Direct preparation of giant proteo-liposomes by in vitro membrane protein synthesis
Nomura, S. M., Kondoh, S., Asayama, W., Asada, A., Nishikawa, S., & Akiyoshi, K. (2007) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2007.08.023 · Cited by 83
Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis Inhibitors
Jain, P., Akula, I., & Edlind, T. D. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.10.3195-3201.2003 · Cited by 82
In Vitro Activities of Three Licensed Antifungal Agents against Spanish Clinical Isolates of Aspergillus spp
Gómez‐López, A., García‐Effrón, G., Mellado, E., Monzón, A., Rodrı́guez-Tudela, J. L., & Cuenca‐Estrella, M. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.10.3085-3088.2003 · Cited by 81
Flucytosine Resistance Is Restricted to a Single Genetic Clade of Candida albicans
Pujol, C., Pfaller, M. A., & Soll, D. R. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.1.262-266.2004 · Cited by 81
Clonal Reproduction and Limited Dispersal in an Environmental Population of Cryptococcus neoformans var. gattii Isolates from Australia
Halliday, C. L., & Carter, D. A. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.2.703-711.2003 · Cited by 81
Cross-resistance to polyene and azole drugs in Cryptococcus neoformans
Joseph‐Horne, T., Hollomon, D. W., Loeffler, R. S. T., & Kelly, S. L. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.7.1526 · Cited by 81
Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type Strain
Bader, T., Schröppel, K., Bentink, S., Agabian, N., Köhler, G., & Morschhäuser, J. (2006) · Infection and Immunity · doi:10.1128/iai.00142-06 · Cited by 81
Strain Typing and Determination of Population Structure ofCandida kruseiby Multilocus Sequence Typing
Jacobsen, M. D., Gow, N. A. R., Maiden, M. C. J., Shaw, D. J., & Odds, F. C. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01549-06 · Cited by 81
Candida albicansclades
Soll, D. R., & Pujol, C. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00242-6 · Cited by 80
The transmembrane domain 10 of the yeast Pdr5p ABC antifungal efflux pump determines both substrate specificity and inhibitor susceptibility
Egner, R., BAUER, B. E., & Kuchler, K. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01798.x · Cited by 80
The Candida glabrata putative sterol transporter gene CgAUS1 protects cells against azoles in the presence of serum
Nakayama, H., Tanabe, K., Bard, M., Hodgson, W., Wu, S., Takemori, D., Aoyama, T., Kumaraswami, N. S., Metzler, L., Takano, Y., et al. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm321 · Cited by 80
Self-citation
The Antimalarial Drug Resistance Protein Plasmodium falciparum Chloroquine Resistance Transporter Binds Chloroquine
Zhang, H., Paguio, M. F., & Roepe, P. D. (2004) · Biochemistry · doi:10.1021/bi049137i · Cited by 79
Impact of Mating Type, Serotype, and Ploidy on the Virulence of Cryptococcus neoformans
Lin, X., Nielsen, K., Patel, S., & Heitman, J. (2008) · Infection and Immunity · doi:10.1128/iai.00168-08 · Cited by 78
Impact of Antimicrobial Dosing Regimen on Evolution of Drug Resistance In Vivo: Fluconazole andCandida albicans
Andes, D. R., Forrest, A., Lepak, A. J., Nett, J. E., Marchillo, K., & Lincoln, L. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01053-05 · Cited by 76
Origin of Cryptococcus neoformans var. neoformans Diploid Strains
Cogliati, M., Esposto, M. C., Clarke, D. L., Wickes, B. L., & Viviani, M. A. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.11.3889-3894.2001 · Cited by 76
Fluconazole tolerance in clinical isolates of Cryptococcus neoformans
Venkateswarlu, K., Taylor, M., Manning, N. J., Rinaldi, M. G., & Kelly, S. L. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.4.748 · Cited by 75
Inhibition of fungal ABC transporters by unnarmicin A and unnarmicin C, novel cyclic peptides from marine bacterium
Tanabe, K., Lamping, E., Adachi, K., Takano, Y., Kawabata, K., Shizuri, Y., Niimi, M., & Uehara, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.110 · Cited by 74
Self-citation
Complex Interplay Among Regulators of Drug Resistance Genes in Saccharomyces cerevisiae
Akache, B., MacPherson, S., Sylvain, M.-A., & Turcotte, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403487200 · Cited by 73
Fungal infections in hematopoietic stem cell transplant recipients
Marr, K. A. (2008) · Medical Mycology · doi:10.1080/13693780701885552 · Cited by 73
Sequence resources at the Candida Genome Database
Arnaud, M. B., Costanzo, M. C., Skrzypek, M. S., Shah, P., Binkley, G., Lane, C. D., Miyasato, S. R., & Sherlock, G. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl899 · Cited by 72
Antifungal Agents: In Vitro Susceptibility Testing, Pharmacodynamics, and Prospects for Combination Therapy
Groll, A. H., & Kolve, H. (2004) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1108-6 · Cited by 72
Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance
Rognon, B., Kozovska, Z., Coste, A. T., Pardini, G., & Sanglard, D. (2006) · Microbiology · doi:10.1099/mic.0.29277-0 · Cited by 71
Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance
Niimi, M., Niimi, K., Takano, Y., Holmes, A. R., Fischer, F. J., Uehara, Y., & Cannon, R. D. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh456 · Cited by 69
Self-citation
Evidence for a general-purpose genotype in Candida albicans , highly prevalent in multiple geographical regions, patient types and types of infection
Schmid, J., Herd, S., Hunter, P. R., Cannon, R. D., Yasin, M. S. M., Samad, S., Carr, M., Parr, D. H., McKinney, W. P., Schousboe, M., et al. (1999) · Microbiology · doi:10.1099/00221287-145-9-2405 · Cited by 69
Self-citation
Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2
Holmes, A. R., Tsao, S., Ong, S., Lamping, E., Niimi, K., Monk, B. C., Niimi, M., Kaneko, A., Holland, B. R., Schmid, J., et al. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05357.x · Cited by 68
Self-citation
Function of Candida glabrata ABC transporter gene, PDH1
Izumikawa, K., Kakeya, H., Tsai, H., Grimberg, B., & Bennett, J. E. (2003) · Yeast · doi:10.1002/yea.962 · Cited by 67
Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5
Sauna, Z. E., Bohn, S. S., Rutledge, R. M., Dougherty, M. P., Cronin, S., May, L., Xia, D., Ambudkar, S. V., & Golin, J. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806446200 · Cited by 66
Surface-Active Fungicidal d -Peptide Inhibitors of the Plasma Membrane Proton Pump That Block Azole Resistance
Monk, B. C., Niimi, K., Lin, S. X., Knight, A., Kardos, T. B., Cannon, R. D., Parshot, R., King, A., Lun, D. J., & Harding, D. R. K. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.1.57-70.2005 · Cited by 66
Self-citation
In search of the holy grail of antifungal therapy.
Chapman, S. W., Sullivan, D. C., & Cleary, J. D. (2008) · PubMed Central · Cited by 64
Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients
Lamb, D. C., Corran, A. J., Baldwin, B. C., Kwon‐Chung, J., & Kelly, S. L. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00684-2 · Cited by 64
A fourth gene from the Candida albicans CDR family of ABC transporters
Franz, R., Michel, S., & Morschhäuser, J. (1998) · Gene · doi:10.1016/s0378-1119(98)00412-0 · Cited by 64
Efflux Pumps in Drug Resistance of Candida
Prasad, R., Gaur, N., Gaur, M., & Komath, S. (2006) · Infectious Disorders - Drug Targets · doi:10.2174/187152606784112164 · Cited by 64
Proteomic analysis of experimentally induced azole resistance in Candida glabrata
Rogers, P. D. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl221 · Cited by 64
Candida glabrata ATP-binding Cassette Transporters Cdr1p and Pdh1p Expressed in aSaccharomyces cerevisiae Strain Deficient in Membrane Transporters Show Phosphorylation-dependent Pumping Properties
Wada, S.-I., Niimi, M., Niimi, K., Holmes, A. R., Monk, B. C., Cannon, R. D., & Uehara, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207817200 · Cited by 63
Self-citation
Three-dimensional Reconstruction of the Saccharomyces cerevisiae Multidrug Resistance Protein Pdr5p
Ferreira‐Pereira, A., Marco, S., Decottignies, A., Nader, J., Goffeau, A., & Rigaud, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212198200 · Cited by 63
Self-citation
Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520.
Raymond, M., Ruetz, S., Thomas, D. Y., & Gros, P. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.277 · Cited by 62
Characterization of Heteroresistance to Fluconazole among Clinical Isolates of Cryptococcus neoformans
Yamazumi, T., Pfaller, M. A., Messer, S. A., Houston, A. K., Boyken, L., Hollis, R. J., Furuta, I., & Jones, R. N. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.1.267-272.2003 · Cited by 62
Recombinant N-terminal Nucleotide-binding Domain from Mouse P-glycoprotein
Dayan, G., Baubichon‐Cortay, H., Jault, J., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.11652 · Cited by 60
Palliative Care for Patients With Head and Neck Cancer
Goldstein, N. E., Genden, E. M., & Morrison, R. S. (2008) · JAMA · doi:10.1001/jama.299.15.1818 · Cited by 60
Reduced susceptibility in laboratory-selected mutants of Aspergillus fumigatus to itraconazole due to decreased intracellular accumulation of the antifungal agent
Manavathu, E. K., Vázquez, J. A., & Chandrasekar, P. H. (1999) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(98)00102-2 · Cited by 60
Functional expression of mouse mdr1 in Escherichia coli.
Bibi, E., Gros, P., & Kaback, H. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9209 · Cited by 60
Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients
Maebashi, K., Niimi, M., Kudoh, M., Fischer, F. J., Makimura, K., Niimi, K., Piper, R., Uchida, K., Arisawa, M., Cannon, R. D., et al. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/47.5.527 · Cited by 60
Self-citation
Functional Similarities and Differences between Candida albicans Cdr1p and Cdr2p Transporters
Gauthier, C., Weber, S., Alarco, A., Alqawi, O., Daoud, R., Georges, E., & Raymond, M. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.5.1543-1554.2003 · Cited by 59
Complete In Vivo Reversal of the Multidrug Resistance Phenotype by Jet-injection of Anti-MDR1 Short Hairpin RNA-encoding Plasmid DNA
Stein, U., Walther, W., Stege, A., Kaszubiak, A., Fichtner, I., & Lage, H. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300304 · Cited by 59
Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance
Venkateswarlu, K., Denning, D. W., Manning, N. J., & Kelly, S. L. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.11.2443 · Cited by 58
Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance
Kołaczkowski, M., & Goffeau, A. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00094-6 · Cited by 58
Self-citation
Rates of antifungal resistance among Spanish clinical isolates of Cryptococcus neoformans var. neoformans
Perkins, A., Gómez‐López, A., Mellado, E., Rodrı́guez-Tudela, J. L., & Cuenca‐Estrella, M. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki393 · Cited by 58
Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region
Bakos, É., Klein, I., Welker, E., et al. (1997) · Biochemical Journal · doi:10.1042/bj3230777 · Cited by 58
Antifungal drug susceptibility of Cryptococcus neoformans from clinical sources in Nairobi, Kenya
Bii, C. C., Makimura, K., Abe, S., Taguchi, H., Mugasia, O. M., Revathi, G., Wamae, N., & Kamiya, S. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01293.x · Cited by 57
A novel yeast expression system for the overproduction of quality‐controlled membrane proteins
Griffith, D. A., Delipala, C., Leadsham, J. E., et al. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00952-9 · Cited by 57
Cloning and characterization of CneMDR1: a Cryptococcus neoformans gene encoding a protein related to multidrug resistance proteins
Thornewell, S. J., Peery, R. B., & Skatrud, P. L. (1997) · Gene · doi:10.1016/s0378-1119(97)00421-6 · Cited by 57
Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae
Kołaczkowska, A., Kołaczkowski, M., Goffeau, A., & Moye-Rowley, S. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.045 · Cited by 55
Self-citation
Complete Inhibition of the Pdr5p Multidrug Efflux Pump ATPase Activity by Its Transport Substrate Clotrimazole Suggests that GTP as Well as ATP May Be Used as an Energy Source
Golin, J. E., Kon, Z. N., Wu, C., et al. (2007) · Biochemistry · doi:10.1021/bi701414f · Cited by 55
Regulation of azole drug susceptibility by Candida albicans protein kinase CK2
Bruno, V. M., & Mitchell, A. P. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04562.x · Cited by 55
Selection of a Surrogate Agent (Fluconazole or Voriconazole) for Initial Susceptibility Testing of Posaconazole against Candida spp.: Results from a Global Antifungal Surveillance Program
Pfaller, M. A., Messer, S. A., Boyken, L. B., Tendolkar, S., Hollis, R. J., & Diekema, D. J. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01952-07 · Cited by 55
Mutational analysis of the yeast multidrug resistance ABC transporter Pdr5p with altered drug specificity
Ţuţulan-Cuniţă, A. C., Mikoshi, M., Mizunuma, M., Hirata, D., & Miyakawa, T. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00847.x · Cited by 54
Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter
Tanaka, S., Currier, S. J., Bruggemann, E. P., et al. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91928-l · Cited by 54
Depletion of the Squalene Synthase ( ERG9 ) Gene Does Not Impair Growth of Candida glabrata in Mice
Nakayama, H., Izuta, M., Nakayama, N., Arisawa, M., & Aoki, Y. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2411-2418.2000 · Cited by 54
Yeast – a panacea for the structure–function analysis of membrane proteins?
Bill, R. M. (2001) · Current Genetics · doi:10.1007/s002940100252 · Cited by 54
The yeast Pdr5p multidrug transporter: How does it recognize so many substrates?
Golin, J., Ambudkar, S. V., & May, L. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.011 · Cited by 53
Are Candida albicans natural populations subdivided?
Tibayrenc, M. (1997) · Trends in Microbiology · doi:10.1016/s0966-842x(97)01068-8 · Cited by 53
Current understanding of the modes of action and resistance mechanisms to conventional and emerging antifungal agents for treatment of Candida infections.
Sanglard, D., & Billé, J. (2002) · IRIS · Cited by 52
P-Glycoprotein Efflux Inhibition by Amphiphilic Diblock Copolymers: Relationship between Copolymer Concentration and Substrate Hydrophobicity
Zastre, J. A., Jackson, J. K., Wong, W., et al. (2008) · Molecular Pharmaceutics · doi:10.1021/mp7001347 · Cited by 51
Origin of differences in susceptibility of Candida krusei to azole antifungal agents
Marichal, P., Gorrens, J., Coene, M. C., Jeune, L. L., & BOSSCHE, H. V. (1995) · Mycoses · doi:10.1111/j.1439-0507.1995.tb00032.x · Cited by 51
Pyrosequencing To Detect Mutations in FKS1 That Confer Reduced Echinocandin Susceptibility in Candida albicans
Wiederhold, N. P., Grabinski, J. L., García‐Effrón, G., Perlin, D. S., & Lee, S. A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00959-08 · Cited by 51
Azole Drug Resistance as a Cause of Clinical Relapse in AIDS Patients with Cryptococcal Meningitis
Birley, H., Johnson, E. M., McDonald, P., Parry, C. M., Carey, P. B., & Warnock, D. W. (1995) · International Journal of STD & AIDS · doi:10.1177/095646249500600510 · Cited by 51
DNA Pyrosequencing–Based Identification of Pathogenic Candida Species by Using the Internal Transcribed Spacer 2 Region
Boyanton, B. L., Luna, R. A., Fasciano, L. R., Menne, K. G., & Versalovic, J. A. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2008-132-667-dpiopc · Cited by 49
Chronic Meningitis in Thailand
Helbok, R., Pongpakdee, S., Yenjun, S., et al. (2005) · Neuroepidemiology · doi:10.1159/000089236 · Cited by 47
Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux
Saini, P., Prasad, T., Gaur, N. A., Shukla, S., Jha, S., Komath, S. S., Khan, L. A., Haq, Q. M. R., & Prasad, R. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki183 · Cited by 47
Role of ABC Transporters in Aureobasidin A Resistance
Ogawa, A., Hashida-Okado, T., Endo, M., Yoshioka, H., Tsuruo, T., Takesako, K., & Kato, I. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.4.755 · Cited by 46
Niche-specific gene expression during C. albicans infection
Kumamoto, C. A. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.05.008 · Cited by 45
Use of prophylactic antifungals in the immunocompromised host
Ship, J. A., Vissink, A., & Challacombe, S. (2007) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2006.11.003 · Cited by 44
Responses of Pathogenic and Nonpathogenic Yeast Species to Steroids Reveal the Functioning and Evolution of Multidrug Resistance Transcriptional Networks
Banerjee, D., Lelandais, G., Shukla, S., Mukhopadhyay, G., Jacq, C., Devaux, F., & Prasad, R. (2007) · Eukaryotic Cell · doi:10.1128/ec.00256-07 · Cited by 44
Expression of 25 Human ABC Transporters in the Yeast Pichia pastoris and Characterization of the Purified ABCC3 ATPase Activity
Chloupková, M., Pickert, A., Lee, J., et al. (2007) · Biochemistry · doi:10.1021/bi700020m · Cited by 43
Inhibition of Multidrug Resistance by AdamantylGb3, a Globotriaosylceramide Analog
Rosa, M. F. D., Ackerley, C. A., Wang, B., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705473200 · Cited by 43
Phosphorylation of Candida glabrata ATP-binding Cassette Transporter Cdr1p Regulates Drug Efflux Activity and ATPase Stability
Wada, S.-I., Tanabe, K., Yamazaki, A., Niimi, M., Uehara, Y., Niimi, K., Lamping, E., Cannon, R. D., & Monk, B. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408252200 · Cited by 39
Self-citation
In-vitro susceptibility of Cryptococcus neoformans isolates to fluconazole and itraconazole
Davey, K. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/42.2.217 · Cited by 39
In Vivo Fluconazole Pharmacodynamics and Resistance Development in a Previously SusceptibleCandida albicansPopulation Examined by Microbiologic and Transcriptional Profiling
Andes, D. R., Lepak, A. J., Nett, J. E., Lincoln, L., & Marchillo, K. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01305-05 · Cited by 38
Testing the efficacy of RNA interference constructs in Aspergillus fumigatus
Henry, C., Mouyna, I., & Latgé, J. (2007) · Current Genetics · doi:10.1007/s00294-007-0119-0 · Cited by 38
Identification of two proteins induced by exposure of the pathogenic fungus Candida glabrata to fluconazole
Niimi, M., Nagai, Y., Niimi, K., Wada, S.-I., Cannon, R. D., Uehara, Y., & Monk, B. C. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00668-2 · Cited by 38
Self-citation
Fluconazole-ResistantCryptococcus NeoformansVarGattiiin an Aids Patient
Peetermans, W. E., Bobbaers, H., Verhaegen, J., et al. (1993) · Acta Clinica Belgica · doi:10.1080/17843286.1993.11718338 · Cited by 38
A novel method used to delete a new Aspergillus fumigatus ABC transporter-encoding gene
Langfelder, K., Gattung, S., & Brakhage, A. A. (2002) · Current Genetics · doi:10.1007/s00294-002-0313-z · Cited by 37
Combination antifungal therapy: what can and should we expect?
Johnson, M. D., & Perfect, J. R. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705687 · Cited by 37
Chromosome instability and unusual features of some widely used strains of Candida albicans
Aḥmad, A., Kabir, M. A., Kravets, A., Andaluz, E., Larriba, G., & Rustchenko, E. P. (2008) · Yeast · doi:10.1002/yea.1597 · Cited by 37
Reversal of Multidrug Resistance by Methoxypolyethylene Glycol-Block-Polycaprolactone Diblock Copolymers Through the Inhibition of P-Glycoprotein Function
Elamanchili, P., McEachern, C., & Burt, H. M. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21479 · Cited by 37
Functional expression of the human breast cancer resistance protein in Pichia pastoris
Mao, Q., Conseil, G., Gupta, A., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.012 · Cited by 35
Overexpression, purification, and functional characterization of ATP-binding cassette transporters in the yeast, Pichia pastoris
Cai, J., & Gros, P. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00718-6 · Cited by 34
Functional characterization of the CgPGS1 gene reveals a link between mitochondrial phospholipid homeostasis and drug resistance in Candida glabrata
Batova, M., Borecka-Melkusova, S., Simockova, M., Dzugasova, V., Goffa, E., & Subik, J. (2008) · Current Genetics · doi:10.1007/s00294-008-0187-9 · Cited by 31
Expression of the mammalian renal peptide transporter PEPT2 in the yeastPichia pastorisand applications of the yeast system for functional analysis
Döring, F., Michel, T., Rösel, A., et al. (1998) · Molecular Membrane Biology · doi:10.3109/09687689809027522 · Cited by 31
MOLECULAR-GENETIC APPROACHES TO IDENTIFICATION AND TYPING OF PATHOGENIC CANDIDA YEASTS
Trtkova, J., & Raclavský, V. (2006) · Biomedical Papers · doi:10.5507/bp.2006.005 · Cited by 31
Specificity of drug transport mediated byCaMDR1: A major facilitator ofCandida albicans
Kohli, A., Gupta, V., Krishnamurthy, S., Hasnain, S. E., & Prasad, R. (2001) · Journal of Biosciences · doi:10.1007/bf02703742 · Cited by 31
Inhibition and interaction of cytochrome P450 ofCandida kruseiwith azole antifungal drugs
Venkateswarlu, K., Denning, D. W., & Kelly, S. (1997) · Medical Mycology · doi:10.1080/02681219780000821 · Cited by 31
cDNA microarray analysis of differential gene expression and regulation in clinically drug-resistant isolates of Candida albicans from bone marrow transplanted patients
Xu, Z. Q., Zhang, L., Zhang, J., Cao, Y., Yu, Y.-Y., Wang, D., Ying, K., Chen, W., & Jiang, Y. (2006) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2006.03.004 · Cited by 30
Key physiological differences in Candida albicans CDR1 induction by steroid hormones and antifungal drugs
Larsen, B., Anderson, S., Brockman, A., Essmann, M., & Schmidt, M. (2006) · Yeast · doi:10.1002/yea.1394 · Cited by 30
Membrane homoeostasis and multidrug resistance in yeast
Panwar, S. L., Pasrija, R., & Prasad, R. (2008) · Bioscience Reports · doi:10.1042/bsr20080071 · Cited by 29
Heterologous Expression and ATPase Activity of Mutant versus Wild Type PfMDR1 Protein
Amoah, L. E., Lekostaj, J. K., & Roepe, P. D. (2007) · Biochemistry · doi:10.1021/bi7002026 · Cited by 28
AIDS-associated Cryptococcus infection before and after the highly active antiretroviral therapy era: emerging management problems
Manfredi, R., Calza, L., & Chiodo, F. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(03)00113-4 · Cited by 27
Expression of atrC – encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans – is sensitive to cycloheximide1The sequence of atrC has been deposited in GenBank under the accession number AF082072.1
Angermayr, K., Parson, W., Stöffler, G., & Haas, H. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(98)00107-0 · Cited by 26
Antifungal Resistance Mechanisms of Aspergillus
Qiao, J., Liu, W. Y., & Li, R. (2008) · Nippon Ishinkin Gakkai Zasshi · doi:10.3314/jjmm.49.157 · Cited by 26
Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520
Shukla, S. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh308 · Cited by 25
Domain Interactions in the Yeast ATP Binding Cassette Transporter Ycf1p: Intragenic Suppressor Analysis of Mutations in the Nucleotide Binding Domains
Falcón‐Pérez, J. M., Martı́nez-Burgos, M., Molano, J., Mazón, M. J., & Eraso, P. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.16.4761-4770.2001 · Cited by 24
Translation of New Technologies: From Basic Research to Drug Discovery and Development
Bhogal, N., & Balls, M. (2008) · Current Drug Discovery Technologies · doi:10.2174/157016308785739839 · Cited by 23
Multidermatomal Herpes Zoster in an AIDS Patient
Edelstein, H. E. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.5.975 · Cited by 22
Antifungal Susceptibility of Cryptococcus neoformans Isolates in HIV-Infected Patients to Fluconazole, Itraconazole and Voriconazole in Spain: 1994–1996 and 1997–2005
Aller, A. I., Claro, R. M., Castro, C., Serrano, C., Colom, M. F., & Martín‐Mazuelos, E. (2007) · Chemotherapy · doi:10.1159/000102585 · Cited by 20
Lack of Change in the Distribution of AIDS-Defining Opportunistic Diseases and the Related Degree of Immunodeficiency During the Periods Before and After the Introduction of Highly Active Antiretroviral Therapy
Manfredi, R., Calza, L., & Chiodo, F. (2001) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960100494 · Cited by 20
Characterization of the Saccharomyces cerevisiae sec6-41 mutation and tools to create S. cerevisiae strains containing the sec6-4 allele
Lamping, E., Tanabe, K., Niimi, M., et al. (2005) · Gene · doi:10.1016/j.gene.2005.07.014 · Cited by 18
Self-citation
Functional Analysis of the Promoter of the YeastSNQ2Gene Encoding a Multidrug Resistance Transporter that Confers the Resistance to 4-NitroquinolineN-Oxide
Cui, Z., Hirata, D., & Miyakawa, T. (1999) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.63.162 · Cited by 18
Erratum
(2003) · Clinical Infectious Diseases · doi:10.1086/377516 · Cited by 17
Modulator-Induced Interference in Functional Cross Talk between the Substrate and the ATP Sites of Human P-glycoprotein
Maki, N., Moitra, K., Silver, C., Ghosh, P., Chattopadhyay, A., & Dey, S. (2006) · Biochemistry · doi:10.1021/bi0521745 · Cited by 16
The Fungal Kingdom: Diverse and Essential Roles in Earth's Ecosystem
Casadevall, A., Heitman, J., & Buckley, M. R. (2008) · Cited by 16
Treatment options in candidaemia
Karthaus, M., & Cornely, O. A. (2007) · Mycoses · doi:10.1111/j.1439-0507.2007.01379.x · Cited by 15
Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity
Fish, P. V., Barta, N. S., Gray, D. L., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.06.071 · Cited by 14
Allelic variants of ABC drug transporter Cdr1p in clinical isolates of Candida albicans
Haque, A., Rai, V., Bahal, B. S., Shukla, S., Lattif, A. A., Mukhopadhyay, G., & Prasad, R. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.035 · Cited by 12
Peptide Motifs for Cell-Surface Intervention
Monk, B. C., & Harding, D. R. K. (2005) · BioDrugs · doi:10.2165/00063030-200519040-00005 · Cited by 11
Self-citation
Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520
Raymond, M., Ruetz, S., Thomas, D. Y., & Gros, P. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.277-286.1994 · Cited by 11
Culture and Non-Culture Based Diagnostics for Candida species
Richardson, Carlson, P., & Calderone, R. (2001) · Research Explorer (The University of Manchester) · Cited by 10
Functional protein expression from a DNA based wheat germ cell-free system
Zhao, K. Q., Hurst, R., Slater, M. R., et al. (2007) · Journal of Structural and Functional Genomics · doi:10.1007/s10969-007-9035-2 · Cited by 8
Amino Acid Residues Affecting Drug Pump Function in Candida albicans-C. albicans Drug Pump Function-
Holmes, A. R., Tsao, S., Lamping, E., Niimi, K., Monk, B. C., Tanabe, K., Niimi, M., & Cannon, R. D. (2006) · Nippon Ishinkin Gakkai Zasshi · doi:10.3314/jjmm.47.275 · Cited by 6
Self-citation
Stress responses in Candida albicans.
Quinn, J., Brown, A. J. P., d’Enfert, C., & Hube, B. (2007) · Cited by 5
Yeast as an expression system for the study of P-glycoprotein and other ABC transporters.
Gros, P., Beaudet, L., & Urbatsch, I. L. (1998) · PubMed · Cited by 2

Sorted by citations

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801
Fungal Biofilm Resistance
Ramage, G., Rajendran, R., Sherry, L., & Williams, C. (2012) · International Journal of Microbiology · doi:10.1155/2012/528521 · Cited by 583
Regulatory circuitry governing fungal development, drug resistance, and disease.
Shapiro, R. S., Robbins, N., & Cowen, L. E. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00045-10 · Cited by 576
Candidiasis and Mechanisms of Antifungal Resistance
Bhattacharya, S., Sae-Tia, S., & Fries, B. C. (2020) · Antibiotics · doi:10.3390/antibiotics9060312 · Cited by 474
Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis
Scorzoni, L., de Paula e Silva, A. C. A., Marcos, C. M., Assato, P. A., de Melo, W. C. M. A., de Oliveira, H. C., Costa-Orlandi, C. B., Mendes-Giannini, M. J. S., & Fusco-Almeida, A. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00036 · Cited by 418

See all 608

Authors: Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C.
Affiliations: University of Otago (NZ)
UCLouvain (BE)
National Institute of Infectious Diseases (JP)
Université Catholique de Louvain, Louvain-la-Neuve, Belgium
ORCID: Cannon, Richard D.
Lamping, Erwin
Holmes, Ann R.
Baret, Philippe V.
Keniya, Mikhail V.
Tanabe, Koichi
Monk, Brian C.
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2009-04
Volume: 22
Issue: 2
Pages: 291-321
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.00051-08
PMC: PMC2668233
OpenAlex: W2163758697
Cited by: 608
References: 399
Citations by year: 2026: 28 · 2025: 30 · 2024: 33 · 2023: 35 · 2022: 32 · 2021: 44 · 2020: 42 · 2019: 34 · 2018: 28 · 2017: 40 · 2016: 35 · 2015: 36 · 2014: 51 · 2013: 42 · 2012: 32
FWCI: 3.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Funders: National Institute of Dental and Craniofacial Research (R01DE016885)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: azole resistance, ABC transporters, major facilitator superfamily, pleiotropic drug resistance, echinocandins, fungal stress response, efflux pump inhibition, invasive fungal infections, antifungal drug development
MeSH terms: Antifungal Agents, DNA-Binding Proteins, Fungal Proteins, Fungi, Humans, Membrane Proteins, Mycoses, Transcription Factors, ATP-Binding Cassette Transporters, Drug Resistance, Fungal, Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Efflux-Mediated Antifungal Drug Resistance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks