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Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase
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“Over 20 different PDZ domain-containing proteins have been identified as targets of the high-risk E6 proteins [271]; amongst them are discs of large tumour suppressor (hDlg) [268,269], scribble tumour suppressor (hScrib) [272] and Membrane-associated guanylate kinase inverted 1 (MAGI-1) [273,274]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [272]
In the citing paper
“hDlg, hScrib and MAGI-1 are tumour suppressors; the loss of these proteins facilitates cancer formation (reviewed in [275,276]), and all high-risk E6 proteins target them for proteasome-mediated degradation [272,277,278], most likely leading to the loss of cell polarity and facilitating tumour formation [279,280]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [272]
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Citations
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“E6 has been shown to induce telomerase activity (24), and a mutation in HPV type 16 (HPV16) E6 (SAT8–10) that renders it unable to target p53 leaves intact the ability to induce telomerase activity and to immortalize mammary epithelial cells (22).”
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Cited by
Molecular biology of human papillomavirus infection and cervical cancer
Doorbar, J. (2006) · Clinical Science · doi:10.1042/cs20050369 · Cited by 1,072
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
Brumby, A. M., & Richardson, H. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg548 · Cited by 628
Narisawa‐Saito, M., & Kiyono, T. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00546.x · Cited by 528
Integrated activity of PDZ protein complexes regulates epithelial polarity
Bilder, D., Schober, M., & Perrimon, N. (2003) · Nature Cell Biology · doi:10.1038/ncb897 · Cited by 435
Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436
Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse
Murdoch, J. N. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg014 · Cited by 308
Qin, Y., Capaldo, C., Gumbiner, B. M., & Macara, I. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506094 · Cited by 285
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement
Navarro, C., Nola, S., Audebert, S., Santoni, M.-J., Arsanto, J.-P., Ginestier, C., Marchetto, S., Jacquemier, J., Isnardon, D., Le Bivic, A., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208632 · Cited by 237
Mammalian Scribble Forms a Tight Complex with the βPIX Exchange Factor
Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lécine, P., Bellaiche, Y., Dupont, J.-L., Premont, R. T., Sempéré, C., Strub, J.-M., et al. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.051 · Cited by 218
White, E. A., Kramer, R. E., Tan, M. J. A., Hayes, S. D., Harper, J. W., & Howley, P. M. (2012) · Journal of Virology · doi:10.1128/jvi.02172-12 · Cited by 198
Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses
Javier, R. T., & Rice, A. P. (2011) · Journal of Virology · doi:10.1128/jvi.05410-11 · Cited by 198
Dow, L. E., Kauffman, J. S., Caddy, J., Peterson, A. S., Jane, S. M., Russell, S. M., & Humbert, P. O. (2007) · Oncogene · doi:10.1038/sj.onc.1210016 · Cited by 187
Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58509 · Cited by 185
Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains
Kallay, L. M., McNickle, A., Brennwald, P. J., Hubbard, A. L., & Braiterman, L. T. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20992 · Cited by 156
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Elsum, I. A., Martin, C., & Humbert, P. O. (2013) · Journal of Cell Science · doi:10.1242/jcs.129387 · Cited by 87
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hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells
Métais, J.-Y., Navarro, C., Santoni, M.-J., Audebert, S., & Borg, J.-P. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.062 · Cited by 77
The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction
Nagasaka, K., Pim, D., Massimi, P., Thomas, M., Tomaić, V, Subbaiah, V. K., Kranjec, C., Nakagawa, S., Yano, T., Taketani, Y., et al. (2010) · Oncogene · doi:10.1038/onc.2010.265 · Cited by 75
Self-citationTumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium
Ivanov, A. I., Young, C., Beste, K. D., Capaldo, C. T., Humbert, P. O., Brennwald, P., Parkos, C. A., & Nusrat, A. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090220 · Cited by 73
Vimentin Regulates Scribble Activity by Protecting It from Proteasomal Degradation
Phua, D. C. Y., Humbert, P. O., & Hunziker, W. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0199 · Cited by 68
The Scribble family in cancer: twentieth anniversary
Santoni, M.-J., Kashyap, R., Camoin, L., & Borg, J.-P. (2020) · Oncogene · doi:10.1038/s41388-020-01478-7 · Cited by 62
Role of the polarity protein Scribble for podocyte differentiation and maintenance
Hartleben, B., Widmeier, E., Wanner, N., Schmidts, M., Kim, S. T., Schneider, L., Mayer, B., Kerjaschki, D., Miner, J. H., Walz, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036705 · Cited by 52
Pearson, H. B., McGlinn, E., Phesse, T. J., Schlüter, H., Srikumar, A., Gödde, N. J., Woelwer, C. B., Ryan, A., Phillips, W. A., Ernst, M., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0440-z · Cited by 39
E3 ubiquitin ligases and human papillomavirus-induced carcinogenesis
Lou, Z., & Wang, S. (2014) · Journal of International Medical Research · doi:10.1177/0300060513506655 · Cited by 22
Metadata
- Authors
- Nakagawa, S., & Huibregtse, J. M.
- Affiliations
- Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08855
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-11-01
- Volume
- 20
- Issue
- 21
- Pages
- 8244-8253
- ISSN
- 1098-5549
- Cited by
- 382
- References
- 3
- Language
- en
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