Cited by 181Gut microbiota and healthAutism Spectrum Disorder ResearchChild Nutrition and Feeding Issues

Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder

Open access
Wang, Mingbang, Wan, Jing, Rong, Han, He, Fusheng, Wang, Hui, Zhou, Jiaxiu, Cai, Chunquan, Wang, Yan +3 more·2019·mSystems

Abstract

Multiple lines of evidence suggest that the gut microbiota may play an important role in the pathogenesis of ASD, but the specific mechanism is still unclear. Through a comprehensive gut metagenomic and metabolome study of children with ASD, alterations in gut metabolite composition were found in children with ASD, and these alterations were linked to changes in gut microbiota composition. This may give us a deeper understanding of the role of gut microbiota in the pathogenesis of ASD.

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  • Independent studies have indicated a potential increase in the abundance of Collinsella, Eggerthella, Haemophilus, Klebsiella, and Phyllobacterium bacteria in the intestines of individuals diagnosed with ASD compared to the general population.

    “Furthermore, the findings of independent studies have indicated a potential increase in the abundance of Collinsella, Eggerthella, Haemophilus, Klebsiella, and Phyllobacterium bacteria in the intestines of individuals diagnosed with ASD compared to the general population [18,102,104,111].”
  • A scientific study of bacteria in the Eggerthella genus revealed an increase in the prevalence of Eggerthella lenta and Eggerthella lenta DSM 2243.

    “In addition, a scientific study of bacteria in the Eggerthella genus revealed an increase in the prevalence of two distinct taxa: Eggerthella lenta and Eggerthella lenta DSM 2243 [104].”

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Authors
Wang, M., Wan, J., Rong, H., He, F., Wang, H., Zhou, J., Cai, C., Wang, Y., Xu, R., Yin, Z., & Zhou, W.
Affiliations
  • Fudan University (CN)
  • Division of Neonatology, The People’s Hospital of Dehong Autonomous Prefecture, Mangshi, Yunnan, China
  • Shenzhen KangNing Hospital (CN)
  • Imunobio, Shenzhen, Guangdong, China
  • Children’s Hospital of Fudan University Xiamen Branch (CN)
  • Shenzhen Children's Hospital (CN)
  • Tianjin Children's Hospital (CN)
  • Longgang Central Hospital (CN)
Corresponding author
  • Wang, Mingbang
  • Yin, Zhaoqing
  • Zhou, Wenhao
Venue
mSystems
Published
2019-02-26
Volume
4
Issue
1
ISSN
2379-5077 (ISSN-L)
OpenAlex
W2914854965
Cited by
181
References
31
Citations by year
2026: 14 · 2025: 20 · 2024: 28 · 2023: 23 · 2022: 29 · 2021: 36 · 2020: 22 · 2019: 9
FWCI
7.94
Type
journal article
Language
en
Open access
Locations
  • mSystems (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81701351, 81720108018)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
autism spectrum disorder, gut microbiota, glutamate metabolism, gut metabolome, gut metagenomics, children, ASD pathogenesis, microbial metabolites

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