Cited by 310Physical Activity and HealthTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Benefits from aerobic exercise in patients with major depression: a pilot study

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Dimeo, F, Bauer, M, Varahram, I, Proest, G, Halter, U·2001·British Journal of Sports Medicine

DOI 10.1136/bjsm.35.2.114PMC PMC1724301

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Abstract

Background—Several reports indicate that physical activity can reduce the severity of symptoms in depressed patients. Some data suggest that even a single exercise bout may result in a substantial mood improvement. Objective—To evaluate the short term effects of a training programme on patients with moderate to severe major depression. Methods—Twelve patients (mean (SD) age 49 (10) years; five men, seven women) with a major depressive episode according to the Diagnostic and Statistical Manual of the American Society of Psychiatry (DSM IV) criteria participated. The mean (SD) duration of the depressive episode was 35 (21) weeks (range 12–96). Training consisted of walking on a treadmill following an interval training pattern and was carried out for 30 minutes a day for 10 days. Results—At the end of the training programme, there was a clinically relevant and statistically significant reduction in depression scores (Hamilton Rating Scale for Depression: before, 19.5 (3.3); after, 13 (5.5); p = 0.002. Self assessed intensity of symptoms: before, 23.2 (7); after, 17.7 (8.1); p = 0.006. Values are mean (SD)). Subjective and objective changes in depression scores correlated strongly (r = 0.66, p = 0.01). Conclusions—Aerobic exercise can produce substantial improvement in mood in patients with major depressive disorders in a short time.

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Authors: Dimeo, F., Bauer, M., Varahram, I., Proest, G., & Halter, U.
Affiliations: Freie Universität Berlin (DE)
Corresponding author: Dimeo, F
ORCID: Bauer, M
Venue: British Journal of Sports Medicine
Publisher: BMJ
Published: 2001-04
Volume: 35
Issue: 2
Pages: 114-117
ISSN: 0306-3674 (ISSN-L)
1473-0480
DOI: 10.1136/bjsm.35.2.114
PMC: PMC1724301
OpenAlex: W2106982472
Cited by: 310
References: 19
Citations by year: 2025: 6 · 2024: 14 · 2023: 22 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 9 · 2018: 14 · 2017: 10 · 2016: 19 · 2015: 15 · 2014: 10 · 2013: 27 · 2012: 18
FWCI: 2.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: British Journal of Sports Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: aerobic exercise, major depressive disorder, treadmill walking, interval training, exercise intervention, mood improvement, Hamilton Depression Rating Scale
MeSH terms: Adult, Major Depressive Disorder, Exercise Therapy, Female, Humans, Male, Middle Aged, Pilot Projects

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Benefits from aerobic exercise in patients with major depression: a pilot study

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