A randomised, controlled study on the effects of a short-term endurance training programme in patients with major depression.
Open accessAbstract
OBJECTIVE: To evaluate the short-term effects of exercise in patients with major depression. DESIGN: Prospective, randomised, controlled study. SETTING: A university hospital. PATIENTS: A consecutive series of 38 inpatients with a major depression episode undergoing standard clinical antidepressant drug treatment. INTERVENTIONS: Patients were randomly assigned to an exercise (walking, n = 20) or placebo (low-intensity stretching and relaxation exercises, n = 18) group. Training was carried out for 10 days. MAIN OUTCOME MEASUREMENTS: Severity of depression assessed with the Bech-Rafaelsen Melancholy Scale (BRMS) and the Center for Epidemiologic Studies Depression scale (CES-D). RESULTS: After 10 days, reduction of depression scores in the exercise group was significantly larger than in the placebo group (BRMS: 36% v 18%; CES-D: 41% v 21%; p for both = 0.01); the proportion of patients with a clinical response (reduction in the BRMS scores by more than six points) was also larger for the exercise group (65% v 22%, p<0.01). CONCLUSIONS: Endurance exercise may help to achieve substantial improvement in the mood of selected patients with major depression in a short time.
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The inclusion of AE to a traditional antidepressant intervention has been shown to have a greater impact on reducing depressive symptoms in patients with MDD than antidepressant treatment alone.
“Additionally, the inclusion of AE to a traditional antidepressant intervention has been shown to have greater impact on reducing depressive symptoms in patients with MDD, than antidepressant treatment alone (Knubben et al., 2007; Schuch et al., 2011; Legrand and Neff, 2016).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Knubben et al., 2007
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“Y Y 6 Knubben, Reischies [34] Y Y ?”
BackgroundInfluential
- Authors
- Knubben, K., Reischies, F. M., Adli, M., Schlattmann, P., Bauer, M., & Dimeo, F.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Dimeo, F
- Venue
- British Journal of Sports Medicine
- Publisher
- BMJ
- Published
- 2006-10-24
- Volume
- 41
- Issue
- 1
- Pages
- 29-33
- ISSN
- 0306-3674 (ISSN-L)
- 1473-0480
- PMC
- PMC2465130
- OpenAlex
- W2158906808
- Cited by
- 226
- References
- 32
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 11 · 2023: 3 · 2022: 11 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 12 · 2016: 13 · 2015: 19 · 2014: 19 · 2013: 20 · 2012: 19
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Sports Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- major depressive disorder, endurance exercise, walking, exercise therapy, depression severity, antidepressant treatment, hospitalized patients, brief intervention
- MeSH terms
- Adult, Antidepressive Agents, Combined Modality Therapy, Major Depressive Disorder, Exercise Therapy, Female, Humans, Male, Middle Aged, Physical Endurance, Prospective Studies, Psychiatric Status Rating Scales, Severity of Illness Index, Time Factors, Treatment Outcome
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