Relation between iron stores and non-insulin dependent diabetes in men: case-control study
Open accessAbstract
Non-insulin dependent diabetes mellitus is a common complication of diseases of iron overload such as haemochromatosis; 53-80% of patients with haemochromatosis develop diabetes.1 The development of diabetes in haemochromatosis is related to the magnitude of the excess iron.1 In a cross sectional, population based study of over 1000 middle aged men in eastern Finland we found that fasting concentrations of serum insulin and blood glucose were raised in men with high serum concentrations of ferritin (an indication of raised stores of iron).2 Iron is a catalyst of free radical stress, and it has been suggested that free radicals and lipid peroxidation play a part in the aetiology of diabetes.3 Formation of hydroxyl radicals catalysed by iron may play an important part in the development of diabetes since the cells that produce insulin are extraordinarily sensitive to damage from oxidation.3 In another cohort study low plasma concentrations of …
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Iron excess is a known feature of gestational diabetes and a clear risk factor for diabetes even in normal populations; diabetes is a classical consequence of iron overloading in hereditary haemochromatosis.
“Iron 'excess' is also a known feature of gestational diabetes [591-593], and is a clear risk factor for the disease even in 'normal' populations [594-603], and indeed diabetes is a classical consequence of iron overloading as seen in hereditary haemochromatosis [604].”
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Self-citationAssociation Between Body Iron Stores and the Risk of Acute Myocardial Infarction in Men
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- Authors
- Salonen, J. T., Tuomainen, T.-P., Nyyssönen, K., Lakka, H.-M., & Punnonen, K.
- Affiliations
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
- Corresponding author
- Salonen, Jukka T
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1998-09-12
- Volume
- 317
- Issue
- 7160
- Pages
- 727-730
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC28662
- OpenAlex
- W2157091064
- Cited by
- 242
- References
- 5
- Citations by year
- 2026: 2 · 2024: 7 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 17 · 2012: 21
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-44199, R01HL044199)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- type 2 diabetes, iron stores, ferritin, hemochromatosis, iron overload, free radical stress, lipid peroxidation, hydroxyl radicals, insulin, blood glucose, men
- MeSH terms
- Adult, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Follow-Up Studies, Hemochromatosis, Humans, Iron, Male, Middle Aged, Vitamin E, Cohort Studies
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