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Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
Open accessAbstract
BACKGROUND: Lifestyle interventions focusing on weight loss remain the cornerstone of non-alcoholic fatty liver disease (NAFLD) management. Despite this, the weight losses achieved in research trials are not easily replicated in the clinic and there is an urgent need for therapies independent of weight loss. Aerobic exercise is not well sustained and the effectiveness of the better tolerated resistance exercise upon liver lipid and mediators of liver lipid has not been assessed. METHODS: Sedentary adults with clinically defined NAFLD were assigned to 8 weeks of resistance exercise (n=11) or continued normal treatment (n=8). RESULTS: 8 weeks of resistance exercise elicited a 13% relative reduction in liver lipid (14.0 ± 9.1 vs. 12.2 ± 9.0; p<0.05). Lipid oxidation (submaximal RQ -0.020 ± 0.010 vs. -0.004 ± 0.003; p<0.05), glucose control (-12% vs. +12% change AUC; p<0.01) and homeostasis model assessment insulin resistance (5.9 ± 5.9 to 4.6 ± 4.6 vs. 4.7 ± 2.1 to 5.1 ± 2.5; p<0.05) were all improved. Resistance exercise had no effect on body weight, visceral adipose tissue volume, or whole body fat mass (p>0.05). CONCLUSION: This is the first study to demonstrate that resistance exercise specifically improves NAFLD independent of any change in body weight. These data demonstrate that resistance exercise may provide benefit for the management for non-alcoholic fatty liver, and the long-term impact of this now requires evaluation.
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“Resistance exercise showed significant reduction in ALT levels compared with control groups (WMD = − 15.40 IU/L, 95%CI − 28.60 to − 2.20, P < 0.001)”
From Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials (2025) · cites this paper as [80]
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“Hallsworth et al. [80] assessed the effects of only resistance exercise on liver steatosis in participants with NAFLD, showing no differences between the intervention group and control.”
From Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials (2025) · cites this paper as [80]
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In the citing paper
“Most were effective for steatosis reduction, without a single optimal exercise prescription being identi fi ed for individuals with fi brosis. 315,316”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [315]
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“Based on seven protocols from seven studies, a reduction in hepatic steatosis was observed in 85.7% of the protocols, including five randomized controlled trials (76–82).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [76]
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“Three protocols demonstrated improvements in hepatic steatosis without significant weight loss (76, 80, 83).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [76]
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“MR spectroscopy showed a decrease in intrahepatic lipid levels in three studies (13%; 3%; and 25% reduction from baseline (76–78)).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [76]
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Citations
Cites
Abràmoff, M. D., Magalhães, P. J., & Ram, S. J. (2004) · Utrecht University Repository (Utrecht University) · Cited by 11,816
Angulo, P., Hui, J. M., Marchesini, G., Bugianesi, E., George, J., Farrell, G. C., Enders, F., Saksena, S., Burt, A. D., Bida, J. P., et al. (2007) · Hepatology · doi:10.1002/hep.21496 · Cited by 3,255
Self-citationSzczepaniak, L. S., Nurenberg, P., Leonard, D. S., Browning, J. D., Reingold, J. S., Grundy, S. M., Hobbs, H. H., & Dobbins, R. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00064.2004 · Cited by 1,573
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
Promrat, K., Kleiner, D. E., Niemeier, H. M., Jackvony, E., Kearns, M., Wands, J. R., Fava, J. L., & Wing, R. R. (2010) · Hepatology · doi:10.1002/hep.23276 · Cited by 1,330
MOFRAD, P., Contos, M. J., Haque, M., Sargeant, C., Fisher, R. A., Luketic, V. A., Sterling, R. K., Shiffman, M. L., Stravitz, R. T., & Sanyal, A. J. (2003) · Hepatology · doi:10.1053/jhep.2003.50229 · Cited by 1,199
A position statement on NAFLD/NASH based on the EASL 2009 special conference
Ratziu, V., Bellentani, S., Cortez‐Pinto, H., Day, C., & Marchesini, G. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.04.008 · Cited by 1,083
Self-citationEffect of fatty acids on glucose production and utilization in man.
Ferrannini, E., Barrett, E. J., Bevilacqua, S., & DeFronzo, R. A. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111133 · Cited by 1,050
Java-based graphical user interface for the MRUI quantitation package
Naressi, A., Couturier, C., Devos, J. M., Janssen, M., Mangeat, C., de Beer, R., & Graveron‐Demilly, D. (2001) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/bf02668096 · Cited by 1,003
Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911
Fracanzani, A. L., Valenti, L. V. C., Bugianesi, E., Andreoletti, M., Colli, A., Vanni, E., Bertelli, C., Fatta, E., Bignamini, D., Marchesini, G., et al. (2008) · Hepatology · doi:10.1002/hep.22429 · Cited by 716
Flagged first, then by citations
Cited by
Sorted by citations
Physical activity/exercise and diabetes: A position statement of the American Diabetes Association
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016) · Diabetes Care · doi:10.2337/dc16-1728 · Cited by 2,991
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747
Self-citationCusi, K., Isaacs, S., Barb, D., Basu, R., Caprio, S., Garvey, W. T., Kashyap, S., Mechanick, J. I., Mouzaki, M., Nadolsky, K., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.03.010 · Cited by 1,021
Nonalcoholic fatty liver disease: A precursor of the metabolic syndrome
Lonardo, A., Ballestri, S., Marchesini, G., Angulo, P., & Loria, P. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.09.020 · Cited by 692
Musso, G., Cassader, M., Rosina, F., & Gambino, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2446-4 · Cited by 661
Lim, R. B. T., Wee, W. K., For, W. C., Ananthanarayanan, J. A., Soh, Y. H., Goh, L. M. L., Tham, D. K. T., & Wong, M. L. (2020) · BMC Public Health · doi:10.1186/s12889-019-7969-5 · Cited by 605
Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Keating, S. E., Hackett, D. A., George, J., & Johnson, N. A. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.02.023 · Cited by 548
Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: a systematic review
Hashida, R., Kawaguchi, T., Bekki, M., Omoto, M., Matsuse, H., Nago, T., Takano, Y., Ueno, T., Koga, H., George, J., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.08.023 · Cited by 509
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 545
Taylor, R. (2013) · Diabetes Care · doi:10.2337/dc12-1805 · Cited by 485
Self-citationSarcopenia is an independent risk factor for non-alcoholic steatohepatitis and significant fibrosis
Koo, B. K., Kim, D., Joo, S. K., Kim, J. H., Chang, M. S., Kim, B. G., Lee, K. L., & Kim, W. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.08.019 · Cited by 440
Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus
Targher, G., Lonardo, A., & Byrne, C. D. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.173 · Cited by 397
Prince, S. A., Saunders, T. J., Gresty, K., & Reid, R. D. (2014) · Obesity Reviews · doi:10.1111/obr.12215 · Cited by 382
Pirola, C. J., Gianotti, T. F., Burgueño, A. L., Rey-Funes, M., Loidl, C. F., Mallardi, P., Martino, J. S., Castaño, G. O., & Sookoian, S. (2013) · Gut · doi:10.1136/gutjnl-2012-302962 · Cited by 364
Bacchi, E., Negri, C., Targher, G., Faccioli, N., Lanza, M., Zoppini, G., Zanolin, E., Schena, F., Bonora, E., & Moghetti, P. (2013) · Hepatology · doi:10.1002/hep.26393 · Cited by 350
Wong, V. W., Chan, R., Wong, G. L., Cheung, B., Chu, C. W., Yeung, D. K., Chim, A. M., Lai, J. W.-Y., Li, L. S., Sea, M. M.-M., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.013 · Cited by 346
Kim, D., & Kim, W. R. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.08.028 · Cited by 341
Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans
Pafili, K., & Roden, M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101122 · Cited by 330
Effect of aerobic exercise training dose on liver fat and visceral adiposity
Keating, S. E., Hackett, D. A., Parker, H. M., O’Connor, H. T., Gerofi, J. A., Sainsbury, A., Baker, M. K., Chuter, V. H., Caterson, I. D., George, J., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.022 · Cited by 313
AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions
Lonardo, A., Nascimbeni, F., Targher, G., Bernardi, M., Bonino, F., Bugianesi, E., Casini, A., Gastaldelli, A., Marchesini, G., Marra, F., et al. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.01.147 · Cited by 313
Long, M. T., Noureddin, M., & Lim, J. K. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.023 · Cited by 299
Targher, G., & Byrne, C. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3093 · Cited by 299
The effects of physical exercise on fatty liver disease.
van der Windt, D. J., Sud, V., Zhang, H., Tsung, A., & Huang, H. (2018) · Gene Expression · doi:10.3727/105221617x15124844266408 · Cited by 294
Features, Diagnosis, and Treatment of Nonalcoholic Fatty Liver Disease
Torres, D. M., Williams, C. D., & Harrison, S. A. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.03.011 · Cited by 275
KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease
Kang, S. H., Lee, H. W., Yoo, J., Cho, Y., Kim, S. U., Lee, T. H., Jang, B. K., Ahn, S. B., Ahn, S. B., Kim, H., et al. (2021) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2021.0178 · Cited by 276
Katsagoni, C. N., Georgoulis, M., Papatheodoridis, G. V., Panagiotakos, D. B., & Kontogianni, M. D. (2017) · Metabolism · doi:10.1016/j.metabol.2016.12.006 · Cited by 270
Lifestyle modification in NAFLD/NASH: Facts and figures
Hallsworth, K., & Adams, L. A. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.10.008 · Cited by 281
Self-citationNon-alcoholic fatty liver disease: A patient guideline
Francque, S. M., Marchesini, G., Kautz, A., Walmsley, M., Dorner, R., Lazarus, J. V., Zelber-Sagi, S., Hallsworth, K., Busetto, L., Frühbeck, G., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100322 · Cited by 264
Self-citationBallestri, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i7.1724 · Cited by 266
Current efforts and trends in the treatment of NASH
Ratziu, V., Goodman, Z. D., & Sanyal, A. J. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.041 · Cited by 268
Irisin is inversely associated with intrahepatic triglyceride contents in obese adults
Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.030 · Cited by 234
Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo
Williams, K., Shackel, N. A., Gorrell, M. D., McLennan, S. V., & Twigg, S. M. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1009 · Cited by 235
Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management
Marjot, T., Moolla, A., Cobbold, J. F., Hodson, L., & Tomlinson, J. W. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz009 · Cited by 228
Bozzetto, L., Prinster, A., Annuzzi, G., Costagliola, L., Mangione, A., Vitelli, A., Mazzarella, R., Longobardo, M., Mancini, M., Vigorito, C., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0033 · Cited by 227
Sandireddy, R., Sakthivel, S., Gupta, P., Behari, J., Tripathi, M., & Singh, B. K. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1433857 · Cited by 235
Sung, K., Jeong, W. S., Wild, S. H., & Byrne, C. D. (2012) · Diabetes Care · doi:10.2337/dc11-1853 · Cited by 217
Orci, L. A., Gariani, K., Oldani, G., Delaune, V., Morel, P., & Toso, C. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.04.036 · Cited by 213
Houghton, D., Thoma, C., Hallsworth, K., Cassidy, S., Hardy, T., Burt, A. D., Tiniakos, D., Hollingsworth, K. G., Taylor, R., Day, C. P., et al. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.07.031 · Cited by 209
Self-citationNonalcoholic Fatty Liver Disease
Wang, X., & Malhi, H. (2018) · Annals of Internal Medicine · doi:10.7326/aitc201811060 · Cited by 212
Hallsworth, K., Thoma, C., Hollingsworth, K. G., Cassidy, S., Anstee, Q. M., Day, C. P., & Trenell, M. I. (2015) · Clinical Science · doi:10.1042/cs20150308 · Cited by 201
Self-citationExercise and the Regulation of Hepatic Metabolism
Trefts, E., Williams, A. S., & Wasserman, D. H. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.010 · Cited by 201
Ezpeleta, M., Gabel, K., Cienfuegos, S., Kalam, F., Lin, S., Pavlou, V., Song, Z., Haus, J. M., Koppe, S., Alexandria, S. J., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.001 · Cited by 181
Golabi, P., Locklear, C. T., Austin, P. W., Afdhal, S., Byrns, M., Gerber, L. H., & Younossi, Z. M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i27.6318 · Cited by 180
Resolution of Fatty Liver and Risk of Incident Diabetes
Sung, K., Wild, S. H., & Byrne, C. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1519 · Cited by 172
Bae, J. C., Suh, S., Park, S. E., Rhee, E., Park, C., Oh, K. W., Park, S. W., Kim, S. W., Hur, K. Y., Kim, J. H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046819 · Cited by 165
Insights into the Epidemiology, Pathogenesis, and Therapeutics of Nonalcoholic Fatty Liver Diseases
Yu, Y., Cai, J., She, Z., & Li, H. (2018) · Advanced Science · doi:10.1002/advs.201801585 · Cited by 166
Moore, S. A., Hallsworth, K., Jakovljević, D. G., Blamire, A. M., He, J., Ford, G. A., Rochester, L., & Trenell, M. I. (2014) · Neurorehabilitation and neural repair · doi:10.1177/1545968314562116 · Cited by 173
Self-citationClark, J. E. (2015) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-015-0154-1 · Cited by 158
Oh, S., Shida, T., Yamagishi, K., Tanaka, K., So, R., Tsujimoto, T., & Shoda, J. (2014) · Hepatology · doi:10.1002/hep.27544 · Cited by 159
Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches
Lomonaco, R., Sunny, N. E., Bril, F., & Cusi, K. J. (2013) · Drugs · doi:10.1007/s40265-012-0004-0 · Cited by 159
Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial
Zelber-Sagi, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i15.4382 · Cited by 152
Effect of exercise on the development of new fatty liver and the resolution of existing fatty liver
Sung, K., Ryu, S., Lee, J., Kim, J., Wild, S. H., & Byrne, C. D. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.026 · Cited by 154
Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
Ashcroft, S. P., Stocks, B., Egan, B., & Zierath, J. R. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.008 · Cited by 149
Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
Hallsworth, K., Hollingsworth, K. G., Thoma, C., Jakovljević, D. G., MacGowan, G. A., Anstee, Q. M., Taylor, R., Day, C. P., & Trenell, M. I. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.11.015 · Cited by 149
Self-citationOh, S., So, R., Shida, T., Matsuo, T., Kim, B., Akiyama, K., Isobe, T., Okamoto, Y., Tanaka, K., & Shoda, J. (2017) · Scientific Reports · doi:10.1038/srep43029 · Cited by 146
Effect of Weight Loss, Diet, Exercise, and Bariatric Surgery on Nonalcoholic Fatty Liver Disease
Hannah, W. N., & Harrison, S. A. (2016) · Clinics in Liver Disease · doi:10.1016/j.cld.2015.10.008 · Cited by 152
Fougerat, A., Montagner, A., Loiseau, N., Guillou, H., & Wahli, W. (2020) · Cells · doi:10.3390/cells9071638 · Cited by 150
High intensity interval training improves liver and adipose tissue insulin sensitivity
Marcinko, K., Sikkema, S. R., Samaan, M. C., Kemp, B. E., Fullerton, M. D., & Steinberg, G. R. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.09.006 · Cited by 146
Zelber‐Sagi, S., Godos, J., & Salomone, F. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16638830 · Cited by 141
Role of diet and lifestyle changes in nonalcoholic fatty liver disease.
Nseir, W., Hellou, E., & Assy, N. (2014) · PubMed Central · doi:10.3748/wjg.v20.i28.9338 · Cited by 147
Are Lifestyle Therapies Effective for NAFLD Treatment?
El-Agroudy, N. N., Kurzbach, A., Rodionov, R. N., O’Sullivan, J., Roden, M., Birkenfeld, A. L., & Pesta, D. H. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.013 · Cited by 144
Smart, N. A., King, N., McFarlane, J. R., Graham, P. L., & Dieberg, G. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096197 · Cited by 140
Cuthbertson, D. J., Shojaee-Moradie, F., Sprung, V. S., Jones, H., Pugh, C. J. A., Richardson, P., Kemp, G. J., Barrett, M., Jackson, N. C., Thomas, E. L., et al. (2016) · Clinical Science · doi:10.1042/cs20150447 · Cited by 138
Clinical approaches to non-alcoholic fatty liver disease
Schwenger, K. J. P. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i7.1712 · Cited by 139
Battista, F., Ermolao, A., van Baak, M. A., Beaulieu, K., Blundell, J. E., Busetto, L., Carraça, E. V., Encantado, J., Dicker, D., Farpour‐Lambert, N. J., et al. (2021) · Obesity Reviews · doi:10.1111/obr.13269 · Cited by 167
Kenneally, S., Sier, J. H., & Moore, J. B. (2017) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2017-000139 · Cited by 135
Nutritional therapy for nonalcoholic fatty liver disease
Dongiovanni, P., Lanti, C., Riso, P., & Valenti, L. V. C. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.08.024 · Cited by 133
Shamsoddini, A., Sobhani, V., Ghamar Chehreh, M. E., Alavian, S. M., & Zaree, A. (2015) · Hepatitis Monthly · doi:10.5812/hepatmon.31434 · Cited by 126
Hepatocellular carcinoma and lifestyles
Saran, U., Humar, B., Kolly, P., & Dufour, J. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.08.028 · Cited by 126
Lifestyle and Dietary Interventions in the Management of Nonalcoholic Fatty Liver Disease
Hannah, W. N., & Harrison, S. A. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4153-y · Cited by 129
Clamp, L. D., Hume, D. J., Lambert, E. V., & Kroff, J. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.31 · Cited by 124
Leite, N. C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8377 · Cited by 125
Mouzaki, M., & Allard, J. P. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31824cf51e · Cited by 125
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis
Sabag, A., Way, K. L., Keating, S. E., Sultana, R. N., O'Connor, H. T., Baker, M. K., Chuter, V., George, J., & Johnson, N. A. (2017) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.12.006 · Cited by 126
Preparing for the NASH Epidemic: A Call to Action
Kanwal, F., Shubrook, J. H., Younossi, Z. M., Natarajan, Y., Bugianesi, E., Rinella, M. E., Harrison, S. A., Mantzoros, C. S., Pfotenhauer, K. M., Klein, S., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.04.074 · Cited by 127
Keating, S. E., Sabag, A., Hallsworth, K., Hickman, I. J., Macdonald, G. A., Stine, J. G., George, J., & Johnson, N. A. (2023) · Sports Medicine · doi:10.1007/s40279-023-01918-w · Cited by 119
Self-citationResistance training, visceral obesity and inflammatory response: a review of the evidence
Strasser, B., Arvandi, M., & Siebert, U. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.00988.x · Cited by 120
Fernández, T., Viñuela, M., Vidal, C., & Barrera, F. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263931 · Cited by 117
Non-alcoholic fatty liver disease and lifestyle modifications, focusing on physical activity
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Metadata
- Authors
- Hallsworth, K., Fattakhova, G., Hollingsworth, K. G., Thoma, C., Moore, S., Taylor, R., Day, C. P., & Trenell, M. I.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Trenell, Michael I
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2011-06-27
- Volume
- 60
- Issue
- 9
- Pages
- 1278-1283
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC3152868
- OpenAlex
- W2131294862
- Cited by
- 529
- References
- 58
- Citations by year
- 2026: 36 · 2025: 30 · 2024: 37 · 2023: 34 · 2022: 35 · 2021: 38 · 2020: 40 · 2019: 31 · 2018: 28 · 2017: 38 · 2016: 49 · 2015: 40 · 2014: 36 · 2013: 32 · 2012: 21
- FWCI
- 22.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- National Institute for Health and Care Research (FP7/2007–2013)
- Diabetes UK
- European Commission (2007–2013, FP7 2007-2013, FP7/2007, 241762)
- Medical Research Council (MC_G0802536)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- resistance training, non-alcoholic fatty liver disease, liver fat, hepatic lipid oxidation, insulin resistance, glycemic control, visceral adipose tissue, sedentary adults
- MeSH terms
- Adult, Aged, Anthropometry, Blood Glucose, Body Composition, Exercise Test, Fatty Acids, Nonesterified, Fatty Liver, Female, Humans, Lipids, Liver, Male, Middle Aged, Motor Activity, Oxidation-Reduction, Weight Loss, Treatment Outcome, Lipid Metabolism, Resistance Training, Non-alcoholic Fatty Liver Disease
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