The DOI matches its Crossref record; 133 of the 134 references it cites were found in a registry or an index.
An update on the use and investigation of probiotics in health and disease
Open accessAbstract
Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment. They act through diverse mechanisms affecting the composition or function of the commensal microbiota and by altering host epithelial and immunological responses. Certain probiotic interventions have shown promise in selected clinical conditions where aberrant microbiota have been reported, such as atopic dermatitis, necrotising enterocolitis, pouchitis and possibly irritable bowel syndrome. However, no studies have been conducted that can causally link clinical improvements to probiotic-induced microbiota changes. Whether a disease-prone microbiota pattern can be remodelled to a more robust, resilient and disease-free state by probiotic administration remains a key unanswered question. Progress in this area will be facilitated by: optimising strain, dose and product formulations, including protective commensal species; matching these formulations with selectively responsive subpopulations; and identifying ways to manipulate diet to modify bacterial profiles and metabolism.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“FMT introduces a complete, stable, and durable community of gut microbiota [26] , unlike probiotics, that temporarily alter the metabolic, or immunologic activity, of the native gut microbiota [27] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [27]
In the citing paper
“the use of probiotics in preventive medicine to keep a healthy intestinal function is well documented”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · cited 1×
“92 Factors associated with allergy such as birth delivery mode (caesarean section vs vaginal delivery), 93 antibiotic use in the newborn and infant, and non-breast-milk diets are also associated with shifts in the gut microbiota.”
BackgroundInduction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Global, regional, and national causes of child mortality in 2008: a systematic analysis
Black, R. E., Cousens, S. N., Johnson, H. L., Lawn, J. E., Rudan, I., Bassani, D. G., Jha, P., Campbell, H. J., Walker, C. L. F., Cibulskis, R. E., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60549-1 · Cited by 3,062
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · cited 1×
“Recently, faecal microbiota transplant from non-diabetic donors infused into the duodenum of patients with the metabolic syndrome improved their insulin sensitivity, highlighting the broad potential of this intervention.(116) However, cocktails of defined microbes imparting key functionalities may provide a more accep…”
BackgroundNeu, J., & Walker, W. A. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1005408 · Cited by 2,141
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · cited 1×
“Others have analysed the microbiology in patients with CRC and suggested that the bacterial diversity is less,(72) altered(73) 74 or accompanied by high levels of Fusobacterium nucleatum sequences.(75) Studies in rodents have concentrated on probiotic effects on precancerous lesions and tumours.”
BackgroundMicrobial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
Self-citationThe Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Self-citation
Cited by
Sorted by citations
Items 301–400 of 503
Dalziel, J. E., Anderson, R. C., Peters, J. S., Lynch, A. T., Spencer, N. J., Dekker, J., & Roy, N. C. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00020 · Cited by 13
“Beneficial probiotic bacteria have been shown to improve symptoms of GI discomfort through relief of constipation and/or diarrhea in clinical studies (Ringel et al., 2012; Sanders et al., 2013).”
BackgroundLavari, L., Burns, P., Páez, R., Reinheimer, J. A., & Vinderola, G. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13567 · Cited by 12
“Probiotics are widely used as preventative or therapeutic agents or added into foods, and numerous human intervention studies have been performed to prove their beneficial effects in the last decade (Sanders et al. 2013).”
BackgroundCross‐sectional evaluation of gut microbial–host cometabolites in patients with chronic pancreatitis
Xu, J. J., Meng, Y., Zou, W., Zhao, J. L., Xue, F., Zhang, Y., Zhou, W., Zhang, L., Wang, K. X., Hu, L., et al. (2023) · Journal of Digestive Diseases · doi:10.1111/1751-2980.13162 · Cited by 12
Probiotics: assessing health professionals' knowledge and understanding
Johnson, N., Thomas, L. V., & Jordan, D. (2016) · Gastrointestinal Nursing · doi:10.12968/gasn.2016.14.1.26 · Cited by 12
Immunopathology and Immunomodulation
Metodiev, K. (2015) · InTech eBooks · doi:10.5772/59217 · Cited by 12
Asgari, F., Falak, R., Teimourian, S., Pourakbari, B., Ebrahimnezhad, S., & Shekarabi, M. (2018) · Europe PMC (PubMed Central) · Cited by 12
Safety of Lactobacillus Reuteri DSM 17938 in Healthy Children 2–5 Years of Age
Kosek, M. N., Yori, P. P., Olórtegui, M. P., Lefante, J. J., Ramal-Asayag, C., Zamora-Babilonia, M., Meza‐Sánchez, G., & Oberhelman, R. A. (2018) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002267 · Cited by 11
“Exclusion criteria included were the following: (1) exclusionary household members (another study participant, pregnant or breast-feeding women, infant younger than 6 months, immunosuppressed individuals); (2) allergy to penicillin, cephalosporins or gentamicin; (3) antibiotic use within 30 days; (4) use of probiotics…”
BackgroundXia, T., Wang, N., Tang, Y., Gao, Y., Gao, C., Hao, J., Jiang, Y., Wang, X., Shan, Z., Li, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.926279 · Cited by 11
“Lactobacillus have become the most promising live bacterial vectors due to their probiotic effects (23, 24).”
BackgroundXiong, S., Dong, J., Wang, W., Zheng, G., Wu, N., Xie, J., Wang, R., He, X., & Li, J. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142575 · Cited by 11
Effect of a synbiotic on functional abdominal pain in childhood.
Gholizadeh, A., Mehrabani, S., Dooki, M. E., & Ahmadi, M. H. (2021) · PubMed Central · doi:10.22088/cjim.12.2.194 · Cited by 12
“Now, some growing studies showed efficacy of probiotics as live micro-organisms with health benefits on the host in the treatment of different gastrointestinal disorders (10).”
BackgroundPeng, W., Li, Y., Yang, G., Duan, J., Yang, L., Chen, L., Hou, S.-L., & Huang, X. (2022) · Food & Function · doi:10.1039/d1fo03864h · Cited by 12
Drug discovery approaches to irritable bowel syndrome
Hornby, P. J. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1049528 · Cited by 11
“As summarized recently ‘optimizing strain, dose and product formulations, including protective commensal species; matching these formulations with selectively responsive subpopulations; and identifying ways to manipulate diet to modify bacterial profiles and metabolism’ will be critical for using probiotics in IBS [59…”
BackgroundDalziel, J. E., Mohan, V., Peters, J. S., Anderson, R. C., Gopal, P. K., & Roy, N. C. (2014) · Food & Function · doi:10.1039/c4fo00831f · Cited by 11
Modulation of Stem Cell Progeny by Probiotics during Regeneration of Gastric Mucosal Erosions
Al-Yassir, F., Khoder, G., Sugathan, S., Saseedharan, P., Menhali, A. A., & Karam, S. M. (2021) · Biology · doi:10.3390/biology10070596 · Cited by 11
“DSF has been extensively investigated and is currently recommended for the prevention and treatment of irritable bowel syndrome [13], pouchitis [14], Crohn’s disease [15], and ulcerative colitis [16].”
BackgroundAntimicrobial activity of probiotic Streptococcus salivarius LAB813 on in vitro cariogenic biofilms
Gong, S., El-shennawy, S., Choudhary, P., Dufour, D., & Levesque, C. M. (2023) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2023.105760 · Cited by 12
Liu, Z., Song, H., & Shen, B. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000094 · Cited by 10
“Probiotics are live micro-organisms, which act through diverse mechanisms affecting the composition and function of the commensal microbiota, thereby providing beneficial effects on the host [12].”
BackgroundMichael, H., Srivastava, V., Deblais, L., Amimo, J. O., Chepngeno, J., Saif, L. J., Rajashekara, G., & Vlasova, A. N. (2022) · mSphere · doi:10.1128/msphere.00270-22 · Cited by 10
“Probiotics are increasingly used to enhance oral vaccine responses and treat enteric infections (6) and ulcerative colitis in children (7).”
BackgroundXiang, X., Wang, X., Shang, Y., & Ding, Y. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.03.006 · Cited by 10
Saa, C., Bunout, D., & Hirsch, S. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001322 · Cited by 10
Effects of Bacillus subtilis Natto NB205 and Its Mutant NBMK308 on Egg Quality in Aging Laying Hens
Liao, C., Cui, J., Lei, J., Guo, Y., & Zhang, B. (2023) · Life · doi:10.3390/life13051109 · Cited by 9
“subtilis can survive passage through the gastrointestinal tract nd colonize the intesti es of both humans and animal [29,30], where it can p vide various he lth benefits such as modulating the i mune syste and producing an imicrobial compounds [31].”
BackgroundFaghfoori, Z., Gargari, B. P., Saber, A., Seyyedi, M., & Khosroushahi, A. Y. (2017) · PubMed Central · Cited by 9
Can probiotics enhance vaccine-specific immunity in children and adults?
Kwak, J., & Lamousé-Smith, E. S. N. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0147 · Cited by 9
Screening and Identification of Biosurfactant-Producing Lactic Acid Bacteria
Dong, Y., Shu, G., Dai, C., Zhang, M., & Wan, H. (2019) · Acta Universitatis Cibiniensis. Series E: Food Technology · doi:10.2478/aucft-2019-0011 · Cited by 9
Zhang, J., Wan, S., & Gui, Q. (2021) · Translational Pediatrics · doi:10.21037/tp-21-195 · Cited by 9
“IL-6 is a lymphokine secreted by T lymphocytes, and promotes the secretion of C-reactive protein, induces the production of acute reactive protein and aggravates the degree of inflammation (24).”
BackgroundTakahata, M., Frémont, M., Desreumaux, P., Rousseaux, C., Dubuquoy, C., Shimomiya, Y., Nakamura, Y., & Miyake, Y. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.06.003 · Cited by 9
Probiotics in inflammatory bowel disease: Pathophysiological background and clinical applications
Pagnini, C. (2013) · World Journal of Immunology · doi:10.5411/wji.v3.i3.31 · Cited by 9
Influence of indigenous microbiota on experimental toxoplasmosis in conventional and germ‐free mice
Nascimento, B. B., Cartelle, C. T., Noviello, M. D. L. M., Pinheiro, B. V., Vítor, R. W. A., de Souza, D. D. G., Generoso, S. D. V., Cardoso, V. N., Martins, F. S., Nicoli, J. R., et al. (2017) · International Journal of Experimental Pathology · doi:10.1111/iep.12236 · Cited by 9
“(2017), 98, 191–202 Intestinal microbiota plays an important role in host animal homoeostasis (Sartor 2010; Martins et al. 2013; Sanders et al. 2013) and is vital to many aspects of normal host physiology.”
BackgroundMinj, J., & Vij, S. (2025) · Frontiers in Chemistry · doi:10.3389/fchem.2024.1470704 · Cited by 8
Chen, J., Cai, J., Lin, J., Cheng, Z., & Long, M. (2023) · Current Microbiology · doi:10.1007/s00284-022-03171-2 · Cited by 8
The Developing Intestinal Microbiome: Probiotics and Prebiotics
Neu, J. (2014) · World review of nutrition and dietetics · doi:10.1159/000358465 · Cited by 10
Discovery of Lipids from B. longum subsp. infantis using Whole Cell MALDI Analysis
Timmer, M. S. M., Sauvageau, J., Foster, A. J., Ryan, J. L. J., Lagutin, K., Shaw, O. M., Harper, J. L., Sims, I. M., & Stocker, B. L. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo501016c · Cited by 8
Zhang, Q., Gao, F., Yang, X. F., Hu, Y., Liu, Y., Hou, Y., Li, Y., Zhu, B., Niu, S., Huang, Y., et al. (2020) · Medical Science Monitor · doi:10.12659/msm.924040 · Cited by 8
“We also attributed the latter group of patients (n=93) to the non-probiotic cohort, mainly as the benefits of probiotics for patients with variceal bleeding may need to reach a threshold effective dose [37].”
ResultProbiotics as Live Bio-therapeutics: Prospects and Perspectives
Kaur, J., Singh, B. P., Chaudhary, V., Elshaghabee, F. M. F., Singh, J., Singh, A., Rokana, N., & Panwar, H. (2020) · Microorganisms for sustainability · doi:10.1007/978-981-15-6795-7_5 · Cited by 8
Trends in micronutrient research since the SDGs: a global perspective
Abafe, E. A., Smith, N. W., Maxwell, T. M. R., & McNabb, W. C. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2483801 · Cited by 8
“This approach enhances precision in preventive and therapeutic interventions, including managing conditions like irritable bowel syndrome and colorectal cancer through dietary adjustments and probiotics (Legesse Bedada et al. 2020; Sanders et al. 2013).”
Probiotics supplements for the prevention of atopic dermatitis in children: an umbrella review
Zhong, L., Su, J., Zhou, X., & Wan, H. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1587348 · Cited by 7
“The rapid increase in AD prevalence globally, especially in developed countries, underscores the urgent need for primary prevention strategies (5, 6).”
Magnetism in living magnetically-induced bacteria
Martı́n, M., Garcés, V., Dominguez-Vera, J. M., & Gálvez, N. (2016) · RSC Advances · doi:10.1039/c6ra20295k · Cited by 7
Rossi, R. E., Chen, J., & Caplin, M. E. (2022) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2022.27.2.137 · Cited by 8
Correlating the Gut Microbiome to Health and Disease
Marques, T. M., Mall, J. G., Forsgård, R. A., Wall, R., Brummer, R. J., & de Vos, W. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00010-2 · Cited by 9
Breaking Bad– the two sides of gut microbiota in portal hypertension
Mehta, G., & Mookerjee, R. P. (2014) · Liver International · doi:10.1111/liv.12598 · Cited by 7
“The mechanisms of these beneficial effects remain to be ascertained, but proposed pathways include suppressing growth of pathogenic bacteria, blocking epithelial attachment by pathogens, enhancing mucosal function and directly modulating host immune responses (16).”
BackgroundRafael, E. G.-C., Castillo, F. C., & Arnulfo, T.-D. (2017) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2016.15700 · Cited by 7
“These health benefits include therapeutic effects such as alleviating symptoms of lactose malabsorption, reducing the level of serum cholesterol, irritable bowel syndromes and colon cancer, besides enhancing resistance to gut infections (Kailasapathy and Chin, 2000; Sanders et al., 2013).”
BackgroundProspects of fermented milk products in children with primary hypolactasia of the adult type
Богданова, Н. М., Хавкин, А. И., & Kolobova, O. L. (2020) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2020-65-3-160-168 · Cited by 7
Ali, A., & AlHussaini, K. I. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1740387 · Cited by 6
“Overall, while probiotics may offer benefits, their use in IBD should be personalized and supervised by healthcare professionals to minimize risks and optimize outcomes (Sanders et al., 2013).”
Antibacterial Effects of Compound Bifilact on E.coli and Campylobacter jejuni
Ebrahimnezhad, H., Barzegar, L., & Esmaeili, D. (2020) · Medical Laboratory Journal · doi:10.29252/mlj.14.1.15 · Cited by 6
“They act through different mechanisms, affecting the commensal microbiota and potentially improving and maintaining gut microecology against pathogens (1, 2).”
Nutraceuticals and biotics in pediatric gastrointestinal disorders
Corsello, A., Scatigno, L., Fiore, G., Baresi, S., Eletti, F., Zuccotti, G., Strisciuglio, C., Dilillo, D., & Verduci, E. (2023) · European Journal of Clinical Nutrition · doi:10.1038/s41430-023-01362-z · Cited by 6
“However, despite the validity of the conceptual basis for the use of probiotics, experimental data available from studies conducted on animal models are not univocal, and the existing literature on the utility of probiotics in IBD, particularly in pediatric RCT, is limited [72, 73].”
Rossi, R. E., Rossi, L., & Fassio, F. (2015) · Journal of Contemporary Immunology · doi:10.7726/jci.2015.1003 · Cited by 6
Mitigation of Foodborne Illnesses by Probiotics
Ryan, V., & Bhunia, A. K. (2017) · Springer eBooks · doi:10.1007/978-3-319-56836-2_21 · Cited by 6
Impact of Probiotics in Human Health and Disease Treatment
Tingirikari, J. M. R., Sarathy, M. V., & Karthigarani, A. K. (2018) · Advances in human services and public health (AHSPH) book series · doi:10.4018/978-1-5225-3267-5.ch002 · Cited by 6
Tumor Suppressor Effects of Probiotics
Kahraman, M. S., & Karahan, A. G. (2018) · Turkish Bulletin of Hygiene and Experimental Biology · doi:10.5505/turkhijyen.2018.15428 · Cited by 6
Oberhelman, R. A., Kosek, M. N., Yori, P. P., Olórtegui, M. P., & Connolly, E. (2014) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.13-0639 · Cited by 6
Liu, D., Liu, J., Ran, L., Yang, Z., He, Y., Yang, H., Yu, Y., Fu, L., Zhu, M., & Chen, H. (2024) · Microorganisms · doi:10.3390/microorganisms12061097 · Cited by 5
“They can enhance the immune system; prevent intestinal infections, diarrhea, irritable bowel syndrome, and necrotizing enterocolitis; and stabilize the intestinal mucosal barrier [2,3].”
BackgroundProbiotics: Where Do We Stand?
Marcason, W. (2013) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2013.08.010 · Cited by 5
Szajewska, H. (2013) · Immunotherapy · doi:10.2217/imt.13.85 · Cited by 5
Influence of probiotics on gastrointestinal symptoms in patients undergoing colonoscopy
Hung, J., Liu, T., Yi, C., Wong, M., Lei, W., & Chen, C. (2020) · Advances in digestive medicine · doi:10.1002/aid2.13186 · Cited by 5
Byrne, D. F., Geraghty, A. A., Yelverton, C. A., Murphy, E. F., van Sinderen, D., Cotter, P. D., & McAuliffe, F. M. (2020) · Food & Function · doi:10.1039/d0fo01727b · Cited by 5
Galloway, D. P., & Cohen, M. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-67293-1.00038-4 · Cited by 5
Wang, J., Wen, B., Zeng, Y., Wang, H., Zhao, W. H., Zhou, Y., Liu, L., Wang, P., Pan, K., Jing, B., et al. (2022) · Microbial Pathogenesis · doi:10.1016/j.micpath.2022.105477 · Cited by 5
Centanni, M., Turroni, S., Rampelli, S., Biagi, E., Quercia, S., Consolandi, C., Severgnini, M., Brigidi, P., & Candela, M. (2014) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12515 · Cited by 5
Probiotics in cirrhosis: do we expect too much?
Soriano, G., & Guarner, C. (2013) · Liver International · doi:10.1111/liv.12288 · Cited by 5
“Probiotics are life micro-organisms that produce a beneficial effect to the host when administered in an adequate amount (1).”
BackgroundProbiotics: microbes for human health and beyond
Thakur, A., Sharma, P., Sharma, A. J., Sharma, N., Singh, S., Chamoli, N., & Kumar, R. (2025) · Food Materials Research · doi:10.48130/fmr-0024-0029 · Cited by 5
Pastacılık Ürünlerinde Probiyotiklerin Kullanım Potansiyeli
Şengün, İ. Y., & Kutlu, C. (2019) · Akademik Gıda · doi:10.24323/akademik-gida.613644 · Cited by 4
“Probiyotiklerin özellikle sindirim sistemi (GIS) üzerine olumlu etkiler gösterdiği, kandaki kolesterol seviyesini düşürdüğü, gıda alerjilerini önlediği, bağışıklık sistemini desteklediği, antimikrobiyal, antioksidan, antimutajenik ve antikarsinojenik etkileri olduğu belirlenmiştir [13-19].”
Tolstanova, G. M., Akulenko, I., Serhiichuk, T., Dovbynchuk, T., & Stepanova, N. (2023) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-3-031-19564-8_12 · Cited by 4
The Bifidobacterim bifidum (BIB2) Probiotic Increased Immune System Factors in Men Sprint Athletes
Khani, A. H., Jazayeri, S. M. M., Ebrahimi, E., & Farhadi, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84222 · Cited by 4
“The benefits of probiotics such as reducing toxins, increase immunity and resistance to infection, produce vitamins and nutrients, organic acids, reduce allergic reactions, respiratory infections, reduce the symptoms of irritable bowel syndrome, arthritis, rheumatoid and modulating immune responses have been shown in…”
BackgroundGonzález-Cuello, R., Ortega‐Toro, R., & García‐Zapateiro, L. A. (2018) · Contemporary Engineering Sciences · doi:10.12988/ces.2018.8117 · Cited by 4
“Benefits associated with the probiotics intake include modulation of the gastrointestinal system, stimulation of the immune system and reduction of lactose intolerance and irritable bowel symptoms [15].”
BackgroundFrom the Mediterranean Diet to the Microbiome
Childs, C. E. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy087 · Cited by 4
Mahfouz, M. K., elhamid, O. A., Emam, M. A., & Bakr, M. (2016) · Benha Veterinary Medical Journal · doi:10.21608/bvmj.2016.31306 · Cited by 4
Fehér, J., Kovács, I., Pacella, E., & Radak, Z. O. (2014) · Orvosi Hetilap · doi:10.1556/oh.2014.29987 · Cited by 4
Grossenbacher, F., Gashi, A., & der Vaart, I. B.-V. (2016) · Advances in Microbiology · doi:10.4236/aim.2016.614092 · Cited by 4
Future Impact of Probiotic Therapy of Metabolic Disorder
El‐Sayyad, H. I. (2017) · Cited by 4
Probiotic effect and dietary correlations on faecal microbiota profiles in irritable bowel syndrome
Stevenson, C., Blaauw, R., Fredericks, E., Visser, J., & Roux, S. (2019) · South African Journal of Clinical Nutrition · doi:10.1080/16070658.2019.1697038 · Cited by 5
“Our research has demonstrated that low fibre intake was associated with Bifidobacteria.”
BackgroundInfluentialMarine-derived probiotic microorganisms: A review of their therapeutic applications in human health
Katariya, S., Khapandi, K., Gadhiya, A., & Chhatrodiya, D. (2026) · The Microbe · doi:10.1016/j.microb.2026.100680 · Cited by 3
Tuteja, A. K. (2022) · Federal Practitioner · doi:10.12788/fp.0322 · Cited by 3
Cheng, S., Xiao, W., Shi, F., Zhao, Z., Gao, X., Zhang, Y., Huang, H., Li, F., Cao, C., & Han, J. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c08690 · Cited by 3
Targeting the microbiota in the management of gastrointestinal and liver disease.
Quigley, E. M. M., & Monsour, H. (2013) · PubMed · doi:10.47892/rgp.2013.332.219 · Cited by 3
Self-citationInfant colic: from theory to practice
Валерьевна, К. Е., Maksimov, M. L., Kanner, I. D., Lapkin, N. M., & Gorelov, A. V. (2022) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2022-16-1-115-120 · Cited by 3
Roy, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64046-8.00245-7 · Cited by 4
Schneider, A. E., Zeiler, M. D., Kopp, K., Wagner, G., & Karwautz, A. F. K. (2023) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000930 · Cited by 3
The Role of Probiotics in Sports
Nishihira, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813922-6.00036-9 · Cited by 3
Antibacterial activity of colostrum kefir against foodborne pathogen bacteria
Windayani, N., Kurniati, T., & Rukayadi, Y. (2020) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/472/1/012019 · Cited by 3
Effect of Probiotics in the Mitigation of Clostridium difficile Associated Disease
Adekunle, O. (2022) · Digital Archive @ GSU · doi:10.57709/7032560 · Cited by 3
Research trends and hotspots of nanomaterials in inflammatory bowel disease: a bibliometric analysis
Yu, W., Liu, N., Gui, P., Huang, X., Feng, X., Liu, L., Yang, D., Guo, G., & Xiong, C. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2527594 · Cited by 3
Feng, G., Xu, M., Liang, H., Peng, J., Sun, T., Du, Y., Huang, Y., & Fang, J. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.173286 · Cited by 2
Quigley, E. M. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802189-7.00039-3 · Cited by 3
Self-citationTsuruda, C. T., de Souza, P. C., Nishio, E. K., Almeida, R. S., Panagio, L. A., Baptista, A. A. S., García, S., Pinheiro, D. O., Araújo, E. J. D. A., Chue-Gonçalves, M., et al. (2020) · Microbiology Research Journal International · doi:10.9734/mrji/2020/v30i730238 · Cited by 2
“Probiotics are usually incorporated into nutritional supplements and pharmaceutical products [3].”
Shiriaev, V. A., Lavrentev, F. V., Morozova, O. V., Ashikhmina, M. S., Goltsman, L. M., Kondrateva, S. A., Kazantceva, U. I., Utkin, R. A., Арсеньева, Т. П., & Iakovchenko, N. V. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.17445 · Cited by 2
Probiotics for Allergic Airway Infection and Inflammations
Patil, S. V., Mohite, B. V., & Patil, V. S. (2021) · Springer eBooks · doi:10.1007/978-981-33-6236-9_13 · Cited by 2
Probiotics: A Mainstream Therapy for the Disease Suppression
Ghattargi, V. C., Shouche, Y. S., Dhakephalkar, P. K., Rao, P. K., Ramana, V., Dhotre, D. P., & Lanjekar, V. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00008-5 · Cited by 2
Ouwehand, A. C., & Tennilä, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802189-7.00018-6 · Cited by 2
Tang, Y., & Saris, P. E. J. (2014) · Current Microbiology · doi:10.1007/s00284-014-0610-z · Cited by 2
Interaction between gut microbiota and host immune cells
Nakagawa, R., & Yoshimura, A. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.140 · Cited by 2
Steyer, G. E. (2017) · Erfahrungsheilkunde · doi:10.1055/s-0043-101612 · Cited by 2
Immune System in Undernourished Host
Núñez, I. N., Perdigón, G., & Galdeano, C. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809762-5.00006-1 · Cited by 2
TECHNOLOGY PROSPECTING OF INFANT STOOL AS A SOURCE OF NOVEL PROBIOTIC PRODUCTS
Mendes, H. B. R., Plaza‐Díaz, J., Bomfim, M. R. Q., Hernández, A., & Monteiro‐Neto, V. (2018) · Revista Gestão Inovação e Tecnologias · doi:10.7198/geintec.v8i1.942 · Cited by 2
Lactic Acid Bacteria and Gut Health
Li, H., & Fang, Z. (2019) · Springer eBooks · doi:10.1007/978-981-13-7832-4_8 · Cited by 2
Gut-lung cross talk in COVID-19 pathology and fatality rate
El-Ansary, A. K., Balto, H. A. G., & Al‐Hadlaq, S. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90769-9.00037-2 · Cited by 2
Masche, U. (2015) · pharma-kritik · doi:10.37667/pk.2014.946 · Cited by 2
Modifying the Gut Microbiome Through Diet: Effects on the Immune System of Elderly Subjects
Childs, C. E., & Calder, P. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_160-1 · Cited by 2
Tang, Y. (2014) · Työväentutkimus Vuosikirja · Cited by 2
Probiotic Associated Therapeutic Curli Hybrids (PATCH)Preprint
Praveschotinunt, P., Duraj‐Thatte, A., Gelfat, I., Bahl, F., Chou, D. B., & Joshi, N. S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/464966 · Cited by 2
Gámez, H. J., Romero-Benavides, D. A., & GARCES, A. M. (2016) · Biotecnología en el Sector Agropecuario y Agroindustrial · doi:10.18684/bsaa(14)18-28 · Cited by 1
“los probióticos tienen un efecto benéfico en el tracto intestinal, manteniendo y for taleciendo los mecanismos de defensa, sin alterar las funciones fisiológicas y bioquímicas [2].”
Background
Metadata
- Authors
- Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M., Sartor, R. B., Sherman, P. M., & Mayer, E. A.
- Affiliations
- Dairy & Food Culture Technologies, Centennial, Colorado, USA
- Vall d'Hebron Hospital Universitari (ES)
- University of Virginia (US)
- Rockefeller University (US)
- Houston Methodist (US)
- University of North Carolina at Chapel Hill (US)
- University of Toronto (CA)
- University of California, Los Angeles (US)
- Corresponding author
- Mayer, Emeran A
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2013-03-08
- Volume
- 62
- Issue
- 5
- Pages
- 787-796
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC4351195
- OpenAlex
- W2148017101
- Cited by
- 503
- References
- 134
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 20 · 2023: 29 · 2022: 29 · 2021: 34 · 2020: 37 · 2019: 29 · 2018: 44 · 2017: 46 · 2016: 52 · 2015: 58 · 2014: 61 · 2013: 22
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc)
- PubMed Central (acceptedVersion, cc-by-nc)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- UNC Libraries
- Funders
- Procter and Gamble
- Mead Johnson Nutrition
- Danone
- Ironwood Pharmaceuticals, Incorporated
- Alimentary Health
- Instituto Danone
- Norgine
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK048351, U01DK082370)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, gut microbiota, commensal microbiota, atopic dermatitis, necrotizing enterocolitis, pouchitis, irritable bowel syndrome, host immune response, diet and microbiome, microbiota resilience
- MeSH terms
- Colitis, Ulcerative, Crohn Disease, Cross Infection, Diarrhea, Female, Health Status, Humans, Hypersensitivity, Vaginitis, Colorectal Neoplasms, Meta-Analysis as Topic, Evidence-Based Medicine, Probiotics, Enterocolitis, Necrotizing, Irritable Bowel Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
