Cited by 1,137Gut microbiota and healthNatural Antidiabetic Agents StudiesAdipokines, Inflammation, and Metabolic Diseases

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A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice

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Anhê, Fernando F, Roy, Denis, Pilon, Geneviève, Dudonné, Stéphanie, Matamoros, Sébastien, Varin, Thibault V, Garofalo, Carole, Moine, Quentin, Desjardins, Yves, Levy, Emile, Marette, André·2015·Gut

DOI 10.1136/gutjnl-2014-307142

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Abstract

Objective: The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure of conventional treatments to curb these diseases. The gut microbiota has been put forward as a key player in the pathophysiology of diet-induced T2D. Importantly, cranberry (Vaccinium macrocarpon Aiton) is associated with a number of beneficial health effects. We aimed to investigate the metabolic impact of a cranberry extract (CE) on high fat/high sucrose (HFHS)-fed mice and to determine whether its consequent antidiabetic effects are related to modulations in the gut microbiota. Design: C57BL/6J mice were fed either a chow or a HFHS diet. HFHS-fed mice were gavaged daily either with vehicle (water) or CE (200 mg/kg) for 8 weeks. The composition of the gut microbiota was assessed by analysing 16S rRNA gene sequences with 454 pyrosequencing. Results: CE treatment was found to reduce HFHS-induced weight gain and visceral obesity. CE treatment also decreased liver weight and triglyceride accumulation in association with blunted hepatic oxidative stress and inflammation. CE administration improved insulin sensitivity, as revealed by improved insulin tolerance, lower homeostasis model assessment of insulin resistance and decreased glucose-induced hyperinsulinaemia during an oral glucose tolerance test. CE treatment was found to lower intestinal triglyceride content and to alleviate intestinal inflammation and oxidative stress. Interestingly, CE treatment markedly increased the proportion of the mucin-degrading bacterium Akkermansia in our metagenomic samples. Conclusions: CE exerts beneficial metabolic effects through improving HFHS diet-induced features of the metabolic syndrome, which is associated with a proportional increase in Akkermansia spp. population.

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Authors: Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., & Marette, A.
Affiliations: Institut universitaire de cardiologie et de pneumologie de Québec (CA)
Université Laval (CA)
Centre Hospitalier Universitaire Sainte-Justine (CA)
Corresponding author: Marette, André
ORCID: Anhê, Fernando F
Roy, Denis
Pilon, Geneviève
Dudonné, Stéphanie
Matamoros, Sébastien
Varin, Thibault V
Desjardins, Yves
Levy, Emile
Marette, André
Venue: Gut
Publisher: BMJ
Published: 2014-07-30
Volume: 64
Issue: 6
Pages: 872-883
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2014-307142
OpenAlex: W2099456560
Cited by: 1,137
References: 75
Citations by year: 2026: 53 · 2025: 85 · 2024: 86 · 2023: 98 · 2022: 128 · 2021: 175 · 2020: 134 · 2019: 117 · 2018: 83 · 2017: 71 · 2016: 62 · 2015: 45
FWCI: 24.34
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
Funders: Université Laval
Ministère du Développement Économique, de l’Innovation et de l’Exportation
Agence Universitaire de la Francophonie
Institut sur la Nutrition et les Aliments Fonctionnels
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: cranberry extract, cranberry, polyphenols, diet-induced obesity, insulin resistance, type 2 diabetes, gut microbiota, Akkermansia, high-fat high-sugar diet, visceral obesity, hepatic steatosis, hepatic oxidative stress, intestinal inflammation, metabolic syndrome, mucin-degrading bacteria
MeSH terms: Animals, Enteritis, Hepatitis, Homeostasis, Insulin Resistance, Intestines, Lipids, Lipopolysaccharides, Liver, Male, Mice, Inbred C57BL, Organ Size, Plant Extracts, Triglycerides, Endotoxemia, Vaccinium macrocarpon, Lipid Metabolism, Mice, Obesity, Abdominal, Diet, High-Fat, Polyphenols, Verrucomicrobia, Microbiota

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A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice

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