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A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice
Open accessAbstract
Objective: The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure of conventional treatments to curb these diseases. The gut microbiota has been put forward as a key player in the pathophysiology of diet-induced T2D. Importantly, cranberry (Vaccinium macrocarpon Aiton) is associated with a number of beneficial health effects. We aimed to investigate the metabolic impact of a cranberry extract (CE) on high fat/high sucrose (HFHS)-fed mice and to determine whether its consequent antidiabetic effects are related to modulations in the gut microbiota. Design: C57BL/6J mice were fed either a chow or a HFHS diet. HFHS-fed mice were gavaged daily either with vehicle (water) or CE (200 mg/kg) for 8 weeks. The composition of the gut microbiota was assessed by analysing 16S rRNA gene sequences with 454 pyrosequencing. Results: CE treatment was found to reduce HFHS-induced weight gain and visceral obesity. CE treatment also decreased liver weight and triglyceride accumulation in association with blunted hepatic oxidative stress and inflammation. CE administration improved insulin sensitivity, as revealed by improved insulin tolerance, lower homeostasis model assessment of insulin resistance and decreased glucose-induced hyperinsulinaemia during an oral glucose tolerance test. CE treatment was found to lower intestinal triglyceride content and to alleviate intestinal inflammation and oxidative stress. Interestingly, CE treatment markedly increased the proportion of the mucin-degrading bacterium Akkermansia in our metagenomic samples. Conclusions: CE exerts beneficial metabolic effects through improving HFHS diet-induced features of the metabolic syndrome, which is associated with a proportional increase in Akkermansia spp. population.
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“Researchers have confirmed that a polyphenol-rich cranberry extract and metformin attenuate diet-induced metabolic syndrome in mice in a gut microbiota-dependent manner (16, 17).”
In the citing paper
“These improvements were coupled to dramatic 7-to-10-fold blooms of Akkermansia muciniphila”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [96]
In the citing paper
“Mice fed high-fat diets supplemented with polyphenols showed reduced diet-induced weight gain and adiposity, improved insulin sensitivity, and diminished markers of intestinal inflammation and oxidative stress compared to controls20, 96.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [96]
In the citing paper
“Furthermore, the metabolic benefits of dietary polyphenol, cranberry extract, and metformin are associated with increased amount of this bacterial species in the gut.”
From Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016) · cites this paper as [37]
In the citing paper
“Increased Akkermansia abundance has been linked with reduced intestinal permeability and gut-to-blood leakage of endotoxins (eg, lipopolysaccharides), thereby alleviating diet-induced obesity and insulin resistance (49).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [49]
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Metadata
- Authors
- Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., & Marette, A.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Marette, André
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2014-07-30
- Volume
- 64
- Issue
- 6
- Pages
- 872-883
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2099456560
- Cited by
- 1,137
- References
- 75
- Citations by year
- 2026: 53 · 2025: 85 · 2024: 86 · 2023: 98 · 2022: 128 · 2021: 175 · 2020: 134 · 2019: 117 · 2018: 83 · 2017: 71 · 2016: 62 · 2015: 45
- FWCI
- 24.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université Laval
- Ministère du Développement Économique, de l’Innovation et de l’Exportation
- Agence Universitaire de la Francophonie
- Institut sur la Nutrition et les Aliments Fonctionnels
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- cranberry extract, cranberry, polyphenols, diet-induced obesity, insulin resistance, type 2 diabetes, gut microbiota, Akkermansia, high-fat high-sugar diet, visceral obesity, hepatic steatosis, hepatic oxidative stress, intestinal inflammation, metabolic syndrome, mucin-degrading bacteria
- MeSH terms
- Animals, Enteritis, Hepatitis, Homeostasis, Insulin Resistance, Intestines, Lipids, Lipopolysaccharides, Liver, Male, Mice, Inbred C57BL, Organ Size, Plant Extracts, Triglycerides, Endotoxemia, Vaccinium macrocarpon, Lipid Metabolism, Mice, Obesity, Abdominal, Diet, High-Fat, Polyphenols, Verrucomicrobia, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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