The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.
A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice
Open accessAbstract
Objective: The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure of conventional treatments to curb these diseases. The gut microbiota has been put forward as a key player in the pathophysiology of diet-induced T2D. Importantly, cranberry (Vaccinium macrocarpon Aiton) is associated with a number of beneficial health effects. We aimed to investigate the metabolic impact of a cranberry extract (CE) on high fat/high sucrose (HFHS)-fed mice and to determine whether its consequent antidiabetic effects are related to modulations in the gut microbiota. Design: C57BL/6J mice were fed either a chow or a HFHS diet. HFHS-fed mice were gavaged daily either with vehicle (water) or CE (200 mg/kg) for 8 weeks. The composition of the gut microbiota was assessed by analysing 16S rRNA gene sequences with 454 pyrosequencing. Results: CE treatment was found to reduce HFHS-induced weight gain and visceral obesity. CE treatment also decreased liver weight and triglyceride accumulation in association with blunted hepatic oxidative stress and inflammation. CE administration improved insulin sensitivity, as revealed by improved insulin tolerance, lower homeostasis model assessment of insulin resistance and decreased glucose-induced hyperinsulinaemia during an oral glucose tolerance test. CE treatment was found to lower intestinal triglyceride content and to alleviate intestinal inflammation and oxidative stress. Interestingly, CE treatment markedly increased the proportion of the mucin-degrading bacterium Akkermansia in our metagenomic samples. Conclusions: CE exerts beneficial metabolic effects through improving HFHS diet-induced features of the metabolic syndrome, which is associated with a proportional increase in Akkermansia spp. population.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Researchers have confirmed that a polyphenol-rich cranberry extract and metformin attenuate diet-induced metabolic syndrome in mice in a gut microbiota-dependent manner (16, 17).”
In the citing paper
“These improvements were coupled to dramatic 7-to-10-fold blooms of Akkermansia muciniphila”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [96]
In the citing paper
“Mice fed high-fat diets supplemented with polyphenols showed reduced diet-induced weight gain and adiposity, improved insulin sensitivity, and diminished markers of intestinal inflammation and oxidative stress compared to controls20, 96.”
From The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism (2016) · cites this paper as [96]
In the citing paper
“Furthermore, the metabolic benefits of dietary polyphenol, cranberry extract, and metformin are associated with increased amount of this bacterial species in the gut.”
From Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice (2016) · cites this paper as [37]
In the citing paper
“Increased Akkermansia abundance has been linked with reduced intestinal permeability and gut-to-blood leakage of endotoxins (eg, lipopolysaccharides), thereby alleviating diet-induced obesity and insulin resistance (49).”
From Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice (2021) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice
Caricilli, A. M., Picardi, P. K., de Abreu, L. L., Ueno, M., Prada, P. O., Ropelle, E. R., Hirabara, S. M., Castoldi, Â., Moraes‐Vieira, P. M., Câmara, N. O. S., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001212 · Cited by 285
RetractedApple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation
Denis, M. C., Fürtös, A., Dudonné, S., Montoudis, A., Garofalo, C., Desjardins, Y., DELVIN, E. E., & Levy, E. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053725 · Cited by 124
Self-citationRetractedMcCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Dose translation from animal to human studies revisited.
Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9574lsf · Cited by 6,524
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,317
Research works printed but not linked: 2
- 10.1172/JCI200525102 · DOI · Paper page
- 10.1096/fj.10-164921 · DOI · Paper page
Cited by
Sorted by citations
Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931
You are what you eat: Diet, health and the gut microbiota
Zmora, N., Suez, J., & Elinav, E. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0061-2 · Cited by 1,792
Wu, H., Esteve, E., Tremaroli, V., Khan, M. T., Caesar, R., Mannerås-Holm, L., Ståhlman, M., Olsson, L. M., Serino, M., Planas-Fèlix, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4345 · Cited by 1,632
Human gut microbiome: Hopes, threats and promises
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386
The intestinal barrier: a fundamental role in health and disease
Vancamelbeke, M., & Vermeire, S. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1343143 · Cited by 1,388
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,143
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
Cani, P. D., & de Vos, W. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01765 · Cited by 1,058
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044
The gut microbiome: Relationships with disease and opportunities for therapy
Durack, J., & Lynch, S. V. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180448 · Cited by 979
Burokas, A., Arboleya, S., Moloney, R. D., Peterson, V. L., Murphy, K., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.031 · Cited by 952
Towards a more comprehensive concept for prebiotics
Bindels, L. B., Delzenne, N. M., Cani, P. D., & Walter, J. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.47 · Cited by 914
Schneeberger, M., Everard, A., Gómez-Valadés, A. G., Matamoros, S., Ramírez, S., Delzenne, N. M., Gomis, R., Claret, M., & Cani, P. D. (2015) · Scientific Reports · doi:10.1038/srep16643 · Cited by 798
Self-citationLi, J., Lin, S., Vanhoutte, P. M., Woo, C. W., & Xu, A. (2016) · Circulation · doi:10.1161/circulationaha.115.019645 · Cited by 775
Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754
The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism
Spanogiannopoulos, P., Bess, E. N., Carmody, R. N., & Turnbaugh, P. J. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.17 · Cited by 717
Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview
Samtiya, M., Aluko, R. E., Dhewa, T., & Moreno‐Rojas, J. M. (2021) · Foods · doi:10.3390/foods10040839 · Cited by 686
Recent Research on the Health Benefits of Blueberries and Their Anthocyanins
Kalt, W., Cassidy, A., Howard, L. R., Krikorian, R., Stull, A. J., Tremblay, F., & Zamora‐Ros, R. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz065 · Cited by 705
Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015) · Diabetes · doi:10.2337/db14-1916 · Cited by 678
Shaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637
Liu, B., Liu, X., Liang, Z., & Wang, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i25.3837 · Cited by 662
Williamson, G., Kay, C. D., & Crozier, A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12351 · Cited by 620
The gut microbiota: a key factor in the therapeutic effects of (poly)phenols
Espín, J. C., González-Sarrías, A., & Tomás-Barberán, F. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.033 · Cited by 603
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568
Kawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563
The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids
Cassidy, A., & Minihane, A. M. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.136051 · Cited by 522
Role of dietary polyphenols on gut microbiota, their metabolites and health benefits
Aravind, S. M., Wichienchot, S., Tsao, R., Ramakrishnan, S., & Chakkaravarthi, S. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110189 · Cited by 502
Influence of high-fat diet on gut microbiota
Murphy, E. A., Velázquez, K. T., & Herbert, K. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000209 · Cited by 510
Zhao, L., Zhang, Q., Ma, W., Tian, F., Shen, H., & Zhou, M. (2017) · Food & Function · doi:10.1039/c7fo01383c · Cited by 501
Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further
Rodríguez-Daza, M.-C., Pulido-Mateos, E. C., Lupien‐Meilleur, J., Guyonnet, D., Desjardins, Y., & Roy, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.689456 · Cited by 511
Self-citationOscillospira - a candidate for the next-generation probiotics
Yang, J., Li, Y., Wen, Z., Liu, W., Meng, L., & Huang, H. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1987783 · Cited by 484
The Intestinal Immune System in Obesity and Insulin Resistance
Winer, D. A., Luck, H., Tsai, S. J., & Winer, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.003 · Cited by 493
The Human Microbiome and Obesity: Moving beyond Associations
Maruvada, P., Leone, V., Kaplan, L. M., & Chang, E. B. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.005 · Cited by 476
Tomás‐Barberán, F. A., González‐Sarrías, A., García‐Villalba, R., Núñez‐Sánchez, M. A., Selma, M. V., García‐Conesa, M. T., & Espín, J. C. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500901 · Cited by 465
Do, M. H., Lee, E., Oh, M.-J., Kim, Y., & Park, H.-Y. (2018) · Nutrients · doi:10.3390/nu10060761 · Cited by 441
Nutrients and Oxidative Stress: Friend or Foe?
Tan, B. L., Norhaizan, M. E., & Liew, W.-P.-P. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9719584 · Cited by 455
A next generation probiotic, Akkermansia muciniphila
Zhai, Q., Feng, S., Narbad, A., & Chen, W. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1517725 · Cited by 447
Rodrigues, V. F., Elias‐Oliveira, J., Pereira, Í. S., Pereira, J. A., Barbosa, S. C., Machado, M. S. G., & Carlos, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934695 · Cited by 434
Dietary Polyphenol, Gut Microbiota, and Health Benefits
Wang, X., Qi, Y., & Zheng, H. (2022) · Antioxidants · doi:10.3390/antiox11061212 · Cited by 430
Kaliannan, K., Wang, B., Li, X., Kim, K., & Kang, J. X. (2015) · Scientific Reports · doi:10.1038/srep11276 · Cited by 375
Interactions of gut microbiota with dietary polyphenols and consequences to human health
Tomás-Barberán, F. A., Selma, M. V., & Espı́n, J. C. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000314 · Cited by 372
Rao, Y., Kuang, Z., Li, C., Guo, S., Xu, Y., Zhao, D., Hu, Y., Song, B., Jiang, Z., Ge, Z., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1927633 · Cited by 356
Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway
Nie, Q., Luo, X., Wang, K., Ding, Y., Jia, S., Zhao, Q., Li, M., Zhang, J., Zhuo, Y., Lin, J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.034 · Cited by 356
Çatalkaya, G., Venema, K., Lucini, L., Rocchetti, G., Delmas, D., Daglia, M., Filippis, A. D., Xiao, H., Quiles, J. L., Xiao, J., et al. (2020) · Food Frontiers · doi:10.1002/fft2.25 · Cited by 349
Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota
Shabbir, U., Rubab, M., Daliri, E. B., Chelliah, R., Javed, A., & Oh, D. (2021) · Nutrients · doi:10.3390/nu13010206 · Cited by 346
The gut microbiota in obesity and weight management: microbes as friends or foe?
Hul, M. V., & Cani, P. D. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00794-0 · Cited by 353
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Bisanz, J. E., Upadhyay, V., Turnbaugh, J. A., Ly, K., & Turnbaugh, P. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.06.013 · Cited by 333
How gut microbes talk to organs: The role of endocrine and nervous routes
Cani, P. D., & Knauf, C. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.011 · Cited by 342
Vallianou, N. G., Stratigou, T., Christodoulatos, G. S., & Dalamaga, Μ. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00352-2 · Cited by 325
Unraveling Anthocyanin Bioavailability for Human Health
Lila, M. A., Burton‐Freeman, B. M., Grace, M. H., & Kalt, W. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033346 · Cited by 318
Prebiotic effect of dietary polyphenols: A systematic review
Alves, A. M., Sugizaki, C. S. D. A., Lima, G. C., & Naves, M. M. V. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104169 · Cited by 316
Jiao, X., Wang, Y., Lin, Y., Lang, Y., Li, E., Zhang, X., Zhang, Q., Feng, Y., Meng, X., & Li, B. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.07.008 · Cited by 316
TMAO: how gut microbiota contributes to heart failure
Zhang, Y., Wang, Y., Ke, B., & Du, J. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.007 · Cited by 311
Zhou, K. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.045 · Cited by 309
Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health
Mozaffarian, D., & Wu, J. H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.117.309008 · Cited by 311
Fujio, S., Vasquez, Y., Morales, P., Magne, F., Vera-Wolf, P., Ugalde, J. A., Navarrete, P., & Gotteland, M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01221 · Cited by 309
Dietary polyphenols as antidiabetic agents: Advances and opportunities
Sun, C., Zhao, C., Çapanoğlu, E., Paoli, P., Simal‐Gándara, J., Ramkumar, K. M., Wang, S., Buleu, F. N., Pah, A.-M., Turi, V., et al. (2020) · Food Frontiers · doi:10.1002/fft2.15 · Cited by 309
Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice
Wang, P., Li, D., Ke, W., Liang, D., Hu, X., & Chen, F. (2020) · International Journal of Obesity · doi:10.1038/s41366-019-0332-1 · Cited by 301
Gut liver brain axis in diseases: the implications for therapeutic interventions
Yan, M., Man, S., Sun, B., Ma, L., Guo, L., Huang, L., & Gao, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01673-4 · Cited by 314
Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice
Zhao, S., Liu, W., Wang, J., Shi, J., Sun, Y., Wang, W., Ning, G., Liu, R., & Hong, J. (2017) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0054 · Cited by 298
Dietary polyphenols to combat the metabolic diseases via altering gut microbiota
Gowd, V., Karim, N., Shishir, M. R. I., Xie, L., & Chen, W. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.09.005 · Cited by 298
Lordan, C., Thapa, D., Ross, R. P., & Cotter, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1613124 · Cited by 289
Polyphenols, food and pharma. Current knowledge and directions for future research
Tresserra‐Rimbau, A., Lamuela-Raventós, R. M., & Moreno, J. J. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.050 · Cited by 281
Pei, R., Liu, X., & Bolling, B. W. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.12.018 · Cited by 276
Anhê, F. F., Nachbar, R. T., Varin, T. V., Trottier, J., Dudonné, S., Barz, M. L., Feutry, P., Pilon, G., Barbier, O., Desjardins, Y., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315565 · Cited by 277
Self-citationRegulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors
Fuke, N., Nagata, N., Suganuma, H., & Ota, T. (2019) · Nutrients · doi:10.3390/nu11102277 · Cited by 269
Berry polyphenols metabolism and impact on human gut microbiota and health
Lavefve, L., Howard, L. R., & Carbonero, F. G. (2019) · Food & Function · doi:10.1039/c9fo01634a · Cited by 269
Gut microorganisms as promising targets for the management of type 2 diabetes
Delzenne, N. M., Cani, P. D., Everard, A., Neyrinck, A. M., & Bindels, L. B. (2015) · Diabetologia · doi:10.1007/s00125-015-3712-7 · Cited by 271
Curtis, P. J., van der Velpen, V., Berends, L. M., Jennings, A., Feelisch, M., Umpleby, A. M., Evans, M. L., Fernandez, B. O., Meiss, M. S., Minnion, M., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy380 · Cited by 275
Mosele, J. I., Macià, A., & Motilva, M. (2015) · Molecules · doi:10.3390/molecules200917429 · Cited by 270
Pap, N., Fidelis, M., Azevedo, L. C., do Carmo, M. A. V., Wang, D., Mocan, A., Pereira, E. P. R., Xavier-Santos, D., Sant’Ana, A. S., Yang, B., et al. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.06.003 · Cited by 259
Rethinking healthy eating in light of the gut microbiome
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.016 · Cited by 252
Saccon, T. D., Nagpal, R., Yadav, H., Cavalcante, M. B., Nunes, A. D. D. C., Schneider, A., Gesing, A., Hughes, B., Yousefzadeh, M., Tchkonia, T., et al. (2021) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab002 · Cited by 247
Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential
Ioannou, A., Berkhout, M. D., Geerlings, S. Y., & Belzer, C. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01106-1 · Cited by 259
Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome—A Systematic Review
Zhang, Z., Mocanu, V., Cai, C., Dang, J. T., Slater, L., Deehan, E. C., Walter, J., & Madsen, K. L. (2019) · Nutrients · doi:10.3390/nu11102291 · Cited by 245
Zhang, W., Zou, G.-L., Li, B., Du, X., Sun, Z., Sun, Y., & Jiang, X. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2002.02044 · Cited by 238
Wang, P., Gao, J., Ke, W., Wang, J., Li, D., Liu, R., Jia, Y., Wang, X., Chen, X., Chen, F., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.04.013 · Cited by 237
Review of Functional and Pharmacological Activities of Berries
Головинская, О., & Wang, C. (2021) · Molecules · doi:10.3390/molecules26133904 · Cited by 241
Gil‐Cardoso, K., Ginés, I., Pinent, M., Ardèvol, A., Blay, M., & Terra, X. (2016) · Nutrition Research Reviews · doi:10.1017/s0954422416000159 · Cited by 236
Newsholme, P., Keane, K. N., Carlessi, R., & Cruzat, V. F. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00141.2019 · Cited by 232
Eker, M. E., Aaby, K., Budić-Leto, I., Brnčić, S. R., El, S. N., Karakaya, S., Şimşek, Ş., Manach, C., Wiczkowski, W., & de Pascual‐Teresa, S. (2019) · Foods · doi:10.3390/foods9010002 · Cited by 230
The Interaction between Flavonoids and Intestinal Microbes: A Review
Xiong, H.-H., Lin, S.-Y., Chen, L., Ouyang, K., & Wang, W. (2023) · Foods · doi:10.3390/foods12020320 · Cited by 226
Sun, L., Wang, Y., & Miao, M. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.08.003 · Cited by 225
Masumoto, S., Terao, A., Yamamoto, Y., Mukai, T., Miura, T., & Shoji, T. (2016) · Scientific Reports · doi:10.1038/srep31208 · Cited by 224
Modulation of the human gut microbiota by phenolics and phenolic fiber‐rich foods
Loo, Y. T., Howell, K. S., Chan, M., Zhang, P., & Ng, K. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12563 · Cited by 223
The gut microbiome: a core regulator of metabolism
Fujisaka, S., Watanabe, Y., & Tobe, K. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0111 · Cited by 225
Dey, P. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104367 · Cited by 216
Li, X., Watanabe, K., & Kimura, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01882 · Cited by 216
Fernandez, M. A., & Marette, A. (2017) · Advances in Nutrition · doi:10.3945/an.115.011114 · Cited by 217
Self-citationNie, Q., Chen, H., Hu, J., Fan, S., & Nie, S. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1536646 · Cited by 207
Sun, L., Pang, Y., Wang, X., Wu, Q., Liu, H., Liu, B., Liu, C., Ye, M., Kong, W., & Jiang, C. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.02.004 · Cited by 207
Wang, K., Jin, X., Li, Q., Sawaya, A. C. H. F., Leu, R. K. L., Conlon, M. A., Wu, L., & Hu, F. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800080 · Cited by 204
de Souza, E. L., de Albuquerque, T. M. R., dos Santos, A. S., Massa, N. M. L., & Alves, J. L. D. B. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1425285 · Cited by 206
Interactions between CYP3A4 and Dietary Polyphenols
Basheer, L., & Kerem, Z. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/854015 · Cited by 204
Kang, I., Buckner, T., Shay, N. F., Gu, L., & Chung, S. (2016) · Advances in Nutrition · doi:10.3945/an.116.012575 · Cited by 208
Gut microbiome and metabolic syndrome
Mazidi, M., Rezaie, P., Kengne, A. P., Ghayour‐Mobarhan, M., & Ferns, G. A. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.01.024 · Cited by 199
Lyu, M., Wang, Y., Fan, G., Wang, X., Xu, S.-Y., & Zhu, Y. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02146 · Cited by 197
Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome
Kasprzak‐Drozd, K., Oniszczuk, T., Stasiak, M., & Oniszczuk, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073715 · Cited by 199
Berry anthocyanin intake and cardiovascular health
Cassidy, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.05.002 · Cited by 198
Dietary cellulose prevents gut inflammation by modulating lipid metabolism and gut microbiota
Kim, Y., Hwang, S. W., Kim, S., Lee, Y., Kim, T., Lee, S.-H., Kim, S. J., Yoo, H. J., Kim, E. N., & Kweon, M. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1730149 · Cited by 197
Alard, J., Lehrter, V., Rhimi, M., Mangin, I., Peucelle, V., Abraham, A., Mariadassou, M., Maguin, E., Waligora‐Dupriet, A., Pot, B., et al. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13181 · Cited by 201
Metadata
- Authors
- Anhê, F. F., Roy, D., Pilon, G., Dudonné, S., Matamoros, S., Varin, T. V., Garofalo, C., Moine, Q., Desjardins, Y., Levy, E., & Marette, A.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Marette, André
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2014-07-30
- Volume
- 64
- Issue
- 6
- Pages
- 872-883
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2099456560
- Cited by
- 1,137
- References
- 75
- Citations by year
- 2026: 53 · 2025: 85 · 2024: 86 · 2023: 98 · 2022: 128 · 2021: 175 · 2020: 134 · 2019: 117 · 2018: 83 · 2017: 71 · 2016: 62 · 2015: 45
- FWCI
- 24.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université Laval
- Ministère du Développement Économique, de l’Innovation et de l’Exportation
- Agence Universitaire de la Francophonie
- Institut sur la Nutrition et les Aliments Fonctionnels
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- cranberry extract, cranberry, polyphenols, diet-induced obesity, insulin resistance, type 2 diabetes, gut microbiota, Akkermansia, high-fat high-sugar diet, visceral obesity, hepatic steatosis, hepatic oxidative stress, intestinal inflammation, metabolic syndrome, mucin-degrading bacteria
- MeSH terms
- Animals, Enteritis, Hepatitis, Homeostasis, Insulin Resistance, Intestines, Lipids, Lipopolysaccharides, Liver, Male, Mice, Inbred C57BL, Organ Size, Plant Extracts, Triglycerides, Endotoxemia, Vaccinium macrocarpon, Lipid Metabolism, Mice, Obesity, Abdominal, Diet, High-Fat, Polyphenols, Verrucomicrobia, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review