Cited by 110Immune Response and Inflammationinterferon and immune responsesInflammasome and immune disorders

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Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids

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Hu, Ming-Ming, Shu, Hong-Bing·2018·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev-cellbio-100617-062903

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Abstract

Microbial nucleic acids are major signatures of invading pathogens, and their recognition by various host pattern recognition receptors (PRRs) represents the first step toward an efficient innate immune response to clear the pathogens. The nucleic acid–sensing PRRs are localized at the plasma membrane, the cytosol, and/or various cellular organelles. Sensing of nucleic acids and signaling by PRRs involve recruitment of distinct signaling components, and PRRs are intensively regulated by cellular organelle trafficking. PRR-mediated innate immune responses are also heavily regulated by posttranslational modifications, including phosphorylation, polyubiquitination, sumoylation, and glutamylation. In this review, we focus on our current understanding of recognition of microbial nucleic acid by PRRs, particularly on their regulation by organelle trafficking and posttranslational modifications. We also discuss how sensing of self nucleic acids and dysregulation of PRR-mediated signaling lead to serious human diseases.

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Hu, M.-M., & Shu, H. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01086-x · Cited by 263
Self-citation
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response
Fu, Y.-Z., Wang, S., Zheng, Z.-Q., Huang, Y., Li, W.-W., Xu, Z.-S., & Wang, Y. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00571-x · Cited by 219

See all 110

Authors: Hu, M.-M., & Shu, H.-B.
Affiliations: Wuhan University (CN)
ORCID: Hu, Ming-Ming
Shu, Hong-Bing
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2018-10-06
Volume: 34
Issue: 1
Pages: 357-379
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev-cellbio-100617-062903
OpenAlex: W2887534894
Cited by: 110
References: 163
Citations by year: 2026: 6 · 2025: 19 · 2024: 8 · 2023: 13 · 2022: 23 · 2021: 10 · 2020: 15 · 2019: 14 · 2018: 2
FWCI: 1.05
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31521091, 31630045)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: pattern recognition receptors, innate immunity, organelle trafficking, post-translational modification, phosphorylation, polyubiquitination, SUMOylation, glutamylation, host-pathogen recognition
MeSH terms: Bacteria, Cytoplasm, DNA, Bacterial, Humans, Immunity, Innate, Nucleic Acids, Protein Processing, Post-Translational, Signal Transduction, Receptors, Pattern Recognition, Host-Pathogen Interactions

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Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids

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