Causes of Genome Instability

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798

TRF2 Protects Human Telomeres from End-to-End Fusions

van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709

DNA repair pathways as targets for cancer therapy

Helleday, T., Petermann, E., Lundin, C., Hodgson, B., & Sharma, R. A. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2342 · Cited by 1,666

Elevated recombination rates in transcriptionally active DNA

Thomas, B. J., & Rothstein, R. J. (1989) · Cell · doi:10.1016/0092-8674(89)90584-9 · Cited by 1,603

DNA Damage Foci at Dysfunctional Telomeres

Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409

Mechanisms of change in gene copy number

Hastings, P. J., Lupski, J. R., Rosenberg, S. M., & Ira, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2593 · Cited by 1,316

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292

DNA breaks and chromosome pulverization from errors in mitosis

Crasta, K., Ganem, N. J., Dagher, R., Lantermann, A. B., Ivanova, E. V., Pan, Y., Nezi, L., Protopopov, A., Chowdhury, D., & Pellman, D. (2012) · Nature · doi:10.1038/nature10802 · Cited by 1,227

Regulation of Homologous Recombination in Eukaryotes

Heyer, W.-D., Ehmsen, K. T., & Liu, J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-051710-150955 · Cited by 1,066

R Loops: From Transcription Byproducts to Threats to Genome Stability

Aguilera, A., & García‐Muse, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.009 · Cited by 1,029

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

Sfeir, A., Kosiyatrakul, S. T., Hockemeyer, D., MacRae, S. L., Karlseder, J., Schildkraut, C. L., & de Lange, T. (2009) · Cell · doi:10.1016/j.cell.2009.06.021 · Cited by 990

Repeat instability: mechanisms of dynamic mutations

Pearson, C. E., Edamura, K. N., & Cleary, J. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1689 · Cited by 924 · cited 6×

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880

Genome instability: a mechanistic view of its causes and consequences

Aguilera, A., & Gómez‐González, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2268 · Cited by 830

How Telomeres Solve the End-Protection Problem

de Lange, T. (2009) · Science · doi:10.1126/science.1170633 · Cited by 826

Fork Reversal and ssDNA Accumulation at Stalled Replication Forks Owing to Checkpoint Defects

Sogo, J. M., Lopes, M., & Foiani, M. (2002) · Science · doi:10.1126/science.1074023 · Cited by 824

Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability

Xialu Li, C., & Manley, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.06.008 · Cited by 772

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

Yu, K.-F., Chédin, F., Hsieh, C.-L., Wilson, T. E., & Lieber, M. (2003) · Nature Immunology · doi:10.1038/ni919 · Cited by 767

Checking on DNA damage in S phase

Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1493 · Cited by 758

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

Huertas, P., & Aguilera, A. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.010 · Cited by 750

Chromosome Fragile Sites

Durkin, S. G., & Glover, T. W. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.042007.165900 · Cited by 734

Repeat instability : mechanisms of dynamic mutations

Pearson, C. E. (2005) · Medical Entomology and Zoology · Cited by 711

Non-transcriptional control of DNA replication by c-Myc

Dominguez-Sola, D., Ying, C. Y., Grandori, C., Ruggiero, L., Chen, B., Li, M., Galloway, D. A., Gu, W. J., Gautier, J., & Dalla‐Favera, R. (2007) · Nature · doi:10.1038/nature05953 · Cited by 671

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

Chaudhuri, J., & Alt, F. W. (2004) · Nature reviews. Immunology · doi:10.1038/nri1395 · Cited by 657

Chromatin replication and epigenome maintenance

Alabert, C., & Groth, A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3288 · Cited by 614

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

Dimitrova, N., Chen, Y.-C. M., Spector, D. L., & de Lange, T. (2008) · Nature · doi:10.1038/nature07433 · Cited by 604

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

Helmrich, A., Ballarino, M., & Tora, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.013 · Cited by 603

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

Chan, K., Palmai‐Pallag, T., Ying, S., & Hickson, I. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1882 · Cited by 601

How the Fanconi Anemia Pathway Guards the Genome

Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 601

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

Janssen, A., van der Burg, M. J., Szuhai, K., Kops, G. J. P. L., & Medema, R. H. (2011) · Science · doi:10.1126/science.1210214 · Cited by 582

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Tuduri, S., Crabbé, L., Conti, C., Tourrière, H., Holtgreve-Grez, H., Jauch, A. S., Pantesco, V., Vos, J. D., Thomas, A., Theillet, C. G., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1984 · Cited by 582

ATR Regulates Fragile Site Stability

Casper, A. M., Nghiem, P., Arlt, M. F., & Glover, T. W. (2002) · Cell · doi:10.1016/s0092-8674(02)01113-3 · Cited by 572

Trinucleotide repeats that expand in human disease form hairpin structures in vitro

Gacy, A. M., Goellner, G. M., Juranić, N., Macura, S. I., & McMurray, C. T. (1995) · Cell · doi:10.1016/0092-8674(95)90074-8 · Cited by 569

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

Paeschke, K., Capra, J. A., & Zakian, V. A. (2011) · Cell · doi:10.1016/j.cell.2011.04.015 · Cited by 566 · cited 1×

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M., Guan, A. S., Hesley, J., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.021 · Cited by 564

Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage

Syljuåsen, R. G., Sørensen, C. S., Hansen, L. T., Fugger, K., Lundin, C., Johansson, F., Helleday, T., Sehested, M., Lukas, J., & Bártek, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3553-3562.2005 · Cited by 562

A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response

Masumoto, H., Hawke, D., Kobayashi, R., & Verreault, A. (2005) · Nature · doi:10.1038/nature03714 · Cited by 544

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA

Gottlieb, S., & Esposito, R. E. (1989) · Cell · doi:10.1016/0092-8674(89)90681-8 · Cited by 543

RuvAB Acts at Arrested Replication Forks

Seigneur, M., Bidnenko, V., Ehrlich, S. D., & Michel, B. (1998) · Cell · doi:10.1016/s0092-8674(00)81772-9 · Cited by 538

Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA.Preprint

Duquette, M. L., Handa, P., Vincent, J. A., Taylor, A. F., & Maizels, N. (2004) · Genes & Development · doi:10.1101/gad.1200804 · Cited by 528

Eukaryotic Chromosome DNA Replication: Where, When, and How?

Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., & Oda, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.103205 · Cited by 524

Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

Ibarra, A., Schwob, É., & Méndez, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803978105 · Cited by 511

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

Langevin, F., Crossan, G. P., Rosado, I. V., Arends, M. J., & Patel, K. J. (2011) · Nature · doi:10.1038/nature10192 · Cited by 502

Mechanisms of trinucleotide repeat instability during human development

McMurray, C. T. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2828 · Cited by 496

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

Vannier, J., Pavicic-Kaltenbrunner, V., Petalcorin, M. I. R., Ding, H., & Boulton, S. J. (2012) · Cell · doi:10.1016/j.cell.2012.03.030 · Cited by 491

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

Liu, P., Erez, A., Nagamani, S. C. S., Dhar, S. U., Kołodziejska, K. E., Dharmadhikari, A. V., Cooper, M. L., Wiszniewska, J., Zhang, F., Withers, M. A., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.042 · Cited by 468

AID Is Required for c-myc/IgH Chromosome Translocations In Vivo

Ramiro, A. R., Janković, M., Eisenreich, T., Difilippantonio, S., Chen‐Kiang, S., Muramatsu, M., Honjo, T., Nussenzweig, A., & Nussenzweig, M. C. (2004) · Cell · doi:10.1016/j.cell.2004.08.006 · Cited by 465

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

Barlow, J. H., Faryabi, R. B., Callén, E., Wong, N., Malhowski, A. J., Chen, H. T., Gutierrez-Cruz, G., Sun, H., McKinnon, P. J., Wright, G. W., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.006 · Cited by 464

A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair

Tishkoff, D. X., Filosi, N., Gaida, G. M., & Kolodner, R. D. (1997) · Cell · doi:10.1016/s0092-8674(00)81846-2 · Cited by 435

Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis.Preprint

Hage, A. E., French, S., Beyer, A., & Tollervey, D. (2010) · Genes & Development · doi:10.1101/gad.573310 · Cited by 432

ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

Rita, S., & Kleckner, N. E. (2002) · Science · doi:10.1126/science.1071398 · Cited by 429

DNA double‐strand breaks caused by replication arrest

Michel, B., Ehrlich, S. D., & Uzest, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.430 · Cited by 426

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

Letessier, A., Millot, G. A., Koundrioukoff, S., Lachagès, A.-M., Vogt, N., Hansen, R. S., Malfoy, B., Brison, O., & Debatisse, M. (2011) · Nature · doi:10.1038/nature09745 · Cited by 414

The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements

Lobachev, K. S., Gordenin, D. A., & Resnick, M. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00614-1 · Cited by 412

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

Wahba, L., Amon, J. D., Koshland, D. E., & Vuica‐Ross, M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.017 · Cited by 411

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

Chen, C., & Kolodner, R. D. (1999) · Nature Genetics · doi:10.1038/12687 · Cited by 410

Translesion synthesis: Y-family polymerases and the polymerase switch

LEHMANN, A., NIIMI, A., OGI, T., BROWN, S., SABBIONEDA, S., WING, J., KANNOUCHE, P., & GREEN, C. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.003 · Cited by 389

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in micePreprint

Martínez, P., Thanasoula, M., Muñoz, P., Liao, C., Tejera, Á. M., McNees, C. J., Flores, J. M., Fernández-Capetillo, Ó., Tarsounas, M., & Blasco, M. A. (2009) · Genes & Development · doi:10.1101/gad.543509 · Cited by 385

ATR and ATM regulate the timing of DNA replication origin firing

Shechter, D., Costanzo, V., & Gautier, J. (2004) · Nature Cell Biology · doi:10.1038/ncb1145 · Cited by 383

ALTERED FIDELITY OF MITOTIC CHROMOSOME TRANSMISSION IN CELL CYCLE MUTANTS OF S. CEREVISIAE

Hartwell, L. H., & Smith, D. A. (1985) · Genetics · doi:10.1093/genetics/110.3.381 · Cited by 382

DNA Replication Fork Pause Sites Dependent on Transcription

Deshpande, A. M., & Newlon, C. S. (1996) · Science · doi:10.1126/science.272.5264.1030 · Cited by 379

The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus

Torres‐Rosell, J., Šunjevarić, I., Piccoli, G. D., Sacher, M., Eckert‐Boulet, N., Reid, R. J. D., Jentsch, S., Rothstein, R. J., Aragón, L., & Lisby, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1619 · Cited by 379

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

Ribeyre, C., Lopes, J., Boulé, J., Piazza, A., Guédin, A., Zakian, V., Mergny, J., & Nicolas, A. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000475 · Cited by 367

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli

Kang, S., Jaworski, A., Ohshima, K., & Wells, R. D. (1995) · Nature Genetics · doi:10.1038/ng0695-213 · Cited by 355

Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

Myung, K., Chen, C., & Kolodner, R. D. (2001) · Nature · doi:10.1038/35082608 · Cited by 354

The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates

Liu, B., Larsson, L., Caballero, A., Hao, X., Öling, D., Grantham, J., & Nyström, T. (2010) · Cell · doi:10.1016/j.cell.2009.12.031 · Cited by 351

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

Mischo, H. E., Gómez‐González, B., Grzechnik, P., Rondón, A. G., Wei, W., Steinmetz, L. M., Aguilera, A., & Proudfoot, N. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.007 · Cited by 342

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

Murga, M., Bunting, S., Montaña, M. F., Soria, R., Mulero, F., Cañamero, M., Lee, Y., McKinnon, P. J., Nussenzweig, A., & Fernandez-Capetillo, O. (2009) · Nature Genetics · doi:10.1038/ng.420 · Cited by 340

Dynamics of DNA Replication in Mammalian Somatic Cells

Anglana, M., Apiou, F., Bensimon, A., & Debatisse, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00569-5 · Cited by 339

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

Basu, U., Meng, F., Keim, C., Grinstein, V., Pefanis, E., Eccleston, J., Zhang, T., Myers, D. R., Wasserman, C. R., Wesemann, D. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.001 · Cited by 338

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

Naim, V., & Rosselli, F. (2009) · Nature Cell Biology · doi:10.1038/ncb1883 · Cited by 335

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

Cobb, J. A., Bjergbæk, L., Shimada, K., Frei, C., & Gasser, S. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg391 · Cited by 333

G‐quadruplex‐induced instability during leading‐strand replication

Lopes, J., Piazza, A., Bermejo, R., Kriegsman, B. A., Colosio, A., Teulade‐Fichou, M., Foiani, M., & Nicolas, A. G. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.316 · Cited by 330

A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice

Shima, N., Alcaraz, A., Liachko, I., Buske, T. R., Andrews, C. A., Munroe, R. J., Hartford, S. A., Tye, B., & Schimenti, J. C. (2006) · Nature Genetics · doi:10.1038/ng1936 · Cited by 328

Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

Myung, K., Datta, A., & Kolodner, R. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00227-6 · Cited by 325

Linking RNA Polymerase Backtracking to Genome Instability in E. coli

Dutta, D., Shatalin, K. Y., Epshtein, V., Gottesman, M. E., & Nudler, E. (2011) · Cell · doi:10.1016/j.cell.2011.07.034 · Cited by 322

Replication fork reactivation downstream of a blocked nascent leading strand

Heller, R. C., & Marians, K. J. (2006) · Nature · doi:10.1038/nature04329 · Cited by 318

Recombination Regulation by Transcription-Induced Cohesin Dissociation in rDNA Repeats

Kobayashi, T., & Ganley, A. R. D. (2005) · Science · doi:10.1126/science.1116102 · Cited by 316

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

Jones, R. M., Mortusewicz, O., Afzal, I., Lorvellec, M., García, P., Helleday, T., & Petermann, E. (2012) · Oncogene · doi:10.1038/onc.2012.387 · Cited by 315

Chromosomal Translocations in Yeast Induced by Low Levels of DNA Polymerase

Lemoine, F. J., Degtyareva, N. P., Lobachev, K. S., & Petes, T. D. (2005) · Cell · doi:10.1016/j.cell.2004.12.039 · Cited by 306

Multicolour spectral karyotyping of mouse chromosomes

Liyanage, M., Coleman, A., du Manoir, S., Veldman, T., McCormack, S. J., Dickson, R. B., Barlow, C., Wynshaw-Boris, A. J., Janz, S., Wienberg, J., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-312 · Cited by 306

DNA Topoisomerase II Must Act at Mitosis To Prevent Nondisjunction and Chromosome Breakage

Holm, C., Stearns, T., & Botstein, D. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.1.159-168.1989 · Cited by 297

Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II

Christman, M. F., Dietrich, F. S., & Fink, G. R. (1988) · Cell · doi:10.1016/0092-8674(88)90027-x · Cited by 296

Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicasePreprint

Liberi, G., Maffioletti, G., Lucca, C., Chiolo, I., Baryshnikova, A., Cotta‐Ramusino, C., Lopes, M., Pellicioli, A., Haber, J. E., & Foiani, M. (2005) · Genes & Development · doi:10.1101/gad.322605 · Cited by 296

Impairment of replication fork progression mediates RNA polII transcription‐associated recombination

Prado, F., & Aguilera, A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600602 · Cited by 294

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

Matos, J., Blanco, M. G., Maslen, S., Skehel, M. J., & West, S. C. (2011) · Cell · doi:10.1016/j.cell.2011.08.032 · Cited by 294

Intrinsic coupling of lagging-strand synthesis to chromatin assembly

Smith, D. J., & Whitehouse, I. (2012) · Nature · doi:10.1038/nature10895 · Cited by 293

Recombination-stimulating sequences in yeast ribosomal DNA correspond to sequences regulating transcription by RNA polymerase I

Voelkel‐Meiman, K., Keil, R., & Roeder, G. S. (1987) · Cell · doi:10.1016/0092-8674(87)90714-8 · Cited by 292

dNTP pools determine fork progression and origin usage under replication stress

Poli, J., Tsaponina, O., Crabbé, L., Keszthelyi, A., Pantesco, V., Chabes, A., Lengronne, A., & Pasero, P. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.470 · Cited by 292

Ubc9- and Mms21-Mediated Sumoylation Counteracts Recombinogenic Events at Damaged Replication Forks

Branzei, D., Sollier, J., Liberi, G., Zhao, X., Maeda, D., Seki, M., Enomoto, T., Ohta, K., & Foiani, M. (2006) · Cell · doi:10.1016/j.cell.2006.08.050 · Cited by 291

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

Stehling, O., Vashisht, A. A., Mascarenhas, J., Jónsson, Z. O., Sharma, T., Netz, D. J. A., Pierik, A. J., Wohlschlegel, J. A., & Lill, R. (2012) · Science · doi:10.1126/science.1219723 · Cited by 291

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

Azvolinsky, A., Giresi, P. G., Lieb, J. D., & Zakian, V. A. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.022 · Cited by 285

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication forkPreprint

Calzada, A., Hodgson, B., Kanemaki, M. T., Bueno, A., & Labib, K. P. M. (2005) · Genes & Development · doi:10.1101/gad.337205 · Cited by 285

The arrest of replication forks in the rDNA of yeast occurs independently of transcription

Brewer, B. J., Lockshon, D., & Fangman, W. L. (1992) · Cell · doi:10.1016/0092-8674(92)90355-g · Cited by 274

Immunoglobulin Gene Diversification

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Expanded CAG Repeats Activate the DNA Damage Checkpoint Pathway

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Heterochromatin: Guardian of the Genome

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Drug repurposing for cancer therapy

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Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells

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The presence of extra chromosomes leads to genomic instability

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Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array‐CGH

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