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CAR T Cell Therapy for Solid Tumors
Open accessAbstract
The field of cancer immunotherapy has been re-energized by the application of chimeric antigen receptor (CAR) T cell therapy in cancers. These CAR T cells are engineered to express synthetic receptors that redirect polyclonal T cells to surface antigens for subsequent tumor elimination. Many CARs are designed with elements that augment T cell persistence and activity. To date, CAR T cells have demonstrated tremendous success in eradicating hematologic malignancies (e.g., CD19 CARs in leukemias). However, this success has yet to be extrapolated to solid tumors, and the reasons for this are being actively investigated. We characterize some of the challenges that CAR T cells have to surmount in the solid tumor microenvironment and new approaches that are being considered to overcome these hurdles.
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“Low permeability of cells in solid tumors is a problem for adoptive cell therapy because of the size of living cells and the unfavorable tumor microenvironment. This limits their current clinical application in hematological malignancies.329”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [329]
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Metadata
- Authors
- Newick, K., O'Brien, S., Moon, E., & Albelda, S. M.
- Affiliations
- University of Pennsylvania (US)
- Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104;
- ORCID
- Moon, Edmund
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2017-01-14
- Volume
- 68
- Issue
- 1
- Pages
- 139-152
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2475107749
- Cited by
- 909
- References
- 77
- Citations by year
- 2026: 89 · 2025: 96 · 2024: 97 · 2023: 98 · 2022: 124 · 2021: 128 · 2020: 123 · 2019: 73 · 2018: 48 · 2017: 32
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (K08CA163941)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- CAR T-cell therapy, solid tumors, chimeric antigen receptor, cancer immunotherapy, tumor microenvironment, T cell persistence, hematologic malignancies, CD19, T cell redirection, tumor antigens
- MeSH terms
- Antigens, Neoplasm, Humans, Immune Tolerance, Immunity, Cellular, Neoplasms, Receptors, Antigen, T-Cell, T-Lymphocytes, Immunotherapy, Adoptive, Lymphocytes, Tumor-Infiltrating, Tumor Microenvironment
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