Cited by 592Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.

Addiction Circuitry in the Human Brain

Open access

Volkow, Nora D., Wang, Gene-Jack, Fowler, Joanna S., Tomasi, Dardo·2012·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev-pharmtox-010611-134625PMC PMC3477468

Open this paper in CoChat — free account

Abstract

A major challenge in understanding substance-use disorders lies in uncovering why some individuals become addicted when exposed to drugs, whereas others do not. Although genetic, developmental, and environmental factors are recognized as major contributors to a person's risk of becoming addicted, the neurobiological processes that underlie this vulnerability are still poorly understood. Imaging studies suggest that individual variations in key dopamine-modulated brain circuits, including circuits involved in reward, memory, executive function, and motivation, contribute to some of the differences in addiction vulnerability. A better understanding of the main circuits affected by chronic drug use and the influence of social stressors, developmental trajectories, and genetic background on these circuits is bound to lead to a better understanding of addiction and to more effective strategies for the prevention and treatment of substance-use disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-pharmtox-010611-134625

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229
Wandering minds: the default network and stimulus-independent thought
Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D. M., Grafton, S. T., & Macrae, C. N. (2007) · Science · doi:10.1126/science.1131295 · Cited by 2,792
Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667
Self-citation
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347
A default mode of brain function: a brief history of an evolving idea
Raichle, M. E., & Snyder, A. Z. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.02.041 · Cited by 2,173
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513
The primate basal ganglia: Parallel and integrative networks
Haber, S. N. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2003.10.003 · Cited by 1,479
Synaptic plasticity and addiction
Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397

Show all 91 references

Research works printed but not linked: 3

10.1176/appi.ajp.164.4.622 · DOI · Paper page
Wang GJ, 2010, J. Nucl. Med., 51, 269
Hommer DW, 1999, Alcohol Res. Health, 23, 187

Sorted by citations

Items 101–200 of 592

Cortico-striatal circuits: novel therapeutic targets for substance use disorders
Kravitz, A. V., Tomasi, D., LeBlanc, K. H., Baler, R., Volkow, N. D., Bonci, A., & Ferré, S. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.048 · Cited by 63
Self-citation
An emerging role for the lateral habenula in aggressive behavior
Flanigan, M. E., Aleyasin, H., Takahashi, A., Golden, S. A., & Russo, S. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.05.003 · Cited by 61
Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders
Nock, N. L., Minnes, S., & Alberts, J. L. (2017) · Birth Defects Research · doi:10.1002/bdr2.1182 · Cited by 61
Neural Mechanisms of Circadian Regulation of Natural and Drug Reward
DePoy, L. M., McClung, C. A., & Logan, R. W. (2017) · Neural Plasticity · doi:10.1155/2017/5720842 · Cited by 69
Addiction Research Unit: Affective and cognitive mechanisms of specific Internet‐use disorders
Brand, M., Müller, A., Stark, R. M., Steins‐Loeber, S., Klucken, T., Montag, C., Diers, M., Wolf, O. T., Rumpf, H., Wölfling, K., et al. (2021) · Addiction Biology · doi:10.1111/adb.13087 · Cited by 64
Biobehavioral Mechanisms of Mindfulness as a Treatment for Chronic Stress: An RDoC Perspective
Garland, E. L., Hanley, A. W., Baker, A. K., & Howard, M. O. (2017) · Chronic Stress · doi:10.1177/2470547017711912 · Cited by 65
Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors
Botticelli, L., Bonaventura, E. M. D., Bello, F. D., Giorgioni, G., Piergentili, A., Romano, A., Quaglia, W., Cifani, C., & Bonaventura, M. V. M. D. (2020) · Nutrients · doi:10.3390/nu12082288 · Cited by 63
Aversive motivation and the maintenance of monogamous pair bonding
Resendez, S. L., & Aragona, B. J. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0068 · Cited by 58
Circuit selectivity in drug versus natural reward seeking behaviors
Nall, R. W., Heinsbroek, J. A., Nentwig, T. B., Kalivas, P. W., & Bobadilla, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15297 · Cited by 64
Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol-dependent individuals in early abstinence
Durazzo, T. C., Mon, A., Pennington, D., Abé, C., Gazdzinski, S. P., & Meyerhoff, D. J. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00492.x · Cited by 60
Carrier-Mediated Cocaine Transport at the Blood-Brain Barrier as a Putative Mechanism in Addiction Liability
Chapy, H., Smirnova, M., André, P., Schlatter, J., Chiadmi, F., Couraud, P., Scherrmann, J., Declèves, X., & Cisternino, S. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu001 · Cited by 67
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits
Bisagno, V., González, B., & Urbano, F. J. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.01.013 · Cited by 59
In Vivo Imaging of Cerebral Dopamine D3 Receptors in Alcoholism
Erritzøe, D., Tziortzi, A. C., Bargiela, D., Colasanti, A., Searle, G. E., Gunn, R. N., Beaver, J. D., Waldman, A. D., Nutt, D., Bani, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.18 · Cited by 58
Near-Infrared Fluorescent Nanoprobes for Revealing the Role of Dopamine in Drug Addiction
Feng, P., Chen, Y., Zhang, L., Qian, C., Xiao, X., Xu, H., & Shen, Q. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b12005 · Cited by 58
Stress, sex, and addiction
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 63
A neural mechanism of the relationship between impulsivity and emotion dysregulation in patients with Internet gaming disorder
Shin, Y., Kim, H., Kim, S., & Kim, J. (2020) · Addiction Biology · doi:10.1111/adb.12916 · Cited by 58
Resting state connectivity in alcohol dependent patients and the effect of repetitive transcranial magnetic stimulation
Jansen, J. M., van Wingen, G. A., van den Brink, W., & Goudriaan, A. E. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.019 · Cited by 61
Treating Tobacco Use Disorder in Pregnant Women in Medication-Assisted Treatment for an Opioid Use Disorder: A Systematic Review
Akerman, S. C., Brunette, M. F., Green, A. I., Goodman, D., Blunt, H. B., & Heil, S. H. (2014) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2014.12.002 · Cited by 56
Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults
Durazzo, T. C., Meyerhoff, D. J., & Murray, D. E. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120708198 · Cited by 56
N-acetylcysteine for treating cocaine addiction – A systematic review
Echevarria, M. A. N., Reis, T. A., Capatti, G. R., Soares, V. S., da Silveira, D. X., & Fidalgo, T. M. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.02.024 · Cited by 55
Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention
Deckersbach, T., Das, S. K., Urban, L. E., Salinardi, T., Batra, P., Rodman, A. M., Arulpragasam, A. R., Dougherty, D. D., & Roberts, S. B. (2014) · Nutrition & Diabetes · doi:10.1038/nutd.2014.26 · Cited by 55
Interactions of HIV and Drugs of Abuse
Hauser, K. F., & Knapp, P. E. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00009-9 · Cited by 58
Gaming Disorder Is a Disorder due to Addictive Behaviors: Evidence from Behavioral and Neuroscientific Studies Addressing Cue Reactivity and Craving, Executive Functions, and Decision-Making
Brand, M., Rumpf, H.-J., Demetrovics, Z., King, D. L., Potenza, M. N., & Wegmann, E. (2019) · Current Addiction Reports · doi:10.1007/s40429-019-00258-y · Cited by 53
Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients
Bustamante, J. C., Barrós‐Loscertales, A., Costumero, V., Fuentes‐Claramonte, P., Rosell‐Negre, P., Ventura‐Campos, N., Llopis, J., & Ávila, C. (2013) · Addiction Biology · doi:10.1111/adb.12041 · Cited by 54
Molecular and Functional Imaging of Internet Addiction
Zhu, Y., Zhang, H., & Tian, M. (2015) · BioMed Research International · doi:10.1155/2015/378675 · Cited by 60
Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window
Mihov, Y., & Hasler, G. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw002 · Cited by 56
Adaptations of Presynaptic Dopamine Terminals Induced by Psychostimulant Self-Administration
Siciliano, C. A., Calipari, E. S., Ferris, M. J., & Jones, S. R. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5002705 · Cited by 57
Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency
Um, M., Whitt, Z. T., Revilla, R., Hunton, T., & Cyders, M. A. (2019) · Brain Sciences · doi:10.3390/brainsci9020036 · Cited by 53
Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking
Daiwile, A. P., Jayanthi, S., Ladenheim, B., McCoy, M. T., Brannock, C., Schroeder, J. R., & Cadet, J. L. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz050 · Cited by 54
Decision-making and Related Processes in Internet Gaming Disorder and Other Types of Internet-Use Disorders
Schiebener, J., & Brand, M. (2017) · Current Addiction Reports · doi:10.1007/s40429-017-0156-9 · Cited by 59
Changes in morphine reward in a model of neuropathic pain
Cahill, C. M., Xue, L., Grenier, P., Magnussen, C., Lecour, S., & Olmstead, M. C. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283618ac8 · Cited by 53
NEUROGENETIC IMPAIRMENTS OF BRAIN REWARD CIRCUITRY LINKS TO REWARD DEFICIENCY SYNDROME (RDS) AS EVIDENCED BY GENETIC ADDICTION RISK SCORE (GARS): A CASE STUDY
Blum, K., Han, D. C., Hauser, M., Downs, B. W., Giordano, J., Borsten, J., Winchell, E., Simpatico, T. A., Madigan, M. A., Barh, D., et al. (2013) · Cited by 52
Alcohol Use Disorder with and without Stimulant Use: Brain Morphometry and Its Associations with Cigarette Smoking, Cognition, and Inhibitory Control
Pennington, D., Durazzo, T. C., Schmidt, T. P., Abé, C., Mon, A., & Meyerhoff, D. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122505 · Cited by 51
Relationship between Problematic Smartphone Use, Sleep Quality and Bedtime Procrastination: A Mediation Analysis
Correa-Iriarte, S., Hidalgo-Fuentes, S., & Vilar, M. M. (2023) · Behavioral Sciences · doi:10.3390/bs13100839 · Cited by 66
NIDA-Drug Addiction Treatment Outcome Study (DATOS) Relapse as a Function of Spirituality/Religiosity
Schoenthaler, S. J., Blum, K., Braverman, E. R., Giordano, J., Thompson, B., Oscar‐Berman, M., Badgaiyan, R. D., Madigan, M. A., Dushaj, K., Li, M., et al. (2015) · Journal of Reward Deficiency Syndrome · doi:10.17756/jrds.2015-007 · Cited by 51
Smoking but not cocaine use is associated with lower cerebral metabotropic glutamate receptor 5 density in humans
Hulka, L. M., Treyer, V., Scheidegger, M., Preller, K. H., Vonmoos, M., Baumgartner, M. R., Johayem, A., Ametamey, S. M., Buck, A., Seifritz, E., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.51 · Cited by 50
Behavioral and transcriptomic profiling of mice null forLphn3, a gene implicated in ADHD and addiction
Orsini, C. A., Setlow, B., DeJesus, M. A., Galaviz, S., Loesch, K. A., Ioerger, T. R., & WALLIS, D. E. (2016) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.207 · Cited by 49
Cocaine addiction is associated with abnormal prefrontal function, increased striatal connectivity and sensitivity to monetary incentives, and decreased connectivity outside the human reward circuit
Vaquero, L., Càmara, E., Sampedro, F., Cobos, J. P. D. L., Batlle, F., Fábregas, J. M., Sales, J. A., Cervantes, M., Ferrer, X., Lazcano, G., et al. (2016) · Addiction Biology · doi:10.1111/adb.12356 · Cited by 49
Internet gaming disorder: deficits in functional and structural connectivity in the ventral tegmental area-Accumbens pathway
Wang, R., Li, M., Zhao, M., Yu, D., Hu, Y., Wiers, C. E., Wang, G., Volkow, N. D., & Yuan, K. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9929-6 · Cited by 54
Self-citation
Pharmacological characterization of novel synthetic opioids: Isotonitazene, metonitazene, and piperidylthiambutene as potent μ-opioid receptor agonists
De Luca, M. A., Tocco, G., Mostallino, R., Laus, A., Caria, F., Musa, A., Pintori, N., Ucha, M., Poza, C., Ambrosio, E., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109263 · Cited by 48
Prospective effects of adolescent indicators of behavioral disinhibition on DSM-IV alcohol, tobacco, and illicit drug dependence in young adulthood
Palmer, R. H. C., Knopik, V. S., Rhee, S. H., Hopfer, C. J., Corley, R., Young, S. E., Stallings, M. C., & Hewitt, J. K. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.03.021 · Cited by 55
Extracellular Matrix Signaling Through β3 Integrin Mediates Cocaine Cue–Induced Transient Synaptic Plasticity and Relapse
García‐Keller, C., Neuhofer, D., Bobadilla, A., Spencer, S. M., Chioma, V. C., Monforton, C., & Kalivas, P. W. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.982 · Cited by 49
Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons
Roberts-Wolfe, D., Bobadilla, A., Heinsbroek, J. A., Neuhofer, D., & Kalivas, P. W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0791-18.2018 · Cited by 48
A preliminary examination of cortical neurotransmitter levels associated with heavy drinking in posttraumatic stress disorder
Pennington, D., Abé, C., Batki, S. L., & Meyerhoff, D. J. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.09.004 · Cited by 47
Cocaine self‐administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine
Siciliano, C. A., Ferris, M. J., & Jones, S. R. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12970 · Cited by 50
Recovery in Substance Use Disorders: What to Know to Inform Practice
Worley, J. (2016) · Issues in Mental Health Nursing · doi:10.1080/01612840.2016.1245375 · Cited by 45
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model Organisms
Adkins, A. E., Hack, L. M., Bigdeli, T. B., Williamson, V. S., McMichael, G. O., Mamdani, M., Edwards, A. C., Alıev, F., Chan, R. F., Bhandari, P., et al. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13362 · Cited by 45
The Affective and Neural Correlates of Heroin versus Cocaine Use in Addiction Are Influenced by Environmental Setting But in Opposite Directions
Pirro, S. D., Galati, G., Pizzamiglio, L., & Badiani, A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0019-18.2018 · Cited by 48
Amphetamine sensitization alters hippocampal neuronal morphology and memory and learning behaviors
Arroyo‐García, L. E., Tendilla‐Beltrán, H., Vázquez‐Roque, R. A., Jurado-Tapia, E. E., Díaz, A., Aguilar‐Alonso, P., Brambila, E., Monjaraz, E., de la Cruz, F., Moreno, A. R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0809-2 · Cited by 47
Safety and feasibility clinical trial of nucleus accumbens deep brain stimulation for treatment-refractory opioid use disorder
Rezai, A. R., Mahoney, J. J., Ranjan, M., Haut, M. W., Zheng, W., Lander, L. R., Berry, J. H., Farmer, D. L., Marton, J. L., Tirumalai, P. S., et al. (2023) · Journal of neurosurgery · doi:10.3171/2023.4.jns23114 · Cited by 44
Relationship Between Emotional Processing, Drinking Severity and Relapse in Adults Treated for Alcohol Dependence in Poland
Kopera, M., Jakubczyk, A., Suszek, H., Glass, J. M., Klimkiewicz, A., Wnorowska, A., Brower, K. J., & Wojnar, M. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu099 · Cited by 47
Cognitive dysfunction in individuals with cocaine use disorder: Potential moderating factors and pharmacological treatments.
Mahoney, J. J. (2018) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000245 · Cited by 48
An initial fMRI study on neural correlates of prayer in members of Alcoholics Anonymous
Galanter, M. S., Josipovic, Z., Dermatis, H., Weber, J., & Millard, M. A. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2016.1141912 · Cited by 45
Arguments in favour of compulsory treatment of opioid dependence
Wu, Z. (2013) · Bulletin of the World Health Organization · doi:10.2471/blt.12.108860 · Cited by 42
The accumbofrontal tract: Diffusion tensor imaging characterization and developmental change from childhood to adulthood
Karlsgodt, K. H., John, M., Ikuta, T., Rigoard, P., Peters, B. D., DeRosse, P., Malhotra, A. K., & Szeszko, P. R. (2015) · Human Brain Mapping · doi:10.1002/hbm.22989 · Cited by 42
Predominance of D2 Receptors in Mediating Dopamine's Effects in Brain Metabolism: Effects of Alcoholism
Volkow, N. D., Tomasi, D. G., Wang, G., Telang, F., Fowler, J. S., Logan, J., Maynard, L. J., & Wong, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5261-12.2013 · Cited by 42
Self-citation
Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers
Rademacher, L., Prinz, S., Winz, O., Henkel, K., Dietrich, C., Schmaljohann, J., Shali, S. M., Schabram, I., Stoppe, C., Cumming, P. D., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.009 · Cited by 43
Substance-related disorders: A review of prevalence and correlates among patients with chronic pain
Martel, M. O., Shir, Y., & Ware, M. A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.032 · Cited by 41
Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior
Bonaventura, E. M. D., Botticelli, L., Bello, F. D., Giorgioni, G., Piergentili, A., Quaglia, W., Cifani, C., & Bonaventura, M. V. M. D. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105847 · Cited by 46
Socioeconomic status is associated with striatal dopamine D2/D3 receptors in healthy volunteers but not in cocaine abusers
Wiers, C. E., Shokri-Kojori, E., Cabrera, E., Cunningham, S., Wong, C., Tomasi, D., Wang, G.-J., & Volkow, N. D. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.01.056 · Cited by 41
Self-citation
Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers
Wiers, C. E., Shumay, E., Cabrera, E., Kojori, E. S., Gladwin, T. E., Skarda, E., Cunningham, S. I., Kim, S. W., Wong, T. C., Tomasi, D. G., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.14 · Cited by 41
Self-citation
Investigation of Novel Primary and Secondary Pharmacophores and 3-Substitution in the Linking Chain of a Series of Highly Selective and Bitopic Dopamine D3 Receptor Antagonists and Partial Agonists
Shaik, A. B., Kumar, V., Bonifazi, A., Guerrero, A. M., Cemaj, S., Gadiano, A. J., Lam, J., Xi, Z., Rais, R., Slusher, B. S., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00607 · Cited by 41
Minnesota Center for Twin and Family Research
Wilson, S., Haroian, K., Iacono, W. G., Krueger, R. F., Lee, J. J., Luciana, M. M., Malone, S. M., McGue, M. K., Roisman, G. I., & Vrieze, S. I. (2019) · Twin Research and Human Genetics · doi:10.1017/thg.2019.107 · Cited by 44
Neuromodulation for substance addiction in human subjects: A review
Bari, A., DiCesare, J. A. T., Babayan, D., Runcie, M., Sparks, H. D., & Wilson, B. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.013 · Cited by 46
Pharmacophore‐based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line
Chapy, H., Goracci, L., Vayer, P., Parmentier, Y., Carrupt, P., Declèves, X., Scherrmann, J., Cisternino, S., & Cruciani, G. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13258 · Cited by 42
Voices of Homeless Alcoholics Who Frequent Bellevue Hospital: A Qualitative Study
McCormack, R. P., Hoffman, L. F., Norman, M., Goldfrank, L. R., & Norman, E. M. (2014) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2014.05.025 · Cited by 40
Core Addiction Medicine Competencies for Doctors: An International Consultation on Training
Ayu, A. P., el‐Guebaly, N., Schellekens, A., de Jong, C. A. J., Welle-Strand, G. K., Small, W. C., Wood, E., Cullen, W., & Klimas, J. (2017) · Substance Abuse · doi:10.1080/08897077.2017.1355868 · Cited by 40
The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans
Kenna, G. A., Swift, R. M., Hillemacher, T., & Leggio, L. (2012) · Neuropsychology Review · doi:10.1007/s11065-012-9209-y · Cited by 38
Delineation of Domains Within the Cannabinoid CB1 and Dopamine D2 Receptors That Mediate the Formation of the Heterodimer Complex
Khan, S. S., & Lee, F. J. S. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0181-7 · Cited by 39
PET imaging for addiction medicine
Wiers, C. E., Cabrera, E. A., Skarda, E., Volkow, N. D., & Wang, G. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.016 · Cited by 42
Self-citation
The biology of addiction
MacNicol, B. J. (2016) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-016-0771-2 · Cited by 52
How psychoactive drugs shape human culture: A multi-disciplinary perspective
Wadley, G. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.008 · Cited by 44
Compulsive methamphetamine taking and abstinence in the presence of adverse consequences: Epigenetic and transcriptional consequences in the rat brain
Cadet, J. L., Patel, R., & Jayanthi, S. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.02.009 · Cited by 40
Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review
Marques, R. C., Vieira, L., Marques, D., & Cantilino, A. (2019) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2019-0344 · Cited by 42
Altered core networks of brain connectivity and personality traits in internet gaming disorder
Chun, J., Park, C.-H., Kim, J.-Y., Choi, J., Cho, H., Jung, D. J., Ahn, K. J., Choi, J., Kim, D., & Choi, I. Y. (2020) · Journal of Behavioral Addictions · doi:10.1556/2006.2020.00014 · Cited by 38
Reward Sensitivity of ACC as an Intermediate Phenotype between DRD4-521T and Substance Misuse
Baker, T. E., Stockwell, T. R., Barnes, G. E., Haesevoets, R. J. C., & Holroyd, C. B. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00905 · Cited by 37
Sex- and Brain Region-specific Changes in Gene Expression in Male and Female Rats as Consequences of Methamphetamine Self-administration and Abstinence
Daiwile, A. P., Jayanthi, S., & Cadet, J. L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.025 · Cited by 37
Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity
Cadet, J. L., & Bisagno, V. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00204 · Cited by 40
Mapping Smoking Addiction Using Effective Connectivity Analysis
Tang, R., Razi, A., Friston, K. J., & Tang, Y. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00195 · Cited by 36
Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans
He, Q., Huang, X., Turel, O., Schulte, M. T., Huang, D. Y. C., Thames, A. D., Bechara, A., & Hser, Y. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.024 · Cited by 35
Non-invasive suppression of the human nucleus accumbens (NAc) with transcranial focused ultrasound (tFUS) modulates the reward network: a pilot study
Peng, X., Connolly, D. J., Sutton, F., Robinson, J., Baker-Vogel, B., Short, E. B., & Badran, B. W. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1359396 · Cited by 37
Neurogenetic Impairments of Brain Reward Circuitry Links to Reward Deficiency Syndrome (RDS): Potential Nutrigenomic Induced Dopaminergic Activation
Oscar‐Berman, M. (2012) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000e115 · Cited by 34
Cadherin 13: Human cis-Regulation and Selectively Altered Addiction Phenotypes and Cerebral Cortical Dopamine in Knockout Mice
Drgonová, J., Walther, D. M., Hartstein, G. L., Bukhari, M. O., Baumann, M. H., Katz, J. L., Hall, F. S., Arnold, E. R., Flax, S. M., Riley, A. L., et al. (2016) · Molecular Medicine · doi:10.2119/molmed.2015.00170 · Cited by 33
Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking
Spencer, S. M., García‐Keller, C., Roberts-Wolfe, D., Heinsbroek, J. A., Mulvaney, M., Sorrell, A., & Kalivas, P. W. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.033 · Cited by 34
GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine
McCall, N. M., de Velasco, E. M. F., & Wickman, K. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.3101-18.2019 · Cited by 34
Cue-induced craving and symptoms of online-buying-shopping disorder interfere with performance on the Iowa Gambling Task modified with online-shopping cues
Trotzke, P., Starcke, K., Müller, A., & Brand, M. (2019) · Addictive Behaviors · doi:10.1016/j.addbeh.2019.04.008 · Cited by 35
The insula in nicotine use disorder: Functional neuroimaging and implications for neuromodulation
Regner, M. F., Tregellas, J. R., Kluger, B. M., Wylie, K. P., Gowin, J. L., & Tanabe, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.002 · Cited by 34
Closed Loop Deep Brain Stimulation for PTSD, Addiction, and Disorders of Affective Facial Interpretation: Review and Discussion of Potential Biomarkers and Stimulation Paradigms
Bina, R. W., & Langevin, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00300 · Cited by 37
Hyperactivation to pleasant interoceptive stimuli characterizes the transition to stimulant addiction
Stewart, J. L., May, A. C., Tapert, S. F., & Paulus, M. P. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.07.009 · Cited by 33
Left frontoparietal network activity is modulated by drug stimuli in cocaine addiction
Costumero, V., Rosell‐Negre, P., Bustamante, J. C., Fuentes‐Claramonte, P., Llopis, J. J., Ávila, C., & Barrós‐Loscertales, A. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9799-3 · Cited by 33
Buprenorphine and Methadone as Opioid Maintenance Treatments for Heroin-Addicted Patients Induce Oxidative Stress in Blood
Leventelis, C., Goutzourelas, N., Kortsinidou, A., Spanidis, Y., Toulia, G., Kampitsi, A., Tsitsimpikou, C., Stagos, D., Veskoukis, A. S., & Kouretas, D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9417048 · Cited by 38
A multimodal neuroimaging classifier for alcohol dependence
Guggenmos, M., Schmack, K., Veer, I. M., Lett, T. A. P., Sekutowicz, M., Sebold, M., Garbusow, M., Sommer, C., Wïttchen, H., Zimmermann, U. S., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-56923-9 · Cited by 36
Enhanced memory persistence is blocked by a DNA methyltransferase inhibitor in the snail Lymnaea stagnalis
Lukowiak, K., Heckler, B., Bennett, T. E., Schriner, E. K., Wyrick, K., Jewett, C., Todd, R. P., & Sorg, B. A. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.106765 · Cited by 32
Preclinical Evidence That Activation of Mesolimbic Alpha 6 Subunit Containing Nicotinic Acetylcholine Receptors Supports Nicotine Addiction Phenotype
Brunzell, D. H. (2012) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts089 · Cited by 36
Betel quid dependence is associated with functional connectivity changes of the anterior cingulate cortex: a resting-state fMRI study
Liu, T., Li, J., Zhao, Z., Zhong, Y., Zhang, Z., Xu, Q., Yang, G., Lu, G., Pan, S., & Chen, F. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0784-1 · Cited by 33
25B‐NBOMe, a novel N‐2‐methoxybenzyl‐phenethylamine (NBOMe) derivative, may induce rewarding and reinforcing effects via a dopaminergic mechanism: Evidence of abuse potential
Custodio, R. J. P., Sayson, L. V., Botanas, C. J., Abiero, A., You, K. Y., Kim, M., Lee, H. J., Yoo, S. Y., Lee, K. W., Lee, Y. S., et al. (2019) · Addiction Biology · doi:10.1111/adb.12850 · Cited by 31
Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons
García‐Keller, C., Scofield, M. D., Neuhofer, D., Varanasi, S., Reeves, M. T., Hughes, B. W., Anderson, E. M., Richie, C. T., Mejías-Aponte, C. A., Pickel, J. M., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2666-19.2020 · Cited by 28
How Imaging Glutamate, γ‐Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal
Hillmer, A. T., Mason, G. F., Fucito, L. M., O’Malley, S. S., & Cosgrove, K. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12893 · Cited by 32
Cribado neurocognitivo en adictos a sustancias: la evaluación cognitiva de Montreal
Mota, G. R., Pérez, E. J. P., de León, J. M. R. S., Luque, M. L., & García, C. P. (2013) · Revista de Neurología · doi:10.33588/rn.5603.2012628 · Cited by 30
Cocaine and Caffeine Effects on the Conditioned Place Preference Test: Concomitant Changes on Early Genes within the Mouse Prefrontal Cortex and Nucleus Accumbens
Muñiz, J. A., Prieto, J. P., González, B., Sosa, M. H., Cadet, J. L., Scorza, C., Urbano, F. J., & Bisagno, V. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00200 · Cited by 32

Authors: Volkow, N. D., Wang, G.-J., Fowler, J. S., & Tomasi, D.
Affiliations: National Institutes of Health (US)
Brookhaven National Laboratory (US)
ORCID: Volkow, Nora D.
Wang, Gene-Jack
Tomasi, Dardo
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2012-02-10
Volume: 52
Issue: 1
Pages: 321-336
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev-pharmtox-010611-134625
PMC: PMC3477468
OpenAlex: W2111986556
Cited by: 592
References: 91
Citations by year: 2026: 28 · 2025: 47 · 2024: 18 · 2023: 28 · 2022: 28 · 2021: 24 · 2020: 50 · 2019: 42 · 2018: 46 · 2017: 42 · 2016: 58 · 2015: 59 · 2014: 52 · 2013: 50 · 2012: 19
FWCI: 3.72
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (ZIAAA000550)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: addiction, substance use disorders, dopamine, reward systems, brain circuits, chronic drug use, social stress, developmental trajectories, genetic background, memory, executive function, motivation, addiction prevention, addiction treatment
MeSH terms: Affect, Brain, Dopamine, Humans, Memory, Stress, Psychological, Behavior, Addictive, Substance-Related Disorders, Executive Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Addiction Circuitry in the Human Brain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks