The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Molecular Signatures of Natural Selection
Abstract
There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. The interest stems from a basic desire to learn more about evolutionary processes in humans and other organisms, and from the realization that inferences regarding selection may provide important functional information. This review provides a nonmathematical description of the issues involved in detecting selection from DNA sequences and SNP data and is intended for readers who are not familiar with population genetic theory. Particular attention is placed on issues relating to the analysis of large-scale genomic data sets.
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Positive selection on apoptosis related genes
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“Following the logic of successful approaches developed to detect selective sweeps in nonhybrid populations (Nielsen 2005; Williamson et al. 2007), we deploy the full SFS (rather than summarizing it) and we use the genomic spectrum as a null model (bypassing the need to specify a demographic model).”
MethodInfluentialZanoaga, M.-D., Cavinato, T., Latrille, T., Liska, O., Schoeler, T., Papp, B., & Kutalik, Z. (2026) · doi:10.64898/2026.10.16.759432
Metadata
- Authors
- Nielsen, R.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2005-12-01
- Volume
- 39
- Issue
- 1
- Pages
- 197-218
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2116668053
- Cited by
- 1,641
- References
- 7
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
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