The DOI matches its Crossref record, with a small difference in title or year; 121 of the 121 references it cites were found in a registry or an index.
I NHIBITION OF C ARCINOGENESIS BY D IETARY P OLYPHENOLIC C OMPOUNDS
Abstract
Plants consumed by humans contain thousands of phenolic compounds. The effects of dietary polyphenols are of great current interest due to their antioxidative and possible anticarcinogenic activities. A popular belief is that dietary polyphenols are anticarcinogens because they are antioxidants, but direct evidence for this supposition is lacking. This chapter reviews the inhibition of tumorigenesis by phenolic acids and derivatives, tea and catechins, isoflavones and soy preparations, quercetin and other flavonoids, resveratrol, and lignans as well as the mechanisms involved based on studies in vivo and in vitro. Polyphenols may inhibit carcinogenesis by affecting the molecular events in the initiation, promotion, and progression stages. Isoflavones and lignans may influence tumor formation by affecting estrogen-related activities. The bioavailability of the dietary polyphenols is discussed extensively, because the tissue levels of the effective compounds determine the biological activity. Understanding the bioavailability and blood and tissue levels of polyphenols is also important in extrapolating results from studies in cell lines to animal models and humans. Epidemiological studies concerning polyphenol consumption and human cancer risk suggest the protective effects of certain food items and polyphenols, but more studies are needed for clear-cut conclusions. Perspectives on the application of dietary polyphenols for the prevention of human cancer and possible concerns on the consumption of excessive amounts of polyphenols are discussed.
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“The aleuron layer of wheat bran contains a number of phytoprotectants (i.e., ferulic acid, alkylresorcinols, apigenin, lignans, and phytic acid), which have antioxidative and anti-inflammatory potential, and anticarcinogenic activities in rodent animal models of colon and skin cancer (56–59).”
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Cited by
Sorted by citations
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
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Metadata
- Authors
- Yang, C. S., Landau, J. M., Huang, M.-T., & Newmark, H. L.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- ORCID
- Yang, Chung S
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2001-07
- Volume
- 21
- Issue
- 1
- Pages
- 381-406
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2158944838
- Cited by
- 1,260
- References
- 120
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 23 · 2023: 39 · 2022: 45 · 2021: 55 · 2020: 43 · 2019: 50 · 2018: 52 · 2017: 59 · 2016: 56 · 2015: 61 · 2014: 71 · 2013: 65 · 2012: 69
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA056673, CA56673)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Keywords
- dietary polyphenols, anticarcinogenic activity, carcinogenesis inhibition, antioxidants, phenolic acids, tea catechins, isoflavones, soybean, quercetin, flavonoids, resveratrol, lignans, bioavailability, cancer prevention, cancer risk
- MeSH terms
- Absorption, Antioxidants, Biological Availability, Biotransformation, Catechin, Diet, Flavonoids, Humans, Isoflavones, Phenols, Polymers, Tea, Anticarcinogenic Agents
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