The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women
Abstract
Skeletal muscle stem (satellite) cells supporting growth/regeneration are thought to be activated and incorporated into growing myofibers by both endocrine and locally expressed autocrine/paracrine growth factors, the latter being load sensitive. We recently found that myofiber hypertrophy with resistance training is superior in young men (YM) vs. young women and older adults (Kosek DJ, Kim JS, Petrella JK, Cross JM, and Bamman MM. J Appl Physiol 101: 531-544, 2006). We hypothesized that the advanced myofiber hypertrophy in YM is facilitated by myonuclear addition in response to a milieu promoting stem cell activation. Twenty-six young (27.0 +/- 1 yr, 50% women) and 26 older (63.7 +/- 1 yr, 50% women) adults completed 16 wk of knee extensor resistance training. Vastus lateralis biopsies were obtained at baseline, 24 h after one bout, and after 16 wk. Muscle stem cells were identified immunohistochemically with anti-neural cell adhesion molecule (NCAM+). Muscle transcript levels of IGF-I and mechanogrowth factor (MGF) were determined by RT-PCR. Serum IGF-I, IGF-binding protein (IGFBP)-3, IGFBP-1, total and free testosterone, sex hormone-binding globulin (SHBG), and androstenedione were assessed by radioimmunoassay. Myofiber hypertrophy was twofold greater in YM vs. others, and only YM increased NCAM+ cells per 100 myofibers (49%) and myonuclei per fiber (19%) (P < 0.05). IGF-IEa mRNA was higher in young and increased acutely (29%) with summation by 16 wk (96%) (P < 0.05). MGF mRNA increased only in young after one bout (81%) and by 16 wk (85%) (P < 0.001). Circulating IGF-I was twofold higher in young, whereas IGFBP-1 was lowest in YM (P < 0.05). Among men, free testosterone was 59% higher in YM (P < 0.01). Myonuclear addition was most effectively accomplished in YM, which likely drove the superior growth.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Following activation, proliferation, and fusion, Pax7+ satellite cells donate new myonuclei to the syncytium, thereby expanding the transcriptional and nucleolar infrastructure available to support continued adaptation [25,66,67].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [66]
In the citing paper
“further expansion of ribosome biogenesis and protein synthetic infrastructure may depend, at least in part, on the incorporation of additional myonuclei”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [66]
In the citing paper
“Once the initial gains supported by existing myonuclei have been largely realized, further adaptation may require a slower phase of structural remodeling involving satellite cell participation and myonuclear expansion [66,68].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [66]
In the citing paper
“Because new myonuclei donate new nucleoli to the syncytium, this finding aligns with the requirement to physically expand the architectural space available for ribosome biogenesis [66,96].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [66]
In the citing paper
“Early investigations into these responder clusters, spearheaded by Petrella et al., demonstrated that extreme hypertrophic responders exhibited a high capability for satellite cell activation and myonuclear addition compared to non-responders [66].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [66]
Citations
Cites
SATELLITE CELL OF SKELETAL MUSCLE FIBERS
Mauro, A. (1961) · The Journal of Cell Biology · doi:10.1083/jcb.9.2.493 · Cited by 3,683
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Myogenic satellite cells: physiology to molecular biology
Hawke, T. J., & Garry, D. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.534 · Cited by 1,646
Notch-Mediated Restoration of Regenerative Potential to Aged Muscle
Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121
Södergard, R., Bäckström, T., Shanbhag, V., & Carstensen, H. (1982) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(82)90038-3 · Cited by 1,080
Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J. (1997) · Science · doi:10.1126/science.278.5337.419 · Cited by 980
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
Iannuzzi-Sucich, M., Prestwood, K. M., & Kenny, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.12.m772 · Cited by 890 · cited 1×
“A number of studies have associated age-related declines in circulating anabolic factors, including IGF-I and testosterone, with the muscle atrophy of aging (10, 32, 41), suggesting that these serum factors are important for the constitutive maintenance of muscle mass.”
BackgroundPredictors of skeletal muscle mass in elderly men and women
Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00130-4 · Cited by 809 · cited 1×
“A number of studies have associated age-related declines in circulating anabolic factors, including IGF-I and testosterone, with the muscle atrophy of aging (10, 32, 41), suggesting that these serum factors are important for the constitutive maintenance of muscle mass.”
BackgroundSuction applied to a muscle biopsy maximizes sample size
Evans, W. J., Phinney, S. D., & Young, V. R. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198201000-00018 · Cited by 525
Kosek, D. J., Kim, J.-S., Petrella, J. K., Cross, J. M., & Bamman, M. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01474.2005 · Cited by 503
Self-citationMuscle transplantation between young and old rats: age of host determines recovery
Carlson, B. M., & Faulkner, J. A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.6.c1262 · Cited by 417
Control of the size of the human muscle mass
Rennie, M. J., Wackerhage, H., Spangenburg, E. E., & Booth, F. W. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.052102.134444 · Cited by 399
Malm, C., Nyberg, P., Engström, M., Sjödin, B., Lenkei, R., Ekblom, B. T., & Lundberg, I. E. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00243.x · Cited by 396
The effects of heavy resistance training and detraining on satellite cells in human skeletal muscles
Kadi, F., Schjerling, P., Andersen, L. L., Charifi, N., Madsen, J. L., Christensen, L. R., & Andersen, J. L. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.065904 · Cited by 363
Häkkinen, K., Kraemer, W. J., Newton, R. U., & Alén, M. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00781.x · Cited by 351
Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans
Bamman, M. M., Shipp, J. R., Jiang, J., Gower, B. A., Hunter, G. R., Goodman, A. G., McLafferty, C. L., & Urban, R. J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.3.e383 · Cited by 340
Self-citationRegenerative potential of human skeletal muscle during aging
Renault, V. M., Thorne, L., Eriksson, P., Butler-Browne, G. S., & Mouly, V. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00017.x · Cited by 332
Yang, S. Y., & Goldspink, G. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02918-6 · Cited by 321
Decary, S., Mouly, V., Hamida, C. B., Sautet, A., Barbet, P., & Butler-Browne, G. S. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.12-1429 · Cited by 304
Satellite cells and myonuclei in young and elderly women and men
Kadi, F., Charifi, N., Denis, C., & Lexell, J. E. (2003) · Muscle & Nerve · doi:10.1002/mus.10510 · Cited by 298
Age differences in knee extension power, contractile velocity, and fatigability
Petrella, J. K., Kim, J.-S., Tuggle, S. C., Hall, S. R., & Bamman, M. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00294.2004 · Cited by 270
Self-citationExercise-induced satellite cell activation in growing and mature skeletal muscle
Darr, K. C., & Schultz, E. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.5.1816 · Cited by 268
Kim, J.-S., Cross, J. M., & Bamman, M. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2004 · Cited by 264
Self-citationChanges in satellite cells in human skeletal muscle after a single bout of high intensity exercise.
Crameri, R. M., Langberg, H., Magnusson, P., Jensen, C. H., Schrøder, H. D., Olesen, J. L., Suetta, C., Teisner, B., & Kjaer, M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.061846 · Cited by 262
IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle
Chakravarthy, M. V., Davis, B. S., & Booth, F. W. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.4.1365 · Cited by 262
Satellite cell numbers in young and older men 24 hours after eccentric exercise
Dreyer, H. C., Blanco, C. E., Sattler, F. R., Schroeder, E. T., & Wiswell, R. A. (2006) · Muscle & Nerve · doi:10.1002/mus.20461 · Cited by 256
Rosenblatt, J. D., & Parry, D. J. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.6.2538 · Cited by 252
Plasticity of myonuclear number in hypertrophied and atrophied mammalian skeletal muscle fibers
Allen, D. L., Monke, S. R., Talmadge, R. J., Roy, R. R., & Edgerton, V. R. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.5.1969 · Cited by 240
Owino, V., Yang, S. Y., & Goldspink, G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02825-3 · Cited by 227
Cellular and molecular responses to increased skeletal muscle loading after irradiation.
Adams, G., Caiozzo, V., Haddad, F., & Baldwin, K. (2002) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00173.2002 · Cited by 227
Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise
Bickel, C. S., Slade, J. M., Mahoney, E., Haddad, F., Dudley, G. A., & Adams, G. R. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00895.2004 · Cited by 200
Gender Differences in Resistance-Training-Induced Myofiber Hypertrophy Among Older Adults
Bamman, M. M., Hill, V. J., Adams, G. R., Haddad, F., Wetzstein, C. J., Gower, B. A., Ahmed, A., & Hunter, G. R. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.2.b108 · Cited by 199
Self-citationEffects of anabolic steroids on the muscle cells of strength-trained athletes
KADI, F., ERIKSSON, A., HOLMNER, S., & THORNELL, L.-E. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199911000-00006 · Cited by 190
Cellular adaptation of the trapezius muscle in strength-trained athletes
Kadi, F., Eriksson, A., Holmner, S., Butler-Browne, G. S., & Thornell, L. E. (1999) · Histochemistry and Cell Biology · doi:10.1007/s004180050348 · Cited by 189
Skeletal muscle regeneration and the mitotic clock
Renault, V. M., Piron-Hamelin, G., Forestier, C.-L., Donna, S. D., Decary, S., Hentati, F., Saillant, G., Butler-Browne, G. S., & Mouly, V. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00151-0 · Cited by 179
Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle
Psilander, N., Damsgaard, R., & Pilegaard, H. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00903.2002 · Cited by 178
Illa, I., Leon‐Monzon, M., & Dalakas, M. C. (1992) · Annals of Neurology · doi:10.1002/ana.410310109 · Cited by 178
Hikida, R. S., Staron, R. S., Hagerman, F. C., Walsh, S., Kaiser, E., Shell, S., & Hervey, S. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.7.b347 · Cited by 167
Activation of an adipogenic program in adult myoblasts with age
Taylor-Jones, J. M., McGehee, R. E., Rando, T. A., Lecka‐Czernik, B., Lipschitz, D. A., & Peterson, C. A. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00411-0 · Cited by 165
Effects of endurance training on satellite cell frequency in skeletal muscle of old men.
Charifi, N., Kadi, F., Féasson, L., & Denis, C. (2003) · Muscle & Nerve · doi:10.1002/mus.10394 · Cited by 154
Roth, S. M., Martel, G. F., Ivey, F. M., Lemmer, J. T., Tracy, B. L., Metter, E. J., Hurley, B. F., & Rogers, M. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.6.b240 · Cited by 152
Skeletal Muscle Cell Mass and Growth: The Concept of the Deoxyribonucleic Acid Unit
Cheek, D. B., Holt, A. B., Hill, D. E., & Talbert, J. L. (1971) · Pediatric Research · doi:10.1203/00006450-197107000-00004 · Cited by 145
The control of cell mass and replication. The DNA unit - a personal 20-year study
Cheek, D. B. (1985) · Early Human Development · doi:10.1016/0378-3782(85)90144-6 · Cited by 139
Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle.
SCHUBERT, W. J., Zimmermann, K., Cramer, M., & Starzinski‐Powitz, A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.1.307 · Cited by 139
Barton, E. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01405.2005 · Cited by 135
Kim, J.-S., Kosek, D. J., Petrella, J. K., Cross, J. M., & Bamman, M. M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00513.2005 · Cited by 128
Self-citationNicklas, B., Ryan, A., Treuth, M., Harman, S., Blackman, M., Hurley, B., & Rogers, M. (1995) · International Journal of Sports Medicine · doi:10.1055/s-2007-973035 · Cited by 126 · cited 1×
“Although we and others have shown that serum hormone levels do not change by any appreciable amount over long-term resistance training (6, 45, 50) and return from transient elevations shortly after acute resistance exercise (5, 46), the likelihood remains that basal circulating concentrations of one or more factors pa…”
BackgroundSinanan, A., Hunt, N. P., & Lewis, M. P. (2004) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20030185 · Cited by 120
Skeletal Muscle Regeneration in Very Old Rats
Carlson, B. M., Dedkov, E. I., Borisov, A. B., & Faulkner, J. A. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b224 · Cited by 119
Overnight responses of the circulating IGF-I system after acute, heavy-resistance exercise
Nindl, B. C., Kraemer, W. J., Marx, J. O., Arciero, P. J., Dohi, K., Kellogg, M. D., & Loomis, G. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.4.1319 · Cited by 115
Satellite cell regulation of muscle mass is altered at old age
Gallegly, J. C., Turesky, N. A., Strotman, B. A., Gurley, C. M., Peterson, C. A., & Dupont‐Versteegden, E. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00006.2004 · Cited by 114
Human skeletal muscle satellite cells: aging, oxidative stress and the mitotic clock
Renault, V. M., Thornell, L., Butler-Browne, G. S., & Mouly, V. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00129-8 · Cited by 105
Regulation of skeletal muscle fiber size, shape and function
Edgerton, V. R., & Roy, R. R. (1991) · Journal of Biomechanics · doi:10.1016/0021-9290(91)90383-x · Cited by 104
Myogenic protein expression before and after resistance loading in 26- and 64-yr-old men and women
Bamman, M. M., Ragan, R. C., Kim, J.-S., Cross, J. M., Hill, V. J., Tuggle, S. C., & Allman, R. M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01387.2003 · Cited by 89
Self-citationAge-related changes in the mitotic and metabolic characteristics of muscle-derived cells
Barani, A. E., Durieux, A., Sabido, O., & Freyssenet, D. G. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00437.2003 · Cited by 81
Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling
Akimoto, T., Ushida, T., Miyaki, S., Akaogi, H., Tsuchiya, K., Yan, Z., Williams, R. S., & Tateishi, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.136 · Cited by 77
Pyka, G., Taaffe, D., & Marcus, R. (1994) · Hormone and Metabolic Research · doi:10.1055/s-2007-1001697 · Cited by 73 · cited 1×
“Although we and others have shown that serum hormone levels do not change by any appreciable amount over long-term resistance training (6, 45, 50) and return from transient elevations shortly after acute resistance exercise (5, 46), the likelihood remains that basal circulating concentrations of one or more factors pa…”
BackgroundAging of Skeletal Muscle Does Not Affect the Response of Satellite Cells to Denervation
Dedkov, E. I., Borisov, A. B., Wernig, A., & Carlson, B. M. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305100701 · Cited by 52
Mechanomyographic and electromyographic muscle responses are related to power
Bodor, M. (1999) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199905)22:5 · Cited by 16
Sojka, K. M., Kern, C. B., & Pollenz, R. S. (2000) · The Anatomical Record · doi:10.1002/1097-0185(200012)260:4 · Cited by 12
Flagged first, then by citations
Cited by
Sorted by citations
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003230 · Cited by 1,290
Sarcopenia: etiology, clinical consequences, intervention, and assessment
Lang, T., Streeper, T., Cawthon, P. M., Baldwin, K., Taaffe, D. R., & Harris, T. B. (2009) · Osteoporosis International · doi:10.1007/s00198-009-1059-y · Cited by 815
The Molecular Bases of Training Adaptation
Coffey, V. G., & Hawley, J. A. (2007) · Sports Medicine · doi:10.2165/00007256-200737090-00001 · Cited by 756
Metadata
- Authors
- Petrella, J. K., Kim, J.-S., Cross, J. M., Kosek, D. J., & Bamman, M. M.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2006-11
- Volume
- 291
- Issue
- 5
- Pages
- E937-E946
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2154326737
- Cited by
- 356
- References
- 61
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 15 · 2022: 24 · 2021: 15 · 2020: 18 · 2019: 22 · 2018: 24 · 2017: 17 · 2016: 28 · 2015: 22 · 2014: 20 · 2013: 16 · 2012: 25
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- University of Alabama at Birmingham
- National Institute on Aging (R01AG017896, R01 AG17896)
- National Center for Research Resources (M01RR00032, M01RR000032)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- muscle fiber hypertrophy, resistance training, skeletal muscle stem cells, satellite cells, insulin-like growth factor I, IGFBP-1, IGFBP-3, free testosterone, sex differences, aging, vastus lateralis, CD56, androstenedione, sex hormone-binding globulin
- MeSH terms
- Adult, Aged, Aging, Androstenedione, Cell Nucleus, Female, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, RNA, Messenger, Sex Characteristics, Sex Hormone-Binding Globulin, Testosterone, Exercise, Muscle, Skeletal, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Neural Cell Adhesion Molecules, Satellite Cells, Skeletal Muscle, Cell Size
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
