Cited by 513Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesEating Disorders and Behaviors

The DOI matches its Crossref record; 839 of the 839 references it cites were found in a registry or an index.

Sex differences in the physiology of eating

Open access

Asarian, Lori, Geary, Nori·2013·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00446.2012PMC PMC3882560

Open this paper in CoChat — free account

Abstract

Hypothalamic-pituitary-gonadal (HPG) axis function fundamentally affects the physiology of eating. We review sex differences in the physiological and pathophysiological controls of amounts eaten in rats, mice, monkeys, and humans. These controls result from interactions among genetic effects, organizational effects of reproductive hormones (i.e., permanent early developmental effects), and activational effects of these hormones (i.e., effects dependent on hormone levels). Male-female sex differences in the physiology of eating involve both organizational and activational effects of androgens and estrogens. An activational effect of estrogens decreases eating 1) during the periovulatory period of the ovarian cycle in rats, mice, monkeys, and women and 2) tonically between puberty and reproductive senescence or ovariectomy in rats and monkeys, sometimes in mice, and possibly in women. Estrogens acting on estrogen receptor-α (ERα) in the caudal medial nucleus of the solitary tract appear to mediate these effects in rats. Androgens, prolactin, and other reproductive hormones also affect eating in rats. Sex differences in eating are mediated by alterations in orosensory capacity and hedonics, gastric mechanoreception, ghrelin, CCK, glucagon-like peptide-1 (GLP-1), glucagon, insulin, amylin, apolipoprotein A-IV, fatty-acid oxidation, and leptin. The control of eating by central neurochemical signaling via serotonin, MSH, neuropeptide Y, Agouti-related peptide (AgRP), melanin-concentrating hormone, and dopamine is modulated by HPG function. Finally, sex differences in the physiology of eating may contribute to human obesity, anorexia nervosa, and binge eating. The variety and physiological importance of what has been learned so far warrant intensifying basic, translational, and clinical research on sex differences in eating.

Integrity signals

Registry

Crossref · 10.1152/ajpregu.00446.2012

Cites

839 of 839 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Intrauterine Hormonal Environment and Risk of Developing Anorexia Nervosa
Procopio, M., & Marriott, P. K. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.12.1402 · Cited by 23
Retracted
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700
The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication
Hudson, J. I., Hiripi, E., Pope, H. G., & Kessler, R. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.040 · Cited by 4,973
The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger
Stunkard, A. J., & Messick, S. (1985) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(85)90010-8 · Cited by 4,687
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030

Flagged first, then by citations

Show all 833 references

Research works printed but not linked: 31

Arimura C, 2010, Eat Weight Disord, 15, e226
Asarian L, 2009, Appetite, 52, 817
Austin SB, 2008, Prev Chronic Dis, 5, A114
Cone RD, 2003, William's Textbook of Endocrinology, 81
Datz FL, 1987, J Nucl Med, 28, 1204
Foltin RW, 1983, J Pharmacol Exp Ther, 226, 411
Frye CA, 2011, J Endocrinol Invest, 34, e188
Griffin JE, 2003, Williams Textbook of Endocrinology, 709
Heape W, 1900, Q J Microscopic Sci, 44, 1
Huang YS, 1993, J Assoc Acad Minor Phys, 4, 56
Kemnitz JW, 1977, Int J Obes (Lond), 1, 259
Klump KL, Int J Eat Disord
Knight LC, 1997, Am J Gastroenterol, 92, 968
Larsson H, 1998, J Clin Endocrinol Metab, 83, 4382
Leibel RL, 2008, 32, S98
Leidy LE, 1996, Hum Biol, 68, 967
Long JA, 1922, Mem Univ Calif, 6, 1
Mangiaracina M, 2004, Appetite, 42, 382
McEwen BS, 1999, Endocr Rev, 20, 279
Nance DM, 1975, Pharmacol Biochem Behav, 3, 155
Palmiter RD, 1998, Recent Prog Horm Res, 53, 163
Powell MR, 1999, Genet Soc Gen Psychol Monogr, 125, 333
10.1002/eat.20941 · DOI
Richter CP, 1942, Harvey Lecture Series, 38, 63
Rosenbaum M, 1999, J Clin Endocrinol Metab, 84, 1784
Rosenbaum M, 1996, J Clin Endocrinol Metab, 81, 3424
Rosenbaum M, 2008, J Clin Invest, 118, 2583
Ross GT, 1970, Recent Prog Horm Res, 26, 1
Wade GN, 1985, Int J Obes (Lond), 9, 83
Whitaker KW, 2011, Nutr Metab Cardiovasc Dis
Williams WP, 2012, Front Endocrinol (Lausanne), 3, 60

Sorted by citations

Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101
The sexual dimorphism of obesity
Palmer, B. F., & Clegg, D. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.029 · Cited by 919
Ghrelin, CCK, GLP-1, and PYY(3–36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB
Steinert, R. E., Feinle-Bisset, C., Asarian, L., Horowitz, M., Beglinger, C., & Geary, N. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2014 · Cited by 578
Self-citation
Ovarian hormones and obesity
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407
Self-citation
The Impact of Isolation Measures Due to COVID-19 on Energy Intake and Physical Activity Levels in Australian University Students
Gallo, L. A., Gallo, T. F., Young, S. L., Moritz, K. M., & Akison, L. K. (2020) · Nutrients · doi:10.3390/nu12061865 · Cited by 382
Sex and gender differences in developmental programming of metabolism
Dearden, L., Bouret, S. G., & Ozanne, S. E. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.04.007 · Cited by 353
GLP-1 and weight loss: unraveling the diverse neural circuitry
Kanoski, S. E., Hayes, M. R., & Skibicka, K. P. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00520.2015 · Cited by 290
The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders
Hwang, W. J., Lee, T. Y., Kim, N. S., & Kwon, J. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010373 · Cited by 222
Sex and Species Differences in the Development of Diet-Induced Obesity and Metabolic Disturbances in Rodents
Marić, I., Krieger, J.-P., van der Velden, P., Börchers, S., Asker, M., Vujičić, M., Asterholm, I. W., & Skibicka, K. P. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.828522 · Cited by 192
High-Fat Diet-Induced Adiposity, Adipose Inflammation, Hepatic Steatosis and Hyperinsulinemia in Outbred CD-1 Mice
Gao, M., Ma, Y., & Liu, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119784 · Cited by 156
Sex differences in sleep, circadian rhythms, and metabolism: Implications for precision medicine
Lok, R., Qian, J., & Chellappa, S. L. (2024) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2024.101926 · Cited by 164
Gender-related Differences in Food Craving and Obesity.
Hallam, J., Boswell, R. G., DeVito, E. E., & Hedy Kober, A. (2016) · PubMed · Cited by 156
A narrative review of sex differences in eating disorders: Is there a biological basis?
Culbert, K. M., Sisk, C. L., & Klump, K. L. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.12.003 · Cited by 142
Sex differences in the circadian misalignment effects on energy regulation
Qian, J., Morris, C. J., Caputo, R., Wang, W., Garaulet, M., & Scheer, F. A. J. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914003116 · Cited by 139
Estradiol prevents fat accumulation and overcomes leptin resistance in female high-fat diet mice
Litwak, S. A., Wilson, J. L., Chen, W., Garcia-Rudaz, C., Khaksari, M., Cowley, M. A., & Enriori, P. J. (2014) · Endocrinology · doi:10.1210/en.2014-1342 · Cited by 115
Central regulation of energy metabolism by estrogens
Xu, Y., & López, M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.012 · Cited by 124
Sex and race differences in caloric intake during sleep restriction in healthy adults
Spaeth, A. M., Dinges, D. F., & Goel, N. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.086579 · Cited by 118
Effects of Estrogens on Central Nervous System Neurotransmission: Implications for Sex Differences in Mental Disorders
Krolick, K. N., Zhu, Q., & Shi, H. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.07.008 · Cited by 126
Gut Microbiota Differences According to Ultra-Processed Food Consumption in a Spanish Population
Cuevas‐Sierra, A., Milagro, F. I., Aranaz, P., Martínez, J. A., & Riezu‐Boj, J. I. (2021) · Nutrients · doi:10.3390/nu13082710 · Cited by 124
Intranasal insulin
Hallschmid, M. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12934 · Cited by 113
Sex/gender differences in neural correlates of food stimuli: a systematic review of functional neuroimaging studies
Chao, A. M., Loughead, J., Bakizada, Z. M., Hopkins, C. M., Geliebter, A., Gur, R. C., & Wadden, T. A. (2017) · Obesity Reviews · doi:10.1111/obr.12527 · Cited by 118
Drosophila FIT is a protein-specific satiety hormone essential for feeding control
Sun, J., Liu, C. X., Bai, X., Li, X., Li, J., Zhang, Z., Zhang, Y., Guo, J., & Li, Y. (2017) · Nature Communications · doi:10.1038/ncomms14161 · Cited by 108
Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females
Qiu, J., Rivera, H. M., Bosch, M. A., Padilla, S. L., Stincic, T. L., Palmiter, R. D., Kelly, M. J., & Rønnekleiv, O. K. (2018) · eLife · doi:10.7554/elife.35656 · Cited by 115
Sex and estrogens alter the action of glucagon-like peptide-1 on reward
Richard, J. E., Anderberg, R. H., López-Ferreras, L., Olandersson, K., & Skibicka, K. P. (2016) · Biology of Sex Differences · doi:10.1186/s13293-016-0059-9 · Cited by 102
Microbiota-gut-brain axis drives overeating disorders
Fan, S., Guo, W., Xiao, D., Guan, M., Liao, T., Peng, S., Feng, A., Wang, Z., Yin, H., Li, M., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.09.005 · Cited by 109
The Cognitive, Behavioral, and Emotional Aspects of Eating Habits and Association With Impulsivity, Chronotype, Anxiety, and Depression: A Cross-Sectional Study
Aoun, C., Nassar, L., Soumi, S., Osta, N. E., Papazian, T., & Khabbaz, L. R. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00204 · Cited by 104
Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure
van Veen, J. E., Kammel, L. G., Bunda, P., Shum, M., Reid, M., Massa, M. G., Arneson, D. V., Park, J. W., Zhang, Z., Joseph, A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0189-6 · Cited by 93
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 104
Sex differences in response to short-term high fat diet in mice
Huang, K.-P., Ronveaux, C. C., Knotts, T. A., Rutkowsky, J. M., Ramsey, J. J., & Raybould, H. E. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112894 · Cited by 92
International society of sports nutrition position stand: nutritional concerns of the female athlete
Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 129
Update on Binge Eating Disorder
Guerdjikova, A. I., Mori, N. N., Casuto, L., & McElroy, S. L. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.02.003 · Cited by 108
Sex Differences in Binge Eating: Gonadal Hormone Effects Across Development
Klump, K. L., Culbert, K. M., & Sisk, C. L. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045309 · Cited by 94
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016
Ericson, M. D., Lensing, C. J., Fleming, K. A., Schlasner, K. N., Doering, S. R., & Haskell‐Luevano, C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.020 · Cited by 91
TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis
Wang, C., He, Y., Xu, P., Yang, Y., Saito, K., Xia, Y., Yan, X., Hinton, A. O., Jr., Yan, C., Ding, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03796-7 · Cited by 83
Vagal Interoceptive Modulation of Motivated Behavior
Maniscalco, J. W., & Rinaman, L. (2018) · Physiology · doi:10.1152/physiol.00036.2017 · Cited by 83
GLP-1 and Its Analogs: Does Sex Matter?
Börchers, S., & Skibicka, K. P. (2024) · Endocrinology · doi:10.1210/endocr/bqae165 · Cited by 96
Contributory role of sex differences in the variations of gustatory function
Martin, L. J., & Sollars, S. I. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23819 · Cited by 86
Motives for eating tasty foods associated with binge-eating. Results from a student and a weight-loss seeking population
Boggiano, M. M., Burgess, E. E., Turan, B., Soleymani, T., Daniel, S., Vinson, L. D., Lokken, K., Wingo, B. C., & Morse, A. (2014) · Appetite · doi:10.1016/j.appet.2014.08.026 · Cited by 81
The importance of estradiol for body weight regulation in women
Pilar Vigil, P., Meléndez, J., Petkovic, G., & Río, J. P. D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.951186 · Cited by 84
Sex Differences in the Efficacy of Glucagon‐Like Peptide‐1 Receptor Agonists for Weight Reduction: A Systematic Review and Meta‐Analysis
Yang, Y., He, L., Han, S., Yang, N., Liu, Y., Wang, X., Li, Y., Ping, F., Xu, L., Li, W., et al. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70063 · Cited by 90
Assessing the effects of stress on feeding behaviors in laboratory mice
Francois, M., Delgado, I. C., Shargorodsky, N., Leu, C.-S., & Zeltser, L. M. (2021) · eLife · doi:10.7554/elife.70271 · Cited by 77
Estradiol is a critical regulator of food-reward behavior.
Richard, J. E., López-Ferreras, L., Anderberg, R., Olandersson, K., & Skibicka, K. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.014 · Cited by 66
A review of sex differences in the mechanisms and drivers of overeating
Anversa, R. G., Muthmainah, M., Sketriené, D., Gogos, A., Sumithran, P., & Brown, R. M. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100941 · Cited by 80
Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating
Kirkpatrick, S. L., Goldberg, L. R., Yazdani, N., Babbs, R. K., Wu, J., Reed, E. R., Jenkins, D. F., Bolgioni, A. F., Landaverde, K. I., Luttik, K. P., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.10.021 · Cited by 71
MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update
Støving, R. K. (2018) · European Journal of Endocrinology · doi:10.1530/eje-18-0596 · Cited by 72
Translational value of animal models of obesity—Focus on dogs and cats
Osto, M., & Lutz, T. A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.036 · Cited by 79
Preliminary evidence of sex differences in behavioral and neural responses to palatable food reward in rats
Sinclair, E. B., Hildebrandt, B. A., Culbert, K. M., Klump, K. L., & Sisk, C. L. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.042 · Cited by 70
Sex Differences in Demand for Highly Palatable Foods: Role of the Orexin System
Freeman, L. R., Bentzley, B. S., James, M. H., & Aston‐Jones, G. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa040 · Cited by 70
Mammalian models of diabetes mellitus, with a focus on type 2 diabetes mellitus
Lutz, T. A. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00818-3 · Cited by 68
Regulation of Estrogen ReceptorαExpression in the Hypothalamus by Sex Steroids: Implication in the Regulation of Energy Homeostasis
Liu, X., & Shi, H. (2015) · International Journal of Endocrinology · doi:10.1155/2015/949085 · Cited by 70
Estrogenic suppression of binge‐like eating elicited by cyclic food restriction and frustrative‐nonreward stress in female rats
Bonaventura, M. V. M. D., Lutz, T. A., Romano, A., Pucci, M., Geary, N., Asarian, L., & Cifani, C. (2017) · International Journal of Eating Disorders · doi:10.1002/eat.22687 · Cited by 71
Self-citation
Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities
Reue, K. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.02.040 · Cited by 69
Investigation of the long-term sustainability of changes in appetite after weight loss
Nymo, S., Coutinho, Sr., Eknes, P., Vestbostad, I., Rehfeld, J., Truby, H., Kulseng, B., & Martins, C. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0119-9 · Cited by 68
Glial cells and energy balance
Argente-Arizón, P., Guerra-Cantera, S., García‐Segura, L. M., Argente, J., & Chowen, J. A. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0182 · Cited by 72
Persistent Endocrine-Disrupting Chemicals and Fatty Liver Disease
Deierlein, A. L., Rock, S., & Park, S. (2017) · Current Environmental Health Reports · doi:10.1007/s40572-017-0166-8 · Cited by 65
Sex differences in diurnal rhythms of food intake in mice caused by gonadal hormones and complement of sex chromosomes
Chen, X., Wang, L., Loh, D. H., Colwell, C. S., Taché, Y., Reue, K., & Arnold, A. P. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.07.020 · Cited by 64
Binge Eating Disorder
Guerdjikova, A. I., Mori, N. N., Casuto, L., & McElroy, S. L. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.01.003 · Cited by 72
The Perfect Storm - A Bio-Psycho-Social Risk Model for Developing and Maintaining Eating Disorders
Frank, G. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00044 · Cited by 57
Effects of the estrous cycle and ovarian hormones on cue-triggered motivation and intrinsic excitability of medium spiny neurons in the Nucleus Accumbens core of female rats
Alonso‐Caraballo, Y., & Ferrario, C. R. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104583 · Cited by 56
Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models
Chen, Y., Kim, M., Paye, S. M., & Benayoun, B. A. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105852 · Cited by 59
Exploring the relationships between taste phenotypes, genotypes, ethnicity, gender and taste perception using Chi-square and regression tree analysis
Yang, Q., Williamson, A., Hasted, A. M., & Hort, J. (2020) · Food Quality and Preference · doi:10.1016/j.foodqual.2020.103928 · Cited by 58
Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats
Cognuck, S. Q., Reis, W. L., Silva, M., Debarba, L. K., Mecawi, A. S., de Paula, F. J. A., Franci, C. R., Elias, L. L. K., & Antunes‐Rodrigues, J. (2020) · Physiological Reports · doi:10.14814/phy2.14597 · Cited by 55
Cholecystokinin Switches the Plasticity of GABA Synapses in the Dorsomedial Hypothalamus via Astrocytic ATP Release
Crosby, K. M., Murphy‐Royal, C., Wilson, S. A., Gordon, G. R., Bains, J. S., & Pittman, Q. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0569-18.2018 · Cited by 52
Eating Behavior, Low-Frequency Functional Mutations in the Melanocortin-4 Receptor (MC4R) Gene, and Outcomes of Bariatric Operations: A 6-Year Prospective Study
Bonnefond, A., Keller, R., Meyre, D., Stutzmann, F., Thuillier, D., Stefanov, D. G., Froguel, P., Horber, F., & Kral, J. G. (2016) · Diabetes Care · doi:10.2337/dc16-0115 · Cited by 53
Ovarian Hormones and Reward Processes in Palatable Food Intake and Binge Eating
Ma, R., Mikhail, M. E., Culbert, K. M., Johnson, A. W., Sisk, C. L., & Klump, K. L. (2019) · Physiology · doi:10.1152/physiol.00013.2019 · Cited by 61
Predictive behaviors for anxiety and depression in female Wistar rats subjected to cafeteria diet and stress
da Costa Estrela, D., da Silva, W. A. M., Guimarães, A. T. B., de Oliveira Mendes, B., da Silva Castro, A. L., da Silva Torres, I. L., & Malafaia, G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.07.016 · Cited by 51
Effect of aging, menopause, and age at natural menopause on the trend in body mass index: a 15-year population-based cohort
Montazeri, S. A., Tehrani, F. R., Yarandi, R. B., Erfani, H., Mansournia, M. A., & Azizi, F. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.12.017 · Cited by 51
Gender-specific approach in psychiatric diseases: Because sex matters
Franceschini, A., & Fattore, L. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173895 · Cited by 56
Sex Differences in Cognition Across Aging
Lee, B. H., Richard, J. E., de leon, R. G., Yagi, S., & Galea, L. A. M. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_309 · Cited by 59
Sex differences in sucrose reinforcement in Long-Evans rats
Grimm, J. W., North, K., Hopkins, M., Jiganti, K., McCoy, A., Šulc, J., MacDougall, D., & Sauter, F. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00412-8 · Cited by 50
IL-6–Type Cytokine Signaling in Adipocytes Induces Intestinal GLP-1 Secretion
Wueest, S., Laesser, C. I., Böni‐Schnetzler, M., Item, F., Lucchini, F. C., Borsigova, M., Müller, W., Donath, M. Y., & Konrad, D. (2017) · Diabetes · doi:10.2337/db17-0637 · Cited by 52
Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15
Borner, T., Arnold, M., Ruud, J., Breit, S. N., Langhans, W., Lutz, T. A., Blomqvist, A. G., & Riediger, T. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12169 · Cited by 50
The relationship between emotional intelligence and eating disorders or disordered eating behaviors: A meta-analysis
Zhang, J., Wang, Y., Wu, C., & He, J. (2021) · Personality and Individual Differences · doi:10.1016/j.paid.2021.111239 · Cited by 55
An Evolutionary Genetic Perspective of Eating Disorders
Mayhew, A., Pigeyre, M., Couturier, J. L., & Meyre, D. (2017) · Neuroendocrinology · doi:10.1159/000484525 · Cited by 53
Effects of oat β-glucan consumption at breakfast on ad libitum eating, appetite, glycemia, insulinemia and GLP-1 concentrations in healthy subjects
Zaremba, S., Gow, I. F., Drummond, S., McCluskey, J. T., & Steinert, R. E. (2018) · Appetite · doi:10.1016/j.appet.2018.06.019 · Cited by 50
Nucleus accumbens melanin-concentrating hormone signaling promotes feeding in a sex-specific manner
Terrill, S. J., Subramanian, K. S., Lan, R., Liu, C. M., Cortella, A. M., Noble, E. E., & Kanoski, S. E. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108270 · Cited by 48
Relations Between Mood States and Eating Behavior During COVID-19 Pandemic in a Sample of Italian College Students
Pasquale, C. D., Sciacca, F., Conti, D., Pistorio, M. L., Hichy, Z., Cardullo, R. L., & Nuovo, S. D. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.684195 · Cited by 50
Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity
Deng, G., Morselli, L. L., Wagner, V. A., Balapattabi, K., Sapouckey, S. A., Knudtson, K. L., Rahmouni, K., Cui, H., Sigmund, C. D., Kwitek, A. E., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15137 · Cited by 44
Prevalence and Etiology of Eating Disorders in Polycystic Ovary Syndrome: A Scoping Review
Lalonde-Bester, S., Malik, M., Masoumi, R., Ng, K., Sidhu, S., Ghosh, M., & Vine, D. F. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100193 · Cited by 55
Our stolen figures: The interface of sexual differentiation, endocrine disruptors, maternal programming, and energy balance
Schneider, J. E., Brozek, J. M., & Keen‐Rhinehart, E. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.03.011 · Cited by 48
Estrogen moderates genetic influences on binge eating during puberty: Disruption of normative processes?
Klump, K. L., Fowler, N., Mayhall, L. A., Sisk, C. L., Culbert, K. M., & Burt, S. A. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000352 · Cited by 46
Sex Differences and Estrous Influences on Oxytocin Control of Food Intake
Liu, C. M., Davis, E. A., Suarez, A. N., Wood, R. I., Noble, E. E., & Kanoski, S. E. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.020 · Cited by 44
Influence of Aging and Gender Differences on Feeding Behavior and Ghrelin-Related Factors during Social Isolation in Mice
Yamada, C., Saegusa, Y., Nahata, M., Sadakane, C., Hattori, T., & Takeda, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140094 · Cited by 43
Relationships between Premenstrual Syndrome (PMS) and Diet Composition, Dietary Patterns and Eating Behaviors
Oboza, P., Ogarek, N., Wójtowicz, M., Rhaiem, T. B., Olszanecka‐Glinianowicz, M., & Kocełak, P. (2024) · Nutrients · doi:10.3390/nu16121911 · Cited by 56
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty
Ullah, R., Su, Y. R., Shen, Y., Li, C., Xu, X., Zhang, J., Huang, K., Rauf, N., He, Y., Cheng, J., et al. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0530-y · Cited by 44
Renewal of conditioned responding to food cues in rats: Sex differences and relevance of estradiol
Anderson, L. C., & Petrovich, G. D. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.07.035 · Cited by 40
Chia seed (Salvia Hispanica L.) added yogurt reduces short-term food intake and increases satiety: randomised controlled trial
Ayaz, A., Akyol, A., Eroglu, E. I., Çetin, A. K., Samur, G., & Akbıyık, F. (2017) · Nutrition Research and Practice · doi:10.4162/nrp.2017.11.5.412 · Cited by 44
Early- and Late-Luteal-Phase Estrogen and Progesterone Levels of Women with Premenstrual Dysphoric Disorder
Yen, J.-Y., Lin, H.-C., Lin, P.-C., Liu, T.-L., Long, C.-Y., & Ko, C.-H. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16224352 · Cited by 42
Differential Effects of Estrogen and Progesterone on Genetic and Environmental Risk for Emotional Eating in Women
Klump, K. L., O’Connor, S. M., Hildebrandt, B. A., Keel, P. K., Neale, M. C., Sisk, C. L., Boker, S. M., & Burt, S. A. (2016) · Clinical Psychological Science · doi:10.1177/2167702616641637 · Cited by 42
Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review
Clemente‐Suárez, V. J., Beltrán-Velasco, A. I., Redondo-Flórez, L., Martín-Rodríguez, A., Sepulveda, R. A. Y., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15143106 · Cited by 46
Meal‐Related Acyl and Des‐Acyl Ghrelin and Other Appetite‐Related Hormones in People with Obesity and Binge Eating
Hernandez, D. B., Mehta, N., & Geliebter, A. (2019) · Obesity · doi:10.1002/oby.22431 · Cited by 41
Metabolically healthy obese and metabolic syndrome of the lean: the importance of diet quality. Analysis of MAGNETIC cohort
Osadnik, K., Osadnik, T., Lonnie, M., Lejawa, M., Reguła, R., Fronczek, M., Gawlita, M., Wądołowska, L., Gąsior, M., & Pawlas, N. (2020) · Nutrix Journal · doi:10.1186/s12937-020-00532-0 · Cited by 37
Sex differences in the response of total PYY and GLP-1 to moderate-intensity continuous and sprint interval cycling exercise
Hazell, T. J., Townsend, L. K., Hallworth, J. R., Doan, J. B., & Copeland, J. L. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3547-7 · Cited by 40
Low birth weight is associated with increased fat intake in school-aged boys
Bischoff, A. R., Portella, A. K., Paquet, C., Molle, R. D., Faber, A., Arora, N. K., Levitan, R. D., Silveira, P. P., & Dubé, L. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518000892 · Cited by 38
Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite
Lyngstad, A. S., Nymo, S., Coutinho, S. R., Rehfeld, J. F., Truby, H., Kulseng, B. E., & Martins, C. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz002 · Cited by 42
Appetite, the enteroendocrine system, gastrointestinal disease and obesity
Crooks, B. J., Stamataki, N. S., & McLaughlin, J. T. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120006965 · Cited by 42
Self-Reported Eating Speed Is Associated with Indicators of Obesity in Adults: A Systematic Review and Meta-Analysis
Kolay, E., Bykowska-Derda, A., Abdulsamad, S., Kałużna, M., Samarzewska, K., Ruchała, M., & Człapka-Matyasik, M. (2021) · Healthcare · doi:10.3390/healthcare9111559 · Cited by 42
The emerging role of glucagon-like peptide 1 in binge eating
Balantekin, K. N., Kretz, M. J., & Mietlicki-Baase, E. G. (2024) · Journal of Endocrinology · doi:10.1530/joe-23-0405 · Cited by 38
Sex‐specific effects of relaxin‐3 on food intake and body weight gain
Calvez, J., de Ávila, C., & Timofeeva, E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13530 · Cited by 37
Changes in PYY and gastric emptying across the phases of the menstrual cycle and the influence of the ovarian hormones
Campolier, M., Thondre, S., Clegg, M., Shafat, A., Mcintosh, A., & Lightowler, H. J. (2016) · Appetite · doi:10.1016/j.appet.2016.07.027 · Cited by 39

Authors: Asarian, L., & Geary, N.
Affiliations: University of Zurich (CH)
Schwerzenbach, Switzerland
Corresponding author: Geary, Nori
ORCID: Asarian, Lori
Geary, Nori
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2013-12-01
Volume: 305
Issue: 11
Pages: R1215-R1267
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00446.2012
PMC: PMC3882560
OpenAlex: W2155431359
Cited by: 513
References: 833
Citations by year: 2026: 31 · 2025: 48 · 2024: 38 · 2023: 28 · 2022: 56 · 2021: 47 · 2020: 49 · 2019: 45 · 2018: 56 · 2017: 42 · 2016: 37 · 2015: 21 · 2014: 15
FWCI: 2.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Institutes of Health (5r01mh051135-02)
National Institute of Mental Health (MH 51135, MH65024, R21MH065024)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK054523, DK 54523, DK092608, R01DK092608)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords: sex differences, dietary habits, hypothalamic-pituitary-gonadal axis, reproductive hormones, androgens, estrogen, organizational effects, activational effects, estrogen receptor alpha, prolactin, hedonics, ghrelin, cholecystokinin, glucagon-like peptide-1, leptin, serotonin, melanocortin system, neuropeptide Y, agouti-related protein, dopamine, obesity, anorexia nervosa, binge eating
MeSH terms: Animals, Appetite Regulation, Eating, Feeding Behavior, Female, Humans, Male, Sex Characteristics, Leptin, Glucagon-Like Peptide 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex differences in the physiology of eating

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks