Renal denervation for the treatment of resistant hypertension: review and clinical perspective
Open accessAbstract
When introduced clinically 6 years ago, renal denervation was thought to be the solution for all patients whose blood pressure could not be controlled by medication. The initial two studies, SYMPLICITY HTN-1 and HTN-2, demonstrated great magnitudes of blood pressure reduction within 6 mo of the procedure and were based on a number of assumptions that may not have been true, including strict adherence to medication and absence of white-coat hypertension. The SYMPLICITY HTN-3 trial controlled for all possible factors believed to influence the outcome, including the addition of a sham arm, and ultimately proved the demise of the initial overly optimistic expectations. This trial yielded a much lower blood pressure reduction compared with the previous SYMPLICITY trials. Since its publication in 2014, there have been many analyses to try and understand what accounted for the differences. Of all the variables examined that could influence blood pressure outcomes, the extent of the denervation procedure was determined to be inadequate. Beyond this, the physiological mechanisms that account for the heterogeneous fall in arterial pressure following renal denervation remain unclear, and experimental studies indicate dependence on more than simply reduced renal sympathetic activity. These and other related issues are discussed in this paper. Our perspective is that renal denervation works if done properly and used in the appropriate patient population. New studies with new approaches and catheters and appropriate controls will be starting later this year to reassess the efficacy and safety of renal denervation in humans.
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Renal denervation nearly normalized blood pressure in dogs with established obesity-induced hypertension.
“RDN also nearly normalized BP in dogs with established obesity-induced hypertension160,162 (FIG. 6).”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [162]
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Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,232 · see citing works
A Controlled Trial of Renal Denervation for Resistant Hypertension
Bhatt, D. L., Kandzari, D. E., O'Neill, W. W., D'Agostino, R., Flack, J. M., Katzen, B. T., Leon, M. B., Liu, M., Mauri, L., Negoita, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402670 · Cited by 2,186 · see citing works
Self-citationKrum, H., Schlaich, M., Whitbourn, R., Sobotka, P. A., Sadowski, J., Bartus, K., Kapelak, B., Walton, A., Sievert, H., Thambar, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60566-3 · Cited by 2,108 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.189141 · Cited by 1,404 · see citing works
Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360 · see citing works
Neural control of renal function
DiBona, G. F., & Kopp, U. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.1.75 · Cited by 1,212 · see citing works
Neural Control of Renal Function*
Kopp, U. C., & DiBona, G. F. (2020) · Reflex Control of the Circulation · doi:10.1201/9780367813338-17 · Cited by 1,126 · see citing works
Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension
Schlaich, M. P., Sobotka, P. A., Krum, H., Lambert, E., & Esler, M. D. (2009) · New England Journal of Medicine · doi:10.1056/nejmc0904179 · Cited by 772 · see citing works
Prevalence of Resistant Hypertension in the United States, 2003–2008
Persell, S. D. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.170308 · Cited by 761 · see citing works
Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension
Symplicity HTN-1 Investigators (2011) · Hypertension · doi:10.1161/hypertensionaha.110.163014 · Cited by 743 · see citing works
Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension
Chapman, N., Dobson, J., Wilson, S. L., Dahlöf, B., Sever, P., Wedel, H., & Poulter, N. R. (2007) · Hypertension · doi:10.1161/01.hyp.0000259805.18468.8c · Cited by 630 · see citing works
Krum, H., Schlaich, M. P., Sobotka, P. A., Böhm, M., Mahfoud, F., Rocha‐Singh, K. J., Katholi, R. E., & Esler, M. (2013) · The Lancet · doi:10.1016/s0140-6736(13)62192-3 · Cited by 622 · see citing works
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works
Long-term control of arterial blood pressure
Cowley, A. W. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.1.231 · Cited by 600 · see citing works
Uncontrolled and Apparent Treatment Resistant Hypertension in the United States, 1988 to 2008
Egan, B. M., Zhao, Y., Axon, R. N., Brzezinski, W. A., & Ferdinand, K. C. (2011) · Circulation · doi:10.1161/circulationaha.111.030189 · Cited by 599 · see citing works
Predictors of blood pressure response in the SYMPLICITY HTN-3 trial
Kandzari, D. E., Bhatt, D. L., Brar, S. K., Devireddy, C. M., Esler, M., Fahy, M. P., Flack, J. M., Katzen, B. T., Lea, J. P., Lee, D. P., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu441 · Cited by 548 · see citing works
Self-citationBakris, G. L., Sarafidis, P. A., Weir, M. R., Dahlöf, B., Pitt, B., Jamerson, K., Velazquez, E. J., Staikos-Byrne, L., Kelly, R. Y., Shi, V. C., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62100-0 · Cited by 523 · see citing works
Self-citationSPLANCHNICECTOMY FOR ESSENTIAL HYPERTENSION
Smithwick, R. H. (1953) · JAMA · doi:10.1001/jama.1953.03690160001001 · Cited by 479 · see citing works
Judy, W. V., Watanabe, A. M., Henry, D. P., Besch, H. R., Murphy, W. R. C., & Hockel, G. M. (1976) · Circulation Research · doi:10.1161/01.res.38.6.21 · Cited by 435 · see citing works
The incidence and implications of aldosterone breakthrough
Bomback, A. S., & Klemmer, P. J. (2007) · Nature Reviews Nephrology · doi:10.1038/ncpneph0575 · Cited by 418 · see citing works
Hering, D., Lambert, E. A., Marusic, P., Walton, A. S., Krum, H., Lambert, G. W., Esler, M. D., & Schlaich, M. P. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00194 · Cited by 356 · see citing works
Addition of Spironolactone in Patients With Resistant Arterial Hypertension (ASPIRANT)
Václavík, J., Sedlák, R., Plachý, M., Navrátil, K., Plášek, J., Jarkovský, J., Václavík, T., Husár, R., Kociánová, E., & Táborský, M. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.169961 · Cited by 309 · see citing works
Gaddam, K. K. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.11.1159 · Cited by 301 · see citing works
Kidney function in early diabetes: the tubular hypothesis of glomerular filtration
Thomson, S. C., Vallon, V., & Blantz, R. C. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00208.2003 · Cited by 241 · see citing works
Arterial pressure and hypertension
Guyton, A. C. (1980) · Medical Entomology and Zoology · Cited by 239 · see citing works
Reflex Control of the Circulation
Zucker, I. H., & Gilmore, J. P. (2020) · CRC Press eBooks · doi:10.1201/9780367813338 · Cited by 234 · see citing works
Blood pressure and renal function during chronic changes in sodium intake: role of angiotensin
Hall, J. E., Guyton, A. C., Smith, M. J., & Coleman, T. G. (1980) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1980.239.3.f271 · Cited by 224 · see citing works
Winternitz, S., Katholi, R. E., & Oparil, S. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109966 · Cited by 221 · see citing works
Huggett, R. J., Burns, J., Mackintosh, A. F., & Mary, D. A. S. G. (2004) · Hypertension · doi:10.1161/01.hyp.0000147893.08533.d8 · Cited by 211 · see citing works
Rosa, J., Widimský, P., Toušek, P., Petrák, O., Čurila, K., Waldauf, P., Bednář, F., Zelinka, T., Holaj, R., Štrauch, B., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04019 · Cited by 196 · see citing works
ARTERIAL PRESSURE AND HYPERTENSION
Brewer, T. F. (1981) · CHEST Journal · doi:10.1016/s0012-3692(16)61286-2 · Cited by 194 · see citing works
Resistant hypertension—its identification and epidemiology
Sarafidis, P., Georgianos, P., & Bakris, G. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.260 · Cited by 178 · see citing works
Self-citationBooth, L. C., Nishi, E. E., Yao, S. T., Ramchandra, R., Lambert, G. W., Schlaich, M. P., & May, C. N. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04176 · Cited by 171 · see citing works
Brinkmann, J., Heusser, K., Schmidt, B. M., Menne, J., Klein, G., Bauersachs, J., Haller, H., Sweep, F. C., Diedrich, A., Jordan, J., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.201186 · Cited by 166 · see citing works
Muscle sympathetic nerve activity in renovascular hypertension and primary aldosteronism.
Miyajima, E., Yamada, Y., Yoshida, Y., Matsukawa, T., Shionoiri, H., Tochikubo, O., & Ishii, M. (1991) · Hypertension · doi:10.1161/01.hyp.17.6.1057 · Cited by 163 · see citing works
Blood pressure changes after renal denervation at 10 European expert centers
Persu, A., Jin, Y., Azizi, M., Baelen, M., Völz, S., Elvan, A., Severino, F., Rosa, J., Adıyaman, A., Elmula, F. E. M. F., et al. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.88 · Cited by 150 · see citing works
Mulder, J., Hökfelt, T. G. M., Knuepfer, M. M., & Kopp, U. C. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00599.2012 · Cited by 136 · see citing works
Systemic and Renal-Specific Sympathoinhibition in Obesity Hypertension
Lohmeier, T. E., Iliescu, R., Liu, B., Henegar, J. R., Maric-Bilkan, C., & Irwin, E. D. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.185074 · Cited by 130 · see citing works
Self-citationThe Baroreflex as a Long-Term Controller of Arterial Pressure
Lohmeier, T. E., & Iliescu, R. (2015) · Physiology · doi:10.1152/physiol.00035.2014 · Cited by 126 · see citing works
Self-citationMarked sympathetic activation and baroreflex dysfunction in true resistant hypertension
Grassi, G. M., Seravalle, G., Brambilla, G., Pini, C., Alimento, M., Facchetti, R., Spaziani, D., Cuspidi, C., & Mancia, G. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.09.138 · Cited by 118 · see citing works
Prolonged Activation of the Baroreflex Abolishes Obesity-Induced Hypertension
Lohmeier, T. E., Dwyer, T. M., Irwin, E. D., Rossing, M. A., & Kieval, R. S. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087874 · Cited by 118 · see citing works
Self-citationRapid Onset of Renal Sympathetic Nerve Activation in Rabbits Fed a High-Fat Diet
Armitage, J. A., Burke, S. L., Prior, L. J., Barzel, B., Eikelis, N., Lim, K., & Head, G. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.190413 · Cited by 115 · see citing works
Influence of Prolonged Baroreflex Activation on Arterial Pressure in Angiotensin Hypertension
Lohmeier, T. E., Dwyer, T. M., Hildebrandt, D. A., Irwin, E. D., Rossing, M. A., Serdar, D. J., & Kieval, R. S. (2005) · Hypertension · doi:10.1161/01.hyp.0000187011.44201.2e · Cited by 110 · see citing works
Self-citationLohmeier, T. E., Iliescu, R., Dwyer, T. M., Irwin, E. D., Cates, A. W., & Rossing, M. A. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00372.2010 · Cited by 105 · see citing works
Self-citationFunctional reinnervation and development of supersensitivity to NE after renal denervation in rats
Kline, R. L., & Mercer, P. F. (1980) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1980.238.5.r353 · Cited by 98 · see citing works
Masuo, K., Rakugi, H., Ogihara, T., Esler, M., & Lambert, G. W. (2010) · Current Diabetes Reviews · doi:10.2174/157339910790909396 · Cited by 91 · see citing works
Catheter-Based Radiorefrequency Renal Denervation Lowers Blood Pressure in Obese Hypertensive Dogs
Henegar, J. R., Zhang, Y., Rama, R. D., Hata, C., Hall, M. E., & Hall, J. E. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu048 · Cited by 89 · see citing works
Catheter-Based Radiofrequency Renal Denervation: Location Effects on Renal Norepinephrine
Henegar, J. R., Zhang, Y., Hata, C., Narciso, I., Hall, M. E., & Hall, J. E. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpu258 · Cited by 83 · see citing works
Jacob, F., Ariza, P., & Osborn, J. W. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01029.2002 · Cited by 81 · see citing works
Boustany, C. M., Brown, D. R., Randall, D. C., & Cassis, L. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00507.2004 · Cited by 76 · see citing works
Persistent Sympathetic Activation During Chronic Antihypertensive Therapy
Fu, Q., Zhang, R., Witkowski, S., Arbab‐Zadeh, A., Prasad, A., Okazaki, K., & Levine, B. D. (2005) · Hypertension · doi:10.1161/01.hyp.0000158312.63381.c1 · Cited by 73 · see citing works
Role of renal nerves in onset and maintenance of spontaneous hypertension
Norman, R. A., & Dzielak, D. J. (1982) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1982.243.2.h284 · Cited by 70 · see citing works
Denervation of the Renal Arteries in Metabolic Syndrome
Verloop, W. L., Spiering, W., Vink, E. E., Beeftink, M. M. A., Blankestijn, P. J., Doevendans, P. A., & Voskuil, M. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04798 · Cited by 67 · see citing works
Renal innervation and renin activity in salt metabolism and hypertension
Ra, M., Hd, I., Jh, R., & Murphy, J. C. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.216.4.693 · Cited by 65 · see citing works
Page, I. H., & Heuer, G. J. (1935) · Journal of Clinical Investigation · doi:10.1172/jci100652 · Cited by 63 · see citing works
Eligibility for Renal Denervation
Persu, A., Jin, Y., Baelen, M., Vink, E. E., Verloop, W. L., Schmidt, B. M. W., Blicher, M. K., Severino, F., Wuerzner, G., Taylor, A. H. M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03194 · Cited by 63 · see citing works
The Sympathetic Nervous System in Obesity Hypertension
Lohmeier, T. E., & Iliescu, R. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0356-1 · Cited by 62 · cited 3× · see citing works
“As obesity is prevalent in patients with resistant hypertension and likely contributes to sympathoexcitation (14, 26, 29, 52), the above interrelationships between increased RSNA and E.”
Self-citationHart, E. C., McBryde, F. D., Burchell, A. E., Ratcliffe, L. E. K., Stewart, L. Q., Baumbach, A., Nightingale, A. K., & Paton, J. F. R. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01261 · Cited by 61 · see citing works
THE RELATIONSHIP OF THE EXTRINSIC RENAL NERVES TO THE ORIGIN OF EXPERIMENTAL HYPERTENSION
Page, I. H. (1935) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1935.112.1.166 · Cited by 61 · see citing works
The Sympathetic Nervous System in Hypertension: Back to the Future?
Esler, M. (2015) · Current Hypertension Reports · doi:10.1007/s11906-014-0519-8 · Cited by 60 · see citing works
STUDIES ON EXPERIMENTAL HYPERTENSION
Goldblatt, H., Gross, J., & Hanzal, R. F. (1937) · The Journal of Experimental Medicine · doi:10.1084/jem.65.2.233 · Cited by 60 · see citing works
Sakakura, K., Tunev, S. S., Yahagi, K., O’Brien, A. J., Ladich, E. R., Kolodgie, F. D., Melder, R. J., Joner, M., & Virmani, R. (2015) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.114.001813 · Cited by 56 · see citing works
Hypertension Induced by Chronic Renal Adrenergic Stimulation Is Angiotensin Dependent
Reinhart, G. A., Lohmeier, T. E., & Hord, C. E. (1995) · Hypertension · doi:10.1161/01.hyp.25.5.940 · Cited by 52 · see citing works
Self-citationDorresteijn, J. A. N., Schrover, I. M., Visseren, F. L. J., Scheffer, P. G., Oey, P. L., Danser, A. H. (., & Spiering, W. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835b6c02 · Cited by 50 · see citing works
Robles, R. G., Villa, E., Santirso, R., Martinez, J., Ruilope, L. M., Carmen, C., & Sancho, J. M. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.12.1009 · Cited by 42 · cited 1× · see citing works
“Other studies in experimental animals show that ANG II blockade or angiotensin-converting enzyme (ACE) inhibition attenuates sodium retention, volume expansion, and increased arterial pressure in obesity (8, 73).”
Renal denervation for hypertension: observations and predictions of a founder
Esler, M. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu091 · Cited by 40 · see citing works
Moranne, O., Bakris, G., Fafin, C., Favre, G., Pradier, C., & Esnault, V. (2013) · American Society of Nephrology. Clinical Journal · doi:10.2215/cjn.06960712 · Cited by 39 · see citing works
Self-citationThe sympathetic nervous system and hypertension in primary aldosteronism.
BRAVO, E. L., Tarazi, R. C., Dustan, H. P., & Fouad, F. M. (1985) · Hypertension · doi:10.1161/01.hyp.7.1.90 · Cited by 36 · see citing works
Alnima, T., de Leeuw, P. W., Tan, F. E. S., Kroon, A. A., & for the Rheos Pivotal Trial Investigators (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01159 · Cited by 35 · see citing works
Vink, E. E., Verloop, W. L., Siddiqi, L., van Schelven, L. J., Oey, P. L., & Blankestijn, P. J. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.06.021 · Cited by 34 · see citing works
Renal Responses to Chronic Suppression of Central Sympathetic Outflow
Iliescu, R., Irwin, E. D., Georgakopoulos, D., & Lohmeier, T. E. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193607 · Cited by 34 · see citing works
Self-citationLohmeier, T. E., & Iliescu, R. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00552.2012 · Cited by 32 · see citing works
Self-citationRenal nerves and experimental hypertension: evidence and controversy
Kline, R. L. (1987) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y87-243 · Cited by 30 · see citing works
Role of the renal nerves in one-kidney, one clip hypertension in rats.
Norman, R. A., Murphy, W. R. C., Dzielak, D. J., Khraibi, A., & Carroll, R. G. (1984) · Hypertension · doi:10.1161/01.hyp.6.5.622 · Cited by 29 · see citing works
Global- and Renal-Specific Sympathoinhibition in Aldosterone Hypertension
Lohmeier, T. E., Liu, B., Hildebrandt, D. A., Cates, A. W., Georgakopoulos, D., & Irwin, E. D. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05155 · Cited by 29 · see citing works
Self-citationBooth, L. C., Schlaich, M. P., Nishi, E. E., Yao, S. T., Xu, J., Ramchandra, R., Lambert, G. W., & May, C. N. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.03.440 · Cited by 22 · see citing works
Regulation of Renin Secretion and Arterial Pressure During Prolonged Baroreflex Activation
Hildebrandt, D. A., Irwin, E. D., Cates, A. W., & Lohmeier, T. E. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03788 · Cited by 21 · see citing works
Self-citationRole of Angiotensin II in the Neural Control of Renal Function
Fevre, M. E. L., Guild, S., Ramchandra, R., Barrett, C., & Malpas, S. (2003) · HYPERTENSION · doi:10.1161/01.hyp.0000056600.70321.c5 · Cited by 18 · see citing works
Renal Denervation After SYMPLICITY HTN-3: Where Do We Go?
Briasoulis, Α., & Bakris, G. L. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.12.004 · Cited by 13 · see citing works
Self-citationRenal nerves are not necessary for onset or maintenance of DOC-salt hypertension in rats
Dzielak, D. J., & Norman, R. A. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.249.5.h945 · Cited by 13 · see citing works
Role of renal afferent nerves in obesity-induced hypertension.
ZAPPE, D. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(96)81511-1 · Cited by 12 · cited 1× · see citing works
“While renal denervation abolishes sympathetically mediated obesity-induced hypertension in dogs fed a high-fat diet, findings indicate that this antihypertensive response can be attributed to elimination of efferent sympathetic outflow to the kidneys (54, 87).”
Timing and Efficacy of Alternative Methods of Sympathetic Blockade
Briasoulis, Α., & Bakris, G. L. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0294-3 · Cited by 11 · see citing works
Self-citationMatsukawa, T., & Miyamoto, T. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00471.2007 · Cited by 9 · see citing works
Aldosterone acts on the kidney, not the brain, to cause mineralocorticoid hypertension in sheep
León, L. A. S., McKinley, M. J., McAllen, R. M., & May, C. N. (2002) · Journal of Hypertension · doi:10.1097/00004872-200206000-00034 · Cited by 9 · see citing works
Time course of renal responses to greater splanchnic nerve stimulation
Vliet, B. N. V., Smith, M. J., & Guyton, A. C. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.260.5.r894 · Cited by 8 · see citing works
Role of the renin-angiotensin system in mediating the effects of posture on renal function
Reinhart, G. A., & Lohmeier, T. E. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.1.r282 · Cited by 7 · see citing works
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10. Cardiovascular Disease and Risk Management: <i>Standards of Medical Care in Diabetes—2022</i>
American Diabetes Association Professional Practice Committee (2022) · Diabetes Care · doi:10.2337/dc22-s010 · Cited by 869 · see citing works
Diabetes and hypertension: a position statement by the American Diabetes Association
de Boer, I. H., Bangalore, S., Benetos, A., Davis, A. M., Michos, E. D., Muntner, P., Rossing, P., Zoungas, S., & Bakris, G. (2017) · Diabetes Care · doi:10.2337/dci17-0026 · Cited by 714 · see citing works
Self-citationObesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654 · see citing works
10. Cardiovascular Disease and Risk Management: <i>Standards of Medical Care in Diabetes—2020</i>
American Diabetes Association (2020) · Diabetes Care · doi:10.2337/dc20-s010 · Cited by 487 · see citing works
9. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2018
(2017) · Diabetes Care · doi:10.2337/dc18-s009 · Cited by 490 · see citing works
10. Cardiovascular Disease and Risk Management: <i>Standards of Medical Care in Diabetes—2019</i>
American Diabetes Association (2019) · Diabetes Care · doi:10.2337/dc19-s010 · Cited by 471 · see citing works
10. Cardiovascular Disease and Risk Management: <i>Standards of Medical Care in Diabetes—2021</i>
American Diabetes Association (2021) · Diabetes Care · doi:10.2337/dc21-s010 · Cited by 495 · see citing works
Role of the Immune System in Hypertension
Rodríguez‐Iturbe, B., Pons, H., & Johnson, R. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2016 · Cited by 393 · see citing works
Miller, A. J., & Arnold, A. C. (2018) · Clinical Autonomic Research · doi:10.1007/s10286-018-0572-5 · Cited by 289 · see citing works
Mechanisms of sodium balance: total body sodium, surrogate variables, and renal sodium excretion
Bie, P. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00363.2017 · Cited by 90 · see citing works
Mechanisms and treatment of obesity-related hypertension—Part 1: Mechanisms
Parvanova, A. I., Reseghetti, E., Abbate, M., & Ruggenenti, P. L. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad282 · Cited by 98 · see citing works
Device-Based Neuromodulation for Resistant Hypertension Therapy
Lohmeier, T. E., & Hall, J. E. (2019) · Circulation Research · doi:10.1161/circresaha.118.313221 · Cited by 71 · see citing works
Self-citationde Jong, M. R., Hoogerwaard, A. F., Gal, P., Adiyaman, A., Smit, J. J. J., Delnoy, P. P. H. M., Misier, A. R. R., van Hasselt, B. A. A. M., Heeg, J., de Waroux, J. L. P., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06604 · Cited by 67 · see citing works
Interventional procedures and future drug therapy for hypertension
Lobo, M. D., Sobotka, P. A., & Pathak, A. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw303 · Cited by 53 · see citing works
The renin-angiotensin system and cardiovascular autonomic control in aging
Miller, A. J., & Arnold, A. C. (2021) · Peptides · doi:10.1016/j.peptides.2021.170733 · Cited by 39 · see citing works
Hall, M. E., & Hall, J. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42973-3.00005-6 · Cited by 33 · see citing works
Ye, C., Qiu, Y., Zhang, F., Chen, A., Zhou, Y., Wang, J., Chen, Q., Li, Y., Kang, Y., & Zhu, G. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00417-1 · Cited by 27 · see citing works
Цукровий діабет і артеріальна гіпертензія
Сергієнко, В. О., & Serhiyenko, O. (2021) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.17.2.2021.230573 · Cited by 24 · see citing works
Prolonged Baroreflex Activation Abolishes Salt-Induced Hypertension After Reductions in Kidney Mass
Hildebrandt, D. A., Irwin, E. D., & Lohmeier, T. E. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.08293 · Cited by 15 · see citing works
Self-citationLatic, N., Peitzsch, M., Zupcic, A., Pietzsch, J., & Erben, R. G. (2022) · Biomedicines · doi:10.3390/biomedicines10102510 · Cited by 14 · see citing works
Reduced Renal Mass, Salt-Sensitive Hypertension Is Resistant to Renal Denervation
Tudorancea, I., Lohmeier, T. E., Alexander, B. T., Pieptu, D., Șerban, D. N., & Iliescu, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00455 · Cited by 14 · see citing works
Self-citationWilson, A. L., Gandhi, J., Suh, Y., Joshi, G. S., Smith, N. L., & Khan, S. A. (2019) · Current Hypertension Reviews · doi:10.2174/1573402115666190301154100 · Cited by 13 · see citing works
Choi, S. I., Kim, S. K., Park, S., Kim, J. H., Ihm, S., Kim, G.-I., Kim, W. S., Pyun, W. B., Kim, Y., & Shin, J. (2016) · Clinical Hypertension · doi:10.1186/s40885-016-0045-x · Cited by 11 · see citing works
Salt intake and blood pressure response to percutaneous renal denervation in resistant hypertension
de Beus, E., de Jager, R. L., Beeftink, M. M. A., Sanders, M. F., Spiering, W., Vonken, E.-J. P. A., Voskuil, M., Bots, M. L., Blankestijn, P. J., & the SYMPATHY study group (2017) · Journal of Clinical Hypertension · doi:10.1111/jch.13085 · Cited by 10 · see citing works
Ye, C., Zheng, F., Wang, J.-X., Wang, X., Chen, Q., Li, Y., Kang, Y., & Zhu, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.673950 · Cited by 10 · see citing works
Spironolactone for resistant hypertension—hard to resist?
Sternlicht, H., & Bakris, G. L. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00264-0 · Cited by 9 · see citing works
Self-citationGrisk, O. (2016) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.08.005 · Cited by 9 · see citing works
Obesity and Metabolic Syndrome Hypertension
Hall, M. E., Wang, Z., do Carmo, J. M., Kamimura, D., & Hall, J. E. (2018) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-59918-2_42 · Cited by 8 · see citing works
Heumann, P., Koenen, A., Zavaritskaya, O., Schütze, K., Ramm, A., Schlüter, T., Steinbach, A. C., Rettig, R., Schubert, R., & Grisk, O. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000856 · Cited by 8 · see citing works
Renal denervation restores biomechanics of carotid arteries in a rat model of hypertension
Gkousioudi, A., Razzoli, M., Moreira, J. D., Wainford, R. D., & Zhang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-023-50816-8 · Cited by 7 · see citing works
Effectiveness of renal denervation in the treatment of hypertension: a literature review
Shah, R. T., & Wang, B. (2022) · Clinical Hypertension · doi:10.1186/s40885-022-00194-6 · Cited by 8 · see citing works
Yang, X., Liu, H., Chen, S., Dong, P., & Zhao, D. (2022) · Kidney & Blood Pressure Research · doi:10.1159/000524171 · Cited by 7 · see citing works
Pimenta, E., & Calhoun, D. A. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0634-9 · Cited by 6 · see citing works
Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors
Hosseini-Dastgerdi, H., Kharazmi, F., Pourshanazari, A., & Nematbakhsh, M. (2022) · International Journal of Nephrology · doi:10.1155/2022/8731357 · Cited by 5 · see citing works
High screen failure rate in patients with resistant hypertension: Findings from SYMPLICITY HTN-3
Waksman, R., Bakris, G. L., Steinvil, A., García‐García, H. M., Brown, A. L., Difilippo, W., SCOTT, T. E., Singh, J., DeBruin, V., Jones, D. E., et al. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.06.011 · Cited by 3 · see citing works
Self-citationCatheter-Based Renal Denervation for Resistant Hypertension: Will It Ever Be Ready for “Prime Time”?
Laffin, L. J., & Bakris, G. L. (2016) · American Journal of Hypertension · doi:10.1093/ajh/hpw123 · Cited by 3 · see citing works
Self-citationThe Kidneys, Volume and Blood Pressure Regulation, and Hypertension
Granger, J. P., & Spradley, F. T. (2018) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-59918-2_5 · Cited by 3 · see citing works
Hosseini-Dastgerdi, H., Pourshanazari, A., & Nematbakhsh, M. (2023) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.383705 · Cited by 2 · see citing works
Updated management for patients with cardiovascular disease and diabetes
Dugan, J. A., Butts, A., Collins, B. S., Saini, P. S., & Bradley, S. (2019) · JAAPA · doi:10.1097/01.jaa.0000569804.46658.ce · Cited by 2 · see citing works
The denervation or activation of renal sympathetic nerve and renal blood flow
Kharazmi, F., Hosseini-Dastgerdi, H., Pourshanazari, A., & Nematbakhsh, M. (2023) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_216_23 · Cited by 1 · see citing works
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Al-yacoub, L., Bassil, E., Thomas, G., Laffin, L. J., Nanjundappa, A., Ziada, K. M., & Mehdi, A. (2024) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.91a.24029 · Cited by 1 · see citing works
Self-citationChoi, S. I., Kim, S. K., Park, S., Kim, J. H., Ihm, S., Kim, G.-I., Kim, W. S., Pyun, W. B., Kim, Y., & Shin, J. (2016) · Clinical Hypertension · doi:10.1186/s40885-016-0048-7 · Cited by 1 · see citing works
JALA Special Issue: High-Throughput Imaging
Chow, E. K. (2016) · SLAS TECHNOLOGY · doi:10.1177/2211068216629734
What is the benefit of renal denervation?
Kishi, T. (2016) · Hypertension Research · doi:10.1038/hr.2015.150
Cinza‐Sanjurjo, S. (2016) · Hipertensión y Riesgo Vascular · doi:10.1016/j.hipert.2016.06.001
Secondary Causes: Work-Up and Its Specificities in CKD: Influence of Autonomic Dysfunction
Iliescu, R., & Șerban, D. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-56827-0_10
Self-citationTudorancea, I., Mitu, F., Petriş, A. O., Şerban, D., Șerban, I. L., Iliescu, R., & Pieptu, D. (2018) · The Medical-Surgical Journal
Self-citationNew data, new studies, new hopes for renal denervation in patients with uncontrolled hypertension
Papademetriou, V., Stavropoulos, K., Imprialos, K., Doumas, M. N., Schmieder, R. E., Pathak, A., & Tsioufis, C. P. (2019) · International Journal of Cardiology Hypertension · doi:10.1016/j.ijchy.2019.100022
Renal sympathetic denervation: renal nerve stimulation
de Jong, M. (2019) · doi:10.33612/diss.99857558
Self Organizing Maps for Diabetes Parameter AnalysisPreprint
Alexandru, D. (2019) · doi:10.31219/osf.io/eajms
- Authors
- Iliescu, R., Lohmeier, T. E., Tudorancea, I., Laffin, L., & Bakris, G. L.
- Affiliations
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- University of Mississippi Medical Center (US)
- Department of Physiology, University of Medicine and Pharmacy, “Gr. T. Popa,” Iasi, Romania;
- University of Chicago (US)
- Corresponding author
- Bakris, George L.
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2015-10-01
- Volume
- 309
- Issue
- 7
- Pages
- F583-F594
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- PMC
- PMC4593817
- OpenAlex
- W2314297626
- Cited by
- 50
- References
- 88
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 1
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for the National Institutes of Health (FNIH) (HL-51971)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- renal denervation, resistant hypertension, Symplicity HTN-3 trial, blood pressure reduction, renal sympathetic nerve activity, white coat hypertension, medication adherence
- MeSH terms
- Denervation, Drug Resistance, Humans, Hypertension, Renal, Kidney, Renal Circulation, Sympathectomy
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