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Cited by 630

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Role of muscle loss in the age-associated reduction in VO2 max

Fleg, J. L., Lakatta, E. G.·1988·Journal of Applied Physiology
DOI 10.1152/jappl.1988.65.3.1147
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Abstract

A progressive decline in maximal O2 consumption (VO2max) expressed traditionally as per kilogram body weight generally occurs with advancing age. To investigate the extent to which this decline could be attributable to the age-associated loss of metabolically active tissue, i.e., muscle, we measured 24-h urinary creatinine excretion, an index of muscle mass, in 184 healthy nonobese volunteers, ages 22-87 yr, from the Baltimore Longitudinal Study of Aging who had achieved a true VO2max during graded treadmill exercise. A positive correlation was found between VO2max and creatinine excretion in both men (r = 0.64, P less than 0.001) and women (r = 0.47, P less than 0.001). As anticipated, VO2max showed a strong negative linear relationship with age in both men and women. Creatinine excretion also declined with age in men and women. When VO2max was normalized for creatinine excretion, the variance in the VO2max decline attributable to age declined from 60 to 14% in men and from 50 to 8% in women. Thus comparing the standard age regression of VO2max per kilogram body weight with that in which VO2max is normalized per milligram creatinine excretion, the decline in VO2max between a hypothetical 30 yr old and a 70 yr old was reduced from 39 to 18% in men and from 30 to 14% in women. We conclude that in both sexes, a large portion of the age-associated decline in VO2max in non-endurance-trained individuals is explicable by the loss of muscle mass, which is observed with advancing age.

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Metadata

Authors
Fleg, J. L., & Lakatta, E. G.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1988-09-01
Volume
65
Issue
3
Pages
1147-1151
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1988.65.3.1147
OpenAlex
W2121443655
Cited by
630
References
0
FWCI
14.32
Type
journal article
Language
en
Open access
closed

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