HIF-1: mediator of physiological and pathophysiological responses to hypoxia

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Untitled work

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Endurance exercise training in the elderly: effects on cardiovascular function

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Erythropoietin Receptors on Tumor Cells: What Do They Mean?

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Postmortem quantitative mRNA analyses of death investigation in forensic pathology: An overview and prospects

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Suppression of Retinal Neovascularization by shRNA Targeting HIF-1α

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Hypoxia-Induced Gene Activity in Disused Oxidative Muscle

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Angiotensin-II Receptor Blocker Exerts Cardioprotection in Diabetic Rats Exposed to Hypoxia

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HER-2/neuOverexpression Increases the Viable Hypoxic Cell Population within Solid Tumors without Causing Changes in Tumor Vascularization

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Oxidative stress impairs HIF1α activation: a novel mechanism for increased vulnerability of steatotic hepatocytes to hypoxic stress

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Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma

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Recent Developments in Gene Therapy for Neovascular Age-Related Macular Degeneration: A Review

Finocchio, L., Zeppieri, M., Gabai, A., Toneatto, G., Spadea, L., & Salati, C. (2023) · Biomedicines · doi:10.3390/biomedicines11123221 · Cited by 31

Compression‐induced HIF‐1 enhances thrombosis and PAI‐1 expression in mouse skin

Kaneko, M., Minematsu, T., Yoshida, M., Nishijima, Y., Noguchi, H., Ohta, Y., Nakagami, G., Mori, T., & Sanada, H. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12312 · Cited by 25

Chemically mimicked hypoxia modulates gene expression and protein levels of the sodium calcium exchanger in HEK 293 cell line via HIF-1α

Hudecová, S., Lencesova, L., Csáderová, L., Sirová, M., Cholujová, D., & Cagala, M. (2011) · General Physiology and Biophysics · doi:10.4149/gpb_2011_02_196 · Cited by 26

Hypoxia-inducible factor-1α and vascular endothelial growth factor in the cardioprotective effects of intermittent hypoxia in rats

Wang, Z., & Si, L. (2013) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2013.766914 · Cited by 25

An integrated analysis of differential miRNA and mRNA expressions in human gallstones

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Absence of IDH1-R132H mutation predicts rapid progression of nonenhancing diffuse glioma in older adults

Olar, A., Raghunathan, A., Albarracin, C. T., Aldape, K., Cahill, D. P., Powell, S. Z.-E., Goodman, J. C., & Fuller, G. N. (2011) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2011.08.010 · Cited by 25

Prognostic Relevance of the Expression of CA IX, GLUT-1, and VEGF in Ovarian Epithelial Cancers

Kim, K., Park, W. Y., Kim, J. Y., Sol, M. Y., Shin, D. H., Park, D. Y., Lee, C. H., Lee, J. H., & Choi, K. U. (2012) · Journal of Pathology and Translational Medicine · doi:10.4132/koreanjpathol.2012.46.6.532 · Cited by 25

Molecular and cellular studies in evolutionary physiology of natural vertebrate populations: influences of individual variation and genetic components on sampling and measurements

Nikinmaa, M., & Waser, W. (2007) · Journal of Experimental Biology · doi:10.1242/jeb.002717 · Cited by 25

Radiotherapy in laryngeal carcinoma: Can a panel of 13 markers predict response?

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Genomics in cardiac metabolism

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Effects of deferoxamine on the osteogenic differentiation of human periodontal ligament cells

Mu, S., Guo, S., Wang, X., Zhan, Y., Li, Y., Jiang, Y., Zhang, R., & Zhang, B. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7810 · Cited by 25

The Transcription Factor Hif-1 Enhances the Radio-Resistance of Mouse MSCs

Calvo‐Asensio, I., Dillon, E., Lowndes, N. F., & Ceredig, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00439 · Cited by 27

Regulation of MicroRNA-155 and Its Related Genes Expression by Inositol Hexaphosphate in Colon Cancer Cells

Kapral, M., Wawszczyk, J., & Węglarz, L. (2019) · Molecules · doi:10.3390/molecules24224153 · Cited by 25

The Breathing Kidney

Fine, L. G., & Norman, J. T. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000024380.91444.c8 · Cited by 25

Computational Modeling of Oxidative Stress in Fatty Livers Elucidates the Underlying Mechanism of the Increased Susceptibility to Ischemia/Reperfusion Injury

Schleicher, J., & Dahmen, U. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.10.013 · Cited by 24

Coagulation disorders and thromboembolic disease in COVID-19: review of current evidence in search of a better approach

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Re-Evaluating the Oxidative Phenotype: Can Endurance Exercise Save the Western World?

Kolodziej, F., & O’Halloran, K. D. (2021) · Antioxidants · doi:10.3390/antiox10040609 · Cited by 28

Human Monocyte Heat Shock Protein 72 Responses to Acute Hypoxic Exercise after 3 Days of Exercise Heat Acclimation

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Intersections between mitochondrial sirtuin signaling and tumor cell metabolism

Herrera, K. N. G., Lee, J. J., & Haigis, M. C. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1031879 · Cited by 25

Up-regulation of HIF-1α expression induced by ginkgolides in hypoxic neurons

Zhu, L., Wu, X., Yang, L., Du, F., & Qian, Z. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.003 · Cited by 24

Evaluation of Anti-HIF and Anti-Angiogenic Properties of Honokiol for the Treatment of Ocular Neovascular Diseases

Vavilala, D. T., Ponnaluri, V. K. C., Kanjilal, D., & Mukherji, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113717 · Cited by 23

Rodent-specific hypoxia response elements enhance PAI-1 expression through HIF-1 or HIF-2 in mouse hepatoma cells

An (2010) · International Journal of Oncology · doi:10.3892/ijo_00000817 · Cited by 24

Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation

Coudyzer, P., Lemoine, P., Jordan, B. F., Gallez, B., Galant, C., Nisolle, M., Courtoy, P. J., Henriet, P., & Marbaix, É. (2013) · The FASEB Journal · doi:10.1096/fj.13-232074 · Cited by 24

A journey between high altitude hypoxia and critical patient hypoxia: What can it teach us about compression and the management of critical disease?

Chavala, M. L. A. (2018) · Medicina Intensiva (English Edition) · doi:10.1016/j.medine.2018.05.013 · Cited by 24

Growth arrest-specific gene 6 transfer promotes mesenchymal stem cell survival and cardiac repair under hypoxia and ischemia via enhanced autocrine signaling and paracrine action

Shan, S., Liu, Z., Guo, T., Wang, M., Tian, S., Zhang, Y., Wang, K., Zheng, H., Zhao, X., Zuo, P., et al. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.10.016 · Cited by 26

Iron and Sphingolipids as Common Players of (Mal)Adaptation to Hypoxia in Pulmonary Diseases

Ottolenghi, S., Zulueta, A., & Caretti, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010307 · Cited by 25

Molecular and morphological modifications occurring in rat heart exposed to intermittent hypoxia: role for protein kinase C α

Cataldi, A., Bianchi, G., Rapino, C., Sabatini, N., Centurione, L., Giulio, C. D., Bosco, D., & Antonucci, A. T. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.010 · Cited by 24

Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B

Malik, M. T., Peng, Y., Kline, D. D., Adhikary, G., & Prabhakar, N. R. (2004) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2004.08.009 · Cited by 24

Hypoxia inducible factor-1 α knockout does not impair acute thermal tolerance or heat hardening in zebrafish

Joyce, W., & Perry, S. F. (2020) · Biology Letters · doi:10.1098/rsbl.2020.0292 · Cited by 25

E2F1 represses β‐catenin/TCF activity by direct up‐regulation of Siah1

Xie, W., Jin, L., Mei, Y., & Wu, M. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00423.x · Cited by 23

Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis

Lago, C. U., Nowinski, S. M., Rundhaug, J. E., Pfeiffer, M. E., Kiguchi, K., Hirasaka, K., Yang, X., Abramson, E. M., Bratton, S. B., Rho, O., et al. (2012) · Oncogene · doi:10.1038/onc.2011.630 · Cited by 23

The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats

Dokucu, A. İ., Öztürk, H., Ozturk, H., Tuncer, M. C., & Yılmaz, F. (2008) · International Urology and Nephrology · doi:10.1007/s11255-008-9460-6 · Cited by 23

Regulatory Role of Hypoxia Inducible Factor in the Biological Behavior of Nucleus Pulposus Cells

Li, H., Liang, C. Z., & Chen, Q. X. (2013) · Yonsei Medical Journal · doi:10.3349/ymj.2013.54.4.807 · Cited by 23

AK-1, a SIRT2 inhibitor, destabilizes HIF-1α and diminishes its transcriptional activity during hypoxia

Lee, S. D., Kim, W., Jeong, J., Park, J., & Kim, J. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.01.031 · Cited by 23

Tf-PEG-PLL-PLGA nanoparticles enhanced chemosensitivity for hypoxia-responsive tumor cells

Chen, B., Liu, P., Zhang, H., Wu, X., Guo, L., Wang, F., Xia, G., Yin, H., Wang, Y., & Li, X. (2016) · OncoTargets and Therapy · doi:10.2147/ott.s108169 · Cited by 23

An extracellular oxygen carrier during prolonged pulmonary preservation improves post-transplant lung function

Ali, A., Watanabe, Y., Galasso, M., Watanabe, T., Chen, M., Fan, E., Brochard, L. J., Ramadan, K. Z., Ribeiro, R. V. P., Stansfield, W. E., et al. (2020) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2020.03.027 · Cited by 23

GC7 blocks epithelial-mesenchymal transition and reverses hypoxia-induced chemotherapy resistance in hepatocellular carcinoma cells.

Zhou, Q., Tu, C., Shao, C., Wang, W.-K., Zhu, J., Cai, Y., Mao, J., & Chen, W. (2017) · Europe PMC (PubMed Central) · Cited by 22

No Amplifications of Hypoxia‐Inducible Factor‐1α Gene in Invasive Breast Cancer: A Tissue Microarray Study

Vleugel, M. M., Bos, R., Buerger, H., van der Groep, P., Saramäki, O. R., Visakorpi, T., van der Wall, E., & van Diest, P. J. (2004) · Analytical Cellular Pathology · doi:10.1155/2004/532413 · Cited by 23

Selective ETAR antagonist atrasentan inhibits hypoxia-induced breast cancer cell invasion

Smollich, M., Götte, M., Kersting, C., Fischgräbe, J., Kiesel, L., & Wülfing, P. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9589-5 · Cited by 23

The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrupts Rat Lung Branching

Granja, S., Morais-Santos, F., Miranda‐Gonçalves, V., Viana-Ferreira, M., Nogueira, R. N., Nogueira‐Silva, C., Correia‐Pinto, J., & Baltazar, F. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000356617 · Cited by 23

Neuron-specific phosphorylation of c-Jun N-terminal kinase increased in the brain of hypoxic preconditioned mice

Zhang, N., Gao, G., Bu, X., Han, S., Fang, L., & Li, J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.07.028 · Cited by 23

Regeneration of Three Layers Vascular Wall by using BMP2-Treated MSC Involving HIF-1α and Id1 Expressions Through JAK/STAT Pathways

Belmokhtar, K., Bourguignon, T., Worou, M. E., Khamis, G., Bonnet, P., Domenech, J., & Eder, V. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9254-6 · Cited by 23

Molecular Characterization of Hypoxic Alveolar Epithelial Cells After Lung Contusion Indicates an Important Role for HIF-1α

Sherman, M. A., Suresh, M. V., Dolgachev, V. A., McCandless, L. K., Xue, X., Li, Z., Machado-Aranda, D., Shah, Y. M., & Raghavendran, K. (2016) · Annals of Surgery · doi:10.1097/sla.0000000000002070 · Cited by 23

In Cultured Astrocytes, p53 and MDM2 Do Not Alter Hypoxia-inducible Factor-1α Function Regardless of the Presence of DNA Damage

Rempe, D. A., Lelli, K. M., Vangeison, G., Johnson, R. S., & Federoff, H. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702203200 · Cited by 23

Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta

Ozolinš, T. R. S., Fisher, T. S., Nadeau, D. M., Stock, J. L., Klein, A. S., Milici, A. J., Morton, D. G., Wilhelms, M. B., Brissette, W. H., & Li, B. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.057 · Cited by 23

Role of Hypoxia-Inducible Factors in Acute Kidney Injury

Andringa, K. K., & Agarwal, A. (2014) · Nephron Clinical Practice · doi:10.1159/000363669 · Cited by 22

Plasma expression of HIF‐1α as novel biomarker for the diagnosis of obstructive sleep apnea‐hypopnea syndrome

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Effect of space flight on the behavior of human retinal pigment epithelial ARPE-19 cells and evaluation of coenzyme Q10 treatment

Cialdai, F., Bolognini, D., Vignali, L., Iannotti, N., Cacchione, S., Magi, A., Balsamo, M., Vukich, M., Neri, G., Donati, A., et al. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03989-2 · Cited by 22

Shogaol potentiates sevoflurane mediated neuroprotection against ischemia/reperfusion-induced brain injury via regulating apoptotic proteins and PI3K/Akt/mTOR/s6K signalling and HIF-1α/HO-1 expression

Jia, S., Zhang, H., Li, L., Wang, F., & Zhang, B. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.07.038 · Cited by 22

Oxidative Stress Response’s Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia Exposures

Lévêque, C., Mrakic‐Sposta, S., Lafère, P., Vezzoli, A., Germonpré, P., Beer, A., Mievis, S., Virgili, F., Lambrechts, K., Theunissen, S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010664 · Cited by 22

High-altitude adaptation of Tibetan chicken from MT-COI and ATP-6 perspective

Zhao, X., Wu, N., Zhu, Q., Gaur, U., Gu, T., & Li, D. (2015) · Mitochondrial DNA Part A · doi:10.3109/19401736.2015.1015006 · Cited by 22

Effects of GinkgobilobaExtract on Cultured Human Retinal Pigment Epithelial Cells under Chemical Hypoxia

Oh, J.-H., Oh, J., Togloom, A., Kim, S., & Huh, K. (2013) · Current Eye Research · doi:10.3109/02713683.2013.804093 · Cited by 22

The Tyrosine Phosphatase SHP-1 Regulates Hypoxia Inducible Factor-1α (HIF-1α) Protein Levels in Endothelial Cells under Hypoxia

Alig, S., Stampnik, Y., Pircher, J., Rotter, R., Gaitzsch, E., Ribeiro, A., Wörnle, M., Krötz, F., & Mannell, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121113 · Cited by 21

The induction of tuftelin expression in PC12 cell line during hypoxia and NGF‐induced differentiation

Leiser, Y., Silverstein, N., Blumenfeld, A., Shilo, D., Haze, A., Rosenfeld, E., Shay, B., Tabakman, R., Lecht, S., Lazarovici, P., et al. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22318 · Cited by 22

The Effect of Silencing HIF-1α Gene in BxPC-3 Cell Line on Glycolysis-Related Gene Expression, Cell Growth, Invasion, and Apoptosis

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Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors

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A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling

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Nitric Oxide Regulates Expression of Sonic Hedgehog and Hypoxia-Inducible Factor-1α in an Experimental Model of Kidney Ischemia-Reperfusion

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Effect of hypoxia on the expression of iron regulatory proteins 1 and the mechanisms involved

Luo, Q., Wang, D., Yu, M., & Zhu, L. (2011) · IUBMB Life · doi:10.1002/iub.419 · Cited by 22

Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid's anti-metastatic effect in 4T1 tumor bearing mice

Gao, J., Shui, Y.-M., Jiang, W., Huang, E., Shou, Q., Ji, X., He, B., Lv, G., & He, T. (2016) · Oncotarget · doi:10.18632/oncotarget.12375 · Cited by 22

Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1α and MTF-1

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Physiological oxygen tension modulates soluble growth factor profile after crosstalk between chondrocytes and osteoblasts

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Hypoxia-induced RNASEH2A limits activation of cGAS-STING signaling in HCC and predicts poor prognosis

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Facts and Perspectives: Implications of tumor glycolysis on immunotherapy response in triple negative breast cancer

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Biomaterials delivery strategies to repair degenerated intervertebral discs by regulating the inflammatory microenvironment

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Epigenetic signature of human immune aging in the GESTALT study

Roy, R., Kuo, P., Candia, J., Sarantopoulou, D., Ubaida‐Mohien, C., Hernandez, D. G., Kaileh, M., Arepalli, S., Singh, A., Bektas, A., et al. (2023) · eLife · doi:10.7554/elife.86136 · Cited by 21

Mechanistic target of rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia

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Opportunities and challenges facing biomarker development for personalized head and neck cancer treatment

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Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?

Kim, J. A., Kim, S. J., Do, I., Jin, J., Nam, D., Ko, Y. H., Kım, K., & Kim, W. S. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2010.542261 · Cited by 21

Effect of hindlimb unweighting on expression of hypoxia-inducible factor-1α vascular endothelial growth factor, angiopoietin, and their receptors in mouse skeletal muscle

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The pivotal role of HIF-1α in lung inflammatory injury induced by septic mesenteric lymph

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