HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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Untitled work

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Systemic Inflammation and Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: State of the Art and Novel Insights in Regulation of Muscle Plasticity

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Hypoxia-Inducible Factor 1-α (HIF-1α) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways

Zhao, X., Liu, L., Li, R., Wei, X., Luan, W., Liu, P., & Zhao, J. (2018) · Medical Science Monitor · doi:10.12659/msm.913384 · Cited by 64

Apelin/APJ signaling in hypoxia-related diseases

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Novel role for the δ‐opioid receptor in hypoxic preconditioning in rat retinas

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Apnea stimulates the adaptive response to oxidative stress in elephant seal pups

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Roles for hypoxia-regulated genes during cervical carcinogenesis: Somatic evolution during the hypoxia–glycolysis–acidosis sequence

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Behavioral Responses to Hypoxia in Drosophila Larvae Are Mediated by Atypical Soluble Guanylyl Cyclases

Vermehren‐Schmaedick, A., Ainsley, J. A., Johnson, W. A., Davies, S. A., & Morton, D. B. (2010) · Genetics · doi:10.1534/genetics.110.118166 · Cited by 61

Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension

Tofovic, S. P., & Jackson, E. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010116 · Cited by 63

PERSISTENT HIF-1?? ACTIVATION IN GUT ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BACTERIA AND LIPOPOLYSACCHARIDE

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Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease—a comprehensive review from the ERA CKD-MBD working group

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Cellular and Molecular Mechanisms Underlying Oxygen-Dependent Radiosensitivity

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High Intensity Interval and Endurance Training Have Opposing Effects on Markers of Heart Failure and Cardiac Remodeling in Hypertensive Rats

Holloway, T. M., Bloemberg, D., da Silva, M. L., Simpson, J. A., Quadrilatero, J., & Spriet, L. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121138 · Cited by 60

Aquaporins in spinal cord injury: the janus face of aquaporin 4

Nesic, O., Guest, J. D., Živadinović, D., Narayana, P. A., Herrera, J. J., Grill, R., Mokkapati, V. U. L., Gelman, B. B., & Lee, J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.037 · Cited by 59

Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1α-independent manner

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Over-expression of microRNA-494 up-regulates hypoxia-inducible factor-1 alpha expression via PI3K/Akt pathway and protects against hypoxia-induced apoptosis

Sun, G., Zhou, Y., Li, H., Guo, Y., Shan, J., Xia, M., Li, Y., Li, S., Long, D., & Li, F. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-100 · Cited by 59

Whom to blame for metastasis, the epithelial–mesenchymal transition or the tumor microenvironment?

Pietilä, M., Ivaska, J., & Mani, S. A. (2016) · Cancer Letters · doi:10.1016/j.canlet.2015.12.033 · Cited by 63

Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase

Temes, E., Martín-Puig, S., Acosta‐Iborra, B., Castellanos, M. C., Feijoo‐Cuaresma, M., Olmos, G., Aragonés, J., & Landázuri, M. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414694200 · Cited by 59

HIF‐1α cytoplasmic accumulation is associated with cell death in old rat cerebral cortex exposed to intermittent hypoxia

Rapino, C., Bianchi, G., Giulio, C. D., Centurione, L., Cacchio, M., Antonucci, A. T., & Cataldi, A. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00161.x · Cited by 60

Role of hypoxia inducible factors 1α and 2α in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice

Molinas, C. R., Campo, R., Elkelani, O. A., Binda, M. M., Carmeliet, P., & Koninckx, P. R. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00779-9 · Cited by 59

Oxygen sensing strategies in mammals and bacteria

Taabazuing, C. Y., Hangasky, J. A., & Knapp, M. J. (2014) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2013.12.010 · Cited by 58

HIF-1α regulates bone formation after osteogenic mechanical loading

Tomlinson, R. E., & Silva, M. J. (2014) · Bone · doi:10.1016/j.bone.2014.12.015 · Cited by 59

ERK/MAPK activation involves hypoxia‐induced MGr1‐Ag/37LRP expression and contributes to apoptosis resistance in gastric cancer

Liu, L., Zhang, H., Sun, L. J., Gao, Y., Jin, H., Liang, S., Wang, Y., Dong, M., Shi, Y., Li, Z., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.25098 · Cited by 58

Isoflurane Preconditioning Decreases Myocardial Infarction in Rabbits via Up-regulation of Hypoxia Inducible Factor 1 That Is Mediated by Mammalian Target of Rapamycin

Raphael, J., Zuo, Z., Abedat, S., Beeri, R., & Gozal, Y. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318164cab1 · Cited by 57

The Role of LDH Serum Levels in Predicting Global Outcome in HCC Patients Undergoing TACE: Implications for Clinical Management

Scartozzi, M., Faloppi, L., Bianconi, M., Giampieri, R., Maccaroni, E., Bittoni, A., Prete, M. D., Loretelli, C., Belvederesi, L., Svegliati‐Baroni, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032653 · Cited by 58

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD

Russell, K. E., Chung, K. F., Clarke, C. J., Durham, A. L., Mallia, P., Footitt, J., Johnston, S. L., Barnes, P. J., Hall, S. R., Simpson, K. D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146102 · Cited by 58

The effects of altitude/hypoxic training on oxygen delivery capacity of the blood and aerobic exercise capacity in elite athletes – a metaanalysis

Park, H., Hwang, H., Park, J., Lee, S.-N., & Lim, K. (2016) · Physical Activity and Nutrition · doi:10.20463/jenb.2016.03.20.1.3 · Cited by 58

Low oxygen tension increases mitochondrial membrane potential and enhances expression of antioxidant genes and implantation protein of mouse blastocyst cultured in vitro

Ma, Y.-Y., Chen, H., & Tzeng, C. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0344-1 · Cited by 57

Long-Term Effects of In Vivo Genome Editing in the Mouse Retina Using Campylobacter jejuni Cas9 Expressed via Adeno-Associated Virus

Jo, D. H., Koo, T., Cho, C. S., Kim, J. H., Kim, J.-S., & Kim, J. H. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.10.009 · Cited by 57

Hypoxia-inducible factor-1α-induced differentiation of myeloid leukemic cells is its transcriptional activity independent

Song, L.-P., Zhang, J., Wu, S.-F., Huang, Y., Zhao, Q., CAO, J. C., Wu, Y.-L., Wang, L., & Chen, G.-Q. (2007) · Oncogene · doi:10.1038/sj.onc.1210670 · Cited by 58

Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro

McKay, T. B., Hjortdal, J., Priyadarsini, S., & Karamichos, D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176017 · Cited by 59

Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome

Carosso, G. A., Boukas, L., Augustin, J. J., Nguyen, H. N., Winer, B. L., Cannon, G. H., Robertson, J. D., Zhang, L., Hansen, K. D., Goff, L. A., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129375 · Cited by 57

O2-sensing signal cascade: clamping of O2 respiration, reduced ATP utilization, and inducible fumarate respiration

Sridharan, V., Guichard, J. L., Li, C., Muise‐Helmericks, R. C., Beeson, C. C., & Wright, G. L. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00466.2007 · Cited by 57

Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure

Eckle, T. D. L. G., Bertazzo, J., Khatua, T. N., Tabatabaei, S. R. F., Bakhtiari, N. M., Walker, L. A., & Martino, T. A. (2024) · Circulation Research · doi:10.1161/circresaha.123.323522 · Cited by 57

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors

Warshakoon, N. C., Wu, S., Boyer, A. S., Kawamoto, R. M., Sheville, J., Renock, S., Xu, K., Pokross, M. E., Zhou, S., Winter, C., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.040 · Cited by 56

Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma

Seeber, L. M., Horrée, N., van der Groep, P., van der Wall, E., Verheijen, R. H., & van Diest, P. J. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-307 · Cited by 55

High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1α Transcription

Kawada, H., Kaneko, M., Sawanobori, M., Uno, T., Matsuzawa, H., Nakamura, Y., Matsushita, H., & Ando, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062717 · Cited by 55

Hypoxia‐inducible factor‐1α regulates matrix metalloproteinase‐1 activity in human bone marrow‐derived mesenchymal stem cells

Lin, J.-L., Wang, M. J., Lee, D., Liang, C.-C., & Lin, S. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.033 · Cited by 55

p53-Dependent and p53-Independent Induction of Insulin-Like Growth Factor Binding Protein-3 by Deoxyribonucleic Acid Damage and Hypoxia

Grimberg, A., Coleman, C. M., Burns, T. F., Himelstein, B. P., Koch, C. J., Cohen, P., & El‐Deiry, W. S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1213 · Cited by 55

Therapeutic angiogenesis in the heart: protect and serve

Molin, D. G. M., & Post, M. J. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.10.006 · Cited by 55

Oxygen tension modulates the expression of pulmonary vascular BKCachannel α- and β-subunits

Resnik, E., Herron, J. M., Fu, R., Ivy, D. D., & Cornfield, D. N. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00283.2005 · Cited by 55

Hypoxia inducible factor stabilization leads to lasting improvement of hippocampal memory in healthy mice

Adamcio, B., Sperling, S., Hagemeyer, N., Walkinshaw, G., & Ehrenreich, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.010 · Cited by 54

Advances in nanoparticle-based radiotherapy for cancer treatment

He, M., Chen, S., Yu, H., Fan, X., Wu, H., Wang, Y., Wang, H., & Yin, X. (2024) · iScience · doi:10.1016/j.isci.2024.111602 · Cited by 54

Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain

Ndubuizu, O. I., Tsipis, C. P., Li, A., & LaManna, J. C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.064 · Cited by 53

Identification of Thioredoxin-Interacting Protein 1 as a Hypoxia-Inducible Factor 1α-Induced Gene in Pancreatic Cancer

Baker, A. F., Koh, M. Y., Williams, R. R., James, B. P., Wang, H., Tate, W. R., Gallegos, A. C., Hoff, D. D. V., Han, H., & Powis, G. (2008) · Pancreas · doi:10.1097/mpa.0b013e31815929fe · Cited by 54

Prophylactic neuroprotection against stroke: Low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function

Zhao, Y., & Rempe, D. A. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.230 · Cited by 54

Microstructured templates for directed growth and vascularization of soft tissue in vivo

Zheng, Y. Y., Henderson, P. W., Choi, N., Bonassar, L. J., Spector, J. A., & Stroock, A. D. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.001 · Cited by 54

Differential effects of TGF-β1 and BMP-4 on the hypoxic induction of cyclooxygenase-2 in human pulmonary artery smooth muscle cells

Sheares, K. K. K., Jeffery, T. K., Long, L., Yang, X., & Morrell, N. W. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00012.2004 · Cited by 54

Impact of MicroRNAs in the Cellular Response to Hypoxia

Bertero, T., Rezzonico, R., Pottier, N., & Mari, B. P. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.03.006 · Cited by 56

Curcumin inhibited growth of human melanoma A375 cells via inciting oxidative stress

Liao, W., Xiang, W., Wang, F., Wang, R., & Ding, Y. P. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.026 · Cited by 54

Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis

Liu, H., Du, Y., Zhang, Z., Lv, L., Xiong, W., Zhang, L., Li, N., He, H., Li, Q., & Liu, Y. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy128 · Cited by 53

The evolutionary and physiological significance of the Hif pathway in teleost fishes

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Differential activation of Toll-like receptor-mediated apoptosis induced by hypoxia

Mkaddem, S. B., Bens, M., & Vandewalle, A. (2010) · Oncotarget · doi:10.18632/oncotarget.209 · Cited by 54

Cellular memory of hypoxia elicits neuroblastoma metastasis and enables invasion by non-aggressive neighbouring cells

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Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α

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Hypoxia Inducible Factor-1α Directly Induces the Expression of Receptor Activator of Nuclear Factor-κB Ligand in Periodontal Ligament Fibroblasts

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Genetic variation in hypoxia-inducible factor 1α and its possible association with high altitude adaptation in Sherpas

Suzuki, K., Kizaki, T., Hitomi, Y., Nukita, M., Kimoto, K., Miyazawa, N., Kobayashi, K., Ohnuki, Y., & Ohno, H. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00178-6 · Cited by 53

Hypoxia, anoxia, and O2 sensing: the search continues

Schumacker, P. T. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00205.2002 · Cited by 55

Inhibition of proteasome activity is involved in cobalt-induced apoptosis of human alveolar macrophages

Araya, J., Maruyama, M., Inoue, A., Fujita, T., Kawahara, J., Sassa, K., Hayashi, R., Kawagishi, Y., Yamashita, N., Sugiyama, E., et al. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00422.2001 · Cited by 53

Hypoxia-inducible factor-1: A potential pharmacological target to manage psoriasis

Zhu, W., Li, P., Wang, L., & Xu, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106689 · Cited by 52

Molecular indicators of hypoxia in the blue crab Callinectes sapidus

Brown‐Peterson, N. J., Larkin, P., Denslow, N. D., King, C., Manning, S., & Brouwer, M. H. (2005) · Marine Ecology Progress Series · doi:10.3354/meps286203 · Cited by 53

Sensory plasticity of the carotid body: Role of reactive oxygen species and physiological significance

Prabhakar, N. R. (2011) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2011.05.012 · Cited by 52

Role of HIF-1 on phosphofructokinase and fructose 1, 6-bisphosphatase expression during hypoxia in the white shrimp Litopenaeus vannamei

Cota-Ruiz, K., Leyva‐Carrillo, L., Peregrino-Uriarte, A. B., Valenzuela-Soto, E. M., Gollas‐Galván, T., Gómez‐Jiménez, S., Hernández, J., & Yepiz-Plascencia, G. M. (2016) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2016.03.015 · Cited by 52

CD36 Upregulation Mediated by Intranasal LV-NRF2 Treatment Mitigates Hypoxia-Induced Progression of Alzheimer's-Like Pathogenesis

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Metabolic Adaptation of the Fetal and Postnatal Ovine Heart: Regulatory Role of Hypoxia-Inducible Factors and Nuclear Respiratory Factor-1

Nau, P. N., Natta, T. V., Ralphe, J. C., TenEyck, C. J., Bedell, K. A., Caldarone, C. A., Segar, J. L., & SCHOLZ, T. D. (2002) · Pediatric Research · doi:10.1203/00006450-200208000-00021 · Cited by 52

Hypoxia and Carbon Monoxide in the Vasculature

Kourembanas, S. (2002) · Antioxidants and Redox Signaling · doi:10.1089/152308602753666343 · Cited by 53

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Balaban, D. Y., Duffin, J., Preiss, D. A., Mardimae, A., Vesely, A. E., Slessarev, M., Zubieta-Calleja, G. R., Greene, E. R., MacLeod, D. B., & Fisher, J. A. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2012.12.011 · Cited by 51

The Janus-Faced Effects of Hypoxia on Astrocyte Function

Vangeison, G., & Rempe, D. A. (2009) · The Neuroscientist · doi:10.1177/1073858409332405 · Cited by 49

Is Structural Remodeling of Fibrillated Atria the Consequence of Tissue Hypoxia?

Ogi, H., Nakano, Y., Niida, S., Dote, K., Hirai, Y., Suenari, K., Tonouchi, Y., Oda, N., Makita, Y., Ueda, S., et al. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0969 · Cited by 53

Control of erythropoiesis after high altitude acclimatization

Savourey, G., Launay, J.-C., Besnard, Y., Guinet, A., Bourrilhon, C., Cabane, D., Martin, S., Caravel, J.-P., Péquignot, J.-M., & Cottet-Émard, J. M. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1159-5 · Cited by 51

Thyroid Hormone Induces Hypoxia-Inducible Factor 1α Gene Expression through Thyroid Hormone Receptor β/Retinoid X Receptor α-Dependent Activation of Hepatic Leukemia Factor

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Glycosylation as new pharmacological strategies for diseases associated with excessive angiogenesis

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Non-circadian aspects of BHLHE40 cellular function in cancer

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Expression and localization of hypoxia inducible factor-1alpha mRNA in the porcine ovary.

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Cellular and Molecular Mechanisms Associated with Carotid Body Adaptations to Chronic Hypoxia

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Expression of heme oxygenase in the oxygen-sensing regions of the rostral ventrolateral medulla

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Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb

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Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia

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