Cited by 1,822Cancer, Hypoxia, and MetabolismErythropoietin and Anemia TreatmentAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Semenza, Gregg L.·2000·Journal of Applied Physiology

DOI 10.1152/jappl.2000.88.4.1474

Open this paper in CoChat — free account

Abstract

All organisms can sense O 2 concentration and respond to hypoxia with adaptive changes in gene expression. The large body size of mammals necessitates the development of multiple complex physiological systems to ensure adequate O 2 delivery to all cells under normal conditions. The transcriptional regulator hypoxia-inducible factor 1 (HIF-1) is an essential mediator of O 2 homeostasis. HIF-1 is required for the establishment of key physiological systems during development and their subsequent utilization in fetal and postnatal life. HIF-1 also appears to play a key role in the pathophysiology of cancer, cardiovascular disease, and chronic lung disease, which represent the major causes of mortality among industrialized societies. Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders.

Integrity signals

Registry

Crossref · 10.1152/jappl.2000.88.4.1474

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
Self-citation
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,585
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Self-citation
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citation
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Self-citation
Untitled work
(1999) · PubMed · Cited by 2,204
Self-citation
Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway
Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094
Self-citation

Flagged first, then by citations

Show all 83 references

2 of the 83 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

Brizel DM, 1996, Cancer Res, 56, 941
Feldser D, 1999, Cancer Res, 59, 3915
Gu Y-Z, 1998, Gene Expr, 7, 205
Hockel M, 1996, Cancer Res, 56, 4509
Jiang B-H, 1997, Cancer Res, 57, 5328
Ozaki H, 1999, Invest Ophthalmol Vis Sci, 40, 182
Zhong H, 1998, Cancer Res, 58, 5280
Zhong H, 1999, Cancer Res, 59, 5830

Sorted by citations

Items 301–400 of 1,001

HIF‐1 and AP‐1 Cooperate to Increase Gene Expression in Hypoxia: Role of MAP Kinases
Michiels, C., Minet, E., Michel, G., Mottet, D., Piret, J., & Raes, M. J. (2001) · IUBMB Life · doi:10.1080/15216540252774766 · Cited by 104
Hypoxia-inducible factor-1 and hypoxia response elements mediate the induction of plasminogen activator inhibitor-1 gene expression by insulin in primary rat hepatocytes
Kietzmann, T., Samoylenko, A., Roth, U., & Jungermann, K. A. (2003) · Blood · doi:10.1182/blood-2002-06-1693 · Cited by 103
Quantum mechanical, spectroscopic study (FT-IR and FT - Raman), NBO analysis, HOMO-LUMO, first order hyperpolarizability and docking studies of a non-steroidal anti-inflammatory compound
Sakthivel, S., Alagesan, T., Muthu, S., Abraham, C. S., & Geetha, E. (2017) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2017.12.024 · Cited by 104
Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies
Annese, T., Tamma, R., Ruggieri, S., & Ribatti, D. (2019) · Cancers · doi:10.3390/cancers11030381 · Cited by 103
Immunometabolism of Phagocytes During Mycobacterium tuberculosis Infection
Kumar, R., Singh, P., Kolloli, A., Shi, L., Bushkin, Y., Tyagi, S., & Subbian, S. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00105 · Cited by 103
HIF-1α: a Valid Therapeutic Target for Tumor Therapy
Hong, S., Lee, H., & Kim, K. (2004) · Cancer Research and Treatment · doi:10.4143/crt.2004.36.6.343 · Cited by 108
White Adipocyte Vascular Endothelial Growth Factor: Regulation by Insulin
Mick, G. J., Wang, X., & McCormick, K. L. (2002) · Endocrinology · doi:10.1210/endo.143.3.8673 · Cited by 103
Transcriptional regulation of hypoxia inducible factors alpha (HIF-α) and their inhibiting factor (FIH-1) of channel catfish (Ictalurus punctatus) under hypoxia
Geng, X., Feng, J., Liu, S., Wang, Y., Arias, C. R., & Liu, Z. (2014) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2013.12.007 · Cited by 101
Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma
Horn, D., Heß, J., Freier, K., Hoffmann, J., & Freudlsperger, C. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1012157 · Cited by 104
Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia
Weir, Ε. K., & Olschewski, A. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.04.014 · Cited by 101
HIF-VEGF-VEGFR-2, TNF-α and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array
Tuomisto, T. T., Rissanen, T. T., Vajanto, I., Korkeela, A., Rutanen, J., & Ylä‐Herttuala, S. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.01.015 · Cited by 101
Peripheral Chemoreception and Arterial Pressure Responses to Intermittent Hypoxia
Prabhakar, N. R., Peng, Y., Kumar, G. K., & Nanduri, J. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140039 · Cited by 113
Hyperbaric Oxygen, Vasculogenic Stem Cells, and Wound Healing
Fosen, K. M., & Thom, S. R. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5940 · Cited by 104
Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications
Zhang, Y., Zhang, H., Wang, M., Schmid, T., Xin, Z., Kozhuharova, L., Yu, W.-K., Huang, Y., Cai, F., & Biskup, E. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.652266 · Cited by 103
Hypoxia‐induced ischemic tolerance in neonatal rat brain involves enhanced ERK1/2 signaling
Jones, N. M., & Bergeron, M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02324.x · Cited by 100
Acute hypoxia increases the aggressive characteristics and survival properties of prostate cancer cells
Ghafar, M. A. A., Anastasiadis, A. G., Chen, M., Burchardt, M., Olsson, L. E., Xie, H. W., Benson, M. C., & Buttyan, R. (2002) · The Prostate · doi:10.1002/pros.10162 · Cited by 100
Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia
McClelland, G. B., & Brooks, G. A. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01069.2001 · Cited by 100
Implication of the hypoxia response element of the Vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development
Vinores, S. A., Xiao, W., Aslam, S., Shen, J., Oshima, Y., Nambu, H., Liu, H., Carmeliet, P., & Campochiaro, P. A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20525 · Cited by 99
The selective hypoxia inducible factor-1 inhibitor PX-478 providesin vivoradiosensitization through tumor stromal effects
Schwartz, D. L., Powis, G., Thitai-Kumar, A., He, Y., Bankson, J. A., Williams, R. R., Lemos, R., Oh, J., Volgin, A., Soghomonyan, S., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0981 · Cited by 99
Resveratrol: a promising agent in promoting cardioprotection against coronary heart diseaseThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue).
Penumathsa, S. V., & Maulik, N. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-013 · Cited by 99
JNK1 Mediates Degradation HIF-1α by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70
Zhang, D., Li, J., Costa, M., Gao, J., & Huang, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-0448 · Cited by 99
HIF-1α Is Up-Regulated in Activated Mast Cells by a Process That Involves Calcineurin and NFAT
Walczak‐Drzewiecka, A., Ratajewski, M., Wagner, W., & Dastych, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1665 · Cited by 98
Culture in low levels of oxygen enhances in vitro proliferation potential of satellite cells from old skeletal muscles
Chakravarthy, M. V., Spangenburg, E. E., & Booth, F. W. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000929 · Cited by 96
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
Pan, Y., Oprysko, P. R., Asham, A. M., Koch, C. J., & Simon, M. C. (2004) · Oncogene · doi:10.1038/sj.onc.1207657 · Cited by 98
AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1α/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo
Zhang, P., Liu, X., Li, M., Ma, Y., Sun, H., Tian, X., Wang, Y., Liu, M., Fu, L.-S., Wang, Y., et al. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113771 · Cited by 97
The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management
Faloppi, L., Scartozzi, M., Bianconi, M., Svegliati‐Baroni, G., Toniutto, P., Giampieri, R., Prete, M. D., Minicis, S. D., Bitetto, D., Loretelli, C., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-110 · Cited by 97
Hypoxia-inducible Factor-1 Mediates Neuronal Expression of the Receptor for Advanced Glycation End Products following Hypoxia/Ischemia
Pichiule, P., Chavez, J. C., Schmidt, A. M., & Vannucci, S. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706407200 · Cited by 97
HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport
Li, Y., Lim, S., Hoffman, D. L., Aspenström, P., Federoff, H. J., & Rempe, D. A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200811033 · Cited by 99
Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells
Dai, Z.-J., Gao, J., Ma, X., Yan, K., Liu, X.-X., Kang, H., Zongzheng, J., Guan, H., & Wang, X.-J. (2012) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-31-28 · Cited by 99
HIF-1α inhibition promotes the efficacy of immune checkpoint blockade in the treatment of non-small cell lung cancer
Luo, F., Lu, F.-T., Cao, J.-X., Ma, W.-J., Xia, Z.-F., Zhan, J.-H., Zeng, K.-M., Huang, Y., Zhao, H.-Y., & Zhang, L. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.01.027 · Cited by 95
Progress toward Overcoming Hypoxia-Induced Resistance to Solid Tumor Therapy
Reginato, M., & Karakashev, S. (2015) · Cancer Management and Research · doi:10.2147/cmar.s58285 · Cited by 95
Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers.
Bobarykina, A. Y., Minchenko, D. O., Opentanova, I. L., Moenner, M., Caro, J., Esumi, H., & Minchenko, О. H. (2006) · Acta Biochimica Polonica · doi:10.18388/abp.2006_3308 · Cited by 96
Hypoxic Preconditioning Induces Neuroprotective Stanniocalcin-1 in Brain via IL-6 Signaling
Westberg, J. A., Serlachius, M., Lankila, P., Penkowa, M., Hidalgo, J., & Andersson, L. C. (2007) · Stroke · doi:10.1161/01.str.0000258113.67252.fa · Cited by 95
Identification of the Hypoxia-Inducible Factor 1α-Responsive HGTD-P Gene as a Mediator in the Mitochondrial Apoptotic Pathway
Lee, M., Kim, J., Suk, K., & Park, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.9.3918-3927.2004 · Cited by 93
Non-coding RNA in endothelial-to-mesenchymal transition
Hulshoff, M. S., del Monte‐Nieto, G., Kovacic, J. C., & Krenning, G. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz211 · Cited by 93
Hypoxia-Inducible Factor-1α Is Essential for Hypoxia-Induced Mesenchymal Stem Cell Mobilization into the Peripheral Blood
Liu, L., Yu, Q., Lin, J., Lai, X., Cao, W., Du, K., Wang, Y., Wu, K., Hu, Y., Zhang, L., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2010.0453 · Cited by 94
Hypoxia-Induced Changes in Neuronal Network Properties
Peña‐Ortega, F., & Ramirez, J. (2005) · Molecular Neurobiology · doi:10.1385/mn:32:3:251 · Cited by 96
Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery
Wang, J., Weigand, L. A., Wang, W., Sylvester, J. T., & Shimoda, L. A. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00379.2004 · Cited by 94
Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer
Schwartz, D. L., Bankson, J. A., Lemos, R., Lai, S. Y., Thittai, A. K., He, Y., Hostetter, G. H., Demeure, M. J., Hoff, D. D. V., & Powis, G. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0768 · Cited by 94
Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells
Kelley, E. E., Hock, T., Khoo, N. K. H., Richardson, G. R., Johnson, K. K., Powell, P. C., Giles, G. I., Agarwal, A., Lancaster, J. R., & Tarpey, M. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.11.008 · Cited by 93
Redox Regulation of Lung Inflammation by Thioredoxin
Nakamura, T., Nakamura, H., Hoshino, T., Ueda, S., Wada, H., & Yodoi, J. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.60 · Cited by 93
The Oncogene HER2/neu (ERBB2) Requires the Hypoxia-inducible Factor HIF-1 for Mammary Tumor Growth and Anoikis Resistance
Whelan, K. A., Schwab, L. P., Karakashev, S. V., Franchetti, L. D., Johannes, G. J., Seagroves, T. N., & Reginato, M. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426999 · Cited by 98
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses
Chun, Y., Choi, E., Yeo, E.-J., Lee, J.-H., Kim, M.-S., & Park, J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.22.4051 · Cited by 93
Intrinsic and extrinsic erythropoietin enhances neuroprotection against ischemia and reperfusion injury in vitro
Liu, R., Suzuki, A., Guo, Z., Mizuno, Y., & Urabe, T. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03597.x · Cited by 93
Performing at extreme altitude: muscle cellular and subcellular adaptations
HOWALD, H., & Hoppeler, H. H. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0872-9 · Cited by 91
Aquaporin 1 – a novel player in spinal cord injury
Nesic, O., Lee, J., Unabia, G. C., Johnson, K. M., Ye, Z., Vergara, L. A., Hulsebosch, C. E., & Perez-Polo, J. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05177.x · Cited by 91
Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1α, GLUT1, and CAIX
Chen, C., Chu, J., Su, W., Huang, S.-C., & Lee, W. (2010) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-010-0938-0 · Cited by 91
Analysis of ARD1 Function in Hypoxia Response Using Retroviral RNA Interference
Fisher, T. S., Etages, S. D., Hayes, L. S., Crimin, K., & Li, B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412055200 · Cited by 91
An Updated Panorama of “Living Low-Training High” Altitude/Hypoxic Methods
Girard, O., Brocherie, F., Goods, P. S. R., & Millet, G. P. (2020) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2020.00026 · Cited by 90
Hypoxia and Regulation of Cancer Cell Stemness
Yun, Z., & Lin, Q. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_2 · Cited by 92
Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans
Chang, A. J., & Bargmann, C. I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802164105 · Cited by 90
Hypoxia‐driven proliferation of human pulmonary artery fibroblasts: cross‐talk between HIF‐1α and an autocrine angiotensin system
Krick, S., Hänze, J., Eul, B. G., Savai, R., Seay, U., Grimminger, F., Lohmeyer, J., Klepetko, W., Seeger, W., & Rose, F. (2005) · The FASEB Journal · doi:10.1096/fj.04-2890fje · Cited by 87
Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells
Kim, M.-H., Jeong, Y., Cho, H.-J., Hoe, H., Park, K., Park, Y.-Y., Choi, Y. H., Kim, C., Chang, H., Park, Y. H., et al. (2016) · Oncology Reports · doi:10.3892/or.2016.5296 · Cited by 89
Redox Control of Endoplasmic Reticulum Function
Csala, M., Margittai, É., & Bánhegyi, G. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2529 · Cited by 89
Sequence variation in hypoxia-inducible factor 1α (HIF1A): association with maximal oxygen consumption
Prior, S. J., Hagberg, J. M., Phares, D. A., Brown, M. D., Fairfull, L. D., Ferrell, R. E., & Roth, S. M. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00061.2003 · Cited by 88
Skeletal Muscle HIF-1α Expression Is Dependent on Muscle Fiber Type
Pisani, D. F., & Dechesne, C. A. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200509265 · Cited by 90
The Forkhead Transcription Factor FOXO4 Induces the Down-regulation of Hypoxia-inducible Factor 1α by a von Hippel-Lindau Protein-independent Mechanism
Tang, T. T.-L., & Lasky, L. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302042200 · Cited by 87
c-JUN Gene Induction and AP-1 Activity Is Regulated by a JNK-Dependent Pathway in Hypoxic HepG2 Cells
Minet, E., Michel, G., Mottet, D., Piret, J., Barbieux, A., Raes, M. J., & Michiels, C. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5180 · Cited by 92
Hypoxia-inducible factor-1α expression correlates with focal macrophage infiltration, angiogenesis and unfavourable prognosis in urothelial carcinoma
Chai, C.-Y., Chen, W.-T., Hung, W., Kang, W., Huang, Y.-C., Su, Y., & Yang, C.-H. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.050666 · Cited by 87
Sildenafil‐mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: role of VEGF/angiopoietin‐1
Koneru, S., Penumathsa, S. V., Thirunavukkarasu, M., Vidavalur, R., Zhan, L., Singal, P. K., Engelman, R. M., Das, D. K., & Maulik, N. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00319.x · Cited by 87
Chronic intermittent hypercapnic hypoxia increases pulmonary arterial pressure and haematocrit in rats
McGuire, S., & Bradford, A. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.00078801 · Cited by 87
Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
Lin, C.-W., Wang, L.-K., Wang, S.-P., Chang, Y.-L., Wu, Y.-Y., Chen, H.-Y., Hsiao, T.-H., Lai, W.-Y., Lu, H.-H., Chang, Y.-H., et al. (2016) · Nature Communications · doi:10.1038/ncomms13867 · Cited by 86
Genome-Wide Association Study Reveals Multiple Novel QTL Associated with Low Oxygen Tolerance in Hybrid Catfish
Zhong, X., Wang, X., Zhou, T., Jin, Y., Tan, S., Chen, J., Geng, X., Li, N., Shi, H., Zeng, Q., et al. (2017) · Marine Biotechnology · doi:10.1007/s10126-017-9757-5 · Cited by 88
Oxygen-dependent regulation of nitric oxide production by inducible nitric oxide synthase
Robinson, M. A., Baumgardner, J. E., & Otto, C. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.034 · Cited by 88
Multiple tissue gene expression analyses in Japanese medaka (Oryzias latipes) exposed to hypoxia
Ju, Z., Wells, M. C., Heater, S. J., & Walter, R. B. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.06.012 · Cited by 86
Animal Models of Acute Moderate Hypoxia Are Associated with a Down-Regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and Up-Regulation of CYP3A6 and P-glycoprotein in Liver
Fradette, C., Batonga, J., Teng, S., Piquette‐Miller, M., & du Souich, P. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.013508 · Cited by 85
Tumor oxygenation status as a prognostic marker
Menon, C., & Fraker, D. L. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.06.029 · Cited by 86
A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model
Wiegman, C., Li, F., Clarke, C. J., Jazrawi, E., Kirkham, P., Barnes, P. J., Adcock, I. M., & Chung, K. F. (2013) · Clinical Science · doi:10.1042/cs20130039 · Cited by 86
Vitexin reduces hypoxia–ischemia neonatal brain injury by the inhibition of HIF-1alpha in a rat pup model
Min, J., Hu, J.-J., He, M., Sanchez, R. M., Huang, W., Liu, Y., Bsoul, N., Han, S. H., Yin, J., Liu, W., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.007 · Cited by 87
Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia
Zhi, Y., Guo, Q., Xia, P., Wang, N., Wang, E., & Yuan, Y. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.050 · Cited by 86
Comparison of the Hydroxylase Inhibitor Dimethyloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing
Duscher, D., Januszyk, M., Maan, Z. N., Whittam, A. J., Hu, M. S.-M., Walmsley, G. G., Dong, Y., Khong, S. M. L., Longaker, M. T., & Gurtner, G. C. (2017) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000003072 · Cited by 86
Oxygen‐regulated expression of GLUT‐1, GLUT‐3, and VEGF in the mouse blastocyst
Kind, K. L., Collett, R. A., Harvey, A. J., & Thompson, J. G. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20183 · Cited by 87
Molecular Mechanisms and Regulation of Iron Transport
Chung, J., & Wessling‐Resnick, M. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609332 · Cited by 86
A3 Adenosine Receptors Modulate Hypoxia-inducible Factor-1a Expression in Human A375 Melanoma Cells
Merighi, S., Benini, A., Mirandola, P., Gessi, S., Varani, K., Leung, E., MacLennan, S., Baraldi, P. G., & Borea, P. A. (2005) · Neoplasia · doi:10.1593/neo.05334 · Cited by 85
Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1
Piret, J., Lecocq, C., Toffoli, S., Ninane, N., Raes, M. J., & Michiels, C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.01.024 · Cited by 86
Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells: Involvement of cytosolic phospholipase A2 activity.
Ottino, P., Finley, J., Rojo–Niersbach, E. G., Ottlecz, A., Lambrou, G. N., Bazán, H. E. P., & Bazan, N. G. (2004) · PubMed · Cited by 85
Chicken or the egg: Warburg effect and mitochondrial dysfunction
Senyilmaz, D., & Teleman, A. A. (2015) · F1000Prime Reports · doi:10.12703/p7-41 · Cited by 89
MiR-24 induces chemotherapy resistance and hypoxic advantage in breast cancer
Roscigno, G., Puoti, I., Giordano, I., Donnarumma, E., Russo, V. M., Affinito, A., Adamo, A., Quintavalle, C., Todaro, M., Vivanco, M. D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14470 · Cited by 85
Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
Bowler, E., Porazinski, S. R., Uzor, S., Thibault, P., Durand, M., Lapointe, E., Rouschop, K. M. A., Hancock, J. T., Wilson, I. D., & Ladomery, M. (2018) · BMC Cancer · doi:10.1186/s12885-018-4227-7 · Cited by 81
Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models
Ruiz, S., Zhao, H., Chandakkar, P., Papoin, J., Choi, H., Nomura-Kitabayashi, A., Patel, R., Gillen, M. C., Diao, L., Chatterjee, P. K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127425 · Cited by 89
The Molecular Basis for Abnormal Human Lung Development
Groenman, F. A., Unger, S. L., & Post, M. (2004) · Neonatology · doi:10.1159/000082595 · Cited by 84
Molecular and Cellular Response of Co-cultured Cells toward Cobalt Chloride (CoCl2)-Induced Hypoxia
Tripathi, V., Subramaniyan, S. A., & Hwang, I. (2019) · ACS Omega · doi:10.1021/acsomega.9b01474 · Cited by 83
Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
Alique, M., Sánchez‐López, E., Bodega, G., Giannarelli, C., Carracedo, J., & Ramírez, R. (2020) · Cells · doi:10.3390/cells9010195 · Cited by 88
The role of hypoxia inducible factor-1alpha in gynecological cancer
Seeber, L. M. S., Horrée, N., Vooijs, M., Heintz, A. P. M., van der Wall, E., Verheijen, R. H. M., & van Diest, P. J. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.05.003 · Cited by 85
Effect of noble gases on oxygen and glucose deprived injury in human tubular kidney cells
Rizvi, M., Jawad, N., Li, Y., Vizcaychipi, M. P., Maze, M., & Ma, D. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009366 · Cited by 82
Hypoxia‐driven proliferation of embryonic neural stem/progenitor cells – role of hypoxia‐inducible transcription factor‐1α
Zhao, T., Zhang, C., Liu, Z., Wu, L., Huang, X. H., Wu, H., Xiong, L., Wang, X., Wang, X., Zhu, L., et al. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06340.x · Cited by 85
Coping with physiological oxidative stress: a review of antioxidant strategies in seals
Vázquez‐Medina, J. P., Zenteno‐Savín, T., Elsner, R., & Ortiz, R. M. (2012) · Journal of Comparative Physiology B · doi:10.1007/s00360-012-0652-0 · Cited by 82
Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (Review)
Sifakis, S. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2012.898 · Cited by 82
Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes
Casals, G., Ros, J., Sionís, A., Davidson, M. M., Morales‐Ruiz, M., & Jiménez, W. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00250.2009 · Cited by 83
Comparison of hypoxia-inducible factor-1 alpha in hypoxia-sensitive and hypoxia-tolerant fish species
Rytkönen, K. T., Vuori, K. A. M., Primmer, C. R., & Nikinmaa, M. (2007) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2007.03.001 · Cited by 84
Transcriptional repression of human cad gene by hypoxia inducible factor-1
Chen, K. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki839 · Cited by 83
Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice
Chen, S., Okahara, F., Osaki, N., & Shimotoyodome, A. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00418.2014 · Cited by 83
Redox regulation of HIF-1α levels and HO-1 expression in renal medullary interstitial cells
Yang, Z.-Z., Zhang, A. Y., Yi, F.-X., Li, P., & Zou, A.-P. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00017.2002 · Cited by 80
Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1α-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites
Li, J., Shworak, N. W., & Simons, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.9.1951 · Cited by 82
?-amyloid protein induces the formation of purine dimers in cellular DNA
Duker, N. J., Sperling, J. M., Soprano, K. J., Druin, D. P., Davis, A., & Ashworth, R. (2001) · Journal of Cellular Biochemistry · doi:10.1002/1097-4644(20010601)81:3 · Cited by 20
Selected Contribution: Osteocytes upregulate HIF-1α in response to acute disuse and oxygen deprivation
Gross, T. S., Akeno, N., Clemens, T. L., Komarova, S. V., Srinivasan, S., Weimer, D. A., & Mayorov, S. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2514 · Cited by 82
HIF‐1α reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion
Matrone, C., Pignataro, G., Molinaro, P., Irace, C., Scorziello, A., Renzo, G. F. D., & Annunziato, L. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02483.x · Cited by 81
Hypoxic Preconditioning Increases Brain Glycogen and Delays Energy Depletion from Hypoxia-Ischemia in the Immature Rat
Brucklacher, R. M., Vannucci, R. C., & Vannucci, S. J. (2002) · Developmental Neuroscience · doi:10.1159/000069051 · Cited by 81
A potential role for reactive oxygen species and the HIF-1α–VEGF pathway in hypoxia-induced pulmonary vascular leak
Irwin, D. C., McCord, J. M., Nozik‐Grayck, E., Beckly, G., Foreman, B., Sullivan, T., White, M., Crossno, J. T., Bailey, D. M., Flores, S. C., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.03.027 · Cited by 78
Hypoxia Mimetic Agents for Ischemic Stroke
Davis, C. K., Jain, S. A., Bae, O., Majid, A., & Rajanikant, G. K. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00175 · Cited by 85

Authors: Semenza, G. L.
Affiliations: Johns Hopkins University (US)
Corresponding author: Semenza, Gregg L.
ORCID: Semenza, Gregg L.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2000-04-01
Volume: 88
Issue: 4
Pages: 1474-1480
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.2000.88.4.1474
OpenAlex: W2143343444
Cited by: 1,822
References: 83
Citations by year: 2026: 28 · 2025: 54 · 2024: 53 · 2023: 55 · 2022: 67 · 2021: 77 · 2020: 62 · 2019: 55 · 2018: 76 · 2017: 85 · 2016: 78 · 2015: 83 · 2014: 72 · 2013: 78 · 2012: 74
FWCI: 5.80
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk039869-16)
National Heart, Lung, and Blood Institute (R01HL55338, R01HL055338)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK39869)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: HIF-1, hypoxia, oxygen homeostasis, oxygen sensing, transcriptional regulation, gene expression, fetal development, postnatal development, cancer, cardiovascular disease, chronic lung disease
MeSH terms: Animals, Hypoxia, DNA-Binding Proteins, Gene Expression Regulation, Humans, Mammals, Nuclear Proteins, Oxygen, Transcription Factors, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks