The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
Abstract
All organisms can sense O 2 concentration and respond to hypoxia with adaptive changes in gene expression. The large body size of mammals necessitates the development of multiple complex physiological systems to ensure adequate O 2 delivery to all cells under normal conditions. The transcriptional regulator hypoxia-inducible factor 1 (HIF-1) is an essential mediator of O 2 homeostasis. HIF-1 is required for the establishment of key physiological systems during development and their subsequent utilization in fetal and postnatal life. HIF-1 also appears to play a key role in the pathophysiology of cancer, cardiovascular disease, and chronic lung disease, which represent the major causes of mortality among industrialized societies. Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“ROS can damage TCA-cycle enzymes, especially aconitase and α-ketoglutarate dehydrogenase (62, 168, 249, 250, 277).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [277]
Citations
Cites
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
Self-citationThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,585
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Self-citationSemenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citationRole of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476
Self-citation(1999) · PubMed · Cited by 2,204
Self-citationHuang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094
Self-citation
Flagged first, then by citations
2 of the 83 references couldn’t be matched to a known paper.
Research works printed but not linked: 8
- Brizel DM, 1996, Cancer Res, 56, 941
- Feldser D, 1999, Cancer Res, 59, 3915
- Gu Y-Z, 1998, Gene Expr, 7, 205
- Hockel M, 1996, Cancer Res, 56, 4509
- Jiang B-H, 1997, Cancer Res, 57, 5328
- Ozaki H, 1999, Invest Ophthalmol Vis Sci, 40, 182
- Zhong H, 1998, Cancer Res, 58, 5280
- Zhong H, 1999, Cancer Res, 59, 5830
Cited by
Sorted by citations
Items 701–800 of 1,001
Oxygen and Cell Fate Decisions
Lin, Q., Kim, Y., Alarcon, R. M., & Yun, Z. (2008) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s434 · Cited by 40
Hypoxia-inducible factor-1α has a key role in hypoxic preconditioning
Taie, S., Ono, J., Iwanaga, Y., Tomita, S., Asaga, T., Chujo, K., & Ueki, M. (2009) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2008.09.024 · Cited by 40
Protocol of radiotherapy for glioblastoma according to the expression of HIF-1
Irie, N., Matsuo, T., & Nagata, I. (2004) · Brain Tumor Pathology · doi:10.1007/bf02482169 · Cited by 40
Postpneumonectomy lung expansion elicits hypoxia-inducible factor-1α signaling
Zhang, Q., Bellotto, D. J., Ravikumar, P., Moe, O. W., Hogg, R. T., Hogg, D. C., Estrera, A. S., Johnson, R. L., & Hsia, C. C. W. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00393.2006 · Cited by 40
Jiang, Y., Wang, J., TIAN, H., Li, G., Zhu, H., Liu, L., Hu, R., & Dai, A. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2209 · Cited by 41
Yadav, S., Kalra, N., Ganju, L., & Singh, M. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3082-1 · Cited by 40
Simintiras, C. A., Sánchez, J. M., McDonald, M., & Lonergan, P. (2019) · Scientific Reports · doi:10.1038/s41598-019-44040-6 · Cited by 42
Hypoxia-inducible factor (HIF) inhibitors: a patent survey (2016–2020)
Ban, H. S., Uto, Y., & Nakamura, H. (2021) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2021.1874345 · Cited by 40
Mairbäurl, H., Schwöbel, F., Höschele, S., Maggiorini, M., Gibbs, S., Swenson, E. R., & Bärtsch, P. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01156.2002 · Cited by 40
Does the tumor microenvironment influence radiation-induced apoptosis?
Hunter, A., Hendrikse, A., Renan, M. J., & Abratt, R. P. (2006) · APOPTOSIS · doi:10.1007/s10495-006-9789-1 · Cited by 40
Li, M. Y., Mi, C., Wang, K. S., Wang, Z., Zuo, H. X., Piao, L. X., Xu, G. H., Li, X., Ma, J., & Jin, X. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.06.029 · Cited by 41
Groot, A. J., Verheesen, P., Westerlaken, E. J., Gort, E. H., van der Groep, P., Bovenschen, N., van der Wall, E., van Diest, P. J., & Shvarts, A. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700395 · Cited by 40
Caenorhabditis elegans—a paradigm for aging research: advantages and limitations
Gershon, H. E., & Gershon, D. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00401-8 · Cited by 40
Prabhakar, N. R., Kumar, G. K., & Nanduri, J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05034.x · Cited by 39
Saboo, A., Rathnayake, A., Vangaveti, V., & Malabu, U. H. (2015) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2015.04.006 · Cited by 39
The Role of the Endometrium in Endocrine Regulation of the Animal Oestrous Cycle
Krzymowski, T., & Stefańczyk‐Krzymowska, S. (2007) · Reproduction in Domestic Animals · doi:10.1111/j.1439-0531.2007.00859.x · Cited by 39
Liu, Y., Liu, W.-C., Sun, Y., Shen, X., Wang, X., Shu, H., Pan, R., Liu, C., Liu, W., Liu, K. J., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9932-0 · Cited by 39
Lee, S., Kim, J.-S., Lee, M.-S., & Lee, H. (2016) · BMC Cancer · doi:10.1186/s12885-016-2730-2 · Cited by 39
Oh, S., Ok, S., Jung, T.-S., Jeon, S.-O., Park, J.-M., Jung, J.-W., & Ryu, D. (2017) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/j.apjtm.2017.08.017 · Cited by 39
Merelli, A., Ramos, A. J., Lazarowski, A., & Auzmendi, J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00750 · Cited by 38
Reactive Oxygen Species Drives Myocardial Angiogenesis?
Maulik, N. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2161 · Cited by 39
Liu, H., Kitazato, K. T., Uno, M., Yagi, K., Kanematsu, Y., Tamura, T., Tada, Y., Kinouchi, T., & Nagahiro, S. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283013b6e · Cited by 39
Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors
Warshakoon, N. C., Wu, S., Boyer, A. S., Kawamoto, R. M., Sheville, J., Bhatt, R. T., Renock, S., Xu, K., Pokross, M. E., Zhou, S., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.026 · Cited by 39
Meißner, U., Hänisch, C., Östreicher, I., Knerr, I., Hofbauer, K., Blum, W. F., Allabauer, I., Rascher, W., & Dötsch, J. (2004) · Endocrinology · doi:10.1210/en.2004-0782 · Cited by 39
The effect of hyperbaric oxygen on intracephalic angiogenesis in rats with intracerebral hemorrhage
Peng, Z., Yang, A., & Yang, Q. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.04.037 · Cited by 38
Non-Coding RNAs as Potential Neuroprotectants against Ischemic Brain Injury
Kaur, P., Liu, F., Tan, J., Lim, K. J., Sepramaniam, S., Karolina, D. S., Armugam, A., & Jeyaseelan, K. (2013) · Brain Sciences · doi:10.3390/brainsci3010360 · Cited by 38
Low-dose Radiation Induces Antitumor Effects and Erythrocyte System Hormesis
Yu, H., Liu, Z., Yu, X., Song, A., Liu, N., & Wang, H. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.7.4121 · Cited by 38
High altitude hypoxia: An intricate interplay of oxygen responsive macroevents and micromolecules
Sarkar, S., Banerjee, P. K., & Selvamurthy, W. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026080320034 · Cited by 39
Hypoxic stress‐induced changes in adrenergic function: role of HIF1α
Tai, T. C., Wong‐Faull, D. C., Claycomb, R., & Wong, D. L. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05978.x · Cited by 37
Gonidakis, S., Finkel, S. E., & Longo, V. D. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00618.x · Cited by 38
Li, X., Kimura, H., Hirota, K., Sugimoto, H., Kimura, N., Takahashi, N., Fujii, H., & Yoshida, H. (2007) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl766 · Cited by 39
Song, G., Kim, J., Bazer, F. W., & Spencer, T. E. (2008) · Endocrinology · doi:10.1210/en.2007-1530 · Cited by 43
Human pulmonary vascular responses to hypoxia and hypercapnia
Dorrington, K. L., & Talbot, N. P. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-004-1296-z · Cited by 38
Partridge, M. R. (2004) · Thorax · doi:10.1136/thx.2003.016451 · Cited by 38
Wang, J., Guise, C. P., Dachs, G. U., Phung, Y., Hsu, A., Lambie, N., Patterson, A. V., & Wilson, W. R. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.003 · Cited by 37
A novel treatment for glioblastoma: integrin inhibition
Chamberlain, M. C., Cloughsey, T., Reardon, D. A., & Wen, P. Y. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.188 · Cited by 37
Iwasaki, K., Yabushita, H., Ueno, T., & Wakatsuki, A. (2015) · Oncology Letters · doi:10.3892/ol.2015.3524 · Cited by 40
Li, X., Xing, J., Wang, H., & Yu, E. (2018) · Bioscience Reports · doi:10.1042/bsr20180268 · Cited by 37
Cheng, C.-C., Chi, P., Shen, M.-C., Shu, C., Wann, S., Liu, C., Tseng, C., & Huang, W. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061468 · Cited by 37
Pei, X., Chu, M., Tang, P., Zhang, H., Zhang, X., Zheng, X., Li, J., Mei, J., Wang, T., & Yin, S. (2021) · Fish Physiology and Biochemistry · doi:10.1007/s10695-021-00989-8 · Cited by 36
Ye, J., Tipoe, G. L., Fung, P. C. W., & Fung, M. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0785-1 · Cited by 37
Vascular endothelial growth factor in neonates with perinatal asphyxia
Aly, H. Z., Hassanein, S. M. A., Nada, A., Mohamed, M. H., Atef, S. H., & Atiea, W. (2008) · Brain and Development · doi:10.1016/j.braindev.2008.09.004 · Cited by 37
Kolyada, A. Y., Tighiouart, H., Perianayagam, M. C., Liangos, O., Madias, N. E., & Jaber, B. L. (2009) · Kidney International · doi:10.1038/ki.2009.68 · Cited by 37
Ischemic Preconditioning: A Novel Target for Neuroprotective Therapy
Blanco, M., Lizasoaín, I., Sobrino, T., Vivancos, J., & Castillo, J. (2006) · Cerebrovascular Diseases · doi:10.1159/000091702 · Cited by 37
Sheng, B., Liu, J., & Li, G. H. (2012) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2012.04.009 · Cited by 38
Paeng, S. H., Jung, W., Park, W. S., Lee, D.-S., Kim, G., Choi, Y. H., Seo, S., Jang, W. H., Choi, J. S., Lee, Y., et al. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2116 · Cited by 40
Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter
Zatyka, M., Morrissey, C., Kuzmin, I., Lerman, M. I., Latif, F., Richards, F. M., & Maher, E. R. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.7.463 · Cited by 37
Cho, S., Cho, S.-M., Park, E., Kim, B., Sohn, E. J., Oh, B., Lee, E., Lee, H., & Kim, S. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.03.084 · Cited by 36
Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC
Guo, Y., Wang, J., Zhou, K., Lv, J., Wang, L., Gao, S., Keller, E. T., Zhang, Z., Wang, Q., & Yao, Z. (2020) · The FASEB Journal · doi:10.1096/fj.201903266rr · Cited by 36
Song, X., Tang, Y., Zhu, J., Tian, Y., Song, Z.-H., Hu, X. F., Hong, C., Cai, Y., & Kang, F. (2020) · Tissue and Cell · doi:10.1016/j.tice.2020.101402 · Cited by 37
Long, G., Chen, H., Wu, M., Li, Y., Gao, L., Huang, S., Zhang, Y., Jia, Z., & Xia, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01191 · Cited by 36
Naidu, S. A. G., Wallace, T. C., Davies, K. J. A., & Naidu, A. S. (2021) · Journal of Dietary Supplements · doi:10.1080/19390211.2021.1922567 · Cited by 35
Interaction of mitochondrial potassium channels with the permeability transition pore
Cheng, Y., Dębska–Vielhaber, G., & Siemen, D. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.12.038 · Cited by 38
Chu, C.-Y., Cheng, C., Yang, C.-H., & Huang, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8231-y · Cited by 36
OASIS modulates hypoxia pathway activity to regulate bone angiogenesis
Cui, M., Kanemoto, S., Cui, X., Kaneko, M., Asada, R., Matsuhisa, K., Tanimoto, K., Yoshimoto, Y., Shukunami, C., & Imaizumi, K. (2015) · Scientific Reports · doi:10.1038/srep16455 · Cited by 37
Adaptation of the myoglobin knockout mouse to hypoxic stress
Schlieper, G., Kim, J.-H., Molojavyi, A., Jacoby, C., Laußmann, T., Flögel, U., Gödecke, A., & Schrader, J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00043.2003 · Cited by 36
Mortazavi-Haghighat, R., Khiabani, K. T., David, S., Kerrigan, C. L., & Philip, A. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00413.2001 · Cited by 36
Akanchise, T., & Angelova, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051562 · Cited by 37
Lee, C. S., Choi, E. Y., Lee, S. C., Koh, H. J., Lee, J. H., & Chung, J. H. (2015) · Yonsei Medical Journal · doi:10.3349/ymj.2015.56.6.1678 · Cited by 35
Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia–reperfusion injury
Yoshioka, J., & Lee, R. T. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2013.06.007 · Cited by 35
Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib
Serova, M., Tijeras‐Raballand, A., Santos, C. D., Martinet, M., Neuzillet, C., Lopez, A., Mitchell, D., Bryan, B. A., Gapihan, G., Janin, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9542 · Cited by 38
Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis
Kuang, Y., Han, X., Xu, M., & Yang, Q. (2018) · Cancer Medicine · doi:10.1002/cam4.1410 · Cited by 35
Akt phosphorylation is required for heat acclimation‐induced neuroprotection
Shein, N. A., Tsenter, J., Alexandrovich, A. G., Horowitz, M., & Shohami, E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04862.x · Cited by 35
Zhu, L., Ke, Y., Wu, X., Yang, L., Yang, L., & Ming, Q. Z. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21427 · Cited by 35
Parisi, Q., Biondi‐Zoccai, G., Abbate, A., Santini, D., Vasaturo, F., Scarpa, S., Bussani, R., Leone, A. M., Petrolini, A., Silvestri, F., et al. (2004) · International Journal of Cardiology · doi:10.1016/j.ijcard.2003.11.038 · Cited by 35
Forkel, J., Chen, X., Wandinger, S., Keser, F. D., Duschin, A., Schwanke, U., Frede, S., Massoudy, P., Schulz, R., Jakob, H. G., et al. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00022.2003 · Cited by 35
Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells
Sandbichler, A. M., Jansen, B., Peer, B. A., Paulitsch, M., Pelster, B., & Egg, M. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489058 · Cited by 35
Antiangiogenics and radiotherapy
Shannon, A. M., & Williams, K. J. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.8.0009 · Cited by 35
Ciafrè, S. A., Niola, F., Giorda, E., Farace, M. G., & Caporossi, D. (2006) · Free Radical Research · doi:10.1080/10715760601096799 · Cited by 35
Hypoxia-Regulated Angiogenic Inhibitors
Messmer-Blust, A. F., An, X., & Li, J. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.02.006 · Cited by 34
Gonsalves, C. S., Li, C., Mpollo, M. E. M., Pullarkat, V. A., Malik, P., Tahara, S. M., & Kalra, V. K. (2015) · Biochemical Journal · doi:10.1042/bj20141138 · Cited by 33
HYPOXIA AND REPRODUCTIVE HEALTH: The presence and role of hypoxia in the endometrium
Martínez-Aguilar, R., Kershaw, L. E., Reavey, J. J., Critchley, H., & Maybin, J. A. (2020) · Reproduction · doi:10.1530/rep-20-0268 · Cited by 34
Han, X., Zhang, W., Wang, Q. L., Li, M., Zhang, C., Yang, Z., Tan, R., Gan, L., Zhang, L.-L., Lan, X., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17003 · Cited by 35
Role of Exercise Intensity on Th1/Th2 Immune Modulations During the COVID-19 Pandemic
Supriya, R., Gao, Y., Gu, Y., & Baker, J. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.761382 · Cited by 33
The Role of Imaging Biomarkers to Guide Pharmacological Interventions Targeting Tumor Hypoxia
Gallez, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.853568 · Cited by 35
Expression of hypoxia-inducible factor 1 alpha ameliorate myocardial ischemia in rat
Jianqiang, P., Ping, Z., Xinmin, F., Yuan, Z., Ming, Z., & Guo, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.046 · Cited by 35
Investigation of hypoxia‐inducible factor‐1α in hippocampal sclerosis: A postmortem study
Feast, A. R., Martinian, L., Liu, J. Y. W., Catarino, C. B., Thom, M., & Sisodiya, S. M. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03591.x · Cited by 34
Development of a novel antimicrobial peptide, AG‐30, with angiogenic properties
Nishikawa, T., Hironori Nakagami, A., Maeda, A., Morishita, R., Miyazaki, N., Ogawa, T., Tabata, Y., Kikuchi, Y., Hayashi, H., Tatsu, Y., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00341.x · Cited by 34
Experimental strategies to improve in vitro models of renal ischemia
Russ, A. L., Haberstroh, K. M., & Rundell, A. E. (2007) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2007.03.002 · Cited by 34
López-Reyes, A. G., Rodrı́guez-Pérez, J. M., Fernández‐Torres, J., Martínez‐Rodríguez, N., Pérez‐Hernández, N., Fuentes-Gómez, A. J., Aguilar-González, C. A., Álvarez-León, E., Posadas‐Romero, C., Villarreal-Molina, M. T., et al. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.04.010 · Cited by 34
Xiaojian, N., Yingchun, Z., Ma, J., Xia, T., Xiaoan, L., Qiang, D., Xiaoming, Z., & Shui, W. (2013) · Journal of Biomedical Research · doi:10.7555/jbr.27.20130021 · Cited by 34
Ergorul, C., Ray, A., Huang, W. C., Darland, D. C., Luo, Z. K., & Grosskreutz, C. L. (2008) · PubMed Central · Cited by 34
Sproul, A. D., Steele, S. L., Thai, T. L., Yu, S.-P., Klein, J. D., Sands, J. M., & Bell, P. D. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00666.2010 · Cited by 35
Adverse Intrauterine Environment and Cardiac miRNA Expression
Lock, M. C., Botting, K. J., Tellam, R. L., Brooks, D. A., & Morrison, J. L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122628 · Cited by 35
Oxygen in wound healing: More than a nutrient
Davidson, J. D., & Mustoe, T. A. (2001) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2001.00175.x · Cited by 34
Ke, Q., Kluz, T., & Costa, M. (2005) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph2005010010 · Cited by 34
Gene Transfer for Therapeutic Vascular Growth in Myocardial and Peripheral Ischemia
Rissanen, T. T., Rutanen, J., & Ylä‐Herttuala, S. (2004) · Advances in genetics · doi:10.1016/s0065-2660(04)52004-7 · Cited by 35
Hida, W., Tun, Y., Kikuchi, Y., Okabe, S., & Shirato, K. (2002) · Respirology · doi:10.1046/j.1440-1843.2002.00366.x · Cited by 34
The dance of macrophage death: the interplay between the inevitable and the microenvironment
Makuch, M., Stepanechko, M., & Bzowska, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1330461 · Cited by 35
Flight‐induced changes in gene expression in the Glanville fritillary butterfly
Kvist, J., Mattila, A. L. K., Somervuo, P. J., Ahola, V., Koskinen, P., Paulin, L. G., Salmela, L., Fountain, T., Rastas, P. M. A., Ruokolainen, A., et al. (2015) · Molecular Ecology · doi:10.1111/mec.13359 · Cited by 32
Baze, M. M., Hunter, K. W., & Hayes, J. P. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.054544 · Cited by 33
Chen, S., Fang, X., Wang, Q., Wang, S., Hu, Z., Zhou, Z., Xu, W., Wang, J., Qin, A., & Fan, S.-W. (2016) · Laboratory Investigation · doi:10.1038/labinvest.2016.32 · Cited by 33
Zhao, X., & Yu, C.-Z. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.05.011 · Cited by 33
Sundaram, R. L., Sali, V. K., & Vasanthi, H. R. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.09.229 · Cited by 33
Circadian-Hypoxia Link and its Potential for Treatment of Cardiovascular Disease
Bartman, C. M., & Eckle, T. D. L. G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190516081612 · Cited by 33
Jia, Y., Gao, Y., Wan, J., Gao, Y., Li, J., & Guan, C. (2021) · Fish Physiology and Biochemistry · doi:10.1007/s10695-021-00970-5 · Cited by 33
Wu, D., Liu, Y., Chen, W., Shao, J., Zhuoma, P., Zhao, D., Yu, Y., Liu, T., Yu, R., Gan, Y., et al. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac120 · Cited by 33
Gong, G., Hu, L., LIU, Y., Bai, S., Dai, X., YIN, L., Sun, Y., Wang, X., & Hou, L. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1850 · Cited by 31
HIF-1αmRNA gene expression levels in improved diagnosis of early stages of prostate cancer
Pipinikas, C., Carter, N. D., Corbishley, C. M., & Fenske, C. D. (2008) · Biomarkers · doi:10.1080/13547500802591992 · Cited by 33
Xu, X., Chen, P., Zheng, Q., Wang, Y., & Chen, W. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.03.019 · Cited by 34
Metadata
- Authors
- Semenza, G. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Semenza, Gregg L.
- ORCID
- Semenza, Gregg L.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-04-01
- Volume
- 88
- Issue
- 4
- Pages
- 1474-1480
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2143343444
- Cited by
- 1,822
- References
- 83
- Citations by year
- 2026: 28 · 2025: 54 · 2024: 53 · 2023: 55 · 2022: 67 · 2021: 77 · 2020: 62 · 2019: 55 · 2018: 76 · 2017: 85 · 2016: 78 · 2015: 83 · 2014: 72 · 2013: 78 · 2012: 74
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk039869-16)
- National Heart, Lung, and Blood Institute (R01HL55338, R01HL055338)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK39869)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- HIF-1, hypoxia, oxygen homeostasis, oxygen sensing, transcriptional regulation, gene expression, fetal development, postnatal development, cancer, cardiovascular disease, chronic lung disease
- MeSH terms
- Animals, Hypoxia, DNA-Binding Proteins, Gene Expression Regulation, Humans, Mammals, Nuclear Proteins, Oxygen, Transcription Factors, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review