HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α

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Untitled work

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Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway

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Purification and Characterization of Hypoxia-inducible Factor 1

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Arsenic trioxide inhibits the growth of human lung cancer cell lines via cell cycle arrest and induction of apoptosis at both normoxia and hypoxia

Ge-ping, Q., Xiu, Q., Li, B., Yong-an, L., & Lingzhen, Z. (2009) · Toxicology and Industrial Health · doi:10.1177/0748233709345936 · Cited by 33

Interleukin-17 upregulates vascular endothelial growth factor by activating the JAK/STAT pathway in nucleus pulposus cells

Hu, B., Wang, J., Wu, X., Chen, Y., Yuan, W., & Chen, H. (2016) · Joint Bone Spine · doi:10.1016/j.jbspin.2016.05.014 · Cited by 33

Long-Term Regulation of Carotid Body Function: Acclimatization and Adaptation – Invited Article

Prabhakar, N. R., Peng, Y., Kumar, G. K., Nanduri, J., Giulio, C. D., & Lahiri, S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-2259-2_35 · Cited by 32

Tissue-specific transcriptional regulation of monocarboxylate transporters (MCTs) during short-term hypoxia in zebrafish (Danio rerio)

Ngan, A. K., & Wang, Y. S. (2009) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2009.08.003 · Cited by 32

The protein level of hypoxia‐inducible factor‐1α is increased in the plateau pika (Ochotona curzoniae) inhabiting high altitudes

Li, H., Ren, Y., Guo, S., Cheng, L., Wang, D., Yang, J., Chang, Z., & Zhao, X. (2008) · Journal of Experimental Zoology Part A Ecological Genetics and Physiology · doi:10.1002/jez.510 · Cited by 31

Nuclear respiratory factor‐1 (NRF‐1) regulated hypoxia‐inducible factor‐1α (HIF‐1α) under hypoxia in HEK293T

Wang, D., Zhang, J., Lu, Y., Luo, Q., & Zhu, L. X. (2016) · IUBMB Life · doi:10.1002/iub.1537 · Cited by 32

Enzyme-immobilized hydrogels to create hypoxia for in vitro cancer cell culture

Dawes, C. S., Koenig, H., & Lin, C. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.03.007 · Cited by 32

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells

Tao, B., Wang, R., Sun, C., & Zhu, Y. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00657 · Cited by 32

Un viaje entre la hipoxia de la gran altitud y la hipoxia del enfermo crítico: ¿qué puede enseñarnos en la compresión y manejo de las enfermedades críticas?

Chavala, M. L. A. (2017) · Medicina Intensiva · doi:10.1016/j.medin.2017.08.006 · Cited by 32

Metabo-Devo: A metabolic perspective of development

Gándara, L., & Wappner, P. (2018) · Mechanisms of Development · doi:10.1016/j.mod.2018.02.004 · Cited by 31

Hypoxia in Lung Cancer Management: A Translational Approach

Ancel, J., Perotin, J., Dewolf, M., Launois, C., Mulette, P., Nawrocki‐Raby, B., Dalstein, V., Gilles, C., Deslée, G., Polette, M., et al. (2021) · Cancers · doi:10.3390/cancers13143421 · Cited by 32

Phenotypic and genomic adaptations to the extremely high elevation in plateau zokor (Myospalax baileyi)

Zhang, T., Chen, J., Zhang, J., Guo, Y., Zhou, X., Li, M., Zheng, Z., Zhang, T., Murphy, R. W., Nevo, E., et al. (2021) · Molecular Ecology · doi:10.1111/mec.16174 · Cited by 33

Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum

Schlisio, S. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00881.x · Cited by 33

Hypoxia Signature of Splice Forms of Tryptophanyl-tRNA Synthetase Marks Pancreatic Cancer Cells With Distinct Metastatic Abilities

Paley, E. L., Paley, D. E., Merkulova‐Rainon, T., & Subbarayan, P. R. (2011) · Pancreas · doi:10.1097/mpa.0b013e318222e635 · Cited by 32

Characterization of the Activation of Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) by Hypoxia Inducible Factor-2 Alpha

Wang, V., Davis, D. A., Veeranna, R. P., Haque, M., & Yarchoan, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009641 · Cited by 32

Targeting HIF-1 α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?

Sethi, K. D., Rao, K., Bolton, D. M., Patel, O., & Ischia, J. J. (2018) · International Journal of Cell Biology · doi:10.1155/2018/9852791 · Cited by 32

Cardiolipin remodeling in Barth syndrome and other hereditary cardiomyopathies

Bertero, E., Kutschka, I., Maack, C., & Dudek, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165803 · Cited by 30

Role of the lysyl oxidase family in organ development (Review)

Wei, S., Gao, L., Wu, C., Qin, F., & Yuan, J. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8731 · Cited by 34

Prolonged fasting activates hypoxia inducible factors-1α, -2α and -3α in a tissue-specific manner in northern elephant seal pups

Soñanez‐Organis, J. G., Vázquez‐Medina, J. P., Crocker, D. E., & Ortiz, R. M. (2013) · Gene · doi:10.1016/j.gene.2013.05.004 · Cited by 33

Hypoxia regulates PGE2 release and EP1 receptor expression in osteoblastic cells

Lee, C. M., Genetos, D. C., You, Z., & Yellowley, C. E. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21017 · Cited by 31

Echinomycin in the prevention of heterotopic ossification – An experimental antibiotic agent shows promising results in a murine model

Zimmermann, S. M., Würgler‐Hauri, C. C., Wanner, G. A., Simmen, H., & Werner, C. M. L. (2013) · Injury · doi:10.1016/j.injury.2012.12.030 · Cited by 31

Dynamic mRNA and miRNA expression analysis in response to hypoxia and reoxygenation in the blunt snout bream (Megalobrama amblycephala)

Sun, S., Xuan, F., Ge, X., Zhu, J. X., & Zhang, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-12537-7 · Cited by 31

HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta

Smeyne, M., Sladen, P. E., Jiao, Y., Dragatsis, I., & Smeyne, R. J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.015 · Cited by 32

Chronic hypoxia and VEGF differentially modulate abundance and organization of myosin heavy chain isoforms in fetal and adult ovine arteries

Hubbell, M. C., Semotiuk, A., Thorpe, R. B., Adeoye, O. O., Butler, S. M., Williams, J. M., Khorram, O., & Pearce, W. J. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00408.2011 · Cited by 30

SDF-1α/CXCR4 Axis Mediates The Migration of Mesenchymal Stem Cells to The Hypoxic-Ischemic Brain Lesion in A Rat Model.

Yu, Q., Liu, L., Lin, J., Wang, Y., Xuan, X., Guo, Y., & Hu, S. (2015) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2015.504 · Cited by 30

Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma

Gao, Y., Liu, B., Feng, L., Sun, B., He, S., Yang, Y., Wu, G., Guoji, E., Liu, C., Gao, Y., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00033 · Cited by 30

Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study

Fernández‐Torres, J., Hernández‐Díaz, C., Espinosa-Morales, R., Camacho-Galindo, J., Galindo-Sevilla, N., López-Macay, Á., Zamudio-Cuevas, Y. E., Martínez‐Flores, K., Santamaría‐Olmedo, M., Pineda, C., et al. (2015) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-015-0678-z · Cited by 30

Sirtuin 3 Deficiency Does Not Augment Hypoxia-Induced Pulmonary Hypertension

Waypa, G. B., Osborne, S. W., Marks, J. D., Berkelhamer, S. K., Kondapalli, J., & Schumacker, P. T. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0191oc · Cited by 32

Hipoxia tumoral. Papel del factor inducible por hipoxia

Fraga, A. M., Ribeiro, R. J. T., & Medeiros, R. (2009) · Actas Urológicas Españolas · doi:10.1016/s0210-4806(09)72891-8 · Cited by 37

Coexistence of Hypercholesterolemia and Hypertension Impairs Adventitial Vascularization

Kai, H., Kuwahara, F., Tokuda, K., Shibata, R., Kusaba, K., Niiyama, H., Tahara, N., Nagata, T., & Imaizumi, T. (2002) · Hypertension · doi:10.1161/hy0202.103001 · Cited by 30

Effects of exposure to a simulated altitude of 5500 m on energy metabolic pathways in rats

Ou, L. C., & Leiter, J. C. (2004) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2004.04.001 · Cited by 30

Parabronchial remodeling in chicks in response to embryonic hypoxia

Amaral‐Silva, L., Lambertz, M., Zara, F. J., Klein, W., Gargaglioni, L. H., & Bícego, K. C. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.197970 · Cited by 29

Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targets

Nisar, A., Khan, S., Li, W., Hu, L., Samarawickrama, P. N., Gold, N. M., Zi, M., Mehmood, S. A., Miao, J., & He, Y. (2024) · MedComm · doi:10.1002/mco2.786 · Cited by 33

Physiological Mechanisms of Treatment Resistance

Vaupel, P. W. (2009) · Medical radiology · doi:10.1007/978-3-540-74386-6_15 · Cited by 28

Hypoxia and Hypoxia Mimetics Decrease Aquaporin 5 (AQP5) Expression through Both Hypoxia Inducible Factor-1α and Proteasome-Mediated Pathways

Kawedia, J. D., Yang, F., Sartor, M. A., Gozal, D., Czyzyk-Krzeska, M., & Menon, A. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057541 · Cited by 29

Tumor Hypoxia As an Enhancer of Inflammation-Mediated Metastasis: Emerging Therapeutic Strategies

DiGiacomo, J. W., & Gilkes, D. M. (2018) · Targeted Oncology · doi:10.1007/s11523-018-0555-4 · Cited by 29

Hypoxia-inducible factor (HIF)-1alpha knockout accelerates intervertebral disc degeneration in mice.

Meng, X., Zhuang, L., Wang, J., Liu, Z., Wang, Y., Xiao, D., & Zhang, X. (2018) · PubMed Central · Cited by 29

Troxerutin attenuates oxygen‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes

Yu, Z., Yu, H., Li, J., Li, C., Hua, X., & Sheng, X. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11207 · Cited by 29

YAP nuclear translocation induced by HIF-1α prevents DNA damage under hypoxic conditions

Chang, H.-A., Yang, R.-Z. O., Su, J.-M., Nguyen, T. M. H., Sung, J., Tang, M., & Chiu, W. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01687-5 · Cited by 29

Simvastatin treatment inhibits hypoxia inducible factor 1-alpha-(HIF-1alpha)-prolyl-4-hydroxylase 3 (PHD-3) and increases angiogenesis after myocardial infarction in streptozotocin-induced diabetic rat

Thirunavukkarasu, M., Selvaraju, V., Dunna, N. R., Foye, J. L. C., Joshi, M., Otani, H., & Maulik, N. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.03.005 · Cited by 29

Insight into Hypoxia Tolerance in Cowpea Bruchid: Metabolic Repression and Heat Shock Protein Regulation via Hypoxia-Inducible Factor 1

Ahn, J., Zhou, X. Y., Dowd, S. E., Chapkin, R. S., & Zhu‐Salzman, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057267 · Cited by 29

Hypoxia inducible factor-1α expression is associated with hippocampal apoptosis during epileptogenesis

Long, Q., Fan, C., Kai, W., Luo, Q., Xin, W., Wang, P., Wang, A., Wang, Z., Han, R., Fei, Z., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.028 · Cited by 29

Regulation of gene expression for neurotransmitters during adaptation to hypoxia in oxygen‐sensitive neuroendocrine cells

Paulding, W. R., Schnell, P. O., Bauer, A. L., Striet, J. B., Nash, J. A., Kuznetsova, A. V., & Czyzyk-Krzeska, M. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10192 · Cited by 29

Repair and regeneration of the human endometrium

Maybin, J. A., & Critchley, H. (2009) · Expert Review of Obstetrics & Gynecology · doi:10.1586/eog.09.6 · Cited by 29

Therapeutic Targeting of Cancer Cell Metabolism: Role of Metabolic Enzymes, Oncogenes and Tumor Suppressor Genes

Majeed, R., & Hamid, A. (2012) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000156 · Cited by 28

A3 adenosine receptor agonist, CF102, protects against hepatic ischemia/reperfusion injury following partial hepatectomy

Ohana, G., Cohen, S., Rath‐Wolfson, L., & Fishman, P. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5746 · Cited by 29

Signaling mediators modulated by cardioprotective interventions in healthy and diabetic myocardium with ischaemia–reperfusion injury

Feyzizadeh, S., Javadi, A., Badalzadeh, R., & Vafaee, M. S. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318756420 · Cited by 29

A Simple and Effective Sample Preparation Strategy for MALDI-MS Imaging of Neuropeptide Changes in the Crustacean Brain Due to Hypoxia and Hypercapnia Stress

Buchberger, A. R., Vu, N. Q., Johnson, J., DeLaney, K., & Li, L. (2020) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.9b00107 · Cited by 31

Promoter activity and regulation of the corneal CYP4B1 gene by hypoxia

Mastyugin, V., Mezentsev, A., Zhang, W., Ashkar, S., Dunn, M. W., & Schwartzman, M. L. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20018 · Cited by 29

Capillary supply and gene expression of angiogenesis‐related factors in murine skeletal muscle following denervation

Wagatsuma, A., Tamaki, H., & Ogita, F. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2004.029769 · Cited by 29

Expression of hypoxia-inducible factor-1 in the cochlea of newborn rats

Gross, J., Rheinländer, C., Fuchs, J., Mazurek, B., Machulik, A., Andreeva, N., & Kietzmann, T. (2003) · Hearing Research · doi:10.1016/s0378-5955(03)00222-3 · Cited by 29

Therapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi?

Simons, M. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.5.h1923 · Cited by 29

Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes

Zera, K. A., & Zastre, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186707 · Cited by 29

Periodization and Programming for Individual 400 m Medley Swimmers

Hermosilla-Perona, F., González‐Ravé, J. M., Castillo, J. A. D., & Pyne, D. B. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18126474 · Cited by 31

Physiological Responses to Hypoxia on Triglyceride Levels

Morin, R., Goulet, N., Mauger, J., & Imbeault, P. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.730935 · Cited by 28

Hypoxia-inducible adrenomedullin accelerates hepatocellular carcinoma cell growth

Park, S. C., Yoon, J., Lee, J., Yu, S. J., Myung, S. J., Kim, W. K., Gwak, G., Lee, S., Lee, S.-M., Jang, J. J., et al. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.06.019 · Cited by 28

Ischemic tolerance in the brain

Kapinya, K. J. (2005) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.92.2005.1.9 · Cited by 28

ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1α (HIF-1α) Binding and Mediates HIF-1α Expression by Bafilomycin A1

Lim, J.-H., Park, J., Kim, S. J., Kim, M.-S., Park, S.-K., Johnson, R. S., & Chun, Y. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030296 · Cited by 28

Hypoxia-inducible factor-1: A possible link between inhalational anesthetics and tumor progression?

Zhao, H., Iwasaki, M., Yang, J., Savage, S., & Ma, D. (2014) · Acta anaesthesiologica Taiwanica · doi:10.1016/j.aat.2014.05.008 · Cited by 28

Anti-apoptotic effects of Z α1-antitrypsin in human bronchial epithelial cells

Greene, C. M., Miller, S. D. W., Carroll, T. P., Oglesby, I. K., Ahmed, F., O'Mahony, M., Taggart, C. C., McElvaney, N. G., & O'Neill, S. J. (2009) · European Respiratory Journal · doi:10.1183/09031936.00191908 · Cited by 28

Sex-related dimorphic response of HIF-1α expression in myocardial ischemia

Zampino, M., Yuzhakova, M., Hansen, J., McKinney, R. D., Goldspink, P. H., Geenen, D. L., & Buttrick, P. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00580.2005 · Cited by 27

Live high, train low – influence on resting and post‐exercise hepcidin levels

Govus, A. D., Peeling, P., Abbiss, C. R., Lawler, N. G., Swinkels, D. W., Laarakkers, C. M., Thompson, K., Peiffer, J. J., Gore, C. J., & Garvican‐Lewis, L. A. (2016) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12685 · Cited by 28

Pharmacological effects of asiatic acid in glioblastoma cells under hypoxia

Thakor, F. K., Wan, K., Welsby, P. J., & Welsby, G. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-2965-5 · Cited by 29

Effect of extract of Pueraria tuberosa on expression of hypoxia inducible factor-1α and vascular endothelial growth factor in kidney of diabetic rats

Shukla, R., Pandey, N., Banerjee, S., & Tripathi, Y. B. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.045 · Cited by 28

A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice

Ciarlillo, D., Céleste, C., Carmeliet, P., Boerboom, D., & Theoret, C. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180586 · Cited by 28

Hypoxic adaptations of hemoglobin in Tibetan chick embryo: High oxygen-affinity mutation and selective expression

Gou, X., Li, N., Lian, L., Yan, D., Zhang, H., Wei, Z. H., & Wu, C. (2007) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2006.11.031 · Cited by 28

Ascochlorin inhibits growth factor‐induced HIF‐1α activation and tumor‐angiogenesis through the suppression of EGFR/ERK/p70S6K signaling pathway in human cervical carcinoma cells

Jeong, J.-H., Jeong, Y., Cho, H., Shin, J., Kang, J. H., Park, K., Park, Y., Chung, I., Chang, H., Magae, J., et al. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24001 · Cited by 28

New Molecular Mechanisms of Duodenal Ulceration

Szabó, S., Deng, X., Khomenko, T., Chen, L., Tolstanova, G. M., Ősapay, K., Sandor, Z., & Xiong, X. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1391.033 · Cited by 27

Hypoxia inducible factor-1: regulation by nitric oxide in posthypoxic microvascular endothelium

Natarajan, R., Jones, D. G., Fisher, B. J., Wallace, T. J., Ghosh, S., & Fowler, A. A. (2005) · Biochemistry and Cell Biology · doi:10.1139/o05-047 · Cited by 28

Von Hippel-Lindau Disease: Genetic and Clinical Observations

Iliopoulos, O. (2001) · KARGER eBooks · doi:10.1159/000061052 · Cited by 27

Mechanisms of Postischemic Stroke Angiogenesis: A Multifaceted Approach

Hu, B., Pei, J., Wan, C., Liu, S., Xu, Z., Zou, Y., Li, Z., & Tang, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s461427 · Cited by 27

Recent advances in ophthalmic molecular imaging

de Carvalho, E. R., Verbraak, F. D., Aalders, M. C. G., Noorden, C. J. F. V., & Schlingemann, R. O. (2013) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2013.09.005 · Cited by 27

Comparative transcriptome analysis of the swimbladder reveals expression signatures in response to low oxygen stress in channel catfish,Ictalurus punctatus

Yang, Y., Fu, Q., Wang, X., Liu, Y., Zeng, Q., Li, Y., Gao, S., Bao, L., Liu, S., Gao, D., et al. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00125.2017 · Cited by 27

Modulation of hypoxia-inducible factor-1α/cyclo-oxygenase-2 pathway associated with attenuation of intestinal mucosa inflammatory damage by Acanthopanax senticosus polysaccharides in lipopolysaccharide-challenged piglets

Fan, C., Han, J., Liu, X., Zhang, F., Long, Y., & Xie, Q. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519001363 · Cited by 27

Hypoxic environment may enhance migration/penetration of endocrine resistant MCF7- derived breast cancer cells through monolayers of other non-invasive cancer cells in vitro

Barrak, N. H., Khajah, M. A., & Luqmani, Y. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-58055-x · Cited by 29

Effects of Intermittent Hypoxia in Training Regimes and in Obstructive Sleep Apnea on Aging Biomarkers and Age-Related Diseases: A Systematic Review

Tessema, B., Sack, U., König, B., Serebrovska, Z. O., & Egorov, E. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.878278 · Cited by 29

siRNA targeting HIF-1alpha induces apoptosis of pancreatic cancer cells through NF-kappaB-independent and -dependent pathways under hypoxic conditions.

Chen, C., & Yu, Z. (2009) · PubMed · Cited by 27

HIF-1–Dependent Stromal Adaptation to Ischemia Mediates In Vivo Tumor Radiation Resistance

Schwartz, D. L., Bankson, J. A., Bidaut, L. M., He, Y., Williams, R. R., Lemos, R., Thitai, A. K., Oh, J., Volgin, A., Soghomonyan, S., et al. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0469 · Cited by 27

Levels and patterns of expression of hypoxia‐inducible factor‐1α, vascular endothelial growth factor, glucose transporter‐1 and CD105 in adenoid cystic carcinomas with high‐grade transformation

Costa, A. F., Tasso, M. G., Mariano, F. V., Soares, A. B., Chone, C. T., Crespo, A. N., Fresno, M., Llorente, J. L., Suarez, C. M., de Araújo, V. C., et al. (2012) · Histopathology · doi:10.1111/j.1365-2559.2011.04128.x · Cited by 26

Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer

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Enhancement of radiotherapy efficacy by pleiotropic liposomes encapsulated paclitaxel and perfluorotributylamine

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The impact of hypoxia on the activity of lactate dehydrogenase in two different pre-clinical tumour models

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Autofluorescence spectroscopy of rat liver during experimental transplantation procedure. An approach for hepatic metabolism assessment

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Transcriptomic responses of juvenile Pacific whiteleg shrimp,Litopenaeus vannamei, to hypoxia and hypercapnic hypoxia

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Increased HIF‐1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides

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FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential Anti-Angiogenic Factor during Zebrafish Vascular Development

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Cell-Autonomous and Non-Cell-Autonomous Neuroprotective Functions of RORα in Neurons and Astrocytes during Hypoxia

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RNA‐binding protein, human antigen R regulates hypoxia‐induced autophagy by targeting ATG7/ATG16L1 expressions and autophagosome formation

Palanisamy, K., Tsai, T., Yu, T., Sun, K., Yu, S., Lin, F., Wang, I., & Li, C. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27502 · Cited by 26

Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells

Kim, A., & Yeul, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01455 · Cited by 26

Dietary GABA enhances hypoxia tolerance of a bottom-dwelling carp, Cirrhinus mrigala by modulating HIF-1α, thyroid hormones and metabolic responses

Varghese, T., Rejish Kumar, V. J., Anand, G., Dasgupta, S., & Pal, A. K. (2019) · Fish Physiology and Biochemistry · doi:10.1007/s10695-019-00708-4 · Cited by 26

SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen‑receptor‑positive breast cancer

Törnroos, R., Tina, E., & Eremo, A. G. (2021) · Oncology Reports · doi:10.3892/or.2021.8228 · Cited by 26

Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases

Diaz, S., Wang, K., Sjögren, B., & Liu, X. (2022) · Biomolecules · doi:10.3390/biom12030416 · Cited by 27

Cyclic processes in the uterine tubes, endometrium, myometrium, and cervix: pathways and perturbations

Holdsworth‐Carson, S. J., Menkhorst, E. M., Maybin, J. A., King, A., & Girling, J. E. (2023) · Molecular Human Reproduction · doi:10.1093/molehr/gaad012 · Cited by 28

Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy.

Chng, C. L., Lai, O. F., Chew, C. S.-M., Peh, Y. P., Fook-Chong, S. M. C., Seah, L. L., & Khoo, D. H. C. (2014) · PubMed Central · doi:10.3980/j.issn.2222-3959.2014.03.03 · Cited by 26

Delayed myocardial preconditioning induced by cobalt chloride in the rat: HIF‐1α and iNOS involvement

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Valproic acid overcomes hypoxia-induced resistance to apoptosis

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Growth patterns of the heart and kidney suggest inter-organ collaboration in facultative fetal growth

Lampl, M., Kuzawa, C. W., & Jeanty, P. (2005) · American Journal of Human Biology · doi:10.1002/ajhb.20109 · Cited by 26

High-intensity interval and endurance training are associated with divergent skeletal muscle adaptations in a rodent model of hypertension

Holloway, T. M., Bloemberg, D., da Silva, M. L., Quadrilatero, J., & Spriet, L. L. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00048.2015 · Cited by 27

UVB induces a biphasic response of HIF‐1α in cultured human keratinocytes

Wunderlich, L., Paragh, G., Wikonkál, N. M., Bánhegyi, G., Kárpáti, S., & Mandl, J. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00640.x · Cited by 27

Hypoxia-Inducible Factor-1 Alpha in the Heart

Hashmi, S., & Al‐Salam, S. (2012) · Cardiology in Review · doi:10.1097/crd.0b013e31826287f6 · Cited by 26

HIF-1: a key mediator in hypoxia (Review)

Adams, J., DiFazio, L. T., Rolandelli, R. H., Luján, J., Haskó, G., Csóka, B., Selmeczy, Z., & Németh, Z. H. (2009) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.96.2009.1.2 · Cited by 152

Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

Semenza, G. L., Agani, F., Feldser, D., Lyer, N., Kotch, L., Laughner, E., & Yu, 1. (2006) · Advances in Experimental Medicine and Biology · doi:10.1007/0-306-46825-5_12 · Cited by 241

Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (2009) · Physiology · doi:10.1152/physiol.00045.2008 · Cited by 926

Life with Oxygen

Semenza, G. L. (2007) · Science · doi:10.1126/science.1147949 · Cited by 706