HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

The Biology of Vascular Endothelial Growth Factor

Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,585

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617

Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502

Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476

Untitled work

(1999) · PubMed · Cited by 2,204

Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathway

Huang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094

S-nitrosylation: a potential new paradigm in signal transduction

Martı́nez-Ruiz, A. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.013 · Cited by 255

Hypoxia induces lytic replication of Kaposi sarcoma–associated herpesvirus

Davis, D. A., Rinderknecht, A. S., Zoeteweij, J. P., Aoki, Y., Read-Connole, E., Tosato, G., Blauvelt, A., & Yarchoan, R. (2001) · Blood · doi:10.1182/blood.v97.10.3244 · Cited by 254

Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease

Wouters, E. F. �. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200408-039ms · Cited by 256

Hypoxia-Inducible Factor-1α Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

Generali, D., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., Wigfield, S., Bersiga, A., Allevi, G., Milani, M., Aguggini, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2690 · Cited by 253

Iron in multiple sclerosis: roles in neurodegeneration and repair

Stephenson, E. L., Nathoo, N., Mahjoub, Y., Dunn, J. F., & Yong, V. W. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.118 · Cited by 253

Roxadustat (FG-4592)

Besarab, A., Chernyavskaya, E. A., Motylev, I., Shutov, E. V., Kumbar, L. M., Gurevich, K., Chan, D. T. M., Leong, R., Poole, L., Zhong, M., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015030241 · Cited by 250

HIF-1: Using Two Hands to Flip the Angiogenic Switch

Semenza, G. L. (2000) · Cancer and Metastasis Reviews · doi:10.1023/a:1026544214667 · Cited by 251

Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression

Fandrey, J. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00577.2003 · Cited by 243

Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function

Jackson, M. J. (2002) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00018-3 · Cited by 238

Role of Hypoxia-Inducible Factor 1 in Gastric Cancer Cell Growth, Angiogenesis, and Vessel Maturation

Stoeltzing, O., McCarty, M. F., Wey, J. S., Fan, F., Liu, W., Belcheva, A., Bucana, C. D., Semenza, G. L., & Ellis, L. M. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh168 · Cited by 240

Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1α

Welsh, S., Williams, R., Kirkpatrick, L., Paine-Murrieta, G., & Powis, G. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.233.3.3 · Cited by 240

Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (pfkfb-1-4) expression in vivo

Minchenko, O., Opentanova, I., & Caro, J. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01179-7 · Cited by 236

Exercise and Blood Flow Restriction

Pope, Z. K., Willardson, J. M., & Schoenfeld, B. J. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3182874721 · Cited by 236

Preparation for oxidative stress under hypoxia and metabolic depression: Revisiting the proposal two decades later

Hermes‐Lima, M., Moreira, D. C., Rivera‐Ingraham, G. A., Giraud‐Billoud, M., Genaro‐Mattos, T. C., & Campos, E. G. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.156 · Cited by 246

Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts

Zoll, J., Ponsot, E., Dufour, S. P., Doutreleau, S., Ventura‐Clapier, R., Vogt, M., Hoppeler, H. H., Richard, R., & Flück, M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00359.2005 · Cited by 232

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

Talib, W. H., Alsayed, A. R., Barakat, M. M., Abu-Taha, M. I., & Mahmod, A. I. (2021) · Biomedicines · doi:10.3390/biomedicines9101353 · Cited by 272

Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways

Bazer, F. W., Burghardt, R. C., Johnson, G. A., Spencer, T. E., & Wu, G. (2008) · Reproductive Biology · doi:10.1016/s1642-431x(12)60012-6 · Cited by 233

Tumor Hypoxia: Impact on Radiation Therapy and Molecular Pathways

Sørensen, B. S., & Horsman, M. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00562 · Cited by 239

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization

Kondo, T., Vicent, D., Suzuma, K., Yanagisawa, M., King, G. L., Holzenberger, M., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17455 · Cited by 228

Identification of Functional Hypoxia Response Elements in the Promoter Region of the DEC1 and DEC2 Genes

Miyazaki, K., Kawamoto, T., Tanimoto, K., Nishiyama, M., Honda, H., & Kato, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204938200 · Cited by 227

Hypoxia‐inducible factor‐1α contributes to hypoxia‐induced chemoresistance in gastric cancer

Liu, L., Ning, X., Sun, L. J., Zhang, H., Shi, Y., Guo, C., Han, S., Liu, J., Sun, S., Han, Z., et al. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00643.x · Cited by 230

The A3 adenosine receptor: An enigmatic player in cell biology

Gessi, S., Merighi, S., Varani, K., Leung, E., Lennan, S. M., & Borea, P. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.002 · Cited by 225

Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

Kojima, H., Gu, H., Nomura, S., Caldwell, C. C., Kobata, T., Carmeliet, P., Semenza, G. L., & Sitkovsky, M. V. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052706699 · Cited by 224

Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia

Suzuki, H., Tomida, A., & Tsuruo, T. (2001) · Oncogene · doi:10.1038/sj.onc.1204742 · Cited by 228

Physiological role of reactive oxygen species as promoters of natural defenses

Roy, J., Galano, J., Durand, T., Guennec, J. L., & Lee, J. C. (2017) · The FASEB Journal · doi:10.1096/fj.201700170r · Cited by 234

Adenosine receptors and cancer

Gessi, S., Merighi, S., Sacchetto, V., Simioni, C., & Borea, P. A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.09.020 · Cited by 229

Hypoxic Preconditioning Induces Changes in HIF-1 Target Genes in Neonatal Rat Brain

Jones, N. M., & Bergeron, M. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200109000-00008 · Cited by 222

The role of declining adaptive homeostasis in ageing

Pomatto, L. C. D., & Davies, K. J. A. (2017) · The Journal of Physiology · doi:10.1113/jp275072 · Cited by 231

Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1α and LDHA

Hu, D., Linders, A. N., Yamak, A., Correia, C., Kijlstra, J. D., Garakani, A., Xiao, L., Milan, D. J., van der Meer, P., Serra, M., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.313249 · Cited by 221

Tumor microenvironment in ovarian cancer: function and therapeutic strategy

Yang, Y., Yang, Y., Yang, J., Zhao, X., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00758 · Cited by 218

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

Korvenlaita, N., Pistono, C., Huremagic, B., Jolkkonen, J., Giugno, R., & Malm, T. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12002 · Cited by 221

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels

Masson, N., & Ratcliffe, P. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00655 · Cited by 221

Neovascular Age-Related Macular Degeneration: Therapeutic Management and New-Upcoming Approaches

Ricci, F., Bandello, F. M., Navarra, P., Staurenghi, G., Stumpp, M. T., & Zarbin, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218242 · Cited by 224

Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers

Koedrith, P., & Seo, Y. R. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12129576 · Cited by 209

Signal transduction in pancreatic stellate cells

Masamune, A., & Shimosegawa, T. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0013-2 · Cited by 214

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

Maher, J. C., Krishan, A., & Lampidis, T. J. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0724-7 · Cited by 204

Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer

Spivak-Kroizman, T. R., Hostetter, G., Posner, R., Aziz, M., Hu, C., Demeure, M. J., Von Hoff, D., Hingorani, S. R., Palculict, T. B., Izzo, J., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-11-1433 · Cited by 202

The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells

LeCouter, J. E., Lin, R., Tejada, M. L., Frantz, G. D., Peale, F. V., Jr., Hillan, K. J., & Ferrara, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337667100 · Cited by 202

Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor

Kaga, S., Zhan, L., MATSUMOTO, M., & Maulik, N. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.08.003 · Cited by 199

From transcriptome to biological function: environmental stress in an ectothermic vertebrate, the coral reef fish Pomacentrus moluccensis

Kassahn, K. S., Crozier, R. H., Ward, A. C., Stone, G., & Caley, M. J. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-358 · Cited by 199

Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment

Li, W., Li, F., Zhang, X., Lin, H., & Xu, C. S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00825-8 · Cited by 211

Critical protein GAPDH and its regulatory mechanisms in cancer cells.

Zhang, J., Zhang, F., Hong, C., Giuliano, A. E., Cui, X., Zhou, G.-J., Zhang, G., & Cui, Y. (2015) · PubMed Central · doi:10.7497/j.issn.2095-3941.2014.0019 · Cited by 198

Synergistic Up-Regulation of Vascular Endothelial Growth Factor Expression in Murine Macrophages by Adenosine A2A Receptor Agonists and Endotoxin

Leibovich, S. J., Chen, J., Pinhal‐Enfield, G., Belem, P. C., Elson, G., Rosania, A. R., Ramanathan, M., Montesinos, M. C., Jacobson, M. A., Schwarzschild, M. A., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61170-4 · Cited by 196

Rehabilitation Decreases Exercise-induced Oxidative Stress in Chronic Obstructive Pulmonary Disease

Mercken, E. M., Hageman, G. J., Schols, A. M. W. J., Akkermans, M. A., Bast, A., & Wouters, E. F. �. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200411-1580oc · Cited by 194

Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia

Kuhlicke, J., Frick, J.-S., Morote–Garcia, J. C., Rosenberger, P., & Eltzschig, H. K. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001364 · Cited by 190

HIF-1: the knowns and unknowns of hypoxia sensing.

Zagórska, A., & Dulak, J. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3545 · Cited by 194

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

Chen, B., & Cepko, C. L. (2009) · Science · doi:10.1126/science.1166226 · Cited by 192

Delayed Remote Ischemic Preconditioning ConfersRenoprotection against Septic Acute Kidney Injury via Exosomal miR-21

Pan, T., Jia, P., Chen, N., Fang, Y., Liang, Y., Guo, M., & Ding, X. (2019) · Theranostics · doi:10.7150/thno.29832 · Cited by 191

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

Zimmer, M., Ebert, B. L., Neil, C., Brenner, K., Papaioannou, I., Melas, A., Tolliday, N., Lamb, J., Pantopoulos, K., Golub, T., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.12.004 · Cited by 191

Lactate Dehydrogenase-5 (LDH-5) Expression in Human Gastric Cancer: Association with Hypoxia-Inducible Factor (HIF-1α) Pathway, Angiogenic Factors Production and Poor Prognosis

Kolev, Y., Uetake, H., Takagi, Y., & Sugihara, K. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9955-5 · Cited by 191

Mild Hypoxia Enhances Proliferation and Multipotency of Human Neural Stem Cells

Santilli, G., Lamorte, G., Carlessi, L., Ferrari, D., Nodari, L. R., Binda, E., Delia, D., Vescovi, A. L., & Filippis, L. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008575 · Cited by 198

Aspects of the general biology of adenosine A2A signaling

Fredholm, B. B., Chern, Y., Franco, R., & Sitkovsky, M. V. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.07.005 · Cited by 190

Transcriptional Activation of the Human Leptin Gene in Response to Hypoxia

Ambrosini, G., Nath, A. K., Sierra-Honigmann, M. R., & Flores-Riveros, J. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205172200 · Cited by 188

Transcriptional effects of polyethylene microplastics ingestion in developing zebrafish (Danio rerio)

LeMoine, C. M. R., Kelleher, B. M., Lagarde, R., Northam, C., Elebute, O. O., & Cassone, B. J. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.08.084 · Cited by 199

HIF‐1 and p53: communication of transcription factors under hypoxia

Schmid, T., Zhou, J., & Brüne, B. (2004) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2004.tb00467.x · Cited by 192

Desferrioxamine Induces Delayed Tolerance against Cerebral Ischemia in Vivo and in Vitro

Prass, K., Ruscher, K., Karsch, M., Исаев, Н. К., Megow, D., Priller, J., Scharff, A., Dirnagl, U., & Meisel, A. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200205000-00003 · Cited by 185

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

Kim, Y., Lin, Q., Glazer, P. M., & Yun, Z. (2009) · Current Molecular Medicine · doi:10.2174/156652409788167113 · Cited by 185

The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Görlach, A., & Bonello, S. (2008) · Biochemical Journal · doi:10.1042/bj20080920 · Cited by 188

Hypoxia, Oxidative Stress, and Inflammation: Three Faces of Neurodegenerative Diseases

Merelli, A., Repetto, M. G., Lazarowski, A., & Auzmendi, J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201074 · Cited by 188

Therapeutic angiogenesis in cardiology using protein formulations

Post, M. J. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00216-9 · Cited by 182

Regulation of hypoxia-inducible factor 1α and induction of vascular endothelial growth factor in a rat neonatal stroke model

Mu, D., Jiang, X., Sheldon, R. A., Fox, C. K., Hamrick, S. E. G., Vexler, Z. S., & Ferriero, D. M. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.08.020 · Cited by 178

Metabolic and genetic regulation of cardiac energy substrate preference

Kodde, I. F., van der Stok, J., Smolenski, R. T., & de Jong, J. W. (2006) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2006.09.014 · Cited by 180

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

Minet, E., Michel, G., Mottet, D., Raes, M. J., & Michiels, C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00657-8 · Cited by 184

Molecular Imaging of Temporal Dynamics and Spatial Heterogeneity of Hypoxia-Inducible Factor-1 Signal Transduction Activity in Tumors in Living Mice

Serganova, I. S., Doubrovin, M., Vider, J., Ponomarev, V., Soghomonyan, S., Beresten, T., Ageyeva, L., Serganov, A., Cai, S., Balatoni, J., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0842 · Cited by 178

The Biology of Erythropoietin in the Central Nervous System and Its Neurotrophic and Neuroprotective Potential

Dame, C., Juul, S. E., & Christensen, R. D. (2001) · Neonatology · doi:10.1159/000047097 · Cited by 177

Hypoxia and tissue destruction in pulmonary TB

Belton, M., Brilha, S., Manavaki, R., Mauri, F. A., Nijran, K. S., Hong, Y. T., Patel, N., Dembek, M., Tezera, L. B., Green, J. A., et al. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-207402 · Cited by 174

Hypoxia and aging

Yeo, E.-J. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0233-3 · Cited by 175

The Good, the Bad, and the Cell Type-Specific Roles of Hypoxia Inducible Factor-1α in Neurons and Astrocytes

Vangeison, G., Carr, D., Federoff, H., & Rempe, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5323-07.2008 · Cited by 156

Functional regulation of HIF‐1α under normoxia—is there more than post‐translational regulation?

Kuschel, A., Simon, P. D., & Tug, S. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22798 · Cited by 174

Inflammatory pathways in endometrial disorders

Maybin, J. A., Critchley, H. O. D., & Jabbour, H. N. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.006 · Cited by 170

Diabetic retinopathy: Breaking the barrier

Eshaq, R. S., Aldalati, A. M. Z., Alexander, J. S., & Harris, N. R. (2017) · Pathophysiology · doi:10.1016/j.pathophys.2017.07.001 · Cited by 175

Inhibition of hypoxia inducible factor-1α (HIF-1α) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas

Jensen, R. L., Ragel, B. T., Whang, K., & Gillespie, D. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9103-z · Cited by 167

Uterine bleeding: how understanding endometrial physiology underpins menstrual health

Jain, V., Chodankar, R. R., Maybin, J. A., & Critchley, H. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00629-4 · Cited by 206

Untitled work

(2003) · PubMed · Cited by 167

Ero1-Lα plays a key role in a HIF-1-mediated pathway to improve disulfide bond formation and VEGF secretion under hypoxia: implication for cancer

May, D., Itin, A., Gal, O., Kalinski, H., Feinstein, E., & Keshet, E. (2005) · Oncogene · doi:10.1038/sj.onc.1208325 · Cited by 167

Hypoxia‐inducible factor 1α inhibits the fibroblast‐like markers type I and type III collagen during hypoxia‐induced chondrocyte redifferentiation: Hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia‐inducible factor 1α–dependent redifferentiation of chondrocytes

Duval, E., Leclercq, S., Elissalde, J., Demoor, M., Galéra, P., & Boumédiene, K. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24851 · Cited by 166

Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer

Kim, S. J., Rabbani, Z. N., Dewhirst, M. W., Vujašković, Ž., Vollmer, R. T., Schreiber, E.-G., Oosterwijk, E., & Kelley, M. J. (2005) · Lung Cancer · doi:10.1016/j.lungcan.2005.03.036 · Cited by 167

CO2/H+ sensing: peripheral and central chemoreception

Lahiri, S., & Forster, R. E. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(03)00050-5 · Cited by 166

Modulation of redox-sensitive transcription factors by calorie restriction during aging

Kim, H. J., Jung, K. J., Yu, B. P., Cho, C. G., Choi, J. S., & Chung, H. Y. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00094-5 · Cited by 166

Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing

Waypa, G. B., & Schumacker, P. T. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2004 · Cited by 162

Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species

Vieira, H. L. A., Alves, P. M., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.007 · Cited by 165

Use of the A2A adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo

Sitkovsky, M. V. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01548-4 · Cited by 164

l-γ-Glutamyl-l-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)?

Haddad, J. J., & Harb, H. L. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.09.029 · Cited by 166

Hypoxia‐induced astrocytic reaction and increased vascular permeability in the rat cerebellum

Kaur, C., Sivakumar, V., Zhang, Y., & Ling, E. (2006) · Glia · doi:10.1002/glia.20420 · Cited by 160

Oxygen-regulated transcription factors and their role in pulmonary disease

Semenza, G. L. (2000) · Respiratory Research · doi:10.1186/rr27 · Cited by 160

The PI3-K/AKT-Pathway and Radiation Resistance Mechanisms in Non-small Cell Lung Cancer

Schuurbiers, O. C. J., Kaanders, J. H. A. M., van der Heijden, E. H. F. M., Dekhuijzen, R. P. N., Oyen, W. J. G., & Bussink, J. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181a1084f · Cited by 160

O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?

Prabhakar, N. R. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031922 · Cited by 156

A specific tRNA half, 5’tiRNA-His-GTG, responds to hypoxia via the HIF1α/ANG axis and promotes colorectal cancer progression by regulating LATS2

Tao, E., Wang, H.-L., Cheng, W. Y., Liu, Q., Chen, Y., & Gao, Q. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01836-7 · Cited by 156

Significance of wine and resveratrol in cardiovascular disease: French paradox revisited.

Vidavalur, R., Otani, H., Singal, P. K., & Maulik, N. (2006) · PubMed Central · Cited by 155

Regulation of brain aquaporins

Zelenina, M. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.03.022 · Cited by 156

Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2

Kim, J. H., Park, S., Song, S.-Y., Kim, J. K., & Sung, J.-H. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.117 · Cited by 154

Erythropoietin as neuroprotective and neuroregenerative treatment strategy: Comprehensive overview of 12 years of preclinical and clinical research

Sargin, D., Friedrichs, H., El-Kordi, A., & Ehrenreich, H. (2010) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2010.10.005 · Cited by 150

HIF-1: a key mediator in hypoxia (Review)

Adams, J., DiFazio, L. T., Rolandelli, R. H., Luján, J., Haskó, G., Csóka, B., Selmeczy, Z., & Németh, Z. H. (2009) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.96.2009.1.2 · Cited by 152

Hypoxia‐inducible factors as neuroprotective agent in Alzheimer's disease

Ashok, B. S., Ajith, T. A., & Sivanesan, S. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12717 · Cited by 150

Increased sympathetic activity in rats submitted to chronic intermittent hypoxia

Zoccal, D. B., Bonagamba, L. G. H., Oliveira, F. R. T., Antunes‐Rodrigues, J., & Machado, B. H. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.035501 · Cited by 150

Obstructive sleep apnea and cognitive impairment: Addressing the blood–brain barrier

Lim, D. C., & Pack, A. I. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.12.003 · Cited by 158

Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer

Kazemi, M. H., Mohseni, S. R., Hojjat‐Farsangi, M., Anvari, E., Ghalamfarsa, G., Mohammadi, H., & Jadidi‐Niaragh, F. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25873 · Cited by 149

Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia

Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T. L., & Nishiyama, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011774200 · Cited by 148

Increase of SUMO-1 expression in response to hypoxia: Direct interaction with HIF-1α in adult mouse brain and heart in vivo

Shao, R., Zhang, F.-P., Tian, F., Anders Friberg, P., Wang, X., Sjöland, H., & Billig, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.079 · Cited by 149

HIF-1: a key mediator in hypoxia (Review)

Adams, J., DiFazio, L. T., Rolandelli, R. H., Luján, J., Haskó, G., Csóka, B., Selmeczy, Z., & Németh, Z. H. (2009) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.96.2009.1.2 · Cited by 152

Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

Semenza, G. L., Agani, F., Feldser, D., Lyer, N., Kotch, L., Laughner, E., & Yu, 1. (2006) · Advances in Experimental Medicine and Biology · doi:10.1007/0-306-46825-5_12 · Cited by 241

Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914

Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (2009) · Physiology · doi:10.1152/physiol.00045.2008 · Cited by 926

Life with Oxygen

Semenza, G. L. (2007) · Science · doi:10.1126/science.1147949 · Cited by 706