HIF-1: mediator of physiological and pathophysiological responses to hypoxia

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Identification of Genes Differentially Induced by Hypoxia in Pancreatic Cancer Cells

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Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells

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Targeting Protein–Protein Interactions in the HIF System

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A Mechanism of Oxygen Sensing in Yeast

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MicroRNAs in diabetic wound healing: Pathophysiology and therapeutic opportunities

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MicroRNA-126 regulates Hypoxia-Inducible Factor-1α which inhibited migration, proliferation, and angiogenesis in replicative endothelial senescence

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Hypoxia‐inducible factor‐1 signalling promotes goblet cell hyperplasia in airway epithelium

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Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc

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The Regulation of Vascular Endothelial Growth Factor by Hypoxia and Prostaglandin F2αduring Human Endometrial Repair

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Free radicals in the regulation of damage and cell death - basic mechanisms and prevention.

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Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia

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Molecular mechanisms of hypoxia‐inducible factor‐induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension

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Prenatal smoke exposure alters growth in limb proportions and head shape in the midgestation human fetus

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Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer

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C. Elegans Are Protected from Lethal Hypoxia by an Embryonic Diapause

Miller, D. L., & Roth, M. B. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.066 · Cited by 75

Infarct-related artery occlusion, tissue markers of ischaemia, and increased apoptosis in the peri-infarct viable myocardium

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Hypoxia-Inducible Factor 1 alpha (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Pathway Participates in Angiogenesis of Myocardial Infarction in Muscone-Treated Mice: Preliminary Study

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Hypoxia-Inducible Factor-1: A Potential Target to Treat Acute Lung Injury

Liu, Y., Du, X., Zhang, H., Yao, H., & Wang, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8871476 · Cited by 75

Non-hypoxic Stabilization of Hypoxia-Inducible Factor Alpha (HIF-α): Relevance in Neural Progenitor/Stem Cells

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Hypoxia-inducible factor expression in human RPE cells

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Cardiovascular and renal effects of chronic exposure to high altitude

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The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia

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Efficient translation of mouse hypoxia-inducible factor-1α under normoxic and hypoxic conditions

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The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19

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Transcriptional up‐regulation of FoxM1 in response to hypoxia is mediated by HIF‐1

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Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors

Warshakoon, N. C., Wu, S., Boyer, A. S., Kawamoto, R. M., Renock, S., Xu, K., Pokross, M. E., Evdokimov, A. G., Zhou, S., Winter, C., et al. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.08.017 · Cited by 74

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

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Lactate Dehydrogenase in Hepatocellular Carcinoma: Something Old, Something New

Faloppi, L., Bianconi, M., Memeo, R., Gardini, A. C., Giampieri, R., Bittoni, A., Andrikou, K., Prete, M. D., Cascinu, S., & Scartozzi, M. (2016) · BioMed Research International · doi:10.1155/2016/7196280 · Cited by 74

Hypoxia-inducible factor 1 and its role in viral carcinogenesis

Cuninghame, S., Jackson, R., & Zehbe, I. (2014) · Virology · doi:10.1016/j.virol.2014.02.027 · Cited by 73

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

Dai, X.-Y., Zhuang, L., Wang, D., Zhou, T., Chang, L.-L., Gai, R., Zhu, D., Yang, B., Zhu, H., & He, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.6903 · Cited by 74

Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

Kumar, P., & Prabhakar, N. R. (2012) · Comprehensive physiology · doi:10.1002/j.2040-4603.2012.tb00399.x · Cited by 74

Long‐term administration of AMD3100, an antagonist of SDF‐1/CXCR4 signaling, alters fracture repair

Toupadakis, C. A., Wong, A., Genetos, D. C., Chung, D., Murugesh, D. K., Anderson, M. J., Loots, G. G., Christiansen, B., Kapatkin, A. S., & Yellowley, C. E. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22145 · Cited by 73

HIF1α Is Essential for Normal Intrauterine Differentiation of Alveolar Epithelium and Surfactant Production in the Newborn Lung of Mice

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The β-adrenergic system as a possible new target for pharmacologic treatment of neovascular retinal diseases

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Hypoxia-Inducible Factor-1 α Expression Predicts Superior Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP

Evens, A. M., Sehn, L. H., Farinha, P., Nelson, B. P., Raji, A. A., Lu, Y., Brakman, A., Parimi, V., Winter, J. N., Schumacker, P. T., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.1893 · Cited by 71

From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia

Martín, D., & Windsor, J. S. (2008) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.068296 · Cited by 73

Protecting Neurons

Ferriero, D. M. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00302.x · Cited by 72

Induction of the glucose‐6‐phosphate dehydrogenase gene expression by chronic hypoxia in PC12 cells

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Hypoxia-Inducible Factor-1α Accumulation in the Brain after Experimental Intracerebral Hemorrhage

Jiang, Y., Wu, J., Keep, R. F., Hua, Y., Hoff, J. T., & Xi, G. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200206000-00007 · Cited by 71

Hypoxia-inducible Factor-1α is Associated with Risk of Aggressive Behavior and Tumor Angiogenesis in Gastrointestinal Stromal Tumor

Chen, W., Huang, C., Wu, M., Yang, S., Su, Y., & Chai, C. (2005) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyi067 · Cited by 72

Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics

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Animal models of neonatal stroke

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Hypoxia activates the human placental vascular endothelial growth factor system in vitro and in vivo: Up-regulation of vascular endothelial growth factor in clinically relevant hypoxic ischemia in birth asphyxia

Trollmann, R., Amann, K., Schoof, E., Beinder, E., Wénzel, D., Rascher, W., & Dötsch, J. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.138 · Cited by 70

Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia

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Hypoxia Up-regulates CD36 Expression and Function via Hypoxia-inducible Factor-1- and Phosphatidylinositol 3-Kinase-dependent Mechanisms

Mwaikambo, B. R., Yang, C., Chemtob, S., & Hardy, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033480 · Cited by 74

Gene expression of the liver in response to chronic hypoxia

Baze, M. M., Schlauch, K. A., & Hayes, J. P. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00075.2009 · Cited by 70

Ventilatory Changes During Intermittent Hypoxia: Importance of Pattern and Duration

Prabhakar, N. R., & Kline, D. D. (2002) · High Altitude Medicine & Biology · doi:10.1089/15270290260131920 · Cited by 70

Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes

Wang, Y., Yang, L., Zhou, K., Zhang, Y., Song, Z., & He, S. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv192 · Cited by 69

Effect of hypoxia on gene expression by human hepatocytes (HepG2)

Sonna, L. A., Cullivan, M. L., Sheldon, H. K., Pratt, R. E., & Lilly, C. M. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00104.2002 · Cited by 70

Multiple across-strain and within-strain QTLs suggest highly complex genetic architecture for hypoxia tolerance in channel catfish

Wang, X., Liu, S., Jiang, C., Geng, X., Zhou, T., Li, N., Bao, L., Li, Y., Yao, J., Yang, Y., et al. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1256-2 · Cited by 70

Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches

Carvalho, T. M. A., Molfetta, D. D., Greco, M. R., Koltai, T., Alfarouk, K. O., Reshkin, S. J., & Cardone, R. A. (2021) · Cancers · doi:10.3390/cancers13236135 · Cited by 76

The HIF1 target geneNOX2promotes angiogenesis through urotensin-II

Diebold, I., Petry, A., Sabrane, K., Djordjevic, T., Hess, J., & Görlach, A. (2012) · Journal of Cell Science · doi:10.1242/jcs.094060 · Cited by 72

Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats

Abdulmalek, K., Ashur, F., Ezer, N. N., Ye, F., Magder, S. A., & Hussain, S. N. A. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.3.l582 · Cited by 68

Functional Activation of Heat Shock Factor and Hypoxia-Inducible Factor in the Kidney

Eickelberg, O., Seebach, F. A., Riordan, M., Thulin, G., Mann, A. S., Reidy, K. H., Why, S. K. V., Kashgarian, M. J., & Siegel, N. J. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000022008.30175.5b · Cited by 69

Holo‐Lactoferrin Modified Liposome for Relieving Tumor Hypoxia and Enhancing Radiochemotherapy of Cancer

Zhang, Z., Yang, J., Min, Q.-Q., Ling, C.-J., Maiti, D., Xu, J., Qin, L., & Yang, K. (2019) · Small · doi:10.1002/smll.201803703 · Cited by 68

The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat

Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 70

Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury

Hu, B., Guo, Y., Garbacz, W. G., Jiang, M., Xu, M., Huang, H., Tsung, A., Billiar, T. R., Ramakrishnan, S. K., Shah, Y. M., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.05.030 · Cited by 68

Effect of adding more than 3% oxygen to carbon dioxide pneumoperitoneum on adhesion formation in a laparoscopic mouse model

Elkelani, O. A., Binda, M. M., Molinas, C. R., & Koninckx, P. R. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.07.933 · Cited by 68

Hypoxia-Induced Mesenchymal Stromal Cells Exhibit an Enhanced Therapeutic Effect on Radiation-Induced Lung Injury in Mice due to an Increased Proliferation Potential and Enhanced Antioxidant Ability

Li, B., Li, C., Zhu, M., Zhang, Y., Du, J., Xu, Y., Liu, B., Gao, F., Liu, H., Cai, J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485490 · Cited by 69

Enzymatic features of the glucose metabolism in tumor cells

Herling, A., König, M., Bulik, S., & Holzhütter, H. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08174.x · Cited by 70

Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1

Balanos, G. M., Dorrington, K. L., & Robbins, P. A. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00965.2001 · Cited by 66

The worldwide distribution of the VHL 598C>T mutation indicates a single founding event

Liu, E., Percy, M. J., Amos, C. I., Guan, Y., Shete, S., Stockton, D. W., McMullin, M. F., Polyakova, L. A., Ang, S. O., Pastore, Y. D., et al. (2004) · Blood · doi:10.1182/blood-2003-07-2550 · Cited by 66

Hypoxic osteocytes recruit human MSCs through an OPN/CD44-mediated pathway

Raheja, L. F., Genetos, D. C., & Yellowley, C. E. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.076 · Cited by 66

Autofluorescence properties of isolated rat hepatocytes under different metabolic conditions

Croce, A. C., Ferrigno, A., Vairetti, M., Bertone, R., Freitas, I., & Bottiroli, G. F. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b407358d · Cited by 66

Molecular and cellular response to short-term oxygen variations in the Pacific oyster Crassostrea gigas

Sussarellu, R., Fabioux, C., Camacho‐Sanchez, M., Goïc, N. L., Christophe Lambert, B., Soudant, P., & Moraga, D. (2011) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2011.11.007 · Cited by 72

Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes

Yu, S., Zhao, T., Guo, M., Fang, H., Ma, J., Ding, A.-S., Wang, F., Chan, P., & Fan, M. (2008) · Brain Research · doi:10.1016/j.brainres.2005.04.029 · Cited by 67

A biologic role of HIF-1 in the renal medulla

Manotham, K., Tanaka, T., Ohse, T., Kojima, I., Miyata, T., Inagi, R., Tanaka, H., Sassa, R., Fujita, T., & Nangaku, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00220.x · Cited by 66

Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR

Xu, X., Lv, Y., Gu, W., Tang, L., Wei, J.-K., Zhang, L., & Du, L. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-20 · Cited by 66

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90α autocrine signaling to promote keratinocyte migration

Woodley, D. T., Fan, J., Cheng, C.-F., Li, Y., Chen, M., Bu, G., & Li, W. (2009) · Journal of Cell Science · doi:10.1242/jcs.047894 · Cited by 66

Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs

Arthur, S. A., Blaydes, J. P., & Houghton, F. D. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.02.005 · Cited by 65

Hypoxia and Metastasis in Breast Cancer

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Expression of lactate dehydrogenase A and B genes in different tissues of rats adapted to chronic hypobaric hypoxia

Rossignol, F., Solares, M., Balanza, E., Coudert, J., & Clottes, E. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10484 · Cited by 65

Pulsed high oxygen induces a hypoxic-like response in human umbilical endothelial cells and in humans

Cimino, F., Balestra, C., Germonpré, P., Bels, D. D., Tillmans, F., Saija, A., Speciale, A., & Virgili, F. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00922.2012 · Cited by 65

Transcriptional upregulation of HSP70‐2 by HIF‐1 in cancer cells in response to hypoxia

Huang, W., Xia, L., Zhu, F., Huang, B., Zhou, C. H., Zhu, H., Wang, B., Chen, B., Lei, P., Shen, G., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23906 · Cited by 65

Analysis of hypoxia-inducible factor alpha polyploidization reveals adaptation to Tibetan plateau in the evolution of schizothoracine fish

Guan, L., Chi, W., Xiao, W., Chen, L., & He, S. (2014) · BMC Evolutionary Biology · doi:10.1186/s12862-014-0192-1 · Cited by 62

Hypoxia Inducible Factor-1α (HIF-1α) and Some HIF-1 Target Genes are Elevated in Experimental Glaucoma

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