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Cited by 56Spaceflight effects on biologyMuscle metabolism and nutritionNutrition and Health in Aging

WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women

Lee, Stuart M. C., Schneider, Suzanne M., Feiveson, Alan H., Macias, Brandon R., Smith, Scott M., Watenpaugh, Donald E., Hargens, Alan R.·2014·Journal of Applied Physiology
DOI 10.1152/japplphysiol.00590.2013
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Abstract

The objectives of this study were to evaluate the efficacy of two separate countermeasures, exercise and protein supplementation, to prevent muscle strength and lean tissue mass losses during 60 days of bed rest (BR) in women and whether countermeasure efficacy was influenced by pre-BR muscular fitness (strength, endurance, tissue mass). Twenty-four women were assigned to an exercise (EX, n = 8), a no-exercise control (CON, n = 8), or a no-exercise protein supplementation group (PROT, n = 8). EX performed supine treadmill exercise within lower body negative pressure 3-4 days/wk and maximal concentric and eccentric supine leg- and calf-press exercises 2-4 days/wk. PROT consumed a diet with elevated protein content compared with CON and EX (1.6 vs. 1.0 g·kg(-1)·day(-1)). Knee and calf isokinetic strength and endurance, isotonic leg-press strength, and leg lean mass were measured before and after BR. Post-BR knee extensor strength and endurance, ankle strength, and leg lean mass were significantly greater and leg-press strength tended to be higher in EX than in CON and PROT. Post-BR measures in PROT were not different than those in CON. Exercise countermeasure efficacy was less, and strength, endurance, and leg lean mass losses in CON and PROT were greater, in subjects who were more fit pre-BR. An exercise protocol combining resistive and aerobic exercise training protects against losses in strength, endurance, and leg lean mass in women during BR, while a nutritional countermeasure without exercise was not effective. Exercise countermeasures may require individualization to protect higher levels of strength and endurance.

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Crossref · 10.1152/japplphysiol.00590.2013

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  • A combined resistance and aerobic exercise program prevents losses in strength, endurance, and protects lower limb muscle mass, whereas initiating a dietary intervention only may not be effective in preventing these side-effects.

    “Literature has suggested that a combined resistance and aerobic exercise program prevents losses in strength, endurance, and protects lower limb muscle mass, whereas initiating a dietary intervention only may not be effective in preventing these side-effects [45].”

    From Activity Restriction and Hospitalization in Pregnancy: Can Bed-Rest Exercise Prevent Deconditioning? A Narrative Review (2023) · cites this paper as [45]

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Authors
Lee, S. M. C., Schneider, S. M., Feiveson, A. H., Macias, B. R., Smith, S. M., Watenpaugh, D. E., & Hargens, A. R.
Affiliations
  • Wyle (United States) (US)
  • University of New Mexico (US)
  • National Aeronautics and Space Administration (US)
  • Sleep Associates, Inc., Fort Worth, Texas; and
  • University of California San Diego (US)
Corresponding author
Lee, Stuart M. C.
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2014-03-15
Volume
116
Issue
6
Pages
654-667
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.00590.2013
OpenAlex
W1970865631
Cited by
56
References
56
Citations by year
2026: 2 · 2025: 7 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 12 · 2015: 1 · 2014: 2
FWCI
3.77
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
muscle deconditioning, bed rest, women, exercise countermeasures, protein supplementation, muscle strength, lean body mass, isokinetic strength, leg press strength, lower body negative pressure
MeSH terms
Adult, Bed Rest, Bicycling, Biomechanical Phenomena, Combined Modality Therapy, Dietary Proteins, Exercise Therapy, Female, Humans, Lower Body Negative Pressure, Muscle Contraction, Muscular Atrophy, Physical Endurance, Space Flight, Time Factors, Walking, Treatment Outcome, Weightlessness Simulation, Muscle, Skeletal, Weightlessness Countermeasures, Lower Extremity, Muscle Strength, Sarcopenia

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