Circadian Entrainment to Temperature, But Not Light, in the Isolated Suprachiasmatic Nucleus

Herzog, Erik D.; Huckfeldt, Rachel M.

doi:10.1152/jn.00129.2003

Cited by 82Circadian rhythm and melatoninSleep and Wakefulness ResearchSleep and Work-Related Fatigue

Circadian Entrainment to Temperature, But Not Light, in the Isolated Suprachiasmatic Nucleus

Herzog, Erik D., Huckfeldt, Rachel M.·2003·Journal of Neurophysiology

DOI 10.1152/jn.00129.2003

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Abstract

The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian rhythms in mammalian physiology and behavior. The abilities to synchronize to daily cycles in the environment and to keep accurate time over a range of physiologic temperatures are two fundamental properties of circadian pacemakers. Recordings from a bioluminescent reporter ( Per1-luc) of Period1 gene activity in rats showed that the cultured SCN entrained to daily, 1.5°C cycles of temperature, but did not synchronize to daily light cycles. Temperature entrainment developed by 1 day after birth. Light cycles failed to affect the isolated SCN of rats aged 2 to 339 days. Entrainment to a 3-h shift in the warm-cool cycle was possible in <3 days with 3°C cycles. Importantly, Per1-luc expression in vitro was similar to that seen in vivo where peak expression occurs approximately 1 h prior to the daily increase in temperature. In addition, the firing rate of individual mouse SCN neurons continued to express near 24-h rhythms from 24–37°C. At lower temperatures, the percentage of rhythmic cells was reduced, but periodicity was temperature compensated. The results indicate that normal rhythms in brain temperature may serve to stabilize rhythmicity of the circadian system in vivo and that temperature compensation of this period is determined at the level of individual SCN cells.

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The SCN becomes sensitive to ambient temperature cycles only if communication between its neurons is restricted, as in early development or with tetrodotoxin application.
“The SCN itself becomes sensitive to ambient temperature cycles only if communication between its neurons is restricted, as is the case in early development [39] or can be accomplished with application of tetrodotoxin [9].”
From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [39]

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Authors: Herzog, E. D., & Huckfeldt, R. M.
Affiliations: Washington University in St. Louis (US)
ORCID: Herzog, Erik D.
Huckfeldt, Rachel M.
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 2003-08
Volume: 90
Issue: 2
Pages: 763-770
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.00129.2003
OpenAlex: W1968306032
Cited by: 82
References: 74
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 7 · 2012: 3
FWCI: 1.54
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH62517, R01MH063104, R01MH062517, MH 63104)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: suprachiasmatic nucleus, circadian entrainment, temperature entrainment, light entrainment, circadian pacemaker, brain temperature, temperature compensation, neuronal firing rate, mice
MeSH terms: Action Potentials, Animals, Circadian Rhythm, Electrophysiology, Light, Luminescent Proteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Neurons, Suprachiasmatic Nucleus, Temperature, Cell Culture Techniques, Animals, Genetically Modified, Culture Techniques, Mice, Rats

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