Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension
Open accessAbstract
Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively ( P <0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate ( P <0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P <0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.
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An obstructive sleep apnea model demonstrated that cecal microbial transplantation from OSA mice transmitted elevated blood pressure to the recipient.
“Similarly, an obstructive sleep apnea (OSA) model also demonstrated that cecal microbial transplantation from the OSA mice transmitted elevated blood pressure to the recipient85.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [85]
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Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. R. (2016) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,285 · see citing works
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243 · see citing works
Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478 · see citing works
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450 · see citing works
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Canani, R. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i12.1519 · Cited by 1,381 · see citing works
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,301 · see citing works
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191 · see citing works
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,124 · see citing works
Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L., & Hooper, L. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808723105 · Cited by 1,019 · see citing works
Identifying biologically relevant differences between metagenomic communities
Parks, D. H., & Beiko, R. G. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq041 · Cited by 942 · see citing works
Pedrosa, R. P., Drager, L. F., Gonzaga, C. C., Sousa, M. G., de Paula, L. K. G., Amaro, A. C. S., Amodeo, C., Bortolotto, L. A., Krieger, E. M., Bradley, T. D., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.179788 · Cited by 668 · see citing works
The contributory role of gut microbiota in cardiovascular disease
Tang, W. H. W., & Hazen, S. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72331 · Cited by 641 · see citing works
Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563 · see citing works
Diabetes, obesity and gut microbiota
Everard, A., & Cani, P. D. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.007 · Cited by 546 · see citing works
The epigenetic effects of butyrate: potential therapeutic implications for clinical practice
Berni Canani, R., Di Costanzo, M., & Leone, L. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-4 · Cited by 431 · see citing works
Immune Responses to the Microbiota at the Intestinal Mucosal Surface
Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424 · see citing works
Evidence for a link between gut microbiota and hypertension in the Dahl rat
Mell, B., Jala, V. R., Mathew, A. V., Byun, J., Waghulde, H., Zhang, Y., Haribabu, B., Vijay-Kumar, M., Pennathur, S., & Joe, B. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2014 · Cited by 400 · see citing works
Sleep Apnea and Cardiovascular Disease
Kasai, T., Floras, J. S., & Bradley, T. D. (2012) · Circulation · doi:10.1161/circulationaha.111.070813 · Cited by 383 · see citing works
Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex
Logan, A. G., Tkacova, R., Perlikowski, S. M., Leung, R. S. T., Tislér, A., Floras, J. S., & Bradley, T. D. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00035402 · Cited by 296 · see citing works
Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats
Petriz, B. A., Castro, A. P., Almeida, J. A., Gomes, C. P., Fernandes, G. R., Kruger, R. H., Pereira, R. W., & Franco, O. L. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-511 · Cited by 293 · see citing works
Dysbiotic Events in Gut Microbiota: Impact on Human Health
Schippa, S., & Conte, M. (2014) · Nutrients · doi:10.3390/nu6125786 · Cited by 247 · see citing works
Lyte, M. (2014) · Gut Microbes · doi:10.4161/gmic.28682 · Cited by 225 · see citing works
The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review
Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219 · see citing works
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Parati, G., Lombardi, C., & Narkiewicz, K. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00400.2007 · Cited by 205 · see citing works
Cerebrovascular Consequences of Obstructive Sleep Apnea
Durgan, D. J., & Bryan, R. M. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.111.000091 · Cited by 195 · see citing works
Self-citationThe immune system and hypertension
Singh, M. V., Chapleau, M. W., Harwani, S. C., & Abboud, F. M. (2014) · Immunologic Research · doi:10.1007/s12026-014-8548-6 · Cited by 176 · see citing works
Prevalence of sleep apnoea and snoring in hypertensive men: a population based study
Sjöström, C. D. (2002) · Thorax · doi:10.1136/thorax.57.7.602 · Cited by 144 · see citing works
Sun, Y., Fihn, B.-M., Sjövall, H., & Jodal, M. (2004) · Gut · doi:10.1136/gut.2003.015867 · Cited by 58 · see citing works
Plasma Lactate and Incident Hypertension in the Atherosclerosis Risk in Communities Study
Juraschek, S. P., Bower, J. K., Selvin, E., Shantha, G. P. S., Hoogeveen, R. C., Ballantyne, C. M., & Young, J. H. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu117 · Cited by 57 · see citing works
Crossland, R. F., Durgan, D. J., Lloyd, E. E., Phillips, S. C., Reddy, A. K., Marrelli, S. P., & Bryan, R. M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00244.2013 · Cited by 42 · see citing works
Self-citationDurgan, D. J., Crossland, R. F., Lloyd, E. E., Phillips, S. C., & Bryan, R. M. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.214 · Cited by 24 · see citing works
Self-citationLloyd, E. E., Durgan, D. J., Martini, S. R., & Bryan, R. M. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05764 · Cited by 16 · see citing works
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Gut microbiota dysbiosis contributes to the development of hypertension
Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., Wu, S., Liu, W., Cui, Q., Geng, B., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0222-x · Cited by 1,685 · see citing works
Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789 · see citing works
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753 · see citing works
Kim, S., Goel, R., Kumar, A., Qi, Y., Lobaton, G. O., Hosaka, K., Mohammed, M., Handberg, E. M., Richards, E. M., Pepine, C. J., et al. (2018) · Clinical Science · doi:10.1042/cs20180087 · Cited by 545 · see citing works
Hypertension-Linked Pathophysiological Alterations in the Gut
Santisteban, M. M., Qi, Y., Zubcevic, J., Kim, S., Yang, T., Shenoy, V., Cole-Jeffrey, C. T., Lobaton, G. O., Stewart, D. C., Rubiano, A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.309006 · Cited by 525 · see citing works
Alterations of the Gut Microbiome in Hypertension
Yan, Q., Gu, Y., Li, X., Yang, W. Q., Jia, L., Chen, C., Han, X., Huang, Y., Zhao, L., Li, P., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00381 · Cited by 496 · see citing works
Intestinal Microbiota in Cardiovascular Health and Disease
Tang, W. H. W., Bäckhed, F., Landmesser, U., & Hazen, S. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.024 · Cited by 508 · see citing works
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01496-3 · Cited by 521 · see citing works
Microbial modulation of cardiovascular disease
Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440 · see citing works
Beyond gut feelings: how the gut microbiota regulates blood pressure
Marques, F. Z., Mackay, C. R., & Kaye, D. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.120 · Cited by 400 · see citing works
Gómez-Arango, L. F., Barrett, H. L., McIntyre, D. H., Callaway, L. K., Morrison, M., & Nitert, M. D. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07910 · Cited by 384 · see citing works
Alterations in the gut microbiota can elicit hypertension in rats
Adnan, S., Nelson, J. W., Ajami, N. J., Venna, V. R., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00081.2016 · Cited by 380 · see citing works
Self-citationMicrobial Short-Chain Fatty Acids and Blood Pressure Regulation
Pluznick, J. L. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0722-5 · Cited by 301 · see citing works
Gut Microbiota Composition and Blood Pressure
Sun, S., Lulla, A., Sioda, M., Winglee, K., Wu, M. C., Jacobs, D. R., Shikany, J. M., Lloyd‐Jones, D. M., Launer, L. J., Fodor, A. A., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12109 · Cited by 281 · see citing works
Revisit gut microbiota and its impact on human health and disease
Ding, R., Goh, W.-R., Wu, R., Yue, X., Luo, X. G., Khine, W. W. T., Wu, J., & Lee, Y. K. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.12.012 · Cited by 269 · see citing works
Yan, X., Jin, J., Su, X., Yin, X., Gao, J., Wang, X., Zhang, S., Bu, P., Wang, M., Zhang, Y., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316394 · Cited by 235 · see citing works
Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study
Calderón-Pérez, L., Gosalbes, M. J., Yuste, S., Valls, R. M., Pedret, A., Llauradó, E., Jiménez‐Hernández, N., Artacho, A., Pla‐Pagà, L., Companys, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63475-w · Cited by 224 · see citing works
Konopelski, P., & Mogilnicka, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031222 · Cited by 218 · see citing works
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works
Ganesh, B. P., Nelson, J. W., Eskew, J. R., Ganesan, A., Ajami, N. J., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11695 · Cited by 190 · see citing works
Self-citationShort-chain fatty acid, acylation and cardiovascular diseases
Chen, X., Chen, X., & Tang, X. (2020) · Clinical Science · doi:10.1042/cs20200128 · Cited by 186 · see citing works
The gut microbiota as a novel regulator of cardiovascular function and disease
Battson, M. L., Lee, D. M., Weir, T. L., & Gentile, C. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.010 · Cited by 185 · see citing works
Ko, C., Liu, Q., Su, H., Zhang, H.-P., Fan, J., Yang, J., Hu, A., Liu, Y., Chou, D., & Zeng, Y. (2019) · Clinical Science · doi:10.1042/cs20180891 · Cited by 175 · see citing works
The impact of gut microbiota on kidney function and pathogenesis
Mahmoodpoor, F., Saadat, Y. R., Barzegari, A., Ardalan, M., & Vahed, S. Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.066 · Cited by 171 · see citing works
The Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease
Zaky, A. A., Glastras, S. J., Wong, M. Y. W., Pollock, C. A., & Saad, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179641 · Cited by 174 · see citing works
Gut microbiota and hypertension: association, mechanisms and treatment
Yang, Z., Wang, Q., Liu, Y., Wang, L., Ge, Z., Li, Z., Feng, S., & Wu, C. (2023) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2023.2195135 · Cited by 170 · see citing works
Examining the Role of the Microbiota-Gut-Brain Axis in Stroke
Durgan, D. J., Lee, J., McCullough, L. D., & Bryan, R. M. (2019) · Stroke · doi:10.1161/strokeaha.119.025140 · Cited by 169 · see citing works
Self-citationThe Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke
Chidambaram, S. B., Rathipriya, A. G., Mahalakshmi, A. M., Sonali, S., Hediyal, T. A., Ray, B., Sunanda, T., Rungratanawanich, W., Kashyap, R. S., Qoronfleh, M. W., et al. (2022) · Cells · doi:10.3390/cells11071239 · Cited by 165 · see citing works
Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
Tomášová, L., Konopelski, P., & Ufnal, M. (2016) · Molecules · doi:10.3390/molecules21111558 · Cited by 156 · see citing works
Differential Analysis of Hypertension-Associated Intestinal Microbiota
Dan, X., Mushi, Z., Baili, W., Han, L., Enqi, W., Huanhu, Z., & Li, S. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.29322 · Cited by 157 · see citing works
Kanbay, M., Onal, E. M., Afşar, B., Dağel, T., Yerlikaya, A., Covic, A. C., & Vaziri, N. D. (2018) · International Urology and Nephrology · doi:10.1007/s11255-018-1873-2 · Cited by 154 · see citing works
Jiang, Z., Zhuo, L., He, Y., Fu, Y., Shen, L., Xu, F., Gou, W., Miao, Z., Shuai, M., Liang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30712-x · Cited by 156 · see citing works
The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease
Ascher, S., & Reinhardt, C. (2017) · European Journal of Immunology · doi:10.1002/eji.201646879 · Cited by 150 · see citing works
Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors
Pluznick, J. L. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.033 · Cited by 151 · see citing works
Overby, H., & Ferguson, J. F. (2021) · Current Hypertension Reports · doi:10.1007/s11906-020-01125-2 · Cited by 153 · see citing works
Xia, W.-J., Xu, M., Yu, X., Du, M., Li, X., Yang, T., Lu, L., Li, Y., Kang, K. B., Su, Q., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1854642 · Cited by 146 · see citing works
Yan, J., Pan, Y., Shao, W., Wang, C., Wang, R., He, Y., Zhang, M., Wang, Y., Li, T., Wang, Z., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01390-0 · Cited by 148 · see citing works
Gut microbes in cardiovascular diseases and their potential therapeutic applications
Jin, L., Shi, X., Yang, J., Zhao, Y., Xue, L., Xu, L., & Cai, J. (2020) · Protein & Cell · doi:10.1007/s13238-020-00785-9 · Cited by 143 · see citing works
Antihypertensive Effects of Probiotics
Robles‐Vera, I., Toral, M., Romero, M., Jiménez, R., Sánchez, M., Pérez‐Vizcaíno, F., & Duarte, J. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0723-4 · Cited by 137 · see citing works
Kuvat, N., Tanrıverdi, H., & Armutçu, F. (2020) · The Clinical Respiratory Journal · doi:10.1111/crj.13175 · Cited by 136 · see citing works
The Gut, Its Microbiome, and Hypertension
Richards, E. M., Pepine, C. J., Raizada, M. K., & Kim, S. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0734-1 · Cited by 136 · see citing works
Hu, X.-F., Zhang, W., Wen, Q., Chen, W., Wang, Z., Chen, J., Zhu, F., Liu, K., Cheng, L., Yang, J., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.042 · Cited by 132 · see citing works
Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment
Yang, F., Chen, H., Gao, Y., An, N., Li, X., Pan, X., Yang, X., Tian, L., Sun, J., Xiong, X., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110503 · Cited by 131 · see citing works
Olson, C. A., Iñiguez, A. J., Yang, G. E., Fang, P., Pronovost, G. N., Jameson, K. G., Rendon, T. K., Paramo, J., Barlow, J. T., Ismagilov, R. F., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.07.004 · Cited by 125 · see citing works
The Microbiome and Blood Pressure: Can Microbes Regulate Our Blood Pressure?
Khodor, S. A., Reichert, B., & Shatat, I. F. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00138 · Cited by 120 · see citing works
Hypertension as a Metabolic Disorder and the Novel Role of the Gut
Tanaka, M., & Itoh, H. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0964-5 · Cited by 118 · see citing works
Silveira‐Nunes, G., Durso, D. F., Júnior, L. R. A. D. O., Cunha, E. H. M., Maioli, T. U., Vieira, A. T., Speziali, E., Corrêa‐Oliveira, R., Martins‐Filho, O. A., Teixeira‐Carvalho, A., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00258 · Cited by 117 · see citing works
Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals
Palmu, J., Salosensaari, A., Havulinna, A. S., Cheng, S. C., Inouye, M., Jain, M., Salido, R. A., Sanders, K., Brennan, C., Humphrey, G., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016641 · Cited by 116 · see citing works
Improving obesity and blood pressure
Tanaka, M. (2019) · Hypertension Research · doi:10.1038/s41440-019-0348-x · Cited by 110 · see citing works
Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure
Shi, H., Zhang, B., Abo‐Hamzy, T., Nelson, J. W., Ambati, C. S. R., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2021) · Circulation Research · doi:10.1161/circresaha.120.318155 · Cited by 112 · see citing works
Self-citationGut Microbiome and Neuroinflammation in Hypertension
Richards, E. M., Li, J., Stevens, B. R., Pepine, C. J., & Raizada, M. K. (2022) · Circulation Research · doi:10.1161/circresaha.121.319816 · Cited by 114 · see citing works
Brown, J. M., & Hazen, S. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.765388 · Cited by 108 · see citing works
Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 112 · see citing works
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Winek, K., Dirnagl, U., & Meisel, A. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0475-x · Cited by 108 · see citing works
Toral, M., Robles‐Vera, I., de la Visitación, N., Romero, M., Sánchez, M., Gómez‐Guzmán, M., Rodríguez‐Nogales, A., Yang, T., Jiménez, R., Algieri, F., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13285 · Cited by 105 · see citing works
RetractedThe Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development
Zera, K. A., & Buckwalter, M. S. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00844-3 · Cited by 102 · see citing works
Gut microbiota in cardiovascular disease and heart failure
Kitai, T., & Tang, W. H. W. (2018) · Clinical Science · doi:10.1042/cs20171090 · Cited by 103 · see citing works
Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study
Valentini, F., Evangelisti, M., Arpinelli, M., Nardo, G. D., Borro, M., Simmaco, M., & Villa, M. P. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.10.017 · Cited by 104 · see citing works
The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease
Chi, M., Ma, K., Wang, J., Ding, Z., Li, Y., Zhu, S., Liang, X., Zhang, Q., Song, L., & Liu, C. (2021) · Journal of Immunology Research · doi:10.1155/2021/5516035 · Cited by 98 · see citing works
Cheema, M. U., & Pluznick, J. L. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13155 · Cited by 97 · see citing works
Maki, K. A., Burke, L., Calik, M. W., Watanabe‐Chailland, M., Sweeney, D., Romick‐Rosendale, L. E., Green, S. J., & Fink, A. M. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00039.2020 · Cited by 96 · see citing works
A cross-talk between gut microbiome, salt and hypertension
Naqvi, S., Asar, T. O., Kumar, V., Al-Abbasi, F. A., Alhayyani, S., Kamal, M. A., & Anwar, F. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111156 · Cited by 95 · see citing works
Ghaffari, S., & Roshanravan, N. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108749 · Cited by 91 · see citing works
Altemani, F. H., Barrett, H. L., Gómez-Arango, L. F., Josh, P. F., McIntyre, D. H., Callaway, L. K., Morrison, M., Tyson, G. W., & Nitert, M. D. (2021) · Pregnancy Hypertension · doi:10.1016/j.preghy.2021.01.002 · Cited by 100 · see citing works
The gut microbiome and hypertension
Pevsner‐Fischer, M., Blacher, E., Tatirovsky, E., Ben‐Dov, I. Z., & Elinav, E. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000293 · Cited by 91 · see citing works
Disparate effects of antibiotics on hypertension
Galla, S., Chakraborty, S., Cheng, X., Yeo, J., Mell, B., Zhang, H. Y., Mathew, A. V., Vijay–Kumar, M., & Joe, B. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00073.2018 · Cited by 84 · see citing works
Gut microbiota, hypertension and chronic kidney disease: Recent advances
Sircana, A., Michieli, F. D., Parente, R., Framarin, L., Leone, N., Berrutti, M., Paschetta, E., Bongiovanni, D., & Musso, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.013 · Cited by 86 · see citing works
Liu, J., Li, T., Wu, H., Shi, H., Bai, J., Zhao, W., Jiang, D., & Jiang, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.041 · Cited by 87 · see citing works
Gut microbiota and hypertension: From pathogenesis to new therapeutic strategies
Kang, Y., & Cai, Y. (2017) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2017.09.006 · Cited by 84 · see citing works
Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction
Battson, M. L., Lee, D. M., Jarrell, D. K., Hou, S., Ecton, K. E., Weir, T. L., & Gentile, C. L. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2017 · Cited by 85 · see citing works
Obstructive Sleep Apnea and Systemic Hypertension: Gut Dysbiosis as the Mediator?
Mashaqi, S., & Gozal, D. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7990 · Cited by 81 · see citing works
Badran, M., Khalyfa, A., Ericsson, A. C., & Gozal, D. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113439 · Cited by 85 · see citing works
Wu, B. G., Sulaiman, I., Wang, J., Shen, N., Clemente, J. C., Li, Y., Laumbach, R. J., Lu, S., Udasin, I. G., Le-Hoang, O. T., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0119oc · Cited by 83 · see citing works
Yang, T., Ahmari, N., Schmidt, J. T., Redler, T., Arocha, R., Pacholec, K., Magee, K. L., Malphurs, W. L., Owen, J. L., Krane, G. A., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00220 · Cited by 82 · see citing works
Zhang, X., Wang, S., Xu, H., Yi, H., Guan, J., & Yin, S. (2021) · European Respiratory Review · doi:10.1183/16000617.0220-2020 · Cited by 82 · see citing works
Carnagarin, R., Matthews, V. B., Zaldivia, M. T. K., Peter, K., & Schlaich, M. P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14481 · Cited by 82 · see citing works
Chains of evidence from correlations to causal molecules in microbiome-linked diseases
Chaudhari, S. N., McCurry, M. D., & Devlin, A. S. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00861-z · Cited by 80 · see citing works
Lucking, E. F., O’Connor, K. M., Strain, C., Fouhy, F., Bastiaanssen, T. F. S., Burns, D. P., Golubeva, A. V., Stanton, C., Clarke, G. A., Cryan, J. F., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.010 · Cited by 79 · see citing works
Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers
Xu, H., Zheng, X., Qian, Y., Guan, J., Yi, H., Zou, J., Wang, Y., Meng, L., Zhao, A., Yin, S., et al. (2016) · Scientific Reports · doi:10.1038/srep30958 · Cited by 73 · see citing works
Ryan, S., Cummins, E. P., Farré, R., Gileles‐Hillel, A., Jun, J. C., Oster, H., Pépin, J., Ray, D. W., Reutrakul, S., Sánchez‐de‐la‐Torre, M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02295-2019 · Cited by 70 · see citing works
Probiotics: Protecting Our Health from the Gut
Varela-Trinidad, G. U., Domínguez-Díaz, C., Solórzano-Castanedo, K., Íñiguez-Gutiérrez, L., Hernández-Flores, T. D. J., & Fafutis‐Morris, M. (2022) · Microorganisms · doi:10.3390/microorganisms10071428 · Cited by 78 · see citing works
Farré, N., Farré, R., & Gozal, D. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.03.001 · Cited by 71 · see citing works
Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
Guo, Y., Li, X., Wang, Z., & Yu, B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650227 · Cited by 68 · see citing works
Plant-Based Diets and Hypertension
Joshi, S., Ettinger, L., & Liebman, S. E. (2019) · American Journal of Lifestyle Medicine · doi:10.1177/1559827619875411 · Cited by 69 · see citing works
Raizada, M. K., Joe, B., Bryan, N. S., Chang, E. B., Dewhirst, F. E., Borisy, G. G., Galis, Z. S., Henderson, W. A., José, P. A., Ketchum, C. J., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09699 · Cited by 65 · see citing works
Mushtaq, N., Hussain, S., Zhang, S., Lü, Y., Li, H., Ullah, S., Wang, Y., & Xu, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4235 · Cited by 64 · see citing works
From obesity through gut microbiota to cardiovascular diseases: a dangerous journey
Marzullo, P., Renzo, L. D., Pugliese, G., Siena, M. D., Barrea, L., Muscogiuri, G., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0017-1 · Cited by 64 · see citing works
Glucocorticoids and gut bacteria: “The GALF Hypothesis” in the metagenomic era
Morris, D. J., & Ridlon, J. M. (2017) · Steroids · doi:10.1016/j.steroids.2017.06.002 · Cited by 63 · see citing works
Xu, H., Li, X., Zheng, X., Xia, Y., Fu, Y., Li, X., Qian, Y., Zou, J., Zhao, A., Guan, J., et al. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7336 · Cited by 64 · see citing works
Causality of gut microbiome and hypertension: A bidirectional mendelian randomization study
Li, Y., Fu, R., Li, R., Zeng, J., Liu, T., Li, X., & Jiang, W. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1167346 · Cited by 61 · see citing works
Sodium, hypertension, and the gut: does the gut microbiota go salty?
Smiljanec, K., & Lennon, S. L. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00312.2019 · Cited by 61 · see citing works
Triplett, J. C., Ellis, D., Braddock, A., Roberts, E., Ingram, K., Perez, E., Short, A. Y., Brown, D., Hutzley, V., Webb, C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1701352 · Cited by 57 · see citing works
Li, Q., Xu, T., Shao, C., Gao, W., Wang, M., Dong, Y., Wang, X., Lu, F., Li, D., Tan, H., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-27784-0 · Cited by 57 · see citing works
Yang, T., Mei, X., Tackie‐Yarboi, E., Akere, M. T., Kyoung, J., Mell, B., Yeo, J., Cheng, X., Zubcevic, J. A., Richards, E. M., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18711 · Cited by 56 · see citing works
Microbiota and Hypertension: Role of the Sympathetic Nervous System and the Immune System
Robles‐Vera, I., Toral, M., & Duarte, J. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa103 · Cited by 54 · see citing works
Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats
O’Connor, K. M., Lucking, E. F., Golubeva, A. V., Strain, C., Fouhy, F., Cénit, M. C., Dhaliwal, P., Bastiaanssen, T. F. S., Burns, D. P., Stanton, C., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.029 · Cited by 54 · see citing works
Sroka, N., Rydzewska–Rosołowska, A., Kakareko, K., Rosołowski, M., Głowińska, I., & Hryszko, T. (2022) · Nutrients · doi:10.3390/nu15010090 · Cited by 53 · see citing works
Studying microbial functionality within the gut ecosystem by systems biology
Hornung, B., dos Santos, V. A. P. M., Smidt, H., & Schaap, P. J. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0594-6 · Cited by 57 · see citing works
Childhood Obesity and Respiratory Diseases: Which Link?
di Palmo, E., Filice, E., Cavallo, A., Caffarelli, C., Maltoni, G., Miniaci, A., Ricci, G., & Pession, A. (2021) · Children · doi:10.3390/children8030177 · Cited by 56 · see citing works
Disruptive physiology: olfaction and the microbiome–gut–brain axis
Bienenstock, J., Kunze, W., & Forsythe, P. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12348 · Cited by 52 · see citing works
- Authors
- Durgan, D. J., Ganesh, B. P., Cope, J. L., Ajami, N. J., Phillips, S. C., Petrosino, J. F., Hollister, E. B., & Bryan, R. M.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Hypertension
- Published
- 2016-02
- Volume
- 67
- Issue
- 2
- Pages
- 469-474
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC4713369
- OpenAlex
- W2225428785
- Cited by
- 327
- References
- 34
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 27 · 2023: 26 · 2022: 48 · 2021: 48 · 2020: 43 · 2019: 28 · 2018: 28 · 2017: 28 · 2016: 12
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK56338, P30DK056338)
- National Institute of Neurological Disorders and Stroke (R01NS080531, R21NS094806)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- obstructive sleep apnea, gut microbiota, dysbiosis, high-fat diet, butyrate, short-chain fatty acids, fecal microbiota transplantation, blood pressure, microbiome manipulation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Blood Pressure, Disease Models, Animal, Hypertension, Male, Sleep, Sleep Apnea Syndromes, Polysomnography, Rats, Long-Evans, Rats, Dysbiosis
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