Brain metabolism: a perspective from the blood-brain barrier

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

Uchida, Y., Ohtsuki, S., Katsukura, Y., Ikeda, C., Suzuki, T., Kamiie, J., & Terasaki, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07208.x · Cited by 881

Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain2

Fernstrom, J. D., & Fernstrom, M. H. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.6.1539s · Cited by 755

Vitamin C function in the brain: Vital role of the ascorbate transporter SVCT2

Harrison, F. E., & May, J. M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.018 · Cited by 661

Tryptophan metabolism in the central nervous system: medical implications

Ruddick, J. P., Evans, A. K., Nutt, D. J., Lightman, S. L., Rook, G. A. W., & Lowry, C. A. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406000068 · Cited by 519

Branched-Chain Amino Acids and Brain Function

Fernstrom, J. D. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.6.1539s · Cited by 514

Kinetics of Neutral Amino Acid Transport Across the Blood‐Brain Barrier

Smith, Q. R., Momma, S., Aoyagi, M., & Rapoport, S. I. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb01039.x · Cited by 454

Structure of the Blood–Brain Barrier and Its Role in the Transport of Amino Acids

Hawkins, R. A., O’Kane, R. L., Simpson, I. A., & Viña, J. R. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.218s · Cited by 453

Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells

Mann, G. E., Yudilevich, D. L., & Sobrevia, L. (2003) · Physiological Reviews · doi:10.1152/physrev.00022.2002 · Cited by 430

Cerebral perturbations provoked by prolonged exercise

Nybo, L., & Secher, N. H. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.005 · Cited by 398

Glucose transporter expression in the central nervous system: relationship to synaptic function

McEwen, B. S., & Reagan, L. P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.02.041 · Cited by 331

Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study.

Farrell, C. L., & Pardridge, W. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5779 · Cited by 314

Blood—Brain Barrier Glucose Transporter: Effects of Hypo‐ and Hyperglycemia Revisited

Simpson, I. A., Appel, N. M., Hokari, M., Oki, J., Holman, G. D., Maher, F., Koehler‐Stec, E. M., Vannucci, S. J., & Smith, Q. R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720238.x · Cited by 304

Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus

Epstein, F. H., Cryer, P. E., & Gerich, J. E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507253130405 · Cited by 273

Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

Hoshi, Y., Uchida, Y., Tachikawa, M., Inoue, T., Ohtsuki, S., & Terasaki, T. (2013) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23575 · Cited by 254

Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

Yamamoto, M., Ramirez, S. H., Sato, S., Kiyota, T., Cerny, R. L., Kaibuchi, K., Persidsky, Y., & Ikezu, T. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070076 · Cited by 241

A Historical Review of Brain Drug Delivery

Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219

Glucose-Induced Intracellular Ion Changes in Sugar-Sensitive Hypothalamic Neurons

Silver, I. A., & Erecinska, M. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.4.1733 · Cited by 210

Adaptation in brain glucose uptake following recurrent hypoglycemia.

Boyle, P. J., Nagy, R. J., O'Connor, A. M., Kempers, S. F., Yeo, R. A., & Qualls, C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9352 · Cited by 208

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Hladky, S. B., & Barrand, M. A. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0113-6 · Cited by 206

Diminished brain glucose metabolism is a significant determinant for falling rates of systemic glucose utilization during sleep in normal humans.

Boyle, P. J., Scott, J. C., Krentz, A. J., Nagy, R. J., Comstock, E., & Hoffman, C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117003 · Cited by 202

Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)

Persidsky, Y., Heilman, D., Haorah, J., Zelivyanskaya, M., Persidsky, R., Weber, G. A., Shimokawa, H., Kaibuchi, K., & Ikezu, T. (2006) · Blood · doi:10.1182/blood-2005-11-4721 · Cited by 200

Ingestion of branched‐chain amino acids and tryptophan during sustained exercise in man: failure to affect performance.

van Hall, G., Raaymakers, J. S., Saris, W. H., & Wagenmakers, A. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020854 · Cited by 188

Downregulation of Blood-Brain Barrier Glucose Transporter in Experimental Diabetes

Pardridge, W. M., Triguero, D., & Farrell, C. R. (1990) · Diabetes · doi:10.2337/diab.39.9.1040 · Cited by 184

Blood–brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery

Pardridge, W. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1042364 · Cited by 159

Modest decrements in plasma glucose concentration cause early impairment in cognitive function and later activation of glucose counterregulation in the absence of hypoglycemic symptoms in normal man.

De Feo, P., Gallai, V, Mazzotta, G., Crispino, G., Torlone, E., Perriello, G., Ventura, M. M., Santeusanio, F., Brunetti, P., & Bolli, G. B. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113616 · Cited by 138

Ultrastructural Cytochemistry of Blood-Brain Barrier Endothelia

Vorbrodt, A. W. (1988) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(88)80001-9 · Cited by 108

Carbohydrate Administration and Exercise Performance: What Are the Potential Mechanisms Involved?

Karelis, A. D., Smith, J. W., Passe, D. H., & Péronnet, F. (2010) · Sports Medicine · doi:10.2165/11533080-000000000-00000 · Cited by 101

Glucose Transporter Asymmetries in the Bovine Blood-Brain Barrier

Simpson, I. A., Vannucci, S. J., DeJoseph, M. R., & Hawkins, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010897200 · Cited by 99

The interrelationship between sleep, diet, and glucose metabolism

St-Onge, M.-P., Cherta-Murillo, A., Darimont, C., Mantantzis, K., Martin, F. P., & Owen, L. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101788 · Cited by 79

Oral tyrosine supplementation improves exercise capacity in the heat

Tumilty, L., Davison, G., Beckmann, M., & Thatcher, R. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1921-4 · Cited by 68

Hyperinsulinemia Suppresses Glucose Utilization in Specific Brain Regions:In Vivo Studies Using the Euglycemic Clamp in the Rat

GRUNSTEIN, H. S., JAMES, D. E., STORLIEN, L. H., SMYTHE, G. A., & KRAEGEN, E. W. (1985) · Endocrinology · doi:10.1210/endo-116-2-604 · Cited by 62

Monoaminergic Neuronal Activity in Subcortical Brain Regions in Essential Hypertension

Lambert, G. W., Ferrier, C., Kaye, D. M., Kalff, V., Kelly, M. J., Cox, H. S., Turner, A. G., Jennings, G. L., & Esler, M. D. (1994) · Blood Pressure · doi:10.3109/08037059409101522 · Cited by 32

Untitled work

McEwen (2004) · doi:10.1016/s1054-3589(04)50016-9 · Cited by 22

An integrated model of thermodynamic–hemodynamic–pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in brain hypothermia treatment

Gaohua, L., Maekawa, T., & Kimura, H. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.01.033 · Cited by 14