Are nonnutritive sweeteners obesogenic? Associations between diet, faecal microbiota, and short-chain fatty acids in morbidly obese subjects
Open accessAbstract
Obesity has been associated with changes in the gut microbiota and its metabolites. The study explored changes in the faecal microbiota and short-chain fatty acids (SCFA) associated with the diet (including nonnutritive sweeteners (NNSs)) and evaluated metabolic consequences in subjects with morbid obesity. The diet was assessed with a validated food frequency questionnaire. One unit of NNSs was 100 mL beverage with NNSs or 2 tablets/teaspoons of NNSs. The faecal microbiota was assessed with GA-map® dysbiosis test and SCFA with gas chromatography and flame ionisation detection. Fourteen men and 75 women with a mean age of 44.6 (SD 8.7) years, BMI 41.8 (SD 3.6) kg/m 2 , and intake of NNSs 7.5 units/day (SD 3.2; range 0–43) were included. Faecal butyric acid was positively and negatively associated with the intake of starch (partial correlation = 0.264; p = 0.015 ) and NNSs (partial correlation = −0.274; p = 0.011 ), respectively. NNSs were associated with changes in four out of 39 bacterial groups. Butyric acid has antiobesogenic effects, reduces insulin resistance, and improves dyslipidaemia. Since the weight-reducing effect of NNSs on obese adults trying to lose weight is dubious, it seems imprudent to use NNSs that might counteract the favourable effects of butyric acid.
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Nonnutritive sweeteners have been linked to detrimental effects on microbial diversity and composition and decreased butyrate concentration, but evidence is inconsistent, with some reports concluding no clear effects or that only some sweeteners impact the microbial profile.
“Although earlier human studies indicated detrimental effects on microbial diversity and composition (99, 100) and a more recent study linked consumption of nonnutritive sweeteners to a “dysbiosis” [an increasingly redundant term in microbiome research (171)] and a decrease in butyrate concentration (172), some reports have concluded that no clear effects of sweeteners on the microbiota can be”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [172]
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- Authors
- Farup, P. G., Lydersen, S., & Valeur, J.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Lovisenberg Diakonale Sykehus (NO)
- Corresponding author
- Farup, Per G.
- Venue
- Journal of Obesity
- Publisher
- Wiley
- Published
- 2019-10-01
- Volume
- 2019
- Pages
- 1-8
- ISSN
- 2090-0708 (ISSN-L)
- 2090-0716
- PMC
- PMC6791210
- OpenAlex
- W2977354602
- Cited by
- 29
- References
- 46
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2018: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Obesity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- Innlandet Hospital Trust, Brumunddal
- Norwegian University of Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- artificial sweeteners, morbid obesity, gut microbiota, short-chain fatty acids, butyrate, dietary starch, dysbiosis, insulin resistance, weight loss
- MeSH terms
- Gastrointestinal Microbiome, Adult, Cross-Sectional Studies, Diet, Fatty Acids, Volatile, Feces, Female, Humans, Male, Middle Aged, Obesity, Morbid, Sweetening Agents, Butyric Acid, Young Adult, Non-Nutritive Sweeteners
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