Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population
Open accessAbstract
BACKGROUND: Metagenomic studies confirm that obesity is associated with a composition of gut microbiota. There are some controversies, however, about the composition of gut microbial communities in obese individuals in different populations. To examine the association between body mass index and microbiota composition in Ukrainian population, fecal concentrations of Bacteroidetes, Firmicutes, Actinobacteria and Firmicutes/Bacteroidetes (F/B) ratio were analyzed in 61 adult individuals. RESULTS: The relative abundance of Actinobacteria was small (5-7%) and comparable in different BMI categories. The content of Firmicutes was gradually increased while the content of Bacteroidetes was decreased with increasing body mass index (BMI). The F/B ratio also raised with increasing BMI. In an unadjusted logistic regression model, F/B ratio was significantly associated with BMI (OR = 1.23, 95% CI 1,09-1,38). This association continued to be significant after adjusting for confounders such as age, sex, tobacco smoking and physical activity (OR = 1.33, 95% CI 1,11-1,60). CONCLUSIONS: The obtained data indicate that obese persons in Ukraine adult population have a significantly higher level of Firmicutes and lower level of Bacteroidetes compared to normal-weight and lean adults.
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The Firmicutes/Bacteroidetes ratio is higher in obese people compared to lean people.
“Animal and human data have reported that the Firmicutes/Bacteroidetes ratio is higher (i.e., increased Firmicutes and/or decreased Bacteroidetes) in obese people compared to lean people [79–82].”
From The athletic gut microbiota (2020) · cites this paper as [82]
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1 retracted
Million, M., Angelakis, E., Maraninchi, M., Henry, M., Giorgi, R., Valero, R., Vialettes, B., & Raoult, D. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.20 · Cited by 362 · see citing works
RetractedAn obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works
Human gut microbiota in obesity and after gastric bypass
Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works
Hill, J. O., Wyatt, H. R., & Peters, J. C. (2012) · Circulation · doi:10.1161/circulationaha.111.087213 · Cited by 1,317 · see citing works
Human colonic microbiota associated with diet, obesity and weight loss
Duncan, S. H., Lobley, G. E., Holtrop, G., Ince, J., Johnstone, A. M., Louis, P., & Flint, H. J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.155 · Cited by 1,222 · see citing works
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works
The core gut microbiome, energy balance and obesity
Turnbaugh, P. J., & Gordon, J. I. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174136 · Cited by 993 · see citing works
Effects of gut microbes on nutrient absorption and energy regulation
Krajmalnik‐Brown, R., Ilhan, Z., Kang, D., & DiBaise, J. K. (2012) · Nutrition in Clinical Practice · doi:10.1177/0884533611436116 · Cited by 852 · see citing works
Guinane, C. M., & Cotter, P. D. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13482996 · Cited by 846 · see citing works
Assessment of Physical Activity and Energy Expenditure: An Overview of Objective Measures
Hills, A. P., Mokhtar, N., & Byrne, N. M. (2014) · Frontiers in Nutrition · doi:10.3389/fnut.2014.00005 · Cited by 587 · see citing works
Kasai, C., Sugimoto, K., Moritani, I., Tanaka, J., Oya, Y., Inoue, H., Tameda, M., Shiraki, K., Ito, M., Takei, Y., et al. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0330-2 · Cited by 581 · see citing works
The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight
Karlsson, C., Önnerfält, J., Xu, J., Molin, G., Ahrné, S., & Thorngren‐Jerneck, K. (2012) · Obesity · doi:10.1038/oby.2012.110 · Cited by 536 · see citing works
Gut microbiota and metabolic syndrome
Festi, D., Schiumerini, R., Eusebi, L. H., Marasco, G., Taddia, M., & Colecchia, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i43.16079 · Cited by 534 · see citing works
Gérard, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2061-5 · Cited by 512 · see citing works
Improvement of phylum- and class-specific primers for real-time PCR quantification of bacterial taxa
Gregoris, T. B. D., Aldred, N., Clare, A. S., & Burgess, J. G. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.06.010 · Cited by 431 · see citing works
Ismail, N. A., Ragab, S. H., ElBaky, A. A., Shoeib, A. R. S., Alhosary, Y., & Fekry, D. (2011) · Archives of Medical Science · doi:10.5114/aoms.2011.23418 · Cited by 268 · see citing works
Role of the Gut Microbiome in Obesity and Diabetes Mellitus
Barlow, G. M., Yu, A. T., & Mathur, R. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609896 · Cited by 261 · see citing works
Sweeney, T. E., & Morton, J. M. (2013) · JAMA Surgery · doi:10.1001/jamasurg.2013.5 · Cited by 250 · see citing works
Correlation between body mass index and faecal microbiota from children
Ignácio, A., Fernandes, M. R., Rodrigues, V. A. A., Groppo, F. C., Cardoso, A. L., Ávila-Campos, M. J., & Nakano, V. (2015) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2015.10.031 · Cited by 204 · see citing works
Obesity Alters the Microbial Community Profile in Korean Adolescents
Hu, H., Park, S.-G., Jang, H. B., Choi, M.-G., Park, K., Kang, J., Park, S. I., Lee, H.-J., & Cho, S.-H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134333 · Cited by 169 · see citing works
Mathur, R., & Barlow, G. M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1051029 · Cited by 160 · see citing works
Rial, S. A., Karelis, A. D., Bergeron, K., & Mounier, C. (2016) · Nutrients · doi:10.3390/nu8050281 · Cited by 129 · see citing works
A Widely Applicable Protocol for DNA Isolation from Fecal Samples
Zhang, B., Li, M., Ma, L., & Wei, F. (2006) · Biochemical Genetics · doi:10.1007/s10528-006-9050-1 · Cited by 122 · see citing works
The Obesity Epidemic — Understanding the Disease and the Treatment
Apovian, C. M. (2016) · New England Journal of Medicine · doi:10.1056/nejme1514957 · Cited by 92 · see citing works
Sabbagh, L. C., Revéiz, L., Aponte, D. M., & de Aguiar, S. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-100 · Cited by 66 · see citing works
Higher blood glucose level associated with body mass index and gut microbiota in elderly people
Sepp, E., Kolk, H., Lõivukene, K., & Mikelsaar, M. (2014) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v25.22857 · Cited by 61 · see citing works
The obese gut microbiome across the epidemiologic transition
Dugas, L. R., Fuller, M. H., Gilbert, J. A., & Layden, B. T. (2016) · Emerging Themes in Epidemiology · doi:10.1186/s12982-015-0044-5 · Cited by 49 · see citing works
Has provoking microbiota aggression driven the obesity epidemic?
Chassaing, B., & Gewirtz, A. T. (2016) · BioEssays · doi:10.1002/bies.201500116 · Cited by 36 · see citing works
Gut Microbiota and Energy Expenditure in Health and Obesity
Bakker, G. J., Zhao, J., Herrema, H., & Nieuwdorp, M. (2015) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000363 · Cited by 27 · see citing works
Flagged first, then by citations
1 of the 36 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?
Magne, F., Gotteland, M., Gauthier, L., Zazueta, A., Pesoa, S., Navarrete, P., & Balamurugan, R. (2020) · Nutrients · doi:10.3390/nu12051474 · Cited by 2,335 · see citing works
Stojanov, S., Berlec, A., & Štrukelj, B. (2020) · Microorganisms · doi:10.3390/microorganisms8111715 · Cited by 1,903 · see citing works
The Human Gut Microbiome – A Potential Controller of Wellness and Disease
Kho, Z. Y., & Lal, S. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01835 · Cited by 1,116 · see citing works
Health and disease markers correlate with gut microbiome composition across thousands of people
Manor, O., Dai, C. L., Kornilov, S. A., Smith, B., Price, N. D., Lovejoy, J. C., Gibbons, S. M., & Magis, A. T. (2020) · Nature Communications · doi:10.1038/s41467-020-18871-1 · Cited by 810 · see citing works
Liu, B., Liu, X., Liang, Z., & Wang, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i25.3837 · Cited by 625 · see citing works
Profile of the gut microbiota of adults with obesity: a systematic review
Crovesy, L., Masterson, D., & Rosado, E. L. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-0607-6 · Cited by 610 · see citing works
Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies
Aggarwal, N., Kitano, S., Puah, G. R. Y., Kittelmann, S., Hwang, I. Y., & Chang, M. W. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00431 · Cited by 544 · see citing works
Oral Microbiome: A Review of Its Impact on Oral and Systemic Health
Krishnamurthy, H. K., Bosco, J., Jayaraman, V., Krishna, K., Wang, T., Bei, K., & Rajasekaran, J. J. (2024) · Microorganisms · doi:10.3390/microorganisms12091797 · Cited by 402 · see citing works
Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., West, N. P., Black, K., Gleeson, M., Pyne, D. B., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00353-w · Cited by 378 · see citing works
Gut microbiota markers associated with obesity and overweight in Italian adults
Palmas, V., Pisanu, S., Madau, V., Casula, E., Deledda, A., Cusano, R., Uva, P., Vascellari, S., Loviselli, A., Manzin, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84928-w · Cited by 369 · see citing works
The Safe and Effective Use of Plant-Based Diets with Guidelines for Health Professionals
Craig, W. J., Mangels, A. R., Fresán, U., Marsh, K. A., Miles, F. L., Saunders, A. V., Haddad, E. H., Heskey, C. E., JOHNSTON, P. K., Larson‐Meyer, E., et al. (2021) · Nutrients · doi:10.3390/nu13114144 · Cited by 342 · see citing works
Takagi, T., Naito, Y., Inoüe, R., Kashiwagi, S., Uchiyama, K., Mizushima, K., Tsuchiya, S., Dohi, O., Yoshida, N., Kamada, K., et al. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1488-5 · Cited by 310 · see citing works
Qi, X., Zhang, Y., Zhang, Y., Luo, F., Song, K., Wang, G., & Ling, F. (2023) · Microbiome · doi:10.1186/s40168-023-01574-2 · Cited by 302 · see citing works
Changes of colonic bacterial composition in Parkinson's disease and other neurodegenerative diseases
Gerhardt, S., & Mohajeri, M. H. (2018) · Nutrients · doi:10.3390/nu10060708 · Cited by 298 · see citing works
Григорьева, И. Н. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm11010013 · Cited by 288 · see citing works
Forbes, J. D., Azad, M. B., Vehling, L., Tun, H. M., Konya, T. B., Guttman, D. S., Field, C. J., Lefebvre, D., Sears, M. R., Becker, A. B., et al. (2018) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2018.1161 · Cited by 285 · see citing works
The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation
Rahman, M. M., Islam, F., Harun-Or-Rashid, M., Mamun, A. A., Rahaman, M. S., Islam, M. M., Meem, A. F. K., Sutradhar, P. R., Mitra, S., Mimi, A. A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.903570 · Cited by 267 · see citing works
Ketogenic Diet and Microbiota: Friends or Enemies?
Paoli, A., Mancin, L., Bianco, A., Thomas, E., Mota, J. F., & Piccini, F. (2019) · Genes · doi:10.3390/genes10070534 · Cited by 265 · see citing works
Kaliannan, K., Robertson, R. C., Murphy, K., Stanton, C., Kang, C., Wang, B., Hao, L., Bhan, A. K., & Kang, J. X. (2018) · Microbiome · doi:10.1186/s40168-018-0587-0 · Cited by 263 · see citing works
Pap, N., Fidelis, M., Azevedo, L. C., do Carmo, M. A. V., Wang, D., Mocan, A., Pereira, E. P. R., Xavier-Santos, D., Sant’Ana, A. S., Yang, B., et al. (2021) · Current Opinion in Food Science · doi:10.1016/j.cofs.2021.06.003 · Cited by 259 · see citing works
Lee, S. H., Yun, Y., Kim, S. J., Lee, E., Chang, Y., Ryu, S., Shin, H., Kim, H., Kim, H., & Lee, J. H. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7090282 · Cited by 254 · see citing works
Li, Z., Feng, C., Pang, W. B., Tian, C., & Zhao, Y. (2021) · ACS Nano · doi:10.1021/acsnano.1c02407 · Cited by 250 · see citing works
Machate, D. J., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Hiane, P. A., Bogo, D., Pinheiro, V. A. Z., Oliveira, L. C. S. D., & Pott, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114093 · Cited by 243 · see citing works
The critical role of gut microbiota in obesity
Cheng, Z., Zhang, L., Yang, L., & Chu, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1025706 · Cited by 233 · see citing works
Characteristics of gut microbiota in people with obesity
Duan, M., Wang, Y., Zhang, Q., Zou, R., Guo, M., & Zheng, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255446 · Cited by 233 · see citing works
Zhang, Q., Wang, Y., & Fu, L. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12593 · Cited by 232 · see citing works
The human microbiome in disease and pathology
Manos, J. (2022) · Apmis · doi:10.1111/apm.13225 · Cited by 231 · see citing works
Tan, C., Wu, Q., Wang, H., Gao, X., Xu, R., Cui, Z., Zhu, J., Zeng, X., Zhou, H., He, Y., et al. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1861 · Cited by 229 · see citing works
The Interaction between Flavonoids and Intestinal Microbes: A Review
Xiong, H.-H., Lin, S.-Y., Chen, L., Ouyang, K., & Wang, W. (2023) · Foods · doi:10.3390/foods12020320 · Cited by 222 · see citing works
Modulation of the human gut microbiota by phenolics and phenolic fiber‐rich foods
Loo, Y. T., Howell, K. S., Chan, M., Zhang, P., & Ng, K. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12563 · Cited by 216 · see citing works
Vaiserman, A. M., Romanenko, M., Півень, Л. В., Moseiko, V., Lushchak, O. V., Kryzhanovska, N., Gurianov, V. G., & Koliada, A. K. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01903-7 · Cited by 216 · see citing works
Self-citationProbiotics: How Effective Are They in the Fight against Obesity?
Mazloom, K., Siddiqi, I., & Covașă, M. (2019) · Nutrients · doi:10.3390/nu11020258 · Cited by 198 · see citing works
Min, B. H., Devi, S., Kwon, G.-H., Gupta, H., Jeong, J., Sharma, S. P., Won, S., Oh, K., Yoon, S. J., Park, H., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2307568 · Cited by 190 · see citing works
Diet and microbiota linked in health and disease
Requena, T., Martínez‐Cuesta, M. C., & Peláez, C. (2018) · Food & Function · doi:10.1039/c7fo01820g · Cited by 187 · see citing works
The interaction between smoking, alcohol and the gut microbiome
Capurso, G., & Lahner, E. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.10.006 · Cited by 182 · see citing works
Flavonoids as Antiobesity Agents: A Review
Rufino, A. T., Costa, V. M., Carvalho, F., & Fernandes, E. (2021) · Medicinal Research Reviews · doi:10.1002/med.21740 · Cited by 174 · see citing works
The Gut Microbiome and Type 2 Diabetes Mellitus: Discussing A Complex Relationship
Sikalidis, A. K., & Maykish, A. (2020) · Biomedicines · doi:10.3390/biomedicines8010008 · Cited by 171 · see citing works
Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
Granado-Serrano, A. B., Martín-Garí, M., Sánchez, V., Riart Solans, M., Berdún, R., Ludwig, I. A., Rubió, L., Vilaprinyó, E., Portero-Otín, M., & Serrano, J. C. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-38874-3 · Cited by 169 · see citing works
Koceva, A., Herman, R., Janež, A., Rakuša, M., & Jensterle, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137342 · Cited by 167 · see citing works
Tea Compounds and the Gut Microbiome: Findings from Trials and Mechanistic Studies
Bond, T., & Derbyshire, E. J. (2019) · Nutrients · doi:10.3390/nu11102364 · Cited by 161 · see citing works
Gu, W., Wang, Y., Zeng, L., Dong, J.-C., Bi, Q., Yang, X., Che, Y., He, S., & Yu, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109910 · Cited by 160 · see citing works
Xia, T., Liu, C., Hu, Y., Luo, Z., Chen, F., Yuan, L., & Tan, X. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110717 · Cited by 159 · see citing works
Overby, H., & Ferguson, J. F. (2021) · Current Hypertension Reports · doi:10.1007/s11906-020-01125-2 · Cited by 153 · see citing works
Lee, C. B., Chae, S. U., Jo, S. J., Jerng, U. M., & Bae, S. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073566 · Cited by 149 · see citing works
Risk Factors for Unhealthy Weight Gain and Obesity among Children with Autism Spectrum Disorder
Dhaliwal, K. K., Orsso, C. E., Richard, C., Haqq, A. M., & Zwaigenbaum, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133285 · Cited by 149 · see citing works
Skonieczna‐Żydecka, K., Marlicz, W. M., Misera, A., Koulaouzidis, A., & Łoniewski, I. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120521 · Cited by 148 · see citing works
Green Tea Liquid Consumption Alters the Human Intestinal and Oral Microbiome
Yuan, X., Long, Y., Ji, Z., Gao, J., Fu, T., Yan, M., Zhang, L., Su, H., Zhang, W., Wen, X., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800178 · Cited by 142 · see citing works
The microbiome: An emerging key player in aging and longevity
Kim, M., & Benayoun, B. A. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.07.004 · Cited by 142 · see citing works
The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer
An, J., Kwon, H., & Kim, Y. J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062216 · Cited by 141 · see citing works
Gao, H., Jiang, Q., Ji, H., Ning, J., Li, C., & Zheng, H. X. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165541 · Cited by 139 · see citing works
Implication of Gut Microbiota in Cardiovascular Diseases
Zhou, W., Cheng, Y., Zhu, P., Nasser, M. I., Zhang, X., & Zhao, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5394096 · Cited by 138 · see citing works
Ashrafian, F., Raftar, S. K. A., Lari, A., Shahryari, A., Abdollahiyan, S., Moradi, H. R., Masoumi, M., Davari, M., Khatami, S., Omrani, M. D., et al. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01709-w · Cited by 138 · see citing works
González‐Sarrías, A., Romo‐Vaquero, M., Garcı́a-Villalba, R., Cortés‐Martín, A., Selma, M. V., & Espı́n, J. C. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800160 · Cited by 136 · see citing works
Gut Microbiota as an Objective Measurement for Auxiliary Diagnosis of Insomnia Disorder
Liu, B., Lin, W., Chen, S., Xiang, T., Yang, Y., Yin, Y., Xu, G., Liu, Z., Liu, L., Pan, J., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01770 · Cited by 132 · see citing works
Gut Microbiota Composition Is Related to Cardiorespiratory Fitness in Healthy Young Adults
Durk, R. P., Castillo, E., Márquez-Magaña, L., Grosicki, G. J., Bolter, N. D., Lee, C. M., & Bagley, J. R. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0024 · Cited by 131 · see citing works
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MethodLi, S., Chu, Y., Xie, P., Xie, Y., Chang, H., & Ho, S. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.126892 · Cited by 130 · see citing works
Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota
Loke, Y. L., Chew, M. T., Ngeow, Y. F., Lim, W. W.-D., & Peh, S. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603086 · Cited by 129 · see citing works
The Equine Gastrointestinal Microbiome: Impacts of Age and Obesity
Morrison, P. K., Newbold, C. J., Jones, E., Worgan, H. J., Grove‐White, D., Dugdale, A., Barfoot, C. F., Harris, P. A., & Argo, C. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03017 · Cited by 127 · see citing works
Lee, N. Y., Yoon, S. J., Han, D. H., Gupta, H., Youn, G. S., Shin, M. J., Ham, Y. L., Kwak, M. J., Kim, B., Yu, J. S., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1712984 · Cited by 127 · see citing works
Hu, R., Wu, S., Li, B., Tan, J., Yan, J., Wang, Y., Tang, Z., Liu, M., Fu, C., Zhang, H., et al. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.06.009 · Cited by 124 · see citing works
Kahleová, H., Rembert, E., Alwarith, J., Yonas, W., Tura, A., Holubkov, R., Agnello, M., Chutkan, R. K., & Barnard, N. D. (2020) · Nutrients · doi:10.3390/nu12102917 · Cited by 123 · see citing works
The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
König, R. S., Albrich, W. C., Kahlert, C. R., Bahr, L. S., Löber, U., Vernazza, P., Scheibenbogen, C., & Forslund, S. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628741 · Cited by 123 · see citing works
Chi, L., Khan, I., Lin, Z., Zhang, J., Lee, S. M., Leong, W., Hsiao, W. L. W., & Zheng, Y. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153157 · Cited by 121 · see citing works
Ni, Y., Lohinai, Z., Heshiki, Y., Dome, B., Moldvay, J., Dulka, E., Gálffy, G., Berta, J., Weiss, G., Sommer, M., et al. (2021) · The ISME Journal · doi:10.1038/s41396-021-00998-8 · Cited by 111 · see citing works
Ried, K., Travica, N., & Sali, A. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00122 · Cited by 120 · see citing works
Ortega, M. A., Fraile‐Μartinez, O., Naya, I., García‐Honduvilla, N., Álvarez‐Mon, M., Buján, J., Asúnsolo, Á., & de la Torre, B. (2020) · Nutrients · doi:10.3390/nu12092749 · Cited by 117 · see citing works
Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats
Zhang, Z., Chen, Y., Xiang, L., Wang, Z., Xiao, G. G., & Hu, J. (2017) · Nutrients · doi:10.3390/nu9101146 · Cited by 112 · see citing works
Alqahtani, S. A., & Schattenberg, J. M. (2021) · Clinical Interventions in Aging · doi:10.2147/cia.s295524 · Cited by 113 · see citing works
Silva, C. C. D., Monteil, M., & Davis, E. M. (2020) · Childhood Obesity · doi:10.1089/chi.2019.0280 · Cited by 111 · see citing works
Zhang, Q., Cheng, L., Wang, J., Hao, M., & Che, H. (2021) · Nutrients · doi:10.3390/nu13103315 · Cited by 110 · see citing works
Effects of Flammulina velutipes polysaccharide on immune response and intestinal microbiota in mice
Zhao, R., Hu, Q., Ma, G., Su, A., Xie, M., Li, X., Chen, G., & Zhao, L. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.03.031 · Cited by 110 · see citing works
Saiyasit, N., Chunchai, T., Prus, D., Suparan, K., Pittayapong, P., Apaijai, N., Pratchayasakul, W., Sripetchwandee, J., Chattipakorn, N., & Chattipakorn, S. C. (2019) · Nutrition · doi:10.1016/j.nut.2019.110576 · Cited by 109 · see citing works
Obstructive sleep apnea and metabolic syndrome
Giampá, S. Q. D. C., Lorenzi‐Filho, G., & Drager, L. F. (2023) · Obesity · doi:10.1002/oby.23679 · Cited by 109 · see citing works
Regulation of bile acids and their receptor FXR in metabolic diseases
Li, Y., Wang, L., Qing, Y., Luo, L., & Xiong, Y. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1447878 · Cited by 107 · see citing works
Human intervertebral discs harbour a unique microbiome and dysbiosis determines health and disease
Rajasekaran, S., Soundararajan, D. C. R., Tangavel, C., Raveendran, M., Anand, K. S. S. V., Matchado, M. S., Nayagam, S. M., Shetty, A. P., Kanna, R. M., & Dharmalingam, K. (2020) · European Spine Journal · doi:10.1007/s00586-020-06446-z · Cited by 105 · see citing works
Mendes‐Soares, H., Raveh-Sadka, T., Azulay, S., Ben‐Shlomo, Y., Cohen, Y., Ofek, T., Stevens, J., Bachrach, D., Kashyap, P., Segal, L., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz028 · Cited by 102 · see citing works
Association between the gut and oral microbiome with obesity
Benahmed, A. G., Gasmi, A., Doşa, A., Chirumbolo, S., Mujawdiya, P. K., Aaseth, J., Dadar, M., & Bjørklund, G. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2020.102248 · Cited by 102 · see citing works
Inchingolo, A. D., Malcangi, G., Inchingolo, A. M., Piras, F., Settanni, V., Garofoli, G., Palmieri, G., Ceci, S., Patano, A., Leonardis, N. D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23074027 · Cited by 102 · see citing works
Xiao, J., Chen, X., Zhan, Q., Zhong, L., Hu, Q., & Zhao, L. (2021) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2021.105901 · Cited by 100 · see citing works
Wu, S., Hu, R., Nakano, H., Chen, K., Liu, M., He, X., Zhang, H., He, J., & Hou, D. (2018) · Molecules · doi:10.3390/molecules23123213 · Cited by 99 · see citing works
Jacquier, V., Nelson, A., Jlali, M., Rhayat, L., Brinch, K. S., & Devillard, E. (2019) · Poultry Science · doi:10.3382/ps/pey602 · Cited by 99 · see citing works
Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome
Bowers, S. J., Vargas, F., González, A., He, S., Jiang, P., Dorrestein, P. C., Knight, R. D., Wright, K. P., Lowry, C. A., Fleshner, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229001 · Cited by 99 · see citing works
Lin, S., Wang, Z., Lam, K., Zeng, S., Tan, B. K., & Hu, J. (2019) · Food & Nutrition Research · doi:10.29219/fnr.v63.1518 · Cited by 96 · see citing works
Abuqwider, J., Mauriello, G., & Altamimi, M. (2021) · Microorganisms · doi:10.3390/microorganisms9051098 · Cited by 96 · see citing works
Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction
González-Quilen, C., Rodríguez‐Gallego, E., Beltrán‐Debón, R., Pinent, M., Ardèvol, A., Blay, M., & Terra, X. (2020) · Nutrients · doi:10.3390/nu12010130 · Cited by 95 · see citing works
Gut and obesity/metabolic disease: Focus on microbiota metabolites
Lin, K., Zhu, L., & Li, Y. (2022) · MedComm · doi:10.1002/mco2.171 · Cited by 95 · see citing works
Prochazkova, P., Roubalova, R., Dvorak, J., Tlaskalova-Hogenova, H., Cermakova, M., Tomasova, P., Sediva, B., Kuzma, M., Bulant, J., Bilej, M., et al. (2019) · Microorganisms · doi:10.3390/microorganisms7090338 · Cited by 93 · see citing works
Lodovico, L. D., Mondot, S., Dore, J. M., Mack, I., Hanachi, M., & Gorwood, P. A. P. M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110114 · Cited by 92 · see citing works
Meng, X., Hu, W., Wu, S., Zhu, Z.-X., Lu, R., Yang, G., Qin, C., Yang, L., & Nie, G. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.10.066 · Cited by 91 · see citing works
Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions
Syromyatnikov, M., Nesterova, E. Y., Gladkikh, M. I., Dmitrievna, S. Y., Vladimirovna, G. M., & Popov, V. N. (2022) · Microorganisms · doi:10.3390/microorganisms10091866 · Cited by 91 · see citing works
Li, Y., Wang, K., Zhang, B., Tu, Q., Yao, Y., Cui, B., Ren, B., He, J., Shen, X., Nostrand, J. D. V., et al. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0045-2 · Cited by 90 · see citing works
Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
Kaźmierczak-Siedlecka, K., Dvořák, A., Folwarski, M., Daca, A., Przewłócka, K., & Makarewicz, W. (2020) · Cancers · doi:10.3390/cancers12051326 · Cited by 90 · see citing works
Liu, Y., Gao, Y., Ma, F., Sun, M., Mu, G., & Tuo, Y. (2020) · Food & Function · doi:10.1039/d0fo00439a · Cited by 90 · see citing works
A systematic review on the role of microbiota in the pathogenesis and treatment of eating disorders
Carbone, E. A., D'Amato, P., Vicchio, G., Fazio, P. D., & Segura‐Garcìa, C. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.109 · Cited by 90 · see citing works
Links Between the Circadian Rhythm, Obesity and the Microbiome
RÁCZ, B., Dušková, M., Stárka, L., Hainer, V., & Kunešová, M. (2018) · Physiological Research · doi:10.33549/physiolres.934020 · Cited by 89 · see citing works
Protective effects of Bacillus probiotics against high-fat diet-induced metabolic disorders in mice
Kim, B., Kwon, J., Kim, M., Park, H., Ji, Y., Holzapfel, W. H., & Hyun, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0210120 · Cited by 88 · see citing works
Genoni, A., Christophersen, C. T., Lo, J., Coghlan, M. L., Boyce, M. C., Bird, A. R., Lyons‐Wall, P., & Devine, A. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02036-y · Cited by 88 · see citing works
Zhao, R., Cheng, N., Nakata, P. A., Zhao, L., & Hu, Q. (2019) · Food Research International · doi:10.1016/j.foodres.2019.04.070 · Cited by 87 · see citing works
“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?
Liebert, A. D., Bicknell, B. T., Johnstone, D. M., Gordon, L. C., Kiat, H., & Hamblin, M. R. (2019) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2019.4628 · Cited by 87 · see citing works
Gut and vaginal microbiomes on steroids: implications for women’s health
Graham, M. E., Herbert, W. G., Song, S., Raman, H. N., Zhu, J. E., Gonzalez, P. E., Walther-Antonio, M. R. S., & Tetel, M. J. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.04.014 · Cited by 87 · see citing works
- Authors
- Koliada, A., Syzenko, G., Moseiko, V., Budovska, L., Puchkov, K., Perederiy, V., Gavalko, Y., Dorofeyev, A., Romanenko, M., Tkach, S., Sineok, L., Lushchak, O., & Vaiserman, A.
- Affiliations
- D. F. Chebotarev State Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (UA)
- Bogomolets National Medical University (UA)
- Vasyl Stefanyk Carpathian National University (UA)
- Corresponding author
- Vaiserman, Alexander
- Venue
- BMC Microbiology
- Published
- 2017-05-22
- Volume
- 17
- Issue
- 1
- Pages
- 120-120
- ISSN
- 1471-2180 (ISSN-L)
- PMC
- PMC5440985
- OpenAlex
- W2620098478
- Cited by
- 1,000
- References
- 36
- Citations by year
- 2026: 49 · 2025: 97 · 2024: 112 · 2023: 124 · 2022: 143 · 2021: 150 · 2020: 176 · 2019: 95 · 2018: 51 · 2017: 3
- FWCI
- 36.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Academy of Medical Sciences of Ukraine (0113U002119)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- body mass index, obesity, gut microbiota, Firmicutes/Bacteroidetes ratio, Firmicutes, Bacteroidetes, actinobacteria, fecal microbiota composition
- MeSH terms
- Firmicutes, Bacillota, Gastrointestinal Microbiome, Tobacco Smoking, Adult, Bacteria, DNA, Bacterial, Feces, Female, Humans, Life Style, Male, Middle Aged, Obesity, Ukraine, Exercise, Body Mass Index, Actinobacteria, Bacteroidetes, Gastrointestinal Tract
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