Pharmacokinetics and Pharmacological Activities of Berberine in Diabetes Mellitus Treatment

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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

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Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

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Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension

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Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

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The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

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Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes

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Berberine improves glucose metabolism through induction of glycolysis

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Antioxidant and Anti‐Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus

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Berberine and barberry ( Berberis vulgaris ): A clinical review

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Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats

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Research progress on berberine with a special focus on its oral bioavailability

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Berberis Vulgaris and Berberine: An Update Review

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Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats

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Berberine pharmacology and the gut microbiota: A hidden therapeutic link

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Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

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Transforming berberine into its intestine-absorbable form by the gut microbiota

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Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats

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Tissue Distribution of Berberine and Its Metabolites after Oral Administration in Rats

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Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression

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Berberine Improves Glucose Metabolism in Diabetic Rats by Inhibition of Hepatic Gluconeogenesis

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Application of Berberine on Treating Type 2 Diabetes Mellitus

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Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence

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Acute toxicity of berberine and its correlation with the blood concentration in mice

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The involvement of P-glycoprotein in berberine absorption

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Recent advances in the development of farnesoid X receptor agonists.

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Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats

Zhou, J., Zhou, S., Tang, J., Zhang, K., Guang, L.-X., Huang, Y., Xu, Y. X., Ying, Y., Zhang, L., & Li, D. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.12.056 · Cited by 208 · see citing works

Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism

Wang, Y., Shou, J., Li, X., Zhao, Z., Fu, J., He, C., Feng, R., Ma, C., Wen, B., Guo, F., et al. (2017) · Metabolism · doi:10.1016/j.metabol.2017.02.003 · Cited by 206 · see citing works

Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway

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The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine

Ma, X., Chen, Z., Wang, L., Wang, G., Wang, Z., Dong, X., Wen, B., & Zhang, Z. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00782 · Cited by 189 · see citing works

Insulin Sensitizing and Insulinotropic Action of Berberine from Cortidis Rhizoma

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Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

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Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity

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Chronic Effects of Berberine on Blood, Liver Glucolipid Metabolism and Liver PPARs Expression in Diabetic Hyperlipidemic Rats

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Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota are Attributable to Its Key Ingredient Berberine

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Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21

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Effects of Berberine in the Gastrointestinal Tract — A Review of Actions and Therapeutic Implications

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Berberine Activates GLUT1-Mediated Glucose Uptake in 3T3-L1 Adipocytes

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Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway

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Gut Microbiota-Mediated Personalized Treatment of Hyperlipidemia Using Berberine

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Effects of Berberine on the Gastrointestinal Microbiota

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PEG–lipid–PLGA hybrid nanoparticles loaded with berberine–phospholipid complex to facilitate the oral delivery efficiency

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Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats

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Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism

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Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies

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Learning from berberine: Treating chronic diseases through multiple targets

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Integrative analysis of metabolome and gut microbiota in diet-induced hyperlipidemic rats treated with berberine compounds

Li, M., Shu, X., Xu, H., Zhang, C., Yang, L., Zhang, L. R., & Ji, G. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0987-5 · Cited by 114 · see citing works

Dendrimer encapsulated and conjugated delivery of berberine: A novel approach mitigating toxicity and improving in vivo pharmacokinetics

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Berberine decreases cholesterol levels in rats through multiple mechanisms, including inhibition of cholesterol absorption

Wang, Y., Yi, X., Ghanam, K., Zhang, S., Zhao, T.-T., & Zhu, X. (2014) · Metabolism · doi:10.1016/j.metabol.2014.05.013 · Cited by 112 · see citing works

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes

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Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein

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Excretion of Berberine and Its Metabolites in Oral Administration in Rats

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Berberine inhibits PTP1B activity and mimics insulin action

Chen, C., Zhang, Y., & Huang, C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.153 · Cited by 106 · see citing works

Berberine suppresses LPS‐induced inflammation through modulating Sirt1/NF‐&kgr;B signaling pathway in RAW264.7 cells

Zhang, H., Shan, Y., Wu, Y., Xu, C., Yu, X.-Z., Zhao, J., Yan, J., & Shang, W.-B. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.08.032 · Cited by 106 · see citing works

Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

Jiang, S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7777 · Cited by 104 · see citing works

Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase

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Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats

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Post-inflationary gravitino production revisited

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Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine

Wang, T., Wang, N., Song, H., Xi, X., Wang, J., Hao, A., & Li, T. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.06.015 · Cited by 96 · see citing works

Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation

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Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

Yin, J., Hou, Y., Yin, Y., & Song, X. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s144615 · Cited by 87 · see citing works

CYP2D plays a major role in berberine metabolism in liver of mice and humans

Guo, Y., Li, F., Ma, X., Cheng, X., Zhou, H., & Klaassen, C. D. (2011) · Xenobiotica · doi:10.3109/00498254.2011.597456 · Cited by 86 · see citing works

Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels

Xu, J. H., Liu, X., Pan, W., & Zou, D. J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6321 · Cited by 86 · see citing works

Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice

Xue, M., Zhang, L., Yang, M., Zhang, W., Li, X.-M., Ou, Z., Li, Z., Liu, S.-H., Li, X., & Yang, S. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s84565 · Cited by 84 · see citing works

Developmental toxicity evaluation of berberine in rats and mice

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Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4α miR122 Pathway

Wei, S., Zhang, M., Yu, Y., Lan, X., Yao, F., Yan, X., Chen, L., & Hatch, G. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152097 · Cited by 84 · see citing works

Berberine chloride ameliorates oxidative stress, inflammation and apoptosis in the pancreas of Streptozotocin induced diabetic rats

Chandirasegaran, G., Elanchezhiyan, C., Ghosh, K., & Sethupathy, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.040 · Cited by 83 · see citing works

A metabolomic and pharmacokinetic study on the mechanism underlying the lipid-lowering effect of orally administered berberine

Gu, S., Cao, B., Sun, R., Tang, Y., Paletta, J. L., Wu, X., Liu, L., Zha, W., Zhao, C., Li, Y., et al. (2014) · Molecular BioSystems · doi:10.1039/c4mb00500g · Cited by 82 · see citing works

Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters

Li, X., Zhao, Z., Huang, M., Feng, R., He, C., Ma, C., Luo, S.-H., Fu, J., Wen, B., Ren, L., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0629-3 · Cited by 81 · see citing works

Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration

Feng, R., Zhao, Z., Ma, S.-R., Guo, F., Wang, Y., & Jiang, J.-D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00214 · Cited by 78 · see citing works

Berberine modulates insulin signaling transduction in insulin-resistant cells

Liu, L., Cheung, S. C. K., Lan, L., Ho, S. K. S., Xu, H., Chan, J. C. N., & Tong, P. C. Y. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.027 · Cited by 74 · see citing works

Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice.

Cao, Y. L., Pan, Q., Cai, W., Shen, F., Chen, G., Xu, L., & Fan, J. (2016) · PubMed · Cited by 74 · see citing works

Novel cremochylomicrons for improved oral bioavailability of the antineoplastic phytomedicine berberine chloride: Optimization and pharmacokinetics

Elsheikh, M. A., Elnaggar, Y. S. R., Hamdy, D. A., & Abdallah, O. Y. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.023 · Cited by 71 · see citing works

Berberine improves mesenteric artery insulin sensitivity through up‐regulating insulin receptor‐mediated signalling in diabetic rats

Geng, F., Li, G., Zhang, X., Zhang, P., Dong, M., Zhao, Z., Zhang, Y., Dong, L., & Gao, F. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13466 · Cited by 68 · see citing works

Alteration of hepatic glutathione peroxidase and superoxide dismutase expression in streptozotocin-induced diabetic mice by berberine

Lao‐ong, T., Chatuphonprasert, W., Nemoto, N., & Jarukamjorn, K. (2012) · Pharmaceutical Biology · doi:10.3109/13880209.2012.655377 · Cited by 67 · see citing works

Effects of Berberine on Amelioration of Hyperglycemia and Oxidative Stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo

Liu, C., Wang, Z., Song, Y., Wu, D., Zheng, X., Li, P., Jin, J., Xu, N., & Li, L. (2015) · BioMed Research International · doi:10.1155/2015/313808 · Cited by 63 · see citing works

Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity

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Improvement of superoxide dismutase and catalase in streptozotocin–nicotinamide-induced type 2-diabetes in mice by berberine and glibenclamide

Chatuphonprasert, W., Lao‐ong, T., & Jarukamjorn, K. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2013.839714 · Cited by 61 · see citing works

Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats

Shan, C., Yang, J. H., Kong, Y., Wang, X., Zheng, M., Xu, Y., Wang, Y., Ren, H., Chang, B., & Chen, L. M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0184 · Cited by 59 · see citing works

Preparation and Evaluation of Antidiabetic Agents of Berberine Organic Acid Salts for Enhancing the Bioavailability

Cui, H., Hu, Y., Li, J., Yuan, K., & Guo, Y. (2018) · Molecules · doi:10.3390/molecules24010103 · Cited by 59 · see citing works

Berberine Nanosuspension Enhances Hypoglycemic Efficacy on Streptozotocin Induced Diabetic C57BL/6 Mice

Wang, Z., Wu, J., Zhou, Q. Y., Wang, Y., & Chen, T. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/239749 · Cited by 58 · see citing works

Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR.ALPHA. and PPAR.ALPHA. transcriptional programs

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Significant pharmacokinetic differences of berberine are attributable to variations in gut microbiota between Africans and Chinese

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Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3

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Berberine in type 2 diabetes therapy: a new perspective for an old antidiarrheal drug?

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Berberine inhibits mouse insulin gene promoter through activation of AMP activated protein kinase and may exert beneficial effect on pancreatic β-cell

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Berberine Alleviates Oxidative Stress in Islets of Diabetic Mice by Inhibiting miR‐106b Expression and Up‐Regulating SIRT1

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The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

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Berberine alleviates hepatic lipid accumulation by increasing ABCA1 through the protein kinase C δ pathway

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Molecular Basis of Insulin Action

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Berberine compounds improves hyperglycemia via microbiome mediated colonic TGR5-GLP pathway in db/db mice

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Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes

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Uncoupling protein‐2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS ‐1 E cells and in diabetic mouse islets

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Metabolic profiling analysis of berberine, palmatine, jatrorrhizine, coptisine and epiberberine in zebrafish by ultra-high performance liquid chromatography coupled with LTQ Orbitrap mass spectrometer

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Determination of berberine-upregulated endogenous short-chain fatty acids through derivatization by 2-bromoacetophenone

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SirT3 regulates diabetogenic effects caused by arsenic: An implication for mitochondrial complex II modification

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Protective effect of berberine on serum glucose levels in non-obese diabetic mice

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Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine

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Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin‐Resistant HepG2 Cells through the PPM1B Pathway

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Enzyme-inducing effects of berberine on cytochrome P450 1A2 in vitro and in vivo

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Berberine inhibits glucose oxidation and insulin secretion in rat islets

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Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus.

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A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples

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Discovery of C-9 Modified Berberine Derivatives as Novel Lipid-Lowering Agents

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Bidirectional regulation of adenosine 5′‐monophosphate–activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration

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Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus

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Nandinine, a Derivative of Berberine, Inhibits Inflammation and Reduces Insulin Resistance in Adipocytes via Regulation of AMP-Kinase Activity

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Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin-5f cells

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Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats

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Anti-inflammatory effects of three kinds of traditional Mongolian medicine monomer and its combination on LPS-stimulated RAW264.7 macrophages.

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Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins

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The molecular basis of insulin action

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The therapeutic effects of berberine plus sitagliptin in a rat model of fatty liver disease.

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Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases

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Natural Phytochemicals as SIRT Activators—Focus on Potential Biochemical Mechanisms

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Research progress on the pharmacological effects of berberine targeting mitochondria

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A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant

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Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation

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Addressing the preventive and therapeutic perspective of berberine against diabetes

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Berberine and health outcomes: an overview of systematic reviews

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Berberine as a multi-target therapeutic agent for obesity: from pharmacological mechanisms to clinical evidence

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Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives

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Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

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Berberine—A Promising Therapeutic Approach to Polycystic Ovary Syndrome in Infertile/Pregnant Women

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Berberine ameliorates glucocorticoid-induced hyperglycemia: an in vitro and in vivo study

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Mechanism of traditional Chinese medicine in elderly diabetes mellitus and a systematic review of its clinical application

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Improving the oral bioavailability of berberine: A crystal engineering approach

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Antioxidant and Cytotoxic Properties of Berberis vulgaris (L.) Stem Bark Dry Extract

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Botanical Sources, Pharmacokinetics, and Therapeutic Efficacy of Palmatine and Its Derivatives in the Management of Cancer: A Comprehensive Mechanistic Analysis

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Lack of berberine effect on bone mechanical properties in rats with experimentally induced diabetes

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Improving the Antimicrobial Potency of Berberine for Endodontic Canal Irrigation Using Polymeric Nanoparticles

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A Composition of Phytonutrients for Glycemic and Weight Management

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Advances in Biological Activities and Application of Plant Extracts

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Berberine attenuates TNBS-induced colitis in mice by improving the intestinal microbiota

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Berberine-induced browning and energy metabolism: mechanisms and implications

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Application of prebiotic stachyose on metabolic diseases and other human diseases through regulation of gut microbiota

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From nature to nanotech: Unlocking Berberine's therapeutic approaches

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Berberine inhibits the proliferation of pancreatic cancer cells by targeting pancreatic cancer stem cells through regulating EMT signaling pathway

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Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats

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Comprehensive insights into berberine's hypoglycemic mechanisms: A focus on ileocecal microbiome in db/db mice

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Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway

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Potential Health Effects of the Natural Alkaloid Berberine: A Narrative Review

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Assessing Nutraceuticals for Hepatic Steatosis: A Standardized In Vitro Approach

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Role of glycolysis in diabetic atherosclerosis

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13-Decyl Berberine Derivative Is a Novel Mitochondria-Targeted Antioxidant and a Potent Inhibitor of Ferroptosis

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Alleviation of Diabetic Tendon Injury via Activation of Tendon Fibroblasts Autophagy under Berberine Treatment

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Berberine-gut microbiota interactions based on CiteSpace: current research status and hotspots

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Adverse effects of the dietary supplement berberine studied on ants as models

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Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review

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Tyrosine-Derived Alkaloid Diversity in Some Cultivated Species of Poppies (Genus Papaver): A Review

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Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach

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Relevance of Traditional Antidiabetic Plants in The Covid-19 Pandemic Era

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"Metabolic Syndrome and Berberine: A Framework of Situation"

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Mikrobiota jelitowa i suplementacja probiotyczna w zaburzeniach gospodarki węglowodanowej

Ptaszyńska, D., & Łagowska, K. (2024) · Kosmos · doi:10.36921/kos.2023_2946

Side effects of five products largely used by humans and studied on ants as models: a mini review

Cammaerts, M.-C. (2024) · MOJ Biology and Medicine · doi:10.15406/mojbm.2024.09.00222

Additional file 1 of Berberin sustained-release nanoparticles were enriched in infarcted rat myocardium and resolved inflammation

Zhu, K., Yao, Y., Wang, K., Shao, F., Zhu, Z., Song, Y., Zhou, Z., Jiang, D., Lan, X., & Qin, C. (2024) · Figshare · doi:10.6084/m9.figshare.26564787

Berberine Alleviates Pancreatic β-Cell Ferroptosis and Injury in db/db Mice by Regulating the AGE/RAGE Pathway: Insight from Proteomic Analysis

Liu, X., Liu, Y.-G., Lv, Y., & Deng, B. (2026) · Current Medical Science · doi:10.1007/s11596-026-00168-x

Liposomal Delivery as a Strategy to Improve Berberine Bioavailability: A Double-Blind, Crossover, Randomized Pilot Study in Healthy Males

Purpura, M., Jäger, R., Godavarthi, A., Ceylan, H., Ambrish, C., & Tinsley, G. M. (2026) · Nutrition and Dietary Supplements · doi:10.2147/nds.s582434

Berberine-entrapped albumin nanoparticles ameliorate chemically induced liver injury by restoring oxidative balance and autophagic-apoptotic crosstalk

Zaied, H., Ashmawy, M. I., Karim, A. E. A., Ghareeb, D. A., & Wakil, A. E. (2026) · Scientific Reports · doi:10.1038/s41598-026-43119-1

Natural polyphenol modified ZIF boosted the efficiency of berberine for diabetic kidney disease therapy

Zhang, H., Zou, Y., Wang, M., Gong, M., Wang, H., Yang, Q., Li, X., Chen, X., Zou, X., Li, Y., et al. (2026) · Nano Research · doi:10.26599/nr.2026.94908761

Berberine as a Phytochemical in Metabolic Syndrome Management: Mechanistic Insights and Clinical Evidence

Muneer, A., Noor, M., Jamshed, S., Shahid, A., Anjum, A., Parveen, F., Rahman, A., & Ali, P. A. (2026) · medtigo Journal of Pharmacology · doi:10.63096/medtigo3061322

Metabolic and Anti-Inflammatory Effects of Berberine—Rationale for Its Therapeutic Potential in Polycystic Ovary Syndrome

Szukiewicz, D. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167287

A multi-omics integrative analyses reveals CYBB-mediated apoptotic and immune dysregulation as a key target of berberine in diffuse large B-cell lymphoma

Tan, J., Xu, Y., He, Y., Chen, C., Luo, J., Zhang, C., Zhong, J., & Xiong, D. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1870435

Application of Berberine on Treating Type 2 Diabetes Mellitus

Pang, B., Zhao, L., Zhou, Q., Zhao, T., Wang, H., Gu, C., & Tong, X. (2015) · International Journal of Endocrinology · doi:10.1155/2015/905749 · Cited by 254 · see citing works

Beneficial effects of berberine in the treatment of diabetes and its complications

Liu, S., Shen, J., Xu, F., Niu, L., Wang, F., & Zhao, G. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1701513 · Cited by 6 · see citing works

The Therapeutic Potential of Berberine in Treating Diabetes and Its Complications: Molecular Mechanisms and Future Perspectives

Liao, Y., Gui, Y., Li, T., Zhou, Q., Chen, X., & Chen, H. (2026) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x26500795

The therapeutic potential of Berberine in diabetes and its complications

Mbara, K. C., Kheoane, P. S., & Tarirai, C. (2025) · NUL Research and Publication

Mechaniam of Berberine on Treating 2-DM

Chen, L. (2013) · Liaoning Zhongyiyao Daxue xuebao