ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
Open accessPublished version of a preprint
Abstract
ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of fundamental clinical importance to understand its molecular functions and determine whether ARID1A deficiency can be exploited therapeutically. In this article, we report a key function of ARID1A in regulating the DNA damage checkpoint. ARID1A is recruited to DNA double-strand breaks (DSB) via its interaction with the upstream DNA damage checkpoint kinase ATR. At the molecular level, ARID1A facilitates efficient processing of DSB to single-strand ends and sustains DNA damage signaling. Importantly, ARID1A deficiency sensitizes cancer cells to PARP inhibitors in vitro and in vivo, providing a potential therapeutic strategy for patients with ARID1A-mutant tumors. Significance: ARID1A has been identified as one of the most frequently mutated genes across human cancers. Our data suggest that clinical utility of PARP inhibitors might be extended beyond patients with BRCA mutations to a larger group of patients with ARID1A-mutant tumors, which may exhibit therapeutic vulnerability to PARP inhibitors. Cancer Discov; 5(7); 752–67. ©2015 AACR. This article is highlighted in the In This Issue feature, p. 681
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ARID1A regulates DNA damage checkpoints and sensitizes cells to DNA damage response (DDR) targeting agents.
“ARID1A regulates DNA damage checkpoints and sensitizes cells to DNA damage response (DDR) targeting agents67–69.”
From Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma (2024) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863 · see citing works
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683 · see citing works
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198 · see citing works
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213 · see citing works
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422 · see citing works
ATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works
The DNA Damage Response: Ten Years After
Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705 · see citing works
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works
XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint
Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384 · see citing works
SWI/SNF nucleosome remodellers and cancer
Wilson, B. G., & Roberts, C. W. M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3068 · Cited by 1,286 · see citing works
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,248 · see citing works
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
Ward, I. M., & Chen, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100569200 · Cited by 1,150 · see citing works
Double-strand break repair: 53BP1 comes into focus
Panier, S., & Boulton, S. J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3719 · Cited by 1,090 · see citing works
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology · doi:10.1038/ncb1337 · Cited by 1,064 · see citing works
ATR and ATRIP: Partners in Checkpoint Signaling
Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works
<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951 · see citing works
MDC1 is a mediator of the mammalian DNA damage checkpoint
Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. R., & Elledge, S. J. (2003) · Nature · doi:10.1038/nature01446 · Cited by 874 · see citing works
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
Bennardo, N., Cheng, A., Huang, N., & Stark, J. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000110 · Cited by 867 · see citing works
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex
Kwon, H., Imbalzano, A. N., Khavari, P. A., Kingston, R. E., & Green, M. R. (1994) · Nature · doi:10.1038/370477a0 · Cited by 780 · see citing works
Lou, Z., Minter‐Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.025 · Cited by 629 · see citing works
H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy
Podhorecka, M., Składanowski, A., & Bozko, P. M. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/920161 · Cited by 614 · see citing works
The SWI/SNF complex — chromatin and cancer
Roberts, C. W. M., & Orkin, S. H. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1273 · Cited by 603 · see citing works
Facilitated binding of TATA-binding protein to nucleosomal DNA
Imbalzano, A. N., Kwon, H., Green, M. R., & Kingston, R. E. (1994) · Nature · doi:10.1038/370481a0 · Cited by 591 · see citing works
Shen, Y., Rehman, F. L., Feng, Y., Boshuizen, J., Bajrami, I., Elliott, R. J. R., Wang, B., Lord, C. J., Post, L. E., & Ashworth, A. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1391 · Cited by 478 · see citing works
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
Berkovich, E., Monnat, R. J., & Kastan, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1599 · Cited by 477 · see citing works
ARID1A Mutations in Cancer: Another Epigenetic Tumor Suppressor?
Wu, J. N., & Roberts, C. W. M. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0361 · Cited by 457 · see citing works
Guan, B., Wang, T., & Shih, I. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1562 · Cited by 445 · see citing works
Self-citationARID1B is a specific vulnerability in ARID1A-mutant cancers
Helming, K., Wang, X., Wilson, B. G., Vázquez, F., Haswell, J. R., Manchester, H. E., Kim, Y., Kryukov, G. V., Ghandi, M., Aguirre, A. J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3480 · Cited by 410 · see citing works
Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11
Myers, J. S., & Cortez, D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513265200 · Cited by 294 · see citing works
Involvement of novel autophosphorylation sites in ATM activation
Kozlov, S., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., & Lavin, M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601231 · Cited by 283 · see citing works
ATR autophosphorylation as a molecular switch for checkpoint activation
Liu, S., Shiotani, B., Lahiri, M., Maréchal, A., Tse, A., Leung, C. C. Y., Glover, J. N. M., Yang, X. H., & Zou, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.019 · Cited by 281 · see citing works
BAF complexes facilitate decatenation of DNA by topoisomerase IIα
Dykhuizen, E. C., Hargreaves, D. C., Miller, E. L., Cui, K., Korshunov, A., Kool, M., Pfister, S. M., Cho, Y., Zhao, K., & Crabtree, G. R. (2013) · Nature · doi:10.1038/nature12146 · Cited by 270 · see citing works
The emerging roles of ARID1A in tumor suppression
Wu, R., Wang, T., & Shih, I. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.28411 · Cited by 259 · see citing works
Self-citationChromatin remodeling and cancer, part II: ATP-dependent chromatin remodeling
Wang, G. G., Allis, C. D., & Chi, P. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.07.004 · Cited by 254 · see citing works
Melander, F., Bekker‐Jensen, S., Falck, J., Bártek, J., Mailand, N., & Lukas, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708210 · Cited by 226 · see citing works
The ACF1 Complex Is Required for DNA Double-Strand Break Repair in Human Cells
Lan, L., Ui, A., Nakajima, S., Hatakeyama, K., Hoshi, M., Watanabe, R., Janicki, S. M., Ogiwara, H., Kohno, T., Kanno, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.003 · Cited by 212 · see citing works
Self-citationWang, H., Wang, M., Wang, H., Böcker, W., & Iliakis, G. E. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20141 · Cited by 202 · see citing works
Watanabe, R., Ui, A., Kanno, S., Ogiwara, H., Nagase, T., Kohno, T., & Yasui, A. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3608 · Cited by 191 · see citing works
BRIT1/MCPH1 links chromatin remodelling to DNA damage response
Peng, G., Yim, E.-K., Dai, H., Jackson, A. P., van der Burgt, I., Pan, M., Hu, R., Li, K., & Lin, S. (2009) · Nature Cell Biology · doi:10.1038/ncb1895 · Cited by 186 · see citing works
Self-citationPolo, S. E., Blackford, A. N., Chapman, J. R., Baskcomb, L., Gravel, S., Rusch, A., Thomas, A., Blundred, R., Smith, P., Kzhyshkowska, J. G., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.12.035 · Cited by 183 · see citing works
Two related ARID family proteins are alternative subunits of human SWI/SNF complexes
Xiaomei, W. A. N. G., Nagl, N. G., Wilsker, D. F., Scoy, M. V., Pacchione, S. J., Yaciuk, P., Dallas, P. B., & Morán, E. (2004) · Biochemical Journal · doi:10.1042/bj20040524 · Cited by 178 · see citing works
Cardnell, R. J., Feng, Y., Diao, L., Fan, Y.-H., Masrorpour, F., Wang, J., Shen, Y., Mills, G. B., Minna, J. D., Heymach, J. V., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1975 · Cited by 176 · see citing works
Self-citationCardnell, R. J., & Byers, L. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3391 · Cited by 165 · see citing works
Adams, K. E., Medhurst, A. L., Dart, D. A., & Lakin, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209426 · Cited by 164 · see citing works
Structural Basis for Phototoxicity of the Genetically Encoded Photosensitizer KillerRed
Pletnev, S. V., Gurskaya, N. G., Pletneva, N. V., Lukyanov, K. A., Chudakov, D. M., Martynov, V. I., Popov, V. O., Kovalchuk, M. V., Wlodawer, A., Dauter, Z., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054973 · Cited by 147 · see citing works
Nagl, N. G., Patsialou, A., Haines, D. S., Dallas, P. B., Beck, G. R., & Morán, E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1225 · Cited by 145 · see citing works
SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells.
Eroglu, E., Burkard, T., Jiang, Y.-R., Saini, N., Homem, C. C. F., Reichert, H., & Knoblich, J. A. (2014) · Cell · doi:10.1016/j.cell.2014.01.053 · Cited by 140 · see citing works
Stecklein, S. R., Kumaraswamy, E., Behbod, F., Wang, W., Chaguturu, V., Harlan-Williams, L. M., & Jensen, R. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203326109 · Cited by 135 · see citing works
Nam, E. A., Zhao, R., Glick, G. G., Bansbach, C. E., Friedman, D. B., & Cortez, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248914 · Cited by 126 · see citing works
Structural basis for the phototoxicity of the fluorescent protein KillerRed
Carpentier, P., Violot, S., Blanchoin, L., & Bourgeois, D. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.041 · Cited by 110 · see citing works
Lan, L., Nakajima, S., Wei, L., Sun, L., Hsieh, C.-L., Sobol, R. W., Bruchez, M. P., Houten, B. V., Yasui, A., & Levine, A. S. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1233 · Cited by 98 · see citing works
Self-citationExpression of p270 (ARID1A), a component of human SWI/SNF complexes, in human tumors
Wang, X., Nagl, N. G., Flowers, S. J., Zweitzig, D. R., Dallas, P. B., & Morán, E. (2004) · International Journal of Cancer · doi:10.1002/ijc.20450 · Cited by 93 · see citing works
Wang, Q., Goldstein, M., Alexander, P. B., Wakeman, T. P., Sun, T., Feng, J., Lou, Z., Kastan, M. B., & Wang, X.-F. (2014) · The EMBO Journal · doi:10.1002/embj.201386064 · Cited by 92 · see citing works
Human Nuclease/Helicase DNA2 Alleviates Replication Stress by Promoting DNA End Resection
Peng, G., Dai, H., Zhang, W., Hsieh, H.-J., Pan, M., Park, Y., Tsai, R. Y. L., Bedrosian, I., Lee, J., Ira, G., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3152 · Cited by 74 · see citing works
Self-citationPARP Inhibitors in Cancer Therapy: Promise, Progress, and Puzzles
Ellisen, L. W. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.047 · Cited by 60 · see citing works
GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination
Takizawa, Y., Qing, Y., Takaku, M., Ishida, T., Morozumi, Y., Tsujita, T., Kogame, T., Hirota, K., Takahashi, M., Shibata, T., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq271 · Cited by 39 · see citing works
The ATR-Independent DNA Replication Checkpoint
Brown, E. J. (2003) · Cell Cycle · doi:10.4161/cc.2.3.395 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ROS and the DNA damage response in cancer
Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D. (2019) · Redox Biology · doi:10.1016/j.redox.2018.101084 · Cited by 2,144 · see citing works
State-of-the-art strategies for targeting the DNA damage response in cancer
Pilié, P. G., Tang, C., Mills, G. B., & Yap, T. A. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0114-z · Cited by 1,189 · see citing works
Self-citationThe Dualistic Model of Ovarian Carcinogenesis
Kurman, R. J., & Shih, I. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.011 · Cited by 933 · see citing works
Self-citationAdvances in bladder cancer biology and therapy
Tran, L. L., Xiao, J.-F., Agarwal, N., Duex, J. E., & Theodorescu, D. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00313-1 · Cited by 742 · see citing works
The SWI/SNF complex in cancer — biology, biomarkers and therapy
Mittal, P., & Roberts, C. W. M. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0357-3 · Cited by 705 · see citing works
Aung, K. L., Fischer, S. E., Denroche, R. E., Jang, G.-H., Dodd, A., Creighton, S., Southwood, B., Liang, S.-B., Chadwick, D., Zhang, A., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2994 · Cited by 618 · see citing works
Current recommendations and recent progress in endometrial cancer
Brooks, R. A., Fleming, G. F., Lastra, R. R., Lee, N. K., Moroney, J. W., Son, C. H., Tatebe, K., & Veneris, J. T. (2019) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21561 · Cited by 581 · see citing works
Genetics and biology of pancreatic ductal adenocarcinoma
Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527 · see citing works
Understanding and overcoming resistance to PARP inhibitors in cancer therapy
Dias, M. P., Moser, S. C., Ganesan, S., & Jonkers, J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00532-x · Cited by 526 · see citing works
Regulation of Single-Strand Annealing and its Role in Genome Maintenance
Bhargava, R., Onyango, D. O., & Stark, J. M. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.06.007 · Cited by 475 · see citing works
Prevalence of Homologous Recombination–Related Gene Mutations Across Multiple Cancer Types
Heeke, A. L., Pishvaian, M. J., Lynce, F. C., Xiu, J., Brody, J. R., Chen, W.-J., Baker, T. M., Marshall, J. L., & Isaacs, C. J. (2018) · JCO Precision Oncology · doi:10.1200/po.17.00286 · Cited by 472 · see citing works
Integrated Molecular Characterization of Uterine Carcinosarcoma
Cherniack, A. D., Shen, H., Walter, V., Stewart, C., Murray, B. A., Bowlby, R., Hu, X., Ling, S., Soslow, R. A., Broaddus, R. R., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.010 · Cited by 435 · see citing works
Self-citationSynthetic lethal therapies for cancer: what’s next after PARP inhibitors?
Ashworth, A., & Lord, C. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0055-6 · Cited by 420 · see citing works
Systemic therapies for intrahepatic cholangiocarcinoma
Kelley, R. K., Bridgewater, J. A., Gores, G. J., & Zhu, A. X. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.10.009 · Cited by 405 · see citing works
Secrier, M., Li, X., de Silva, N., Eldridge, M., Contino, G., Bornschein, J., MacRae, S., Grehan, N., O’Donovan, M., Miremadi, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3659 · Cited by 397 · see citing works
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
Williamson, C. T., Miller, R., Pemberton, H. N., Jones, S. E., Campbell, J., Konde, A., Badham, N., Rafiq, R., Brough, R., Gulati, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms13837 · Cited by 382 · see citing works
Mammalian SWI/SNF Chromatin Remodeling Complexes: Emerging Mechanisms and Therapeutic Strategies
Centore, R. C., Sandoval, G. J., Soares, L. M. M., Kadoch, C., & Chan, H. M. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.07.011 · Cited by 384 · see citing works
PARP Inhibitors: Extending Benefit Beyond BRCA -Mutant Cancers
Pilie, P. G., Gay, C. M., Byers, L. A., O’Connor, M. J., & Yap, T. A. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0968 · Cited by 334 · see citing works
Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers
Ogiwara, H., Takahashi, K., Sasaki, M., Kuroda, T., Yoshida, H., Watanabe, R., Maruyama, A., Makinoshima, H., Chiwaki, F., Sasaki, H., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2018.12.009 · Cited by 292 · see citing works
Marked for death: Targeting epigenetic changes in cancer
Pfister, S. X., & Ashworth, A. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.256 · Cited by 288 · see citing works
SNPnexus: a web server for functional annotation of human genome sequence variation (2020 update)
Oscanoa, J., Sivapalan, L., Gadaleta, E., Ullah, A. Z. M. D., Lemoine, N. R., & Chelala, C. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa420 · Cited by 282 · see citing works
Lissanu, Y., Sun, Y., Terranova, C. J., Khan, F., Martínez-Ledesma, E., Gay, J. P., Gao, G., Mullinax, R. A., Khor, T. O., Feng, N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0019-5 · Cited by 262 · see citing works
SWI/SNF Complex–deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract
Agaimy, A., Daum, O., Märkl, B., Lichtmannegger, I., Michal, M., & Hartmann, A. (2015) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000554 · Cited by 242 · see citing works
Park, W., Chen, J., Chou, J. F., Varghese, A. M., Yu, K. H., Wong, W., Capanu, M., Balachandran, V. P., McIntyre, C. A., Dika, I. E., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0418 · Cited by 238 · see citing works
Targeting ARID1A mutations in cancer
Mullen, J., Kato, S., Sicklick, J. K., & Kurzrock, R. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102287 · Cited by 186 · see citing works
Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?
Bradbury, A., Hall, S., Curtin, N. J., & Drew, Y. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107450 · Cited by 176 · see citing works
Endometrial cancer: Molecular markers and management of advanced stage disease
Arend, R. C., Jones, B. A., Martínez, A., & Goodfellow, P. J. (2018) · Gynecologic Oncology · doi:10.1016/j.ygyno.2018.05.015 · Cited by 176 · see citing works
Pancreatic Cancer Genomes: Implications for Clinical Management and Therapeutic Development
Dreyer, S. B., Chang, D. K.-F., Bailey, P. J., & Biankin, A. V. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-2411 · Cited by 160 · see citing works
Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities
Pierre, R. S., & Kadoch, C. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.02.004 · Cited by 161 · see citing works
Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy
Wanior, M., Krämer, A., Knapp, S., & Joerger, A. C. (2021) · Oncogene · doi:10.1038/s41388-021-01781-x · Cited by 157 · see citing works
ARID1A loss in cancer: Towards a mechanistic understanding
Mathur, R. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.001 · Cited by 157 · see citing works
Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer
Yen, T., Wang, T., Fader, A. N., Shih, I., & Gaillard, S. L. (2019) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000000585 · Cited by 163 · see citing works
Self-citationAlessi, J. V., Ricciuti, B., Spurr, L. F., Gupta, H. V., Li, Y. Y., Glass, C., Nishino, M., Cherniack, A. D., Lindsay, J. R., Sharma, B., et al. (2021) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2021.03.024 · Cited by 156 · see citing works
Aurora kinase A, a synthetic lethal target for precision cancer medicine
Mou, P. K., Yang, E. J., Shi, C., Ren, G., Tao, S., & Shim, J. S. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00635-6 · Cited by 144 · see citing works
Wu, C., Lyu, J., Yang, E. J., Liu, Y., Zhang, B., & Shim, J. S. (2018) · Nature Communications · doi:10.1038/s41467-018-05694-4 · Cited by 138 · see citing works
Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy
Saito, M., Suzuki, H. Y., Kono, K., Takenoshita, S., & Kohno, T. (2017) · Surgery Today · doi:10.1007/s00595-017-1497-7 · Cited by 133 · see citing works
Park, Y., Chui, M. H., Rahmanto, Y. S., Yu, Z.-C., Shamanna, R. A., Bellani, M. A., Gaillard, S. L., Ayhan, A., Viswanathan, A., Seidman, M. M., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-4222 · Cited by 134 · see citing works
Self-citationARID1A Mutations Are Associated with Increased Immune Activity in Gastrointestinal Cancer
Li, L., Li, M., Jiang, Z., & Wang, X. (2019) · Cells · doi:10.3390/cells8070678 · Cited by 119 · see citing works
PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer
Chabanon, R. M., Morel, D., Eychenne, T., Daage, L. C., Bajrami, I., Dorvault, N., Garrido, M., Meisenberg, C., Lamb, A. E., Duong-Ngo, C., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0628 · Cited by 118 · see citing works
Epigenomic regulation of oncogenesis by chromatin remodeling
Kumar, R., Li, D.-Q., Müller, S., & Knapp, S. (2016) · Oncogene · doi:10.1038/onc.2015.513 · Cited by 118 · see citing works
Development of synthetic lethality in cancer: molecular and cellular classification
Li, S., Topatana, W., Juengpanich, S., Cao, J., Hu, J., Zhang, B., Ma, D., Cai, X., & Chen, M. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00358-6 · Cited by 117 · see citing works
The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts
Vélez-Cruz, R., & Johnson, D. G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081776 · Cited by 113 · see citing works
SWI/SNF: Complex complexes in genome stability and cancer
Ribeiro-Silva, C., Vermeulen, W., & Lans, H. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.03.007 · Cited by 108 · see citing works
R Loops and Their Composite Cancer Connections
Wells, J. P., White, J., & Stirling, P. C. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.08.006 · Cited by 110 · see citing works
Ostrowski, S. M., & Fisher, D. E. (2020) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2020.08.010 · Cited by 111 · see citing works
Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors
Wang, L., Yang, L., Wang, C., Wei, Z., Ju, Z., Zhang, W., Shen, J., Peng, Y., An, C., Luu, Y. T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci130445 · Cited by 104 · see citing works
Self-citationImmunotherapy in endometrial cancer: rationale, practice and perspectives
Cao, W., Ma, X., Fischer, J. V., Sun, C., Kong, B., & Zhang, Q. H. (2021) · Biomarker Research · doi:10.1186/s40364-021-00301-z · Cited by 103 · see citing works
Chromatin remodellers as therapeutic targets
Malone, H. A., & Roberts, C. W. M. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-00978-5 · Cited by 109 · see citing works
ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies
Caumanns, J. J., Wisman, G. B. A., Berns, K., van der Zee, A. G. J., & de Jong, S. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.005 · Cited by 98 · see citing works
Epigenetic modifiers: activities in renal cell carcinoma
de Cubas, A. A., & Rathmell, W. K. (2018) · Nature Reviews Urology · doi:10.1038/s41585-018-0052-7 · Cited by 93 · see citing works
Medical treatment for cholangiocarcinoma
Adeva, J., Sangro, B., Salati, M., Edeline, J., Casta, A. L., Bittoni, A., Berardi, R., Bruix, J., & Valle, J. W. (2019) · Liver International · doi:10.1111/liv.14100 · Cited by 96 · see citing works
Targeting the replication stress response through synthetic lethal strategies in cancer medicine
Ngoi, N. Y. L., Pham, M. M., Tan, D. S. P., & Yap, T. A. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.06.002 · Cited by 94 · see citing works
Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma
Yousef, A., Yousef, M., Chowdhury, S., Abdilleh, K., Knafl, M., Edelkamp, P., Alfaro-Munoz, K., Chacko, R., Peterson, J., Smaglo, B. G., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-024-00505-0 · Cited by 93 · see citing works
Self-citationMuckenhuber, A., Berger, A. K., Schlitter, A. M., Steiger, K., Konukiewitz, B., Trumpp, A., Eils, R., Werner, J., Friess, H., Esposito, I., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2180 · Cited by 91 · see citing works
Detect accessible chromatin using ATAC-sequencing, from principle to applications
Sun, Y., Miao, N., & Sun, T. (2019) · Hereditas · doi:10.1186/s41065-019-0105-9 · Cited by 93 · see citing works
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response
Mandal, J., Mandal, P., Wang, T.-L., & Shih, I.-M. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00856-5 · Cited by 84 · see citing works
Self-citationWang, W., Friedland, S. C., Guo, B., O'Dell, M. R., Alexander, W. B., Whitney-Miller, C. L., Agostini-Vulaj, D., Huber, A. R., Myers, J. R., Ashton, J., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315541 · Cited by 70 · see citing works
Targeted Therapies for Pancreatic Cancer and Hurdles Ahead
Aslan, M., Shahbazi, R., Ulubayram, K., & Özpolat, B. (2018) · Anticancer Research · doi:10.21873/anticanres.13026 · Cited by 88 · see citing works
PARP Inhibitors Resistance: Mechanisms and Perspectives
Giudice, E., Gentile, M., Salutari, V., Ricci, C., Musacchio, L., Carbone, M. V., Ghizzoni, V., Camarda, F., Tronconi, F., Nero, C., et al. (2022) · Cancers · doi:10.3390/cancers14061420 · Cited by 87 · see citing works
Synthetic Lethal Targeting of ARID1A -Mutant Ovarian Clear Cell Tumors with Dasatinib
Miller, R. E., Brough, R., Bajrami, I., Williamson, C. T., McDade, S. S., Campbell, J., Kigozi, A., Rafiq, R., Pemberton, H. N., Natrajan, R., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0554 · Cited by 87 · see citing works
Samartzis, E. P., Labidi‐Galy, S. I., Moschetta, M., Uccello, M., Kalaitzopoulos, D. R., Fidalgo, J. A. P., & Boussios, S. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-3022a · Cited by 82 · see citing works
Landscape of EBV-positive gastric cancer
Saito, M., & Kono, K. (2021) · Gastric Cancer · doi:10.1007/s10120-021-01215-3 · Cited by 86 · see citing works
Morel, D., Almouzni, G., Soria, J., & Postel-Vinay, S. C. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw552 · Cited by 84 · see citing works
Suenaga, M., Yu, J., Shindo, K., Tamura, K., Almario, J. A., Zaykoski, C., Witmer, P. D., Fesharakizadeh, S., Borges, M., Lennon, A.-M., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2463 · Cited by 81 · see citing works
The Role of ARID1A in Tumors: Tumor Initiation or Tumor Suppression?
Xu, S., & Tang, C. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.745187 · Cited by 80 · see citing works
Cho, K. R., Cooper, K., Croce, S., Djordevic, B., Herrington, C. S., Howitt, B. E., Hui, P., Ip, P. P. C., Köbel, M., Lax, S., et al. (2018) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0000000000000496 · Cited by 80 · see citing works
Self-citationFouassier, L., Marzioni, M., Afonso, M. B., Dooley, S., Gaston, K., Giannelli, G., Rodrigues, C. M. P., Lozano, E., Mancarella, S., Segatto, O., et al. (2019) · Liver International · doi:10.1111/liv.14102 · Cited by 78 · see citing works
Agaimy, A., Bertz, S., Liang Cheng, C., Hes, O., Junker, K., Keck, B., Antonio Lopez-beltran, B., Stöckle, M., Wullich, B., & Hartmann, A. (2016) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-016-1977-y · Cited by 77 · see citing works
ARID2 modulates DNA damage response in human hepatocellular carcinoma cells
Oba, A., Shimada, S., Akiyama, Y., Nishikawaji, T., Mogushi, K., Ito, H., Matsumura, S., Aihara, A., Mitsunori, Y., Ban, D., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2016.12.026 · Cited by 73 · see citing works
Hsiehchen, D., Hsieh, A., Samstein, R. M., Lu, T., Beg, M. S., Gerber, D. E., Wang, T., Morris, L. G. T., & Zhu, H. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100034 · Cited by 74 · see citing works
Khalique, S., Naidoo, K., Attygalle, A. D., Kriplani, D., Daley, F. M., Lowe, A., Campbell, J., Jones, T., Hubank, M. J. F., Fenwick, K., et al. (2018) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.103 · Cited by 74 · see citing works
The impact of ARID1A mutation on molecular characteristics in colorectal cancer
Tokunaga, R., Xiu, J., Goldberg, R. M., Philip, P. A., Seeber, A., Battaglin, F., Arai, H., Lo, J. H., Naseem, M., Puccini, A., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.09.006 · Cited by 71 · see citing works
Self-citationXing, T., Li, L., Chen, Y., Ju, G., Li, G., Zhu, X., Ren, Y., Zhao, J., Cheng, Z., Li, Y., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101264 · Cited by 70 · see citing works
Ooki, A., Osumi, H., Yoshino, K., & Yamaguchi, K. (2024) · Gastric Cancer · doi:10.1007/s10120-024-01523-4 · Cited by 72 · see citing works
ARID1A regulates R-loop associated DNA replication stress
Tsai, S., Chang, E. Y., Fournier, L.-A., Wells, J. P., Minaker, S. W., Zhu, Y. D., Wang, A. Y.-H., Wang, Y., Huntsman, D. D., & Stirling, P. C. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009238 · Cited by 70 · see citing works
Jäkel, C., Bergmann, F., Toth, R., Assenov, Y., van der Duin, D., Strobel, O., Hank, T., Klöppel, G., Dorrell, C., Grompe, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01118-x · Cited by 69 · see citing works
Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines
Zhao, W., Li, J., Chen, M.-J. M., Luo, Y., Ju, Z., Nesser, N. K., Johnson-Camacho, K., Boniface, C. T., Lawrence, Y., Pande, N. T., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.10.008 · Cited by 68 · see citing works
Self-citationFan, Y., Zhu, X., Xu, Y., Lu, X., Xu, Y., Wang, M., Xu, H., Ding, J., Ye, X., Fang, L., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1582 · Cited by 67 · see citing works
Banerjee, S. N., Stewart, J., Porta, N., Toms, C., Leary, A. F., Lheureux, S., Khalique, S., Tai, J., Attygalle, A. D., Vroobel, K. M., et al. (2021) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2021-002973 · Cited by 66 · see citing works
Updates of Pathogenesis, Diagnostic and Therapeutic Perspectives for Ovarian Clear Cell Carcinoma
Zhu, C., Xu, Z., Zhang, T., Qian, L., Xiao, W., Wei, H., Jin, T., & Zhou, Y. Y. (2021) · Journal of Cancer · doi:10.7150/jca.53395 · Cited by 65 · see citing works
Sasaki, M., & Ogiwara, H. (2020) · Cancer Science · doi:10.1111/cas.14311 · Cited by 61 · see citing works
Poly (ADP-ribose) polymerase inhibitors in solid tumours: Systematic review and meta-analysis
Schettini, F., Giudici, F., Bernocchi, O., Sirico, M., Corona, S. P., Giuliano, M., Locci, M., Paris, I., Scambia, G., Placido, S. D., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.02.035 · Cited by 63 · see citing works
Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control
Concannon, K., Morris, B. B., Gay, C. M., & Byers, L. A. (2023) · Molecular Cell · doi:10.1016/j.molcel.2022.12.031 · Cited by 66 · see citing works
PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer
Post, C., Westermann, A. M., Bosse, T., Creutzberg, C. L., & Kroep, J. R. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102973 · Cited by 63 · see citing works
Resolving DNA Damage: Epigenetic Regulation of DNA Repair
Karakaidos, P., Karagiannis, D., & Rampias, T. N. (2020) · Molecules · doi:10.3390/molecules25112496 · Cited by 61 · see citing works
Sen, M., Wang, X., Hamdan, F. H., Rapp, J., Eggert, J., Kosinsky, R. L., Wegwitz, F., Kutschat, A. P., Younesi, F. S., Gaedcke, J., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0690-5 · Cited by 61 · see citing works
Chang, B., Sheng, W., Wang, L., Zhu, X., Tan, C., Ni, S., Weng, W., Huang, D., & Wang, J. (2022) · PubMed · doi:10.1097/pas.0000000000001836 · Cited by 24 · see citing works
Dillon, M. T., Guevara, J., Mohammed, K., Patin, E. C., Smith, S. A., Dean, E. J., Jones, G. N., Willis, S. E., Petrone, M., Silva, C. J. R., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci175369 · Cited by 61 · see citing works
Devarakonda, S. H. K., Sankararaman, S., Herzog, B. H., Gold, K. A., Waqar, S. N., Ward, J. P., Raymond, V. M., Lanman, R. B., Chaudhuri, A. A., Owonikoko, T. K., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0879 · Cited by 61 · see citing works
Schallenberg, S., Bork, J., Essakly, A., Alakus, H., Buettner, R., Hillmer, A. M., Bruns, C. J., Schroeder, W., Zander, T., Loeser, H., et al. (2020) · BMC Cancer · doi:10.1186/s12885-019-6425-3 · Cited by 61 · see citing works
Targeting Chromatin-Remodeling Factors in Cancer Cells: Promising Molecules in Cancer Therapy
Zhang, F.-L., & Li, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112815 · Cited by 61 · see citing works
Bakr, A., Corte, G., Veselinov, O., Kelekçi, S., Chen, M.-J. M., Lin, Y.-Y., Sigismondo, G., Iacovone, M., Cross, A., Syed, R., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae233 · Cited by 65 · see citing works
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks
Harrod, A., Lane, K. A., & Downs, J. A. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102919 · Cited by 60 · see citing works
Lin, X., Chen, D., Zhang, C., Zhang, X., Li, Z., Dong, B., Gao, J., & Shen, L. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0790-7 · Cited by 59 · see citing works
SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancerPreprint
Tordella, L., Khan, S. S., Hohmeyer, A., Banito, A., Klotz, S., Raguz, S., Martin, N., Dhamarlingam, G., Carroll, T. D., González-Meljem, J. M., et al. (2016) · Genes & Development · doi:10.1101/gad.286112.116 · Cited by 59 · see citing works
Booth, L. A., Roberts, J. L., Sander, C., Lee, J., Kirkwood, J. M., Poklepovic, A. S., & Dent, P. (2017) · Oncotarget · doi:10.18632/oncotarget.14829 · Cited by 58 · see citing works
ATR Is a Therapeutic Target in Synovial Sarcoma
Jones, S. E., Fleuren, E. D. G., Frankum, J. R., Konde, A., Williamson, C. T., Krastev, D. B., Pemberton, H. N., Campbell, J., Gulati, A., Elliott, R. J. R., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-2056 · Cited by 59 · see citing works
Jana, S., Brahma, S., Arora, S., Wladyka, C. L., Hoang, P., Blinka, S. M., Hough, R. P., Horn, J. L., Liu, Y., Wang, L., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.03.021 · Cited by 56 · see citing works
Auguste, A., Genestie, C., de Bruyn, M., Adam, J., Formal, A. L., Drusch, F., Pautier, P., Crosbie, E. J., MacKay, H. J., Kitchener, H. C., et al. (2018) · Modern Pathology · doi:10.1038/s41379-018-0055-1 · Cited by 56 · see citing works
Molecular-targeted therapies and precision medicine for endometrial cancer
Mitamura, T., Dong, P., Ihira, K., 工藤, 正., & Watari, H. (2018) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyy159 · Cited by 56 · see citing works
- Authors
- Shen, J., Peng, Y., Wei, L., Zhang, W., Yang, L., Lan, L., Kapoor, P., Ju, Z., Mo, Q., Shih, I.-M., Uray, I. P., Wu, X., Brown, P. H., Shen, X., Mills, G. B., & Peng, G.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- Johns Hopkins University (US)
- 1Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
- Corresponding author
- Peng, Guang
- ORCID
- Venue
- Cancer Discovery
- Published
- 2015-07-01
- Volume
- 5
- Issue
- 7
- Pages
- 752-767
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC4497871
- OpenAlex
- W2123454509
- Cited by
- 522
- References
- 61
- Citations by year
- 2026: 33 · 2025: 53 · 2024: 59 · 2023: 56 · 2022: 53 · 2021: 71 · 2020: 62 · 2019: 43 · 2018: 36 · 2017: 28 · 2016: 24 · 2015: 3
- FWCI
- 13.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Cancer Institute (CA 016672, P50CA098258, P50-CA83639, R00CA149186, K99CA149186, P50CA083639, P30CA016672, R01CA181663)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- ARID1A, SWI/SNF complex, DNA damage checkpoint, PARP inhibitors, ATR kinase, DNA double-strand breaks, tumor suppressor, drug sensitivity
- MeSH terms
- Poly(ADP-ribose) Polymerase Inhibitors, Animals, Breast Neoplasms, DNA Damage, DNA-Binding Proteins, Female, Humans, Lung Neoplasms, Male, Nuclear Proteins, Transcription Factors, Xenograft Model Antitumor Assays, HCT116 Cells, Cell Line, Tumor, Mice, DNA Breaks, Double-Stranded, Ataxia Telangiectasia Mutated Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review