Cited by 159Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingDementia and Cognitive Impairment Research

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Risk Factors for Parkinson’s Disease: The Leisure World Cohort Study

Paganini-Hill, Annlia·2001·Neuroepidemiology

DOI 10.1159/000054770

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Abstract

We conducted a case-control study nested within a prospective cohort study of 13,979 residents of Leisure World Laguna Hills, a retirement community in southern California, for etiologic clues for Parkinson's disease (PD). Between 1981 (when first mailed a health survey) and 1998, we identified 395 PD cases from death certificates, hospital discharge diagnoses and a 1992 follow-up questionnaire. Six controls were individually matched on sex, birth date (+/-2 years), vital status and, if dead, death date (+/-1 year) to each case. Baseline characteristics of the 395 cases and 2,320 controls were analyzed as potential PD risk factors. The risk of PD was significantly reduced among smokers, hypertensives, coffee drinkers and alcohol consumers, and significantly increased among those with 3 or more children and with a high intake of total vitamin A and dietary vitamin C. The multivariate odds ratios (95% confidence intervals) were 0.42 (0.22-0.80) for current cigarette smokers of 1+ pack/day, 0.62 (0.48-0.80) for current users of hypertensive medication, 0.71 (0.52-0.95) for coffee drinkers of 2+ cups/day and 0.77 (0.58-1.03) for drinkers of 2+ alcoholic drinks/day. Risk increased with increasing number of children (1.25 for 1, 1.34 for 2 and 1.90 for 3+ children; p for trend = 0.0003). The increased risks among individuals in the highest third of total vitamin A intake and of dietary vitamin C intake were no longer statistically significant after adjusting for the other variables. These findings suggest several environmental factors that may be related to the development of PD and support a multifactorial etiology.

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Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378
Statistical Methods in Cancer Research
Breslow, N. E. (1980) · Cited by 7,332
Statistical methods in cancer research. Volume I - The analysis of case-control studies.
Breslow, N. E., & Day, N. E. (1980) · PubMed · Cited by 4,895
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
Nehlig, A., Daval, J., & Debry, G. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90012-b · Cited by 1,463
The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
Fahn, S., & Cohen, G. (1992) · Annals of Neurology · doi:10.1002/ana.410320616 · Cited by 927
Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson's disease.
de Rijk, M. C., Tzourio, C., Breteler, M. M., Dartigues, J. F., Amaducci, L., Lopez-Pousa, S., Manubens-Bertran, J. M., Alperovitch, A., & Rocca, W. A. (1997) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.1.10 · Cited by 833
Environmental risk factors and Parkinson's disease
Liou, H., Tsai, M.-C., Chen, C., Jeng, J., Chang, Y. C., Chen, S. Y., & Chen, R.-T. (1997) · Neurology · doi:10.1212/wnl.48.6.1583 · Cited by 616
NUTRIENT SOURCES IN THE AMERICAN DIET: QUANTITATIVE DATA FROM THE NHANES II SURVEY
Block, G., DRESSER, C. M., Hartman, A. M., & Carroll, M. D. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114072 · Cited by 511
Incidence and distribution of parkinsonism in Olmsted County, Minnesota, 1976–1990
Bower, J. H., Maraganore, D. M., McDonnell, S. K., & Rocca, W. A. (1999) · Neurology · doi:10.1212/wnl.52.6.1214 · Cited by 509
Prevalence of Parkinson's disease in the elderly
de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., Ott, A., Grobbee, D. E., van der Meché, F. G. A., & Albert Hofman, D. (1995) · Neurology · doi:10.1212/wnl.45.12.2143 · Cited by 488

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Authors: Paganini-Hill, A.
Venue: Neuroepidemiology
Publisher: S. Karger AG
Published: 2001
Volume: 20
Issue: 2
Pages: 118-124
ISSN: 0251-5350 (ISSN-L)
1423-0208
DOI: 10.1159/000054770
OpenAlex: W2025540146
Cited by: 159
References: 48
Citations by year: 2026: 1 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 12 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 8 · 2013: 4 · 2012: 7
FWCI: 4.26
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Neuroepidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA032197, CA32197)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Parkinson's disease, risk factors, smoking, hypertension, coffee consumption, alcohol consumption, number of children, vitamin A intake, vitamin C intake, multifactorial etiology, environmental risk factors, retirement community residents
MeSH terms: Adult, Aged, Aged, 80 and over, Alcoholism, Ascorbic Acid, Caffeine, California, Catchment Area, Health, Female, Humans, Hypertension, Male, Middle Aged, Parkinson Disease, Prospective Studies, Risk Factors, Smoking, Vitamin A, Cohort Studies, Case-Control Studies

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Risk Factors for Parkinson’s Disease: The Leisure World Cohort Study

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