Uterine stem cells: What is the evidence?
Abstract
The mucosal lining (endometrium) of the human uterus undergoes cyclical processes of regeneration, differentiation and shedding as part of the menstrual cycle. Endometrial regeneration also follows parturition, almost complete resection and in post-menopausal women taking estrogen replacement therapy. In non-menstruating species, there are cycles of endometrial growth and apoptosis rather than physical shedding. The concept that endometrial stem/progenitor cells are responsible for the remarkable regenerative capacity of endometrium was proposed many years ago. However, attempts to isolate, characterize and locate endometrial stem cells have only been undertaken in the last few years as experimental approaches to identify adult stem/progenitor cells in other tissues have been developed. Adult stem cells are defined by their functional properties rather than by marker expression. Evidence for the existence of adult stem/progenitor cells in human and mouse endometrium is now emerging because functional stem cell assays are being applied to uterine cells and tissues. These fundamental studies on endometrial stem/progenitor cells will provide new insights into the pathophysiology of various gynaecological disorders associated with abnormal endometrial proliferation, including endometrial cancer, endometrial hyperplasia, endometriosis and adenomyosis.
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There is good evidence that adult progenitor stem cells contribute to the remarkable regenerative capacity of the endometrium.
“There is good evidence that adult progenitor stem cells contribute to the remarkable regenerative capacity of the endometrium.103,104”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [103]
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Recurrence of endometriosis and its control
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Endometrial stem/progenitor cells: the first 10 years
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Self-citationSchwab, K. E., & Gargett, C. E. (2007) · Human Reproduction · doi:10.1093/humrep/dem265 · Cited by 545 · see citing works
Self-citation<i>Stem Cells and the Pathogenesis of Endometriosis</i>
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Adult stem cells in the endometrium
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Self-citationPathogenesis of uterine adenomyosis, invagination or metaplasia?
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Pathogenesis of adenomyosis, an update on molecular mechanisms
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A novel marker of human endometrial mesenchymal stem-like cells
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Stem cells in endometrium and their role in the pathogenesis of endometriosis
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Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis
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Self-citationThe Pathogenesis of Adenomyosis vis-à-vis Endometriosis
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“Alternatively, endometrial stem/progenitor cells or their niche cells may behave aberrantly for some unknown reason, and their differentiating progeny cells move towards the myometrium, rather than functionalis, resulting in adenomyosis [51].”
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Self-citationCirculating Endothelial Progenitor Cells Are Up-Regulated in a Mouse Model of Endometriosis
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Bone marrow stem cells do not contribute to endometrial cell lineages in chimeric mouse models
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- Authors
- Gargett, C. E.
- Affiliations
- Monash University (AU)
- Corresponding author
- Gargett, C.E.
- ORCID
- Gargett, C.E.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-09-07
- Volume
- 13
- Issue
- 1
- Pages
- 87-101
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2140368652
- Cited by
- 373
- References
- 163
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 16 · 2023: 24 · 2022: 21 · 2021: 20 · 2020: 19 · 2019: 13 · 2018: 22 · 2017: 27 · 2016: 20 · 2015: 24 · 2014: 32 · 2013: 23 · 2012: 16
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Australian and New Zealand College of Obstetricians and Gynaecologists
- Medical Research Council
- National Health and Medical Research Council (284344)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- endometrial stem cells, endometrium, endometrial regeneration, menstrual cycle, stem cell isolation, endometrial cancer, endometrial hyperplasia, endometriosis, adenomyosis, gynecological diseases
- MeSH terms
- Animals, Female, Humans, Uterus, Cell Growth Processes, Adult Stem Cells
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