Cited by 373Mesenchymal stem cell researchReproductive System and PregnancyPluripotent Stem Cells Research

Uterine stem cells: What is the evidence?

Gargett, C.E.·2007·Human Reproduction Update

Abstract

The mucosal lining (endometrium) of the human uterus undergoes cyclical processes of regeneration, differentiation and shedding as part of the menstrual cycle. Endometrial regeneration also follows parturition, almost complete resection and in post-menopausal women taking estrogen replacement therapy. In non-menstruating species, there are cycles of endometrial growth and apoptosis rather than physical shedding. The concept that endometrial stem/progenitor cells are responsible for the remarkable regenerative capacity of endometrium was proposed many years ago. However, attempts to isolate, characterize and locate endometrial stem cells have only been undertaken in the last few years as experimental approaches to identify adult stem/progenitor cells in other tissues have been developed. Adult stem cells are defined by their functional properties rather than by marker expression. Evidence for the existence of adult stem/progenitor cells in human and mouse endometrium is now emerging because functional stem cell assays are being applied to uterine cells and tissues. These fundamental studies on endometrial stem/progenitor cells will provide new insights into the pathophysiology of various gynaecological disorders associated with abnormal endometrial proliferation, including endometrial cancer, endometrial hyperplasia, endometriosis and adenomyosis.

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Crossref · 10.1093/humupd/dml045

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Authors
Gargett, C. E.
Affiliations
Monash University (AU)
Corresponding author
Gargett, C.E.
Venue
Human Reproduction Update
Published
2006-09-07
Volume
13
Issue
1
Pages
87-101
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
OpenAlex
W2140368652
Cited by
373
References
163
Citations by year
2026: 7 · 2025: 8 · 2024: 16 · 2023: 24 · 2022: 21 · 2021: 20 · 2020: 19 · 2019: 13 · 2018: 22 · 2017: 27 · 2016: 20 · 2015: 24 · 2014: 32 · 2013: 23 · 2012: 16
FWCI
1.89
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Royal Australian and New Zealand College of Obstetricians and Gynaecologists
  • Medical Research Council
  • National Health and Medical Research Council (284344)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
endometrial stem cells, endometrium, endometrial regeneration, menstrual cycle, stem cell isolation, endometrial cancer, endometrial hyperplasia, endometriosis, adenomyosis, gynecological diseases
MeSH terms
Animals, Female, Humans, Uterus, Cell Growth Processes, Adult Stem Cells

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