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Perinatal Iron Deficiency Alters Apical Dendritic Growth in Hippocampal CA1 Pyramidal Neurons

Jorgenson, Lyric A., Wobken, Jane D., Georgieff, Michael K.·2003·Developmental Neuroscience

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Abstract

Iron deficiency early in life is associated with cognitive disturbances that persist beyond the period of iron deficiency. Within cognitive processing circuitry, the hippocampus is particularly susceptible to insults during the perinatal period. During the hippocampal growth spurt, which is predominantly postnatal in rodents, iron transport proteins and their messenger RNA stabilizing proteins are upregulated, suggesting an increased demand for iron import during this developmental period. Rat pups deprived of iron during the perinatal period show a 30–40% decrease in hippocampal metabolic activity during postnatal hippocampal development. We hypothesized that this reduced hippocampal neuronal metabolism impedes developmental processes such as neurite outgrowth. The goals of the current study were to investigate the effects of perinatal iron deficiency on apical dendritic segment growth in the postnatal day (P) 15 hippocampus and to determine if structural abnormalities persist into adulthood (P65) following iron treatment. Qualitative and quantitative immunohistochemical analyses of dendritic structure and growth using microtubule-associated protein-2 as an index showed that iron-deficient P15 pups have truncated apical dendritic morphology in CA1 and a persistence of an immature apical dendritic pattern at P65. These results demonstrate that perinatal iron deficiency disrupts developmental processes in the hippocampal subarea CA1 and that these changes persist despite iron repletion. These structural abnormalities may contribute to the learning and memory deficits that occur during and following early iron deficiency.

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Authors: Jorgenson, L. A., Wobken, J. D., & Georgieff, M. K.
Affiliations: University of Minnesota (US)
ORCID: Georgieff, Michael K.
Venue: Developmental Neuroscience
Publisher: S. Karger AG
Published: 2003
Volume: 25
Issue: 6
Pages: 412-420
ISSN: 0378-5866 (ISSN-L)
1421-9859
DOI: 10.1159/000075667
OpenAlex: W2032730227
Cited by: 209
References: 52
Citations by year: 2026: 7 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 11 · 2021: 11 · 2020: 4 · 2019: 8 · 2018: 13 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 10 · 2013: 9 · 2012: 15
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Developmental Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD29421)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: hippocampal CA1, dendritic morphology, pyramidal neurons, iron repletion, MAP2, learning and memory impairment, iron transport proteins
MeSH terms: Iron Deficiencies, Animals, Animals, Newborn, Cell Differentiation, Dendrites, Female, Fluorescent Antibody Technique, Hippocampus, Iron, Male, Microtubule-Associated Proteins, Organ Size, Down-Regulation, Rats, Sprague-Dawley, Pyramidal Cells, Prenatal Nutritional Physiological Phenomena, Rats

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Perinatal Iron Deficiency Alters Apical Dendritic Growth in Hippocampal CA1 Pyramidal Neurons

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