The metabolic syndrome and endothelial dysfunction: Common highway to type 2 diabetes and CVD?

Diamant, Michaela; Tushuizen, Maarten E.

doi:10.1007/s11892-006-0061-4

Cited by 64Nitric Oxide and Endothelin EffectsDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Disease Prevention

The metabolic syndrome and endothelial dysfunction: Common highway to type 2 diabetes and CVD?

Diamant, Michaela, Tushuizen, Maarten E.·2006·Current Diabetes Reports

DOI 10.1007/s11892-006-0061-4

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Abstract

Due to global lifestyle changes, obesity (the main driver of type 2 diabetes and cardiovascular disease ) is reaching pandemic proportions. The metabolic syndrome, which is regarded as a prediabetic state, is characterized by a concurrence of interrelated cardiovascular risk factors, including abdominal obesity, insulin resistance, hypertension, dyslipidemia, and glucose intolerance. Endothelial dysfunction (ED) is common in the metabolic syndrome and is associated with increased risk for T2D and CVD. This review focuses on the mechanisms linking ED to the metabolic syndrome, T2D, and CVD, and the possible therapies that may improve ED and reduce T2D and CVD risk.

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Endothelial dysfunction is widely present in obesity and the metabolic syndrome.
“In addition, endothelial dysfunction is widely present in obesity and the metabolic syndrome (84, 325, 358).”
From Cardiac remodeling in obesity (2008) · cites this paper as [84]

Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works
Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782 · see citing works
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 1× · see citing works
“Moreover, lifestyle interventions prevented or delayed the onset of T2D in a high-risk population [ 50 ].”
Background
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07037-8 · Cited by 8,247 · see citing works
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.
(1998) · PubMed · Cited by 4,290 · see citing works
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129 · see citing works
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress
Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
LaRosa, J. C., Grundy, S. M., Waters, D. D., Shear, C., Barter, P., Fruchart, J.-C., Gotto, A. M., Greten, H., Kastelein, J. J. P., Shepherd, J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050461 · Cited by 3,489 · see citing works
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
Hill, J. M., Zalos, G., Halcox, J. P. J., Schenke, W. H., Waclawiw, M. A., Quyyumi, A. A., & Finkel, T. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022287 · Cited by 3,423 · see citing works
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
Adipose Tissue, Inflammation, and Cardiovascular Disease
Berg, A. H., & Scherer, P. E. (2005) · Circulation Research · doi:10.1161/01.res.0000163635.62927.34 · Cited by 2,113 · see citing works
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works
Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa060900 · Cited by 1,729 · see citing works
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701 · see citing works
Enhanced cellular proliferation in intact stenotic lesions derived from human arteriovenous fistulas and peripheral bypass grafts. Does it correlate with flow parameters?
Hofstra, L., Tordoir, J. H. M., Kitslaar, P. J. E. H. M., Hoeks, A. P. G., & Daemen, M. J. A. P. (1996) · PubMed · doi:10.1161/01.cir.94.6.1283 · Cited by 1,603 · see citing works
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial
(2002) · The Lancet · doi:10.1016/s0140-6736(02)09328-5 · Cited by 1,502 · see citing works
Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works
Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction
Bønaa, K. H., Njølstad, I., Ueland, P. M., Schirmer, H., Tverdal, A., Steigen, T., Wang, H., Nordrehaug, J. E., Arnesen, E., & Rasmussen, K. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055227 · Cited by 1,442 · see citing works
Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378 · see citing works
Preservation of Pancreatic β-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women
Buchanan, T. A., Xiang, A. H., Peters, R. K., Kjos, S. L., Marroquin, A., Goico, J., Ochoa, C., Tan, S., Berkowitz, K., Hodis, H. N., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2796 · Cited by 1,339 · see citing works
Inflammation as a Cardiovascular Risk Factor
Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304 · see citing works
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216 · see citing works
Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial
(2005) · JAMA · doi:10.1001/jama.293.11.1338 · Cited by 1,209 · cited 1× · see citing works
“The use of antioxidants and vitamins, although promising in short-term studies assessing surrogate end points [51], has so far not yielded the expected benefit in long-term prospective trials [ 52 ,53].”
Background
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139 · see citing works
Endothelial Function: Cardiac Events
Lerman, A., & Zeiher, A. M. (2005) · Circulation · doi:10.1161/01.cir.0000153339.27064.14 · Cited by 1,096 · see citing works
The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation
Frühbeck, G., Gómez‐Ambrosi, J., Muruzábal, F., & Burrell, M. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.6.e827 · Cited by 964 · see citing works
Lipotoxic diseases
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875 · see citing works
Epidemiologic and economic consequences of the global epidemics of obesity and diabetes
Yach, D., Stückler, D., & Brownell, K. D. (2006) · Nature Medicine · doi:10.1038/nm0106-62 · Cited by 856 · see citing works
The Burden of Mortality Attributable to Diabetes
Roglić, G., Unwin, N. C., Bennett, P. H., Mathers, C. D., Tuomilehto, J. O., Nag, S., Connolly, V. M., & King, H. O. M. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2130 · Cited by 809 · see citing works
Tissue Angiotensin and Pathobiology of Vascular Disease
Dzau, V. J. (2001) · Hypertension · doi:10.1161/01.hyp.37.4.1047 · Cited by 748 · see citing works
Biomarkers of Endothelial Dysfunction and Risk of Type 2 Diabetes Mellitus
Meigs, J. B. (2004) · JAMA · doi:10.1001/jama.291.16.1978 · Cited by 643 · see citing works
Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: Role of fat and carbohydrate meals
Nappo, F., Esposito, K., Cioffi, M., Giugliano, G., Molinari, A. M., Paolisso, G., Marfella, R., & Giugliano, D. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01741-2 · Cited by 555 · see citing works
Elevated Risk of Cardiovascular Disease Prior to Clinical Diagnosis of Type 2 Diabetes
Hu, F. B., Stampfer, M. J., Haffner, S. M., Solomon, C. G., Willett, W. C., & Manson, J. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.7.1129 · Cited by 552 · see citing works
“Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease
Yudkin, J. S., Eringa, E. C., & Stehouwer, C. D. A. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66585-3 · Cited by 551 · see citing works
Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells
Kukidome, D., Nishikawa, T., Sonoda, K., Imoto, K., Fujisawa, K., Yano, M., Motoshima, H., Taguchi, T., Matsumura, T., & Araki, E. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0943 · Cited by 504 · see citing works
Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase
Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 467 · see citing works
Endothelial Glycocalyx Damage Coincides With Microalbuminuria in Type 1 Diabetes
Nieuwdorp, M., Mooij, H. L., Kroon, J., Atasever, B., Spaan, J. A. E., İnce, C., Holleman, F., Diamant, M., Heine, R. J., Hoekstra, J. B. L., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1619 · Cited by 442 · see citing works
Self-citation
Simvastatin Versus Ezetimibe
Landmesser, U., Bahlmann, F. H., Mueller, M. F., Spiekermann, S., Kirchhoff, N., Schulz, S., Manes, C., Fischer, D., de Groot, K., Fliser, D., et al. (2005) · Circulation · doi:10.1161/01.cir.0000164260.82417.3f · Cited by 425 · see citing works
Blood flow and muscle metabolism: a focus on insulin action
Clark, M. G., Wallis, M. G., Barrett, E. J., Keske, M. A., Richards, S. M., Clerk, L. H., & Rattigan, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00408.2002 · Cited by 355 · see citing works
Endothelial Dysfunction: Cause of the Insulin Resistance Syndrome
Pinkney, J. H., Stehouwer, C. D. A., Coppack, S. W., & Yudkin, J. S. (1997) · Diabetes · doi:10.2337/diab.46.2.s9 · Cited by 350 · see citing works
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
Du, X., Edelstein, D., Obici, S., Higham, N., Zou, M., & Brownlee, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci23354 · Cited by 344 · see citing works
Prevention of Type 2 Diabetes Mellitus Through Inhibition of the Renin-Angiotensin System
Scheen, A. J. (2004) · Drugs · doi:10.2165/00003495-200464220-00004 · Cited by 293 · see citing works
Improved Islet Morphology after Blockade of the Renin- Angiotensin System in the ZDF Rat
Tikellis, C., Wookey, P. J., Candido, R., Andrikopoulos, S., Thomas, M. C., & Cooper, M. E. (2004) · Diabetes · doi:10.2337/diabetes.53.4.989 · Cited by 286 · see citing works
Thiazolidinediones in Type 2 Diabetes Mellitus
Diamant, M., & Heine, R. J. (2003) · Drugs · doi:10.2165/00003495-200363130-00004 · Cited by 278 · see citing works
Self-citation
Role of endothelial dysfunction in insulin resistance
Hsueh, W. A., & Quiñones, M. J. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00611-8 · Cited by 271 · see citing works
A Diabetes Outcome Progression Trial (ADOPT)
Viberti, G. C., Kahn, S. E., Greene, D. A., Herman, W. H., Zinman, B., Holman, R. R., Haffner, S. M., Levy, D. A., Lachin, J. M., Berry, R. A., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1737 · Cited by 270 · see citing works
Testing Endothelial Vasomotor Function
Ganz, P., & Vita, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000089507.19675.f9 · Cited by 249 · see citing works
Coronary vasa vasorum neovascularization precedes epicardial endothelial dysfunction in experimental hypercholesterolemia
Herrmann, J. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00347-9 · Cited by 226 · see citing works
Effects of short‐term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo‐controlled trial
de Jager, J., Kooy, A., Lehert, P., Bets, D., Wulffelé, M. G., Teerlink, T., Scheffer, P. G., Schalkwijk, C., Donker, A. J. M., & Stehouwer, C. D. A. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01420.x · Cited by 219 · see citing works
The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm
Dandona, P., Aljada, A., & Mohanty, P. (2002) · Diabetologia · doi:10.1007/s00125-001-0766-5 · Cited by 218 · see citing works
The effects of rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, on markers of endothelial cell activation, C-reactive protein, and fibrinogen levels in non-diabetic coronary artery disease patients
Sidhu, J. S., Cowan, D., & Kaski, J. C. (2003) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.04.001 · Cited by 197 · see citing works
Hemostatic Markers of Endothelial Dysfunction and Risk of Incident Type 2 Diabetes
Meigs, J. B., O’Donnell, C. J., Tofler, G. H., Benjamin, E. J., Fox, C. S., Lipinska, I., Nathan, D. M., SULLIVAN, L. M., D’Agostino, R. B., & Wilson, P. W. F. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1041 · Cited by 184 · see citing works
Effects of Adipocyte-Derived Cytokines on Endothelial Functions: Implication of Vascular Disease
Kougias, P., Chai, H., Lin, P. H., Yao, Q. C., Lumsden, A. B., & Chen, C. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2004.12.023 · Cited by 161 · see citing works
Rationale, design and recruitment characteristics of a large, simple international trial of diabetes prevention: the DREAM trial
The DREAM Trial Investigators (2004) · Diabetologia · doi:10.1007/s00125-004-1485-5 · Cited by 151 · see citing works
The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: A placebo-controlled, randomized clinical trial
Caballero, A. E., Delgado, A., Aguilar-Salinas, C. A., Herrera, A. N., Castillo, J. L., Cabrera, T., Gomez-Perez, F. J., & Rull, J. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0019 · Cited by 151 · see citing works
Why Syndrome X? From Harold Himsworth to the Insulin Resistance Syndrome
Reaven, G. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.001 · Cited by 142 · see citing works
Effect of plasminogen activator inhibitor–1 in diabetes mellitus and cardiovascular disease
Lyon, C. J., & Hsueh, W. A. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.08.014 · Cited by 131 · see citing works
Two consecutive high‐fat meals affect endothelial‐dependent vasodilation, oxidative stress and cellular microparticles in healthy men
Tushuizen, M. E., Nieuwland, R., Scheffer, P. G., Sturk, A., Heine, R. J., & Diamant, M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01914.x · Cited by 124 · see citing works
Self-citation
Peroxisome Proliferator–Activated Receptor-γ Activation With Pioglitazone Improves Endothelium-Dependent Dilation in Nondiabetic Patients With Major Cardiovascular Risk Factors
Campia, U., Matuskey, L. A., & Panza, J. A. (2006) · Circulation · doi:10.1161/circulationaha.105.549618 · Cited by 112 · see citing works
Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus
Schindhelm, R. K., Diamant, M., Bakker, S. J. L., van Dijk, R. A. J. M., Scheffer, P. G., Teerlink, T., Kostense, P. J., & Heine, R. J. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01502.x · Cited by 105 · see citing works
Self-citation
Postprandial dysmetabolism and cardiovascular disease in type 2 diabetes
Tushuizen, M. E., Diamant, M., & Heine, R. J. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.020511 · Cited by 104 · see citing works
Self-citation
Aggressive lipid lowering does not improve endothelial function in type 2 diabetes: the Diabetes Atorvastatin Lipid Intervention (DALI) Study: a randomized, double-blind, placebo-controlled trial.
van Venrooij, F. V., van de Ree, M. A., Bots, M., Stolk, R., Huisman, M., & Banga, J. (2002) · Diabetes Care · doi:10.2337/diacare.25.7.1211 · Cited by 101 · see citing works
The Association between Abdominal Visceral Fat and Carotid Stiffness Is Mediated by Circulating Inflammatory Markers in Uncomplicated Type 2 Diabetes
Diamant, M., Lamb, H. J., van de Ree, M. A., Endert, E. L., Groeneveld, Y., Bots, M. L., Kostense, P. J., & Radder, J. K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1579 · Cited by 98 · see citing works
Self-citation
Physiological Concentrations of Insulin Induce Endothelin-Dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor-α Dependence on c-Jun N-Terminal Kinase
Eringa, E. C., Stehouwer, C. D. A., Walburg, K. V., Clark, A. D., Amerongen, G. P. V. N., Westerhof, N., & Sipkema, P. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000198248.19391.3e · Cited by 79 · see citing works
Insulin resistance and endothelial dysfunction
Yki‐Järvinen, H. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(03)00033-2 · Cited by 77 · see citing works
Endothelial-Dependent Vasodilation and Incidence of Type 2 Diabetes in a Population of Healthy Postmenopausal Women
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Authors: Diamant, M., & Tushuizen, M. E.
Affiliations: Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
ORCID: Tushuizen, Maarten E.
Venue: Current Diabetes Reports
Publisher: Springer Science and Business Media LLC
Published: 2006-07
Volume: 6
Issue: 4
Pages: 279-286
ISSN: 1534-4827 (ISSN-L)
1539-0829
DOI: 10.1007/s11892-006-0061-4
OpenAlex: W2138371429
Cited by: 64
References: 84
Citations by year: 2026: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 1 · 2015: 5 · 2014: 1 · 2013: 5 · 2012: 5
FWCI: 0.58
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Diabetes Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords: metabolic syndrome, endothelial dysfunction, type 2 diabetes, cardiovascular disease, obesity, insulin resistance, hypertension, dyslipidemia, impaired glucose tolerance, prediabetes, cardiovascular risk factors
MeSH terms: Cardiovascular Diseases, Diabetes Mellitus, Type 2, Endothelium, Vascular, Humans, Hypertension, Obesity, Risk Factors, Glucose Intolerance, Metabolic Syndrome

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The metabolic syndrome and endothelial dysfunction: Common highway to type 2 diabetes and CVD?

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