Oxytocin Mediates Social Neuroprotection After Cerebral Ischemia

The oxytocin receptor system: structure, function, and regulation

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Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

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A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

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Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior

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Oxidants, antioxidants and the ischemic brain

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Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles

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Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome

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Cerebral Interleukin-6 is Neuroprotective during Permanent Focal Cerebral Ischemia in the Rat

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Oxytocin Attenuates Stress-Induced c-<i>fos</i>mRNA Expression in Specific Forebrain Regions Associated with Modulation of Hypothalamo–Pituitary–Adrenal Activity

Windle, R. J., Kershaw, Y. M., Shanks, N., Wood, S. A., Lightman, S. L., & Ingram, C. D. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3432-03.2004 · Cited by 408 · see citing works

Chapter 12 Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis

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Developmental consequences of oxytocin

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Psychosocial and Behavioral Predictors of Inflammation in Middle-Aged and Older Adults: The Chicago Health, Aging, and Social Relations Study

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Social facilitation of wound healing

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Physiological and Endocrine Effects of Social Contact

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Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation

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Simultaneous microdialysis in blood and brain: oxytocin and vasopressin release in response to central and peripheral osmotic stimulation and suckling in the rat

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Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells

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Social Support and Chronic Kidney Disease: An Update

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Central Oxytocin Administration Reduces Stress-Induced Corticosterone Release and Anxiety Behavior in Rats¹

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2006 Curt P. Richter award winner

DeVries, A. C., Craft, T. K. S., Glasper, E. R., Neigh, G. N., & Alexander, J. K. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.04.007 · Cited by 153 · see citing works

Oxytocin Protects Against Sepsis-Induced Multiple Organ Damage: Role of Neutrophils

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Oxytocin ameliorates oxidative colonic inflammation by a neutrophil-dependent mechanism

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The protective effect of oxytocin on renal ischemia/reperfusion injury in rats

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Social isolation alters neuroinflammatory response to stroke

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Interleukin‐6 Up‐Regulates the Oxytocin Receptor in Cultured Uterine Smooth Muscle Cells

Rauk, P. N., Friebe-Hoffmann, U., Chiao, J., Rauk, P. N., & Winebrenner, L. D. (2001) · American Journal of Reproductive Immunology · doi:10.1111/j.8755-8920.2001.450305.x · Cited by 109 · see citing works

Secretory Peptide Hormones Are Biochemical Antioxidants: Structure-Activity Relationship

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Social Support and Stroke and Coronary Heart Disease

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Psychoneuroimmune and endocrine pathways in cancer: Effects of stress and support

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Transcriptional Regulation of Oxytocin Receptor by Interleukin-1β and Interleukin-6

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Social Interaction Improves Experimental Stroke Outcome

Craft, T. K. S., Glasper, E. R., McCullough, L. D., Zhang, N., Sugo, N., Otsuka, T., Hurn, P. D., & DeVries, A. C. (2005) · Stroke · doi:10.1161/01.str.0000177538.17687.54 · Cited by 79 · see citing works

Disability, social support, and distress in rheumatoid arthritis: Results from a thirteen‐year prospective study

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Oxytocin exerts protective effects on in vitro myocardial injury induced by ischemia and reperfusionThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 1 of a 2-part Special Issue).

Ondrejčáková, M., Ravíngerová, T., Bakoš, J., Pancza, D., & Ježová, D. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-108 · Cited by 74 · see citing works

Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats

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Oxytocin alleviates hepatic ischemia–reperfusion injury in rats

Düşünceli, F., İşeri, S. Ö., Ercan, F., Gedik, N., Yeğen, C., & Yeğen, B. Ç. (2008) · Peptides · doi:10.1016/j.peptides.2008.02.010 · Cited by 70 · see citing works

Mechanisms Underlying Oxytocin-Induced Excitation of Supraoptic Neurons: Prostaglandin Mediation of Actin Polymerization

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Vasopressin in vascular regulation and water homeostasis in the brain.

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Structure of the Rat V1a Vasopressin Receptor Gene and Characterization of Its Promoter Region and Complete cDNA Sequence of the 3′-End

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Interleukin‐1β Down‐Regulates the Oxytocin Receptor in Cultured Uterine Smooth Muscle Cells

Rauk, P. N., & Friebe-Hoffmann, U. (2000) · American Journal of Reproductive Immunology · doi:10.1111/j.8755-8920.2000.430204.x · Cited by 42 · see citing works

Social isolation potentiates cell death and inflammatory responses after global ischemia

Weil, Z. M., Norman, G. J., Barker, J. M., Su, A. J., Nelson, R. J., & DeVries, A. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.70 · Cited by 41 · see citing works

Social contact influences histological and behavioral outcomes following cerebral ischemia

Karelina, K., Norman, G. J., Zhang, N., & DeVries, A. C. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.022 · Cited by 38 · see citing works

New nitro-monotetrazolium salts and their use in histochemistry

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Toward a neurology of loneliness

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Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics

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Rethinking minority stress: A social safety perspective on the health effects of stigma in sexually-diverse and gender-diverse populations

Diamond, L. M., & Alley, J. (2022) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104720 · Cited by 412 · see citing works

Is oxytocin “nature’s medicine”

Carter, C. S., Kenkel, W. M., MacLean, E. L., Wilson, S. R., Perkeybile, A. M., Yee, J. R., Ferris, C. F., Nazarloo, H. P., Porges, S. W., Davis, J. M., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019398 · Cited by 394 · see citing works

Social brain, social dysfunction and social withdrawal

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Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

Yuan, L., Liu, S., Bai, X., Gao, Y., Liu, G., Wang, X., Liu, D., Li, T., Hao, A., & Wang, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0541-7 · Cited by 213 · see citing works

One is the deadliest number: the detrimental effects of social isolation on cerebrovascular diseases and cognition

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Oxytocin receptors are expressed on dopamine and glutamate neurons in the mouse ventral tegmental area that project to nucleus accumbens and other mesolimbic targets

Peris, J., MacFadyen, K. A., Smith, J. A., de Kloet, A. D., Wang, L. A., & Krause, E. G. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24116 · Cited by 158 · see citing works

Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions

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Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation

Amini-Khoei, H., Mohammadi-Asl, A., Amiri, S., Hosseini, M.-J., Momeny, M., Hassanipour, M., Rastegar, M., Haj-Mirzaian, A., Mirzaian, A. H., Sanjarimoghaddam, H., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.022 · Cited by 153 · see citing works

The long and short term effects of motherhood on the brain

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Effects of route of administration on oxytocin-induced changes in regional cerebral blood flow in humans

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Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia

McKay, E. C., Beck, J. S., Khoo, S. K., Dykema, K. J., Cottingham, S. L., Winn, M. E., Paulson, H. L., Lieberman, A. P., & Counts, S. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz023 · Cited by 123 · see citing works

The transition to motherhood: linking hormones, brain and behaviour

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Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Mairesse, J., Zinni, M., Pansiot, J., Hassan-Abdi, R., Demené, C., Colella, M., Charriaut‐Marlangue, C., Novais, A. R. B., Tanter, M., Maccari, S., et al. (2018) · Glia · doi:10.1002/glia.23546 · Cited by 97 · see citing works

The psychoneuroimmunology of pregnancy

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Oxytocin-secreting system: A major part of the neuroendocrine center regulating immunologic activity

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Salubrious effects of oxytocin on social stress-induced deficits

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Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro

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A survey of neuroimmune changes in pregnant and postpartum female rats

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Protective effect of oxytocin on LPS-induced acute lung injury in mice

An, X., Sun, X., Hou, Y., Yang, X., Chen, H., Zhang, P., & Wu, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-39349-1 · Cited by 85 · see citing works

Social neuroscience: undoing the schism between neurology and psychiatry

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Why the cognitive ‘fountain of youth’ may be upstream: pathways to dementia risk and resilience through social connectedness

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An examination of changes in maternal neuroimmune function during pregnancy and the postpartum period

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Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways

Wang, P., Wang, S. C., Yang, H.-P., Lv, C., Jia, S., Liu, X., Wang, X., Meng, D., Qin, D., Zhu, H. F., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00454 · Cited by 73 · see citing works

Microbes and Oxytocin

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NF-κB contributes to the detrimental effects of social isolation after experimental stroke

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The inflammatory event of birth: How oxytocin signaling may guide the development of the brain and gastrointestinal system

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Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease

Deems, N. P., & Leuner, B. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100820 · Cited by 63 · see citing works

Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response

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Oxytocin alleviates cognitive and memory impairments by decreasing hippocampal microglial activation and synaptic defects via OXTR/ERK/STAT3 pathway in a mouse model of sepsis-associated encephalopathy

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Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials

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Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1

Moghadam, S. E., Tameh, A. A., Vahidinia, Z., Atlasi, M. A., Bafrani, H. H., & Naderian, H. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.10.020 · Cited by 59 · see citing works

Oxytocin administration prevents cellular aging caused by social isolation

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Neuropeptides: Potential neuroprotective agents in ischemic injury

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Oxytocin attenuates microglial activation and restores social and non-social memory in APP/PS1 Alzheimer model mice

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Neuro-Inflammation Modulation and Post-Traumatic Brain Injury Lesions: From Bench to Bed-Side

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Neuroendocrine regulation in stroke

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Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin

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Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system

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Chronic social isolation in the prairie vole induces endothelial dysfunction: implications for depression and cardiovascular disease

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Salsalate treatment following traumatic brain injury reduces inflammation and promotes a neuroprotective and neurogenic transcriptional response with concomitant functional recovery

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Prestroke Living Situation and Depression Contribute to Initial Stroke Severity and Stroke Recovery

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Reversal of the detrimental effects of post-stroke social isolation by pair-housing is mediated by activation of BDNF-MAPK/ERK in aged mice

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Oxytocin and Related Peptide Hormones: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

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Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration

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