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Cited by 263Stress Responses and CortisolNeuroendocrine regulation and behaviorWound Healing and Treatments

Social facilitation of wound healing

Detillion, Courtney E, Craft, Tara K.S, Glasper, Erica R, Prendergast, Brian J, DeVries, A.Courtney·2004·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2003.10.003
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Abstract

It is well documented that psychological stress impairs wound healing in humans and rodents. However, most research effort into influences on wound healing has focused on factors that compromise, rather than promote, healing. In the present study, we determined if positive social interaction, which influences hypothalamic-pituitary-adrenal (HPA) axis activity in social rodents, promotes wound healing. Siberian hamsters received a cutaneous wound and then were exposed to immobilization stress. Stress increased cortisol concentrations and impaired wound healing in isolated, but not socially housed, hamsters. Removal of endogenous cortisol via adrenalectomy eliminated the effects of stress on wound healing in isolated hamsters. Treatment of isolated hamsters with oxytocin (OT), a hormone released during social contact and associated with social bonding, also blocked stress-induced increases in cortisol concentrations and facilitated wound healing. In contrast, treating socially housed hamsters with an OT antagonist delayed wound healing. Taken together, these data suggest that social interactions buffer against stress and promote wound healing through a mechanism that involves OT-induced suppression of the HPA axis. The data imply that social isolation impairs wound healing, whereas OT treatment may ameliorate some effects of social isolation on health.

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Crossref · 10.1016/j.psyneuen.2003.10.003

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  • The selective bond between mother and lamb appears to be mediated in part by the development of an olfactory memory of the lamb which occurs in the main olfactory bulb.

    “The selective bond appears to be mediated in part by the development of an olfactory memory of the lamb which occurs in the main olfactory bulb [30].”

    From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [30]

  • Intraperitoneally-administered oxytocin lowered cortisol release and increased wound-healing in paired hamsters, whereas a centrally-administered oxytocin agonist decreased wound-healing.

    “Intraperitoneally-administered oxytocin lowered cortisol release and increased wound-healing in paired hamsters, whereas a centrally-administered oxytocin agonist decreased wound-healing (Detillion et al., 2004).”

    From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Detillion et al., 2004

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Authors
Detillion, C. E., Craft, T. K. S., Glasper, E. R., Prendergast, B. J., & DeVries, A. C.
Affiliations
The Ohio State University (US)
Corresponding author
DeVries, A.Courtney
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2004-09
Volume
29
Issue
8
Pages
1004-1011
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2003.10.003
OpenAlex
W2097571882
Cited by
259
References
32
Citations by year
2026: 2 · 2025: 10 · 2024: 10 · 2023: 3 · 2022: 16 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 16 · 2017: 16 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 17
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ohio State University
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords
wound healing, social facilitation, psychological stress, oxytocin, hypothalamic-pituitary-adrenal axis, cortisol, social isolation, Siberian hamster, adrenalectomy, social bonding, skin wounds
MeSH terms
Analysis of Variance, Animals, Cricetinae, Hydrocortisone, Immobilization, Oxytocin, Skin, Social Environment, Social Facilitation, Stress, Psychological, Wound Healing, Phodopus

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