Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles
Abstract
Although oxytocin (OT) and dopamine (DA) have been implicated in pair bond formation in monogamous prairie voles (Microtus ochrogaster), the nature of potential interactions between these two neurochemical systems and the brain circuits important for such interactions in the regulation of pair bonding have not been explored. Here, we demonstrated that access to both OT and DA D2-type receptors is necessary for pair bond formation, as blockade of either type of receptor prevented partner preferences induced by OT or a D2-type agonist. We also demonstrated that the nucleus accumbens (NAcc) is a brain area important for such OT-DA interactions. In NAcc, blockade of OT receptors prevented partner preferences induced by a D2-type agonist whereas blockade of D2-type, but not D1-type, DA receptors blocked OT-induced partner preferences. Together, our data suggest that concurrent activation of OT and DA D2-type receptors in NAcc is essential for pair bond formation in female prairie voles.
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Dopamine acts as a learning signal, helping to imprint details of the partner and to associate those details with positive emotions and relationship-promoting habits.
“It acts as learning signal, helping to imprint details of the partner and to associate those details with positive emotions and relationship-promoting habits (Aragona et al. 2006; Liu and Wang 2003; Curtis et al. 2006).”
From Natural Selection, Childrearing, and the Ethics of Marriage (and Divorce): Building a Case for the Neuroenhancement of Human Relationships (2012) · cites this paper as Liu and Wang 2003
In female prairie voles, direct oxytocin injection into NAcc induces partner preference.
“whereas the direct injection of OXT into the NAcc (7) does so in females”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [7]
Systemic administration of a dopaminergic antagonist effectively blocked the partner preference induced by OXT in female prairie voles.
“Supporting the notion that OXT-DA interactions might contribute to the OXT-induced effects on social bonding (Young et al., 2014), the systemic administration of a dopaminergic antagonist effectively blocked the partner preference induced by OXT in female prairie voles (Liu and Wang, 2003).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Liu and Wang, 2003
The effects of OT on partner preference in female prairie voles could be located in the nucleus accumbens and prefrontal cortex, but these studies did not include males.
“the effects of OT on partner preference in females could be located in the nucleus accumbens and in the prefrontal cortex, but these studies did not include males”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Liu and Wang, 2003
OT injected into the NAC is sufficient to induce pair bonds in female prairie voles without mating and interacts with DA D2R.
“In addition, OT injected into the NAC is sufficient to induce pair bonds in female prairie voles in the absence of mating, and interacts with DA D2R to do so (Liu and Wang 2003).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Liu and Wang 2003
In monogamous but not polygamous vole species, oxytocin receptors are found in the nucleus accumbens, a neural center associated with reward and reinforcement.
“In monogamous but not polygamous vole species, oxytocin receptors are found in the nucleus accumbens, a neural center associated with reward and reinforcement (Liu and Wang, 2003).”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Liu and Wang, 2003
DA, acting within the NAcc, plays a critical role in social bond formation in both male and female prairie voles.
“In addition to the AVP and OT systems, the neurotransmitter dopamine DA, acting within the NAcc, plays a critical role in social bond formation in both male and female prairie voles [24, 25].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [24]
Dopamine acting on D2, but not D1, receptors in the nucleus accumbens promotes partner preference formation in both male and female prairie voles.
“Dopamine (DA) acting on D2, but not on D1, receptors in the nucleus accumbens (NAc) promotes partner preference formation in both male and female prairie voles”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Liu and Wang 2003
Intra-NAc OT receptor activation facilitates partner preference formation in female, but not male, prairie voles.
“several studies have characterized the role of intra-NAc OR activation in facilitating partner preference formation in female, but not male, prairie voles”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Liu and Wang 2003
Endogenous vasopressin, and not oxytocin, regulated pair bonding in male prairie voles by acting at vasopressin 1a receptors in the ventral pallidum and lateral septum.
“It appeared that endogenous vasopressin, and not OT, regulated pair bonding in male prairie voles by acting at V1aR receptors in the ventral pallidum and lateral septum (Lim et al., 2004b; Lim and Young, 2004; Liu and Wang, 2003).”
From Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles (2016) · cites this paper as Liu and Wang, 2003
Dopamine is released in the NAcc during mating.
“Dopamine is released in the NAcc during mating and an intra-NAcc shell injection of dopamine 2 receptor antagonist inhibit mating-induced partner preference or partner preference induced by OT treatment (Aragona et al. 2003; Liu and Wang 2003; Wang et al. 1999).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Liu and Wang 2003
Intra-NAcc shell injection of dopamine 2 receptor antagonist inhibits mating-induced partner preference or partner preference induced by OT treatment.
“Dopamine is released in the NAcc during mating and an intra-NAcc shell injection of dopamine 2 receptor antagonist inhibit mating-induced partner preference or partner preference induced by OT treatment (Aragona et al. 2003; Liu and Wang 2003; Wang et al. 1999).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Liu and Wang 2003
Pair bond development is influenced by dopaminergic activity within the nucleus accumbens.
“Pair bond development is influenced by dopaminergic activity within the nucleus accumbens (Liu and Wang, 2003, Young et al., 1998).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Liu and Wang, 2003
Both D2 receptors and oxytocin receptors must be stimulated in order to facilitate the formation of partner preferences.
“For instance, it appears that both D2 receptors and oxytocin receptors must be stimulated in order to facilitate the formation of partner preferences (Liu and Wang, 2003).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Liu and Wang, 2003
Injection of a D2-receptor antagonist into the nucleus accumbens of female prairie voles can prevent partner preference formation induced by oxytocin and oxytocin antagonists can block partner preference formation induced by D2-receptor agonist administration.
“Injection of a D2-receptor antagonist into the nucleus accumbens of female prairie voles can prevent partner preference formation induced by oxytocin and oxytocin antagonists can block partner preference formation induced by D2-receptor agonist administration (Liu and Wang, 2003).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Liu and Wang, 2003
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A. Bartz, J., & Hollander, E. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.018 · Cited by 311 · see citing works
“Indeed, this notion was supported in two recent studies showing the role of dopamine in prairie vole partner preference formation (Aragona et al., 2006; Liu and Wang, 2003).”
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“In addition , OT injected into the NAC is sufficient to induce pair bonds in female prairie voles in the absence of mating and interacts with DA D2R to do so ( Liu and Wang 2003 ) .”
Alexander, R., Aragón, O. R., Bookwala, J., Cherbuin, N., Gatt, J. M., Kahrilas, I. J., Kästner, N., Lawrence, A. B., Lowe, L. J., Morrison, R., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.002 · Cited by 329 · see citing works
“Multifactorial processes within or between neurochemical groups (e.g., the interaction among dopamine and oxytocin in regulating a number of social behaviors; Liu and Wang, 2003; Pearce et al., 2017b) add to this presently opaque picture (Hung et al., 2017; Pearce et al., 2017b).”
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Biased Oxytocinergic Modulation of Midbrain Dopamine Systems
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“A key example is Oxt release into the vStr, which promotes affiliative social behavior (Liu and Wang, 2003; Shahrokh et al., 2010; Young and Wang, 2004).”
Bethlehem, R. A. I., van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.011 · Cited by 285 · see citing works
“Animal research has shown a great degree of overlap in OT and dopamine receptor binding sites (Baskerville et al., 2009; Liu and Wang, 2003; Smeltzer et al., 2006 As OT was originally associated with induction of labour, it is not surprising to find interactions with gonadal or sex steroid hormones.”
BackgroundCastro, D. C., & Bruchas, M. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.003 · Cited by 287 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
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“Concurrent activation of D2 dopamine and OTRs in the NAcc are necessary for partner preference formation in female prairie voles (Liu & Wang 2003).”
BackgroundThe prairie vole: An emerging model organism for understanding the social brain
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Beyond happiness: Building a science of discrete positive emotions.
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“…injection of a dopamine agonist into the nucleus accumbens can promote prairie vole pair bonding even without mating, but this effect can be reversed with administration of an oxytocin antagonist, suggesting that the pair-bonding process involves oxytocindopamine interaction (Liu & Wang, 2003).”
BackgroundHypothalamic Neural Circuits Regulating Maternal Responsiveness Toward Infants
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“…that studies on prairie voles investigating the synaptic plasticity changes that underlie the formation of longlasting social attachments between mates has also emphasized the positive involvement of DA action on D2 receptors in NAs (Gingrich, Liu, Cascio, Wang, & Insel, 2000; Liu & Wang, 2003).”
BackgroundOxytocin and human social behavior.
Campbell, A. (2010) · Personality and Social Psychology Review · doi:10.1177/1088868310363594 · Cited by 232 · see citing works
“Administration of OT induces central dopamine release and vice versa, and their coaction appears to be critical for partner preference (Edwards & Self, 2006; Liu & Wang, 2003; Young & Wang, 2004).”
BackgroundBreaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268 · see citing works
“So while dopamine (through D2 receptors) and oxytocin work together in the ventral striatum to “cement” partner preferences in monogamous species (Liu and Wang, 2003), oxytocin may inhibit dopamine in the same region to diminish drug reward.”
BackgroundNonapeptides and the evolutionary patterning of sociality
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“…voles, mice and primates) point toward two brain areas as being relevant for monogamous pair bonding — the nucleus accumbens in the case of OXT receptors, and the ventral pallidum in the case of AVP V1a receptors (Wang et al., 1997; Young et al., 1999; Liu and Wang, 2003; Lim et al., 2004a).”
BackgroundGroppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218 · see citing works
“The same effect can be observed when blocking dopamine during mating (22).”
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“Indeed, there is ample research to suggest to that common genetic variation in the receptor structure for these molecules may impact on some aspects of social functioning in humans; additionally, central administration of oxytocin seems to encourage certain social behaviors and cognitive capacities (Meyer-Lindenberg e…”
BackgroundSmeltzer, M. D., Curtis, J. T., Aragona, B. J., & Wang, Z. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.019 · Cited by 222 · see citing works
Self-citationLife in groups: the roles of oxytocin in mammalian sociality
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“…other studies indicate that while OTR activation in the NAc is necessary for male-female attachments in female prairie voles (Young et al., 2001; Liu and Wang, 2003), it is not sufficient to induce such attachments in other species; there must be other circuitry that further determines how…”
BackgroundMethodOxytocin and vasopressin: powerful regulators of social behavior
Caldwell, H. K. (2017) · The Neuroscientist · doi:10.1177/1073858417708284 · Cited by 216 · see citing works
Vasopressin, oxytocin and social behaviour
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“OT receptors are particularly notable in both the shell and the core of the NAcc and have been implicated, together with DA release, in pair bond formation in the monogamous female vole [17 ,32].”
BackgroundOxytocin and social motivation
Gordon, I., Martin, C., Feldman, R., & Leckman, J. F. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.007 · Cited by 211 · see citing works
“In the case of partner preference, mating-induced OT release may link sexual arousal and bonding by activating the mesolimbic dopamine circuit and causing release of DA from the NAcc (Aragona et al., 2003; Insel, 2003; Liu and Wang, 2003; Wang et al., 1999; Young and Wang, 2004).”
Genes, brains and mammalian social bonds
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“Bonding and affiliation in monogamous mammals Although OT-based affiliative bonding is likely to have evolved in mammals to activate maternal care and reinforce the mother–infant bond, other female affiliative interactions in rodents are also regulated by OT. In the monogamous prairie vole Microtus ochrogaster, female…”
BackgroundGoldman, M. B., Marlow-O’Connor, M., Torres, I. J., & Carter, C. S. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.09.019 · Cited by 211 · see citing works
“Antipsychotics are not known to alter oxytocin function, though dopamine and oxytocin may work together to facilitate social behaviors modulated by the nucleus accumbens (Liu and Wang, 2003).”
BackgroundDeconstructing sociality, social evolution and relevant nonapeptide functions
Goodson, J. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.005 · Cited by 206 · see citing works
“Endogenous OT acting via OT receptors (OTRs) in the nucleus accumbens is necessary for pair bonding in female prairie voles (Young et al., 2001; Liu and Wang, 2003); exogenous OT promotes pair bonding in the absence of mating (Liu and Wang, 2003); and viral vector-mediated upregulation of OTR expression in the nucleus…”
BackgroundInfluentialEllingsen, D., Leknes, S., Løseth, G. E., Wessberg, J., & Olausson, H. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01986 · Cited by 201 · see citing works
“These neurotransmitter systems likely interact with MOR and oxytocin processing in key brain regions involved in social and emotional processing (Hagelberg et al., 2002; Liu and Wang, 2003; Depue and Morrone-Strupinsky, 2005a; Lintas et al., 2011; Colasanti et al., 2012; Tops et al., 2014).”
BackgroundAnxiety, cortisol, and attachment predict plasma oxytocin
Tops, M., Van Peer, J. M., Korf, J., Wijers, A. A., & Tucker, D. M. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00510.x · Cited by 197 · see citing works
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“OT may be particularly related to pair-bond formation and parenting behavior in female voles (Liu and Wang, 2003; Olazabal and Young, 2006) and is also associated with mating (Carter, 1992).”
BackgroundFrascella, J., Potenza, M. N., Brown, L. L., & Childress, A. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05420.x · Cited by 191 · see citing works
Johnson, Z. V., Walum, H., Jamal, Y. A., Xiao, Y., Keebaugh, A. C., Inoue, K., & Young, L. J. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.11.011 · Cited by 190 · see citing works
“OT mediates its central effects by binding with high affinity to OT receptors (OTRs) and/or with lower affinity to vasopressin 1a (V1aR) receptors (Schorscher-Petcu et al., 2010; Song et al., 2014).”
Neural circuits of social behaviors: Innate yet flexible
Wei, D., Talwar, V., & Lin, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.012 · Cited by 186 · see citing works
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Walker, S. C., Trotter, P. D., Swaney, W. T., Marshall, A. G., & McGlone, F. P. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.01.001 · Cited by 193 · see citing works
“…monoamine systems, as well as with other neuropeptides, it facilitates a range of sensory and psychological processes essential for adaptive social behaviour, such as pair bonding and attachment formation (Insel and Young, 2001; Liu and Wang, 2003; Mitre et al., 2016; Yoshida et al., 2009).”
BackgroundInfluentialGobrogge, K. L., Liu, Y., Jia, X., & Wang, Z. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21364 · Cited by 178 · see citing works
“Nonetheless, the results from early studies indicate the involvement of brain structures, such as the anterior hypothalamus (AH; Ferris and Potegal, 1988; Adams et al., 1993; Delville et al., 2000; DeLeon et al., 2002b; Albers et al., 2006) and lateral septum (Albert and Brayley, 1979; David et al., 2004; Knyshevski e…”
BackgroundInfluentialSelf-citationHistone deacetylase inhibitors facilitate partner preference formation in female prairie voles
Wang, H., Duclot, F., Liu, Y., Wang, Z., & Kabbaj, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3420 · Cited by 173 · see citing works
Self-citationMaking room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 172 · see citing works
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“In female prairie voles, activation of both D2 and OT receptors is necessary for pair bonding, since blocking either receptor disrupts pair bond formation (Liu and Wang, 2003).”
BackgroundOxytocin and Social Relationships: From Attachment to Bond Disruption
Bosch, O. J., & Young, L. J. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_10 · Cited by 162 · see citing works
“…of OT receptor (OTR) in the NAc than do non-monogamous vole species, and several studies have characterized the role of intra-NAc OTR activation in facilitating partner preference formation in female, but not male, prairie voles (Liu and Wang 2003; Ross et al. 2009a, b; Keebaugh and Young 2011).”
BackgroundResultThe Resilience handbook: approaches to stress and trauma
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Early nurture epigenetically tunes the oxytocin receptor
Perkeybile, A. M., Carter, C. S., Wroblewski, K. L., Puglia, M. H., Kenkel, W. M., Lillard, T. S., Karaoli, T., Gregory, S. G., Mohammadi, N., Epstein, L., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.037 · Cited by 160 · see citing works
Monetary sacrifice among strangers is mediated by endogenous oxytocin release after physical contact
MORHENN, V, PARK, J., PIPER, E., & ZAK, P. (2008) · Evolution and Human Behavior · doi:10.1016/j.evolhumbehav.2008.04.004 · Cited by 158 · see citing works
“In several studies, OT release has been associated with higher ventromedial dopamine (Liu & Wang, 2003) providing a possible proximate motivation for monetary sacrifice.”
Background2006 Curt P. Richter award winner
DeVries, A. C., Craft, T. K. S., Glasper, E. R., Neigh, G. N., & Alexander, J. K. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.04.007 · Cited by 153 · see citing works
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“…of the OTR in the striatum promotes partner preference formation and alloparental care in adult female prairie voles (Olazábal and Young 2006; Keebaugh et al. 2015; Ross et al. 2009; Liu and Wang 2003) and conditioned place preference for social stimuli in adult male mice (Dölen et al. 2013).”
BackgroundOxytocin signaling in the medial amygdala is required for sex discrimination of social cues
Yao, S., Bergan, J., Lanjuin, A., & Dulac, C. (2017) · eLife · doi:10.7554/elife.31373 · Cited by 151 · see citing works
“OXT has been shown to regulate specific brain functions by facilitating the release of other neurotransmitters, in particular dopamine and serotonin (Dluzen et al., 1998; Dluzen et al., 2000; Ross et al., 2009; Liu and Wang, 2003; Olazabal and Young, 2006; Dolen et al., 2013).”
BackgroundBales, K. L., Plotsky, P. M., Young, L. J., Lim, M. M., Grotte, N., Ferrer, E., & Carter, C. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.009 · Cited by 150 · see citing works
“Dopamine has recently been identified for its crucial role both in pair-bonding (Aragona et al., 2003; Aragona et al., 2006; Liu and Wang, 2003; Wang et al., 1999) and parenting behavior (Lonstein, 2002).”
Beery, A. K., Lacey, E. A., & Francis, D. D. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21638 · Cited by 144 · see citing works
“Experimental manipulations of receptor activation and expression corroborate the importance of OT and VP signaling for the expression of social behavior (see, e.g., Liu and Wang, 2003; Lim et al., 2004c).”
BackgroundMattie Tops, A., Koole, S. L., IJzerman, H., & Buisman‐Pijlman, F. T. A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.015 · Cited by 146 · see citing works
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Self-citationThe social brain: Neurobiological basis of affiliative behaviours and psychological well-being
Walker, S. C., & McGlone, F. P. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.008 · Cited by 138 · see citing works
Oxytocin Mediates Social Neuroprotection After Cerebral Ischemia
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Neural Circuits for Social Cognition: Implications for Autism
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“The NAS is an integral part of the pair bonding circuitry and is the site where oxytocin, CRF, and dopamine act to modulate partner preference formation (Young et al, 2005); the CP is an anatomically adjacent region of striatum that is involved in goal-directed behavior and habit formation (Balleine and O’Doherty, 201…”
BackgroundDissecting the Role of Oxytocin in the Formation and Loss of Social Relationships
Hurlemann, R., & Scheele, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.013 · Cited by 136 · see citing works
“As such, this discrepancy compared with the role of OXT in prairie voles, where the peptide is necessary for the formation of new pair bonds (96), may be related to methodological differences in the assessment of pair bonding in rodents and humans or indicate a species-specific function of OXT.”
ResultLabeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques
Lee, M. R., Shnitko, T. A., Blue, S. W., Kaucher, A. V., Winchell, A. J., Erikson, D. W., Grant, K. A., & Leggio, L. (2020) · Nature Communications · doi:10.1038/s41467-020-15942-1 · Cited by 132 · see citing works
Oxytocin-like receptors mediate pair bonding in a socially monogamous songbird
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Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
If I Could Just Stop Loving You: Anti-Love Biotechnology and the Ethics of a Chemical Breakup
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“Another, more speculative, lead for an attachment-dissolving intervention may come from Capgras’s delusion (Capgras and Reboul-Lachaux [1923] 1994).”
BackgroundThe Neurobiology of Social Affiliation and Pair Bonding
Carter, C. S., & Keverne, E. B. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00004-8 · Cited by 128 · see citing works
Neurochemical regulation of pair bonding in male prairie voles
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Self-citationLove is more than just a kiss: a neurobiological perspective on love and affection
de Boer, A., van Buel, E. M., & Ter Horst, G. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.017 · Cited by 123 · see citing works
“…in female prairie voles, where administration of an oxytocin receptor antagonist blocks partner preference induced by D2 activation, whereas blockade of D2 receptors in the nucleus accumbens prevents partner preference formation induced by oxytocin (Young and Wang, 2004; Liu and Wang, 2003).”
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123 · see citing works
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“…et al., 2009; Hirosawa et al., 2012), modulates the social relevance of emotional stimuli (Kirsch et al., 2005), interacts with dopamine to regulate socio-affiliative behaviors (Liu and Wang, 2003; Zeki, 2007) and the appropriate assignment of salience to social stimuli (Skuse and Gallagher, 2009).”
BackgroundDopamine regulation of social choice in a monogamous rodent species
Aragona, B. J. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.015.2009 · Cited by 119 · see citing works
“Further, facilitation of partner preference formation by activation of oxytocin receptors is not effective if D2like receptors are blocked (Liu and Wang, 2003).”
BackgroundInfluentialInvestigating the genetic basis of altruism: the role of the COMT Val158Met polymorphism
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Overview of human oxytocin research
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κ-Opioid Receptors within the Nucleus Accumbens Shell Mediate Pair Bond Maintenance
Resendez, S. L., Kuhnmuench, M., Krzywosinski, T., & Aragona, B. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5779-11.2012 · Cited by 110 · see citing works
“Consistent with the methods established by previous studies (Liu and Wang, 2003; Aragona et al., 2006), subjects were implanted with 26-guage bilateral guide cannulae (Plastics One) anchored to the skull with stainless-steel screws and dental cement and aimed at the NAc shell ( 1.6 mm AP; 1 mm ML;…”
BackgroundMethodInfluentialOxytocin and Autism: A Systematic Review of Randomized Controlled Trials
Preti, A., Melis, M., Siddi, S., Vellante, M., Doneddu, G., & Fadda, R. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0040 · Cited by 114 · see citing works
“The oxytocin system is known to interact with the dopaminergic system (Liu and Wang 2003).”
Oxytocin and vasopressin: genetics and behavioral implications
Caldwell, H. K., & Young, W. S. (2006) · Handbook of Neurochemistry and Molecular Neurobiology · doi:10.1007/978-0-387-30381-9_25 · Cited by 113 · see citing works
- Authors
- Liu, Y., & Wang, Z. X.
- Affiliations
- Florida State University (US)
- Corresponding author
- Wang, Z.X
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 121
- Issue
- 3
- Pages
- 537-544
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2147762584
- Cited by
- 580
- References
- 47
- Citations by year
- 2026: 21 · 2025: 25 · 2024: 20 · 2023: 15 · 2022: 33 · 2021: 25 · 2020: 76 · 2019: 23 · 2018: 27 · 2017: 39 · 2016: 33 · 2015: 36 · 2014: 33 · 2013: 35 · 2012: 17
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh054554-06)
- National Institute of Mental Health (MH 58616, MH54554, MH-66734, R21MH066734, R01MH058616)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, dopamine, pair bonding, nucleus accumbens, dopamine D2 receptor, dopamine D1 receptor, mate preferences, monogamy, Microtus ochrogaster, receptor antagonism
- MeSH terms
- Animals, Behavior, Animal, Benzazepines, Arvicolinae, Dopamine, Dose-Response Relationship, Drug, Drug Administration Routes, Drug Interactions, Female, Hormone Antagonists, Male, Microinjections, Nucleus Accumbens, Oxytocin, Pair Bond, Salicylamides, Stereotaxic Techniques, Time Factors, Infusion Pumps, Implantable, Dopamine Agonists, Dopamine Antagonists, Quinpirole
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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