Neural Emotion Regulation Circuitry Underlying Anxiolytic Effects of Perceived Control over Pain
Open accessAbstract
Anxiolytic effects of perceived control have been observed across species. In humans, neuroimaging studies have suggested that perceived control and cognitive reappraisal reduce negative affect through similar mechanisms. An important limitation of extant neuroimaging studies of perceived control in terms of directly testing this hypothesis, however, is the use of within-subject designs, which confound participants' affective response to controllable and uncontrollable stress. To compare neural and affective responses when participants were exposed to either uncontrollable or controllable stress, two groups of participants received an identical series of stressors (thermal pain stimuli). One group ("controllable") was led to believe they had behavioral control over the pain stimuli, whereas another ("uncontrollable") believed they had no control. Controllable pain was associated with decreased state anxiety, decreased activation in amygdala, and increased activation in nucleus accumbens. In participants who perceived control over the pain, reduced state anxiety was associated with increased functional connectivity between each of these regions and ventral lateral/ventral medial pFC. The location of pFC findings is consistent with regions found to be critical for the anxiolytic effects of perceived control in rodents. Furthermore, interactions observed between pFC and both amygdala and nucleus accumbens are remarkably similar to neural mechanisms of emotion regulation through reappraisal in humans. These results suggest that perceived control reduces negative affect through a general mechanism involved in the cognitive regulation of emotion.
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Cognitive interventions have focused mainly on trying to reduce the threat value of pain, with some good evidence that we are identifying relevant processes.
“Cognitive interventions have focused mainly on trying to reduce the threat value of pain, with some good evidence that we are identifying relevant processes. 1,12,13”
From Patient action as means and end of chronic pain care: Risks and routes to meaningful action (2017) · cites this paper as [12]
The Discussion (page unavailable) identifies a neural circuit associated with reduced anxiety when participants perceived control over painful stimuli, supporting the claim that relevant processes are being identified. It does not establish that cognitive interventions have mainly focused on reducing pain’s threat value; this study examined perceived behavioral control rather than a cognitive intervention. (LLM, conf=0.84)
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- Authors
- Salomons, T. V., Nusslock, R., Detloff, A., Johnstone, T., & Davidson, R. J.
- Affiliations
- University of Wisconsin–Madison (US)
- Northwestern University (US)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2015-02-01
- Volume
- 27
- Issue
- 2
- Pages
- 222-233
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- PMC
- PMC4297314
- OpenAlex
- W1987088919
- Cited by
- 54
- References
- 55
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 5
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- University of Reading
- Curtin University of Technology
- University of Toronto
- National Institute of Mental Health (MH 43454, P50MH069315, MH069315, R01MH43454, R01MH043454, T32MH018931)
- National Center for Complementary and Integrative Health (P01AT004952)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- perceived control, anxiolytic effects, pain, thermal pain, cognitive reappraisal, emotion regulation, state anxiety, amygdala, nucleus accumbens, ventromedial prefrontal cortex, ventrolateral prefrontal cortex, functional connectivity, uncontrollable stress, negative affect
- MeSH terms
- Brain, Brain Mapping, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Pain, Perception, Stress, Psychological, Young Adult
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