Dopamine Alters the Fidelity of Working Memory Representations according to Attentional Demands

Fallon, Sean James; Zokaei, Nahid; Norbury, Agnes; Manohar, Sanjay G.; Husain, Masud

doi:10.1162/jocn_a_01073

Cited by 22Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesCognitive Abilities and Testing

Dopamine Alters the Fidelity of Working Memory Representations according to Attentional Demands

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Fallon, Sean James, Zokaei, Nahid, Norbury, Agnes, Manohar, Sanjay G., Husain, Masud·2017·Journal of Cognitive Neuroscience

DOI 10.1162/jocn_a_01073PMC PMC5889096

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Abstract

Capacity limitations in working memory (WM) necessitate the need to effectively control its contents. Here, we examined the effect of cabergoline, a dopamine D2 receptor agonist, on WM using a continuous report paradigm that allowed us to assess the fidelity with which items are stored. We assessed recall performance under three different gating conditions: remembering only one item, being cued to remember one target among distractors, and having to remember all items. Cabergoline had differential effects on recall performance according to whether distractors had to be ignored and whether mnemonic resources could be deployed exclusively to the target. Compared with placebo, cabergoline improved mnemonic performance when there were no distractors but significantly reduced performance when distractors were presented in a precue condition. No significant difference in performance was observed under cabergoline when all items had to be remembered. By applying a stochastic model of response selection, we established that the causes of drug-induced changes in performance were due to changes in the precision with which items were stored in WM. However, there was no change in the extent to which distractors were mistaken for targets. Thus, D2 agonism causes changes in the fidelity of mnemonic representations without altering interference between memoranda.

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Cabergoline enhanced WM performance in the absence of distractors but impaired WM in the presence of distractors.
“Another study that administered cabergoline (a dopamine D2 receptor agonist) to heathy participants found that cabergoline enhanced WM performance in the absence of distractors but impaired WM in the presence of distractors”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Fallon et al., 2017
Dopamine stimulation does not impair WM per se, but affects selective attention to task-relevant stimuli.
“arguing that dopamine stimulation does not impair WM per se, but affects selective attention to task‐relevant stimuli (Fallon et al., 2017).”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Fallon et al., 2017

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Authors: Fallon, S. J., Zokaei, N., Norbury, A., Manohar, S. G., & Husain, M.
Affiliations: University of Oxford (GB)
University of Cambridge (GB)
John Radcliffe Hospital (GB)
1University of Oxford
ORCID: Fallon, Sean James
Zokaei, Nahid
Norbury, Agnes
Manohar, Sanjay G.
Venue: Journal of Cognitive Neuroscience
Publisher: MIT Press - Journals
Published: 2017-04-01
Volume: 29
Issue: 4
Pages: 728-738
ISSN: 0898-929X (ISSN-L)
1530-8898
DOI: 10.1162/jocn_a_01073
PMC: PMC5889096
OpenAlex: W2558292291
Cited by: 22
References: 72
Citations by year: 2025: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 5
FWCI: 1.69
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 1308 d)
Locations: Journal of Cognitive Neuroscience (publishedVersion, cc-by)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion, cc-by)
PubMed Central (acceptedVersion, cc-by)
Cambridge University Engineering Department Publications Database (submittedVersion)
Funders: Wellcome Trust (206330)
British Academy
Medical Research Council (MR/P00878X/1)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords: working memory, dopamine, cabergoline, dopamine D2 receptor agonist, memory fidelity, attentional gating, distractor interference, precuing, response selection, stochastic modeling
MeSH terms: Cabergoline, Adult, Attention, Dopamine, Ergolines, Female, Humans, Male, Memory, Short-Term, Mental Recall, Task Performance and Analysis, Visual Perception, Receptors, Dopamine D2, Dopamine Agonists, Young Adult

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Dopamine Alters the Fidelity of Working Memory Representations according to Attentional Demands

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