First steps toward noninvasive intraocular pressure monitoring with a sensing contact lens
Open accessAbstract
PURPOSE: To present a novel and minimally invasive approach to intraocular pressure (IOP) monitoring based on a sensing contact lens. METHODS: The key element of this measurement method is a soft contact lens with an embedded microfabricated strain gauge allowing the measurement of changes in corneal curvature correlated to variations in IOP. A prototype of this sensing contact lens was adapted and tested on enucleated porcine eyes. To verify the measurement principle of the device, the posterior chamber of the pig eyes was cannulated and connected to a syringe pump and a pressure sensor for precise control of IOP. The measurements of the contact lens were then compared to the ones from the pressure sensor, while pressure variations were induced through the cannula. RESULTS: Enucleated porcine eyes were stimulated with increasing and decreasing ramps of IOP. Measurements from the sensing contact lens and from the pressure sensor showed very good correlation, proving the high potential of this new measurement principle. In this study, a typical signal from the sensing contact lens obtained during the experiments is presented and discussed. CONCLUSIONS: The sensing contact lens shows the potential for continuously monitoring IOP in enucleated porcine eyes. The ultimate step will be the validation of the system and the reproducibility of results in humans. The device is placed in the same way as a corrective contact lens, no anesthesia is required, and vision remains almost unimpaired. This device would allow minimally invasive IOP monitoring over prolonged periods, regardless of the patient's position and activity, thus opening up new diagnostic and therapeutic methods for the management of glaucoma.
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The requirement for bulky and expensive equipment for signal measurements limits the use of smart contact lenses outside research laboratories or clinical settings by restricting users' external activities.
“(iv) the requirement for bulky and expensive equipment for signal measurements, which limits the use of smart contact lenses outside of research laboratories or clinical settings by restricting users’ external activities (14, 15, 20, 23).”
From Soft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays (2018) · cites this paper as [23]
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- Authors
- Leonardi, M., Leuenberger, P., Bertrand, D., Bertsch, A., & Renaud, P.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Department of Ophthalmology, Hopita¯l Universitaire de Gene`ve, Gene`ve, Switzerland; and the
- Department of Physiology, Centre Me´dical Universitaire, Gene`ve, Switzerland.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2004-09-01
- Volume
- 45
- Issue
- 9
- Pages
- 3113
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2062231812
- Cited by
- 244
- References
- 22
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 11 · 2019: 16 · 2018: 10 · 2017: 13 · 2016: 17 · 2015: 21 · 2014: 17 · 2013: 14 · 2012: 20
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Keywords
- intraocular pressure monitoring, strain gauges, corneal curvature, non-invasive pressure measurement, glaucoma management, porcine eyes, microfabricated sensors
- MeSH terms
- Animals, Contact Lenses, Intraocular Pressure, Monitoring, Physiologic, Swine, Tonometry, Ocular, Eye Enucleation, In Vitro Techniques
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